GREMLIN Database
YQAT - Uncharacterized protein YqaT
UniProt: P45916 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 431 (370)
Sequences: 2538 (2027)
Seq/√Len: 105.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
224_R230_H5.2781.00
278_V402_A4.6981.00
206_E210_Q3.7281.00
50_A117_L3.7161.00
280_V406_A3.1011.00
35_V150_S3.1011.00
119_W150_S2.9841.00
27_Y137_R2.9761.00
223_Y228_K2.9681.00
371_T375_L2.8931.00
161_F166_K2.8851.00
123_C149_L2.8801.00
28_G139_R2.7131.00
288_Y363_I2.6641.00
349_R404_W2.6161.00
121_E150_S2.5211.00
27_Y226_A2.5041.00
308_E311_E2.4501.00
128_Y163_H2.4451.00
197_T200_D2.4371.00
321_A339_M2.3831.00
25_G29_S2.3361.00
371_T403_I2.2991.00
243_E246_P2.2991.00
370_N373_Y2.2431.00
128_Y132_K2.2401.00
27_Y136_G2.2331.00
43_L50_A2.1941.00
120_I126_V2.1251.00
138_L147_M2.1201.00
206_E209_V2.1141.00
293_W312_F2.1021.00
239_L400_L2.0801.00
89_Q97_R2.0781.00
51_L115_I2.0551.00
394_T397_P2.0491.00
300_L308_E2.0441.00
243_E247_H2.0201.00
288_Y361_K1.9871.00
265_G406_A1.9821.00
278_V371_T1.9011.00
54_R60_H1.8901.00
290_Y363_I1.8741.00
293_W367_R1.8581.00
220_P224_R1.8371.00
296_Y370_N1.8081.00
208_Y212_L1.8011.00
131_F149_L1.7911.00
42_K117_L1.7781.00
25_G31_K1.7421.00
20_F191_T1.7171.00
199_D209_V1.7141.00
123_C160_T1.6981.00
274_Y374_E1.6661.00
244_E247_H1.6471.00
199_D228_K1.6431.00
120_I134_L1.6431.00
294_E368_C1.6411.00
153_P229_G1.6361.00
308_E312_F1.6341.00
262_K292_Y1.6261.00
346_Q350_L1.6171.00
195_H230_H1.6161.00
293_W315_T1.6131.00
309_L319_I1.6081.00
272_E398_H1.5981.00
245_R248_E1.5971.00
55_E130_G1.5711.00
240_P244_E1.5541.00
278_V291_I1.5401.00
275_N305_T1.5361.00
307_E335_H1.5241.00
254_I257_I1.5221.00
25_G152_N1.5061.00
241_Q244_E1.5041.00
284_H287_K1.5041.00
346_Q349_R1.5031.00
242_F247_H1.5001.00
303_D331_Y1.4971.00
54_R63_S1.4951.00
60_H100_F1.4881.00
375_L400_L1.4761.00
81_V90_I1.4721.00
242_F248_E1.4571.00
349_R352_Y1.4561.00
43_L96_S1.4491.00
210_Q213_E1.4481.00
110_K226_A1.4451.00
291_I371_T1.4371.00
24_V195_H1.4301.00
25_G229_G1.4241.00
264_V279_R1.4131.00
49_T97_R1.4051.00
296_Y399_T1.4041.00
397_P400_L1.4031.00
84_V89_Q1.3941.00
295_Y308_E1.3761.00
24_V193_Y1.3761.00
375_L403_I1.3751.00
21_Q148_I1.3641.00
26_G198_A1.3350.99
311_E315_T1.3280.99
327_K331_Y1.3260.99
297_K300_L1.3150.99
303_D307_E1.3060.99
213_E223_Y1.2880.99
276_A399_T1.2880.99
307_E311_E1.2800.99
280_V291_I1.2780.99
32_S111_S1.2740.99
327_K330_R1.2690.99
306_A335_H1.2570.99
118_I147_M1.2500.99
14_F38_K1.2480.99
120_I123_C1.2480.99
374_E397_P1.2330.99
137_R226_A1.2250.99
210_Q214_E1.2250.99
43_L98_I1.2240.99
209_V212_L1.2220.99
38_K42_K1.2210.99
328_T332_F1.2180.99
300_L304_K1.2140.99
128_Y162_K1.2090.99
394_T398_H1.1990.99
199_D213_E1.1960.99
265_G280_V1.1950.99
291_I403_I1.1930.99
40_V68_F1.1890.99
241_Q245_R1.1880.99
397_P401_S1.1860.99
330_R334_Q1.1810.99
151_T160_T1.1800.99
219_D222_L1.1800.99
12_F34_H1.1780.99
43_L81_V1.1770.99
