GREMLIN Database
YQAM - Uncharacterized protein YqaM
UniProt: P45910 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (251)
Sequences: 1908 (1534)
Seq/√Len: 96.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_N190_K3.9101.00
149_A184_I3.6841.00
197_M225_V2.9071.00
205_M247_Q2.7011.00
226_E263_K2.6561.00
181_L268_S2.6151.00
44_P47_K2.5601.00
92_K105_E2.5431.00
81_D86_K2.5271.00
179_H183_A2.4071.00
81_D85_G2.3861.00
109_R113_A2.3731.00
83_L86_K2.3721.00
285_S300_G2.2621.00
229_F268_S2.2421.00
184_I266_L2.1781.00
214_N217_A2.1761.00
194_V226_E2.1241.00
146_Y150_V2.1221.00
188_L227_V2.0831.00
272_T275_E2.0441.00
299_R302_R2.0221.00
121_I124_E2.0191.00
173_P285_S2.0141.00
133_F180_L2.0131.00
70_L73_P2.0051.00
81_D88_C1.9991.00
145_A180_L1.9451.00
81_D87_V1.9301.00
80_D84_L1.9251.00
75_D79_E1.9071.00
103_Q107_V1.9061.00
298_I302_R1.9061.00
150_V154_K1.8841.00
186_N190_K1.8721.00
81_D84_L1.8711.00
83_L87_V1.8551.00
135_T146_Y1.8441.00
181_L229_F1.8321.00
85_G88_C1.8161.00
233_L267_I1.8061.00
109_R112_I1.7581.00
153_Y187_N1.7561.00
130_F153_Y1.7161.00
201_Y230_I1.7041.00
43_C51_I1.7001.00
80_D83_L1.6701.00
153_Y188_L1.6641.00
152_Y156_F1.6631.00
201_Y208_L1.6471.00
204_G222_M1.6211.00
93_A96_W1.5551.00
169_L296_V1.5381.00
128_L182_T1.5251.00
181_L266_L1.5221.00
202_V235_K1.5221.00
121_I125_F1.5111.00
208_L246_W1.4961.00
185_M196_C1.4781.00
296_V299_R1.4671.00
223_R250_Q1.4611.00
232_D282_A1.4461.00
63_H67_Q1.4401.00
68_L72_V1.4181.00
130_F183_A1.4151.00
216_E220_D1.3830.99
274_D288_H1.3660.99
211_N215_L1.3610.99
73_P79_E1.3580.99
82_F85_G1.3460.99
223_R254_V1.3440.99
294_Y302_R1.3430.99
61_S65_D1.3220.99
41_F53_V1.3200.99
111_K115_L1.3030.99
185_M229_F1.3010.99
198_Y268_S1.3000.99
40_E44_P1.2980.99
132_N179_H1.2840.99
110_K113_A1.2780.99
137_G301_D1.2700.99
47_K51_I1.2560.99
106_C109_R1.2440.99
151_E155_D1.2430.99
115_L118_A1.2430.99
202_V254_V1.2400.99
273_I291_C1.2140.98
297_I302_R1.2100.98
258_R265_L1.1950.98
282_A286_R1.1950.98
80_D86_K1.1840.98
76_M79_E1.1840.98
196_C229_F1.1780.98
114_R117_A1.1710.98
252_Q256_N1.1650.98
234_F270_E1.1590.98
170_L295_I1.1560.98
209_K244_T1.1520.98
152_Y264_P1.1500.98
145_A296_V1.1460.98
48_D52_V1.1380.98
134_I301_D1.1370.98
83_L88_C1.1350.98
46_C51_I1.1310.98
284_G288_H1.1280.98
60_T63_H1.1140.97
295_I302_R1.1100.97
91_D94_S1.1050.97
73_P77_V1.1010.97
184_I210_A1.0990.97
141_M183_A1.0920.97
70_L74_D1.0870.97
80_D87_V1.0820.97
270_E282_A1.0680.97
84_L87_V1.0590.96
137_G143_K1.0580.96
202_V223_R1.0530.96
257_Y261_N1.0510.96
142_I296_V1.0510.96
168_A269_S1.0500.96
142_I145_A1.0410.96
265_L291_C1.0390.96
125_F128_L1.0350.96
129_L190_K1.0290.96
173_P203_E1.0230.96
85_G89_T1.0220.96
74_D79_E1.0170.95
122_T125_F1.0150.95
209_K212_F1.0140.95
175_S296_V1.0130.95
89_T93_A1.0010.95
267_I291_C1.0010.95
219_L223_R0.9960.95
172_Q175_S0.9930.95
133_F146_Y0.9910.95
259_Y289_Q0.9910.95
130_F184_I0.9900.95
63_H66_E0.9890.95
152_Y167_I0.9880.95
202_V250_Q0.9860.95
150_V187_N0.9830.95
80_D85_G0.9820.95
232_D286_R0.9790.94
38_K61_S0.9700.94
97_K100_Y0.9610.94
200_P203_E0.9580.94
166_S234_F0.9570.94
141_M297_I0.9500.93
219_L254_V0.9450.93
