GREMLIN Database
YQAS - Uncharacterized protein YqaS
UniProt: P45915 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (214)
Sequences: 223 (176)
Seq/√Len: 12.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_K156_E4.4751.00
138_I167_R3.9970.99
18_Y33_K3.6030.99
34_S38_R3.5440.98
205_H209_N3.5230.98
18_Y30_N3.4880.98
212_K216_E3.4020.98
29_V33_K2.8940.95
30_N33_K2.6150.91
136_E167_R2.5040.89
74_A80_N2.3810.86
19_K30_N2.2230.82
118_Q176_S2.1310.79
12_Y15_G2.1130.79
8_A12_Y2.1010.78
143_K158_E1.9670.73
8_A16_M1.9490.73
8_A15_G1.9050.71
31_T38_R1.9010.71
189_F202_K1.8850.70
79_Q82_V1.8560.69
21_L32_I1.8010.66
18_Y29_V1.7900.66
202_K205_H1.7770.65
206_M209_N1.7730.65
216_E220_L1.7540.64
189_F206_M1.7310.63
136_E161_F1.7260.63
202_K206_M1.7140.62
19_K33_K1.7100.62
5_H39_H1.6990.62
31_T34_S1.6740.60
6_I10_K1.6440.59
138_I161_F1.6380.59
203_L209_N1.6330.58
12_Y34_S1.6280.58
56_K60_A1.6250.58
105_R113_D1.5930.57
18_Y37_Q1.5840.56
33_K38_R1.5620.55
56_K61_P1.5360.54
169_A176_S1.5360.54
25_Y39_H1.5340.54
142_K158_E1.5280.53
118_Q179_M1.5140.53
33_K37_Q1.5070.52
30_N37_Q1.5060.52
9_Y34_S1.4900.51
203_L206_M1.4690.50
22_A32_I1.4530.50
67_A70_N1.4450.49
12_Y30_N1.4320.48
161_F167_R1.4190.48
162_Q165_W1.4170.48
19_K53_V1.4120.47
30_N34_S1.4010.47
5_H9_Y1.3890.46
176_S179_M1.3890.46
19_K38_R1.3870.46
18_Y34_S1.3830.46
15_G39_H1.3780.46
18_Y42_Q1.3530.45
11_D28_S1.3520.44
21_L25_Y1.3300.43
193_A206_M1.3190.43
9_Y12_Y1.3100.42
8_A39_H1.3100.42
52_G55_T1.2930.42
25_Y33_K1.2910.41
8_A17_K1.2840.41
175_Q178_A1.2670.40
82_V88_S1.2540.40
16_M24_K1.2520.40
34_S39_H1.2330.39
137_M140_E1.2310.39
212_K217_I1.2140.38
205_H213_K1.2010.37
202_K209_N1.1830.36
29_V34_S1.1690.36
121_A175_Q1.1610.35
201_L214_K1.1520.35
33_K36_K1.1500.35
110_M114_Q1.1480.35
33_K42_Q1.1410.34
12_Y18_Y1.1400.34
19_K29_V1.1330.34
189_F193_A1.1250.34
18_Y36_K1.1210.33
5_H14_K1.1160.33
9_Y32_I1.1090.33
15_G30_N1.0990.33
86_F102_I1.0820.32
7_Q16_M1.0690.31
215_I221_T1.0690.31
24_K38_R1.0630.31
15_G34_S1.0590.31
209_N213_K1.0520.30
12_Y33_K1.0420.30
17_K34_S1.0220.29
190_D194_H1.0180.29
24_K33_K1.0150.29
5_H25_Y1.0050.29
7_Q11_D1.0030.28
21_L35_W1.0020.28
65_K68_L0.9980.28
9_Y14_K0.9900.28
12_Y39_H0.9820.28
19_K34_S0.9800.27
59_G64_N0.9770.27
142_K160_E0.9700.27
5_H12_Y0.9660.27
34_S47_A0.9610.27
17_K33_K0.9590.27
137_M161_F0.9550.26
46_G53_V0.9540.26
16_M30_N0.9500.26
47_A54_H0.9420.26
201_L209_N0.9360.26
66_N69_G0.9360.26
204_E214_K0.9330.26
207_R211_N0.9320.26
8_A11_D0.9320.26
47_A53_V0.9310.26
215_I222_E0.9300.26
5_H36_K0.9170.25
218_E221_T0.9100.25
162_Q166_D0.9070.25
28_S31_T0.8950.24
73_G80_N0.8930.24
81_A177_R0.8930.24
18_Y38_R0.8900.24
17_K38_R0.8840.24
137_M158_E0.8800.24
14_K39_H0.8710.23
136_E140_E0.8710.23
203_L213_K0.8710.23
5_H33_K0.8700.23
23_E26_G0.8660.23
32_I35_W0.8640.23
19_K42_Q0.8620.23
36_K42_Q0.8600.23
18_Y53_V0.8520.23
11_D19_K0.8510.23
210_I214_K0.8510.23
24_K34_S0.8500.23
98_I107_P0.8490.23
160_E165_W0.8390.22
111_I192_L0.8380.22
18_Y25_Y0.8380.22
19_K28_S0.8370.22
11_D18_Y0.8360.22
8_A34_S0.8350.22
33_K53_V0.8320.22
195_S203_L0.8270.22
146_S155_E0.8270.22
69_G75_P0.8270.22
15_G18_Y0.8240.22
6_I9_Y0.8220.22
27_V32_I0.8200.22
18_Y54_H0.8200.22
212_K215_I0.8200.22
189_F203_L0.8130.21
187_K191_E0.8090.21
10_K13_A0.8040.21
8_A18_Y0.8030.21
22_A36_K0.8010.21
9_Y13_A0.7990.21
82_V87_F0.7970.21
31_T47_A0.7890.21
193_A203_L0.7880.20