69_D85_S1.1720.99
398_H404_W1.1710.99
60_H64_T1.1660.99
161_F231_F1.1640.98
208_Y211_Q1.1610.98
323_S344_K1.1600.98
270_F328_T1.1550.98
133_E136_G1.1540.98
48_R116_S1.1520.98
224_R228_K1.1430.98
83_C86_S1.1420.98
268_F321_A1.1260.98
353_T403_I1.1210.98
104_D108_K1.1190.98
265_G278_V1.1110.98
301_T358_R1.1050.98
84_V91_R1.0970.98
115_I118_I1.0950.98
269_G404_W1.0940.98
264_V313_A1.0920.98
120_I149_L1.0880.98
370_N399_T1.0840.98
266_M321_A1.0830.98
244_E248_E1.0820.98
158_N161_F1.0780.98
33_Y67_L1.0760.97
378_L392_E1.0650.97
35_V119_W1.0650.97
295_Y305_T1.0640.97
19_K211_Q1.0620.97
54_R152_N1.0610.97
247_H357_K1.0580.97
345_Y348_S1.0550.97
281_A292_Y1.0530.97
378_L394_T1.0520.97
238_V380_Y1.0490.97
22_F151_T1.0480.97
29_S196_S1.0410.97
397_P404_W1.0410.97
110_K151_T1.0380.97
9_F12_F1.0360.97
33_Y37_L1.0340.97
30_S34_H1.0320.97
28_G113_N1.0290.97
353_T357_K1.0280.97
110_K152_N1.0230.97
400_L403_I1.0130.96
396_D399_T1.0090.96
51_L101_K1.0010.96
40_V72_V0.9990.96
396_D400_L0.9930.96
54_R125_E0.9880.96
49_T116_S0.9850.96
118_I134_L0.9820.96
346_Q354_K0.9820.96
158_N231_F0.9800.96
36_A119_W0.9800.96
112_I115_I0.9760.96
123_C159_W0.9750.95
19_K207_S0.9720.95
197_T228_K0.9710.95
398_H406_A0.9710.95
302_D306_A0.9680.95
266_M275_N0.9660.95
136_G226_A0.9650.95
205_P208_Y0.9620.95
310_K335_H0.9610.95
321_A332_F0.9570.95
25_G54_R0.9540.95
269_G321_A0.9500.95
223_Y227_R0.9500.95
263_R410_Y0.9480.95
253_A256_N0.9460.95
378_L400_L0.9450.95
269_G275_N0.9440.95
293_W316_K0.9410.95
255_S258_N0.9370.94
365_S368_C0.9350.94
350_L378_L0.9320.94
152_N226_A0.9320.94
135_L147_M0.9240.94
21_Q146_H0.9230.94
381_A391_D0.9190.94
276_A402_A0.9190.94
244_E366_D0.9180.94
131_F147_M0.9170.94
234_N237_R0.9160.94
25_G28_G0.9130.94
283_D290_Y0.9110.94
18_Q192_Y0.9100.93
99_I115_I0.9090.93
12_F21_Q0.9060.93
212_L227_R0.9030.93
238_V378_L0.9000.93
38_K148_I0.8990.93
55_E125_E0.8980.93
264_V277_V0.8980.93
393_F397_P0.8950.93
39_I119_W0.8930.93
139_R201_N0.8930.93
154_V225_I0.8910.93
398_H401_S0.8890.93
240_P243_E0.8890.93
53_I126_V0.8880.93
64_T119_W0.8850.93
28_G204_L0.8840.92
331_Y334_Q0.8800.92
266_M277_V0.8800.92
401_S404_W0.8800.92
378_L397_P0.8770.92
11_E14_F0.8770.92
262_K316_K0.8750.92
127_K130_G0.8730.92
24_V231_F0.8710.92
357_K362_I0.8680.92
152_N225_I0.8640.92
350_L354_K0.8630.92
252_T366_D0.8600.91
36_A64_T0.8570.91
225_I231_F0.8550.91
66_S97_R0.8480.91
68_F90_I0.8450.91
60_H65_F0.8430.91
328_T331_Y0.8370.90
20_F135_L0.8370.90
52_V98_I0.8340.90
269_G272_E0.8270.90
209_V213_E0.8270.90
356_I407_L0.8250.90
50_A148_I0.8230.90
283_D288_Y0.8220.89
378_L404_W0.8210.89
279_R292_Y0.8190.89
331_Y335_H0.8170.89
302_D327_K0.8160.89
48_R117_L0.8140.89
396_D401_S0.8100.89
37_L71_L0.8100.89
291_I402_A0.8090.89
20_F131_F0.8090.89
82_R91_R0.8080.89
279_R316_K0.8060.89
23_L35_V0.8060.89
268_F322_D0.8050.88
306_A331_Y0.8050.88
364_C371_T0.8010.88
213_E228_K0.7960.88
85_S88_M0.7940.88
124_S160_T0.7940.88
254_I365_S0.7930.88
9_F30_S0.7910.88
110_K125_E0.7910.88
301_T327_K0.7900.88
323_S326_P0.7900.88
217_E220_P0.7890.87
398_H405_Y0.7870.87
207_S211_Q0.7870.87
57_Y61_R0.7860.87
241_Q246_P0.7850.87
371_T399_T0.7840.87
111_S121_E0.7830.87
356_I361_K0.7820.87
44_L77_L0.7790.87
190_D214_E0.7780.87
26_G229_G0.7760.87
310_K314_E0.7750.87
225_I232_G0.7740.86
92_F96_S0.7720.86
53_I103_M0.7720.86
362_I403_I0.7710.86
27_Y124_S0.7710.86
131_F159_W0.7700.86
67_L113_N0.7680.86
243_E361_K0.7680.86
371_T400_L0.7670.86
125_E154_V0.7670.86
294_E370_N0.7640.86
253_A257_I0.7620.86
270_F330_R0.7600.85
242_F246_P0.7600.85
374_E378_L0.7550.85
61_R89_Q0.7540.85
391_D394_T0.7540.85
356_I359_F0.7540.85
132_K222_L0.7510.85
201_N229_G0.7460.84
140_H143_L0.7440.84
28_G32_S0.7420.84
386_G391_D0.7420.84
33_Y71_L0.7390.84
18_Q21_Q0.7370.84
37_L75_L0.7330.83
350_L353_T0.7260.83
188_S214_E0.7250.83
269_G398_H0.7240.83
364_C368_C0.7210.82
399_T404_W0.7210.82
39_I50_A0.7200.82
400_L404_W0.7190.82
369_E373_Y0.7190.82
350_L357_K0.7170.82
262_K279_R0.7150.82
324_A344_K0.7140.82
344_K347_G0.7140.82
151_T231_F0.7120.82
11_E15_D0.7110.81
348_S352_Y0.7080.81
279_R312_F0.7060.81
274_Y398_H0.7060.81
61_R88_M0.7060.81
21_Q38_K0.7050.81
110_K121_E0.7040.81
31_K229_G0.7040.81
306_A313_A0.7020.81
261_L281_A0.7020.81
270_F326_P0.7010.81
102_G152_N0.7010.81
22_F149_L0.7000.80
63_S111_S0.6980.80
291_I362_I0.6970.80
91_R97_R0.6960.80
52_V119_W0.6940.80
20_F149_L0.6940.80
341_G344_K0.6930.80
274_Y296_Y0.6880.79
46_E96_S0.6880.79
319_I332_F0.6860.79
352_Y408_D0.6840.79
284_H288_Y0.6830.79
303_D334_Q0.6830.79
111_S123_C0.6810.79
131_F135_L0.6770.78
266_M276_A0.6760.78
107_A125_E0.6750.78
278_V403_I0.6730.78
269_G324_A0.6720.78
65_F100_F0.6700.77
25_G201_N0.6670.77
41_L45_R0.6630.77
312_F316_K0.6620.77
305_T309_L0.6620.77
357_K364_C0.6610.77
32_S64_T0.6600.76
25_G196_S0.6590.76
279_R313_A0.6570.76
38_K117_L0.6570.76
360_R363_I0.6560.76
16_W192_Y0.6560.76
83_C88_M0.6550.76
239_L378_L0.6520.76
255_S363_I0.6510.75
24_V152_N0.6500.75
262_K281_A0.6500.75
110_K124_S0.6490.75
268_F324_A0.6490.75
266_M305_T0.6460.75
241_Q247_H0.6460.75
149_L159_W0.6450.75
346_Q404_W0.6440.75
67_L70_E0.6420.74
390_E393_F0.6390.74
117_L148_I0.6390.74
118_I138_L0.6380.74
378_L398_H0.6370.74
35_V148_I0.6350.74
379_A393_F0.6350.74
136_G227_R0.6340.74
309_L312_F0.6340.74
342_A345_Y0.6330.73
40_V43_L0.6310.73
406_A410_Y0.6280.73
261_L317_E0.6260.73
72_V83_C0.6260.73
190_D210_Q0.6240.72
297_K308_E0.6240.72
400_L406_A0.6230.72
30_S201_N0.6220.72
251_M255_S0.6200.72
299_G302_D0.6190.72
268_F325_E0.6180.72
61_R85_S0.6180.72
19_K147_M0.6180.72
268_F329_I0.6160.71
125_E151_T0.6150.71
123_C126_V0.6150.71
261_L282_V0.6150.71
401_S405_Y0.6140.71
28_G31_K0.6130.71
10_K15_D0.6130.71
349_R353_T0.6130.71
54_R103_M0.6110.71
99_I112_I0.6090.71
238_V350_L0.6090.71
80_I92_F0.6070.70
27_Y110_K0.6070.70
280_V403_I0.6040.70
29_S152_N0.6040.70