6_I14_K0.7860.20
35_W39_H0.7820.20
208_L213_K0.7810.20
34_S46_G0.7780.20
18_Y27_V0.7770.20
221_T226_P0.7730.20
138_I160_E0.7660.20
30_N54_H0.7630.20
16_M20_D0.7620.20
53_V56_K0.7610.20
196_E207_R0.7570.19
11_D39_H0.7560.19
144_K155_E0.7550.19
158_E161_F0.7550.19
59_G66_N0.7530.19
206_M213_K0.7530.19
24_K29_V0.7520.19
121_A172_L0.7480.19
154_V157_E0.7430.19
118_Q175_Q0.7420.19
193_A202_K0.7410.19
171_F179_M0.7380.19
33_K45_K0.7360.19
121_A124_R0.7350.19
167_R170_T0.7280.19
12_Y31_T0.7250.19
63_G66_N0.7240.18
5_H15_G0.7210.18
38_R47_A0.7200.18
17_K20_D0.7180.18
139_K163_F0.7150.18
38_R46_G0.7090.18
129_M169_A0.7090.18
62_L211_N0.7070.18
114_Q181_E0.7070.18
24_K45_K0.7050.18
48_P51_K0.7030.18
46_G49_L0.7020.18
67_A73_G0.7000.18
133_D136_E0.6950.18
129_M175_Q0.6930.18
116_Q120_A0.6870.17
137_M167_R0.6850.17
108_V189_F0.6830.17
173_N185_L0.6820.17
122_I178_A0.6760.17
51_K54_H0.6740.17
219_E223_E0.6720.17
5_H8_A0.6710.17
137_M142_K0.6680.17
52_G59_G0.6630.17
52_G56_K0.6620.17
222_E226_P0.6610.17
215_I220_L0.6600.17
191_E195_S0.6560.17
129_M176_S0.6520.16
79_Q88_S0.6500.16
25_Y29_V0.6500.16
28_S34_S0.6450.16
4_K13_A0.6390.16
17_K28_S0.6390.16
87_F119_Y0.6370.16
223_E226_P0.6350.16
190_D206_M0.6350.16
126_Q175_Q0.6330.16
5_H13_A0.6320.16
68_L73_G0.6300.16
143_K156_E0.6240.16
169_A179_M0.6210.16
11_D24_K0.6200.16
122_I175_Q0.6180.15
204_E213_K0.6170.15
70_N73_G0.6120.15
201_L207_R0.6110.15
118_Q169_A0.6110.15
139_K142_K0.6090.15
33_K43_R0.6090.15
5_H18_Y0.6070.15
5_H34_S0.6040.15
108_V202_K0.6010.15
145_K155_E0.6010.15
33_K47_A0.6010.15
25_Y46_G0.5990.15
111_I189_F0.5980.15
215_I223_E0.5920.15
175_Q181_E0.5900.15
114_Q179_M0.5880.15
34_S42_Q0.5880.15
11_D25_Y0.5870.15
124_R175_Q0.5850.15
8_A14_K0.5820.15
142_K163_F0.5810.15
17_K30_N0.5790.14
189_F205_H0.5790.14
212_K218_E0.5770.14
180_A184_N0.5770.14
13_A39_H0.5750.14
204_E209_N0.5720.14
9_Y33_K0.5700.14
218_E226_P0.5690.14
138_I142_K0.5690.14
110_M120_A0.5680.14
34_S45_K0.5610.14
137_M163_F0.5590.14
24_K31_T0.5580.14
38_R42_Q0.5570.14
14_K32_I0.5560.14
9_Y15_G0.5550.14
125_A168_H0.5540.14
9_Y39_H0.5530.14
193_A205_H0.5520.14
156_E161_F0.5510.14
208_L217_I0.5510.14
30_N38_R0.5460.14
122_I182_L0.5460.14
193_A209_N0.5430.14
95_T121_A0.5410.14
182_L187_K0.5410.14
11_D30_N0.5370.13
59_G69_G0.5360.13
10_K30_N0.5330.13
4_K25_Y0.5310.13
143_K161_F0.5290.13
172_L176_S0.5250.13
172_L175_Q0.5240.13
151_T154_V0.5230.13
8_A53_V0.5210.13
11_D38_R0.5200.13
97_S101_G0.5200.13
64_N67_A0.5200.13
63_G77_G0.5200.13
180_A183_R0.5190.13
129_M178_A0.5180.13
67_A74_A0.5170.13
219_E224_D0.5150.13
132_S138_I0.5150.13
29_V38_R0.5140.13
213_K217_I0.5130.13
121_A176_S0.5120.13
96_L113_D0.5110.13
141_L145_K0.5100.13
146_S157_E0.5100.13
3_D17_K0.5090.13
57_K61_P0.5080.13
84_H176_S0.5080.13
31_T54_H0.5070.13
6_I16_M0.5060.13
28_S44_K0.5060.13
10_K31_T0.5020.13
112_W131_V0.5010.13
22_A37_Q0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mzyA 1 0.2301 95.6 0.924 Contact Map
2lfwA 1 0.2636 95 0.927 Contact Map
2x48A 1 0.159 94.6 0.928 Contact Map
1tc3C 1 0.1883 94.3 0.929 Contact Map
2jn6A 1 0.364 94 0.93 Contact Map
2m8eA 1 0.1883 92.6 0.934 Contact Map
1jkoC 1 0.1548 92.4 0.934 Contact Map
1k78A 1 0.3891 92.2 0.935 Contact Map
2elhA 1 0.2552 91.1 0.936 Contact Map
3hugA 3 0.2176 90.9 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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