48_R96_S0.6040.70
82_R93_S0.6020.70
134_L139_R0.6010.70
276_A294_E0.6010.70
22_F164_F0.6000.69
129_E132_K0.6000.69
244_E372_I0.5980.69
325_E328_T0.5980.69
378_L393_F0.5960.69
62_D99_I0.5960.69
255_S259_R0.5960.69
124_S225_I0.5950.69
399_T403_I0.5940.69
393_F396_D0.5930.69
38_K146_H0.5930.69
19_K190_D0.5920.68
110_K154_V0.5910.68
248_E253_A0.5900.68
133_E226_A0.5890.68
108_K125_E0.5860.68
265_G402_A0.5820.67
12_F23_L0.5810.67
19_K131_F0.5810.67
242_F245_R0.5800.67
55_E59_T0.5780.67
268_F294_E0.5780.67
247_H360_R0.5760.66
318_L340_V0.5760.66
266_M319_I0.5760.66
268_F326_P0.5690.65
348_S351_Q0.5680.65
162_K166_K0.5670.65
349_R397_P0.5660.65
54_R121_E0.5640.65
313_A316_K0.5630.65
141_P205_P0.5620.64
152_N229_G0.5600.64
132_K163_H0.5590.64
50_A98_I0.5590.64
55_E104_D0.5570.64
292_Y297_K0.5560.64
134_L138_L0.5550.63
280_V402_A0.5550.63
85_S91_R0.5540.63
54_R59_T0.5530.63
69_D86_S0.5530.63
81_V92_F0.5530.63
51_L109_L0.5510.63
300_L305_T0.5500.63
269_G378_L0.5490.63
364_C372_I0.5470.62
161_F165_F0.5470.62
8_H200_D0.5470.62
49_T66_S0.5460.62
41_L44_L0.5440.62
352_Y356_I0.5440.62
198_A227_R0.5420.62
252_T256_N0.5420.62
53_I120_I0.5410.61
274_Y277_V0.5410.61
251_M254_I0.5410.61
40_V98_I0.5400.61
25_G150_S0.5390.61
39_I117_L0.5370.61
342_A348_S0.5350.61
27_Y54_R0.5330.60
68_F71_L0.5320.60
403_I406_A0.5310.60
19_K143_L0.5310.60
36_A67_L0.5300.60
268_F272_E0.5290.60
23_L150_S0.5290.60
57_Y104_D0.5290.60
124_S154_V0.5280.60
42_K46_E0.5280.60
254_I259_R0.5270.59
320_K409_D0.5270.59
236_I349_R0.5270.59
303_D335_H0.5270.59
198_A228_K0.5270.59
277_V309_L0.5260.59
407_L410_Y0.5260.59
124_S151_T0.5250.59
301_T304_K0.5250.59
279_R293_W0.5230.59
253_A365_S0.5230.59
369_E372_I0.5230.59
254_I260_P0.5220.59
321_A328_T0.5210.59
266_M309_L0.5210.59
26_G231_F0.5190.58
124_S136_G0.5180.58
291_I296_Y0.5180.58
136_G139_R0.5180.58
52_V65_F0.5180.58
396_D405_Y0.5160.58
282_V288_Y0.5160.58
26_G110_K0.5160.58
151_T198_A0.5160.58
260_P284_H0.5150.58
31_K153_P0.5150.58
240_P245_R0.5150.58
62_D101_K0.5140.58
21_Q194_H0.5130.57
96_S116_S0.5130.57
368_C372_I0.5130.57
157_D373_Y0.5130.57
329_I339_M0.5120.57
165_F231_F0.5120.57
42_K146_H0.5120.57
59_T108_K0.5110.57
275_N309_L0.5100.57
70_E107_A0.5090.57
272_E393_F0.5080.57
130_G133_E0.5080.57
234_N239_L0.5070.57
36_A71_L0.5060.56
63_S152_N0.5060.56
201_N204_L0.5040.56
322_D405_Y0.5030.56
42_K45_R0.5000.56
120_I147_M0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4idhA 1 0.9002 100 0.421 Contact Map
3cpeA 1 0.8933 100 0.501 Contact Map
4znkA 1 0.5267 100 0.61 Contact Map
2wbnA 1 0.3991 100 0.668 Contact Map
4bijA 3 0.826 99.9 0.69 Contact Map
4dkwA 1 0.4176 99.9 0.708 Contact Map
2o0jA 1 0.4919 99.9 0.712 Contact Map
3c6aA 1 0.3968 99.6 0.801 Contact Map
1rifA 1 0.3875 98.8 0.866 Contact Map
1wrbA 2 0.4014 98.6 0.872 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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