81_D89_T0.9430.93
82_F87_V0.9380.93
112_I115_L0.9340.93
83_L93_A0.9270.93
166_S264_P0.9270.93
73_P76_M0.9260.93
148_C294_Y0.9150.92
74_D77_V0.9100.92
80_D88_C0.9030.92
70_L79_E0.8940.91
91_D95_E0.8930.91
197_M221_A0.8890.91
115_L193_S0.8860.91
82_F88_C0.8820.91
148_C151_E0.8810.91
127_K132_N0.8810.91
212_F215_L0.8780.90
129_L183_A0.8770.90
234_F282_A0.8760.90
202_V253_S0.8740.90
69_D73_P0.8730.90
89_T95_E0.8710.90
208_L213_D0.8700.90
234_F241_P0.8680.90
86_K89_T0.8630.90
243_A247_Q0.8510.89
184_I229_F0.8490.89
88_C96_W0.8430.89
106_C110_K0.8360.88
189_I196_C0.8350.88
129_L186_N0.8330.88
99_T104_C0.8290.88
96_W106_C0.8280.88
57_H60_T0.8240.87
58_K62_W0.8190.87
172_Q281_E0.8190.87
207_D221_A0.8140.87
212_F247_Q0.8130.87
219_L250_Q0.8100.87
84_L88_C0.8060.86
124_E262_H0.8050.86
131_G266_L0.8020.86
104_C107_V0.7920.85
88_C94_S0.7910.85
254_V258_R0.7900.85
59_D63_H0.7890.85
37_E41_F0.7880.85
235_K270_E0.7880.85
208_L212_F0.7860.85
202_V249_E0.7830.85
107_V110_K0.7830.85
220_D224_K0.7780.84
97_K106_C0.7780.84
154_K192_K0.7770.84
101_S108_R0.7760.84
211_N218_K0.7640.83
200_P256_N0.7640.83
98_D101_S0.7630.83
256_N285_S0.7630.83
288_H293_D0.7620.83
39_A46_C0.7590.83
295_I299_R0.7570.83
98_D107_V0.7560.83
38_K43_C0.7530.82
99_T109_R0.7520.82
113_A120_G0.7480.82
100_Y104_C0.7460.82
210_A216_E0.7450.82
99_T103_Q0.7400.81
200_P279_I0.7400.81
43_C46_C0.7380.81
149_A167_I0.7380.81
81_D93_A0.7360.81
84_L89_T0.7360.81
201_Y234_F0.7350.81
267_I287_I0.7340.81
171_G231_D0.7330.81
189_I285_S0.7320.80
93_A104_C0.7280.80
89_T94_S0.7270.80
114_R118_A0.7270.80
250_Q253_S0.7240.80
101_S106_C0.7230.80
295_I300_G0.7210.79
145_A204_G0.7190.79
89_T92_K0.7160.79
84_L107_V0.7090.78
115_L195_H0.7070.78
92_K95_E0.7060.78
82_F109_R0.7040.78
125_F182_T0.7040.78
145_A294_Y0.6980.77
42_D46_C0.6980.77
39_A43_C0.6970.77
56_V60_T0.6960.77
40_E43_C0.6930.77
245_D249_E0.6930.77
98_D104_C0.6930.77
271_L276_I0.6850.76
100_Y106_C0.6830.76
39_A42_D0.6810.76
234_F267_I0.6780.75
208_L215_L0.6780.75
108_R112_I0.6770.75
57_H63_H0.6700.74
276_I284_G0.6690.74
141_M145_A0.6670.74
229_F266_L0.6650.74
168_A287_I0.6650.74
44_P77_V0.6640.74
208_L219_L0.6620.73
199_F222_M0.6610.73
168_A276_I0.6600.73
101_S104_C0.6570.73
235_K282_A0.6570.73
259_Y287_I0.6550.73
207_D218_K0.6550.73
157_Q192_K0.6540.73
82_F89_T0.6440.71
195_H226_E0.6430.71
134_I137_G0.6430.71
216_E219_L0.6420.71
154_K224_K0.6410.71
166_S290_M0.6370.71
168_A251_I0.6370.71
295_I298_I0.6360.70
188_L246_W0.6330.70
157_Q276_I0.6310.70
124_E127_K0.6310.70
197_M227_V0.6300.70
91_D96_W0.6300.70
209_K246_W0.6270.69
95_E101_S0.6250.69
93_A97_K0.6240.69
212_F250_Q0.6200.69
185_M268_S0.6190.68
234_F258_R0.6170.68
75_D78_S0.6150.68
94_S102_K0.6130.68
143_K147_E0.6100.67
123_E126_E0.6090.67
223_R253_S0.6080.67
203_E207_D0.6000.66
71_M78_S0.5980.66
249_E254_V0.5910.65
38_K42_D0.5850.64
168_A234_F0.5850.64
143_K150_V0.5850.64
258_R264_P0.5840.64
170_L201_Y0.5830.64
145_A199_F0.5820.64
203_E221_A0.5790.63
136_D301_D0.5780.63
200_P206_G0.5750.63
97_K102_K0.5710.62
83_L89_T0.5700.62
200_P251_I0.5690.62
78_S83_L0.5690.62
294_Y298_I0.5670.62
268_S289_Q0.5660.62
119_S227_V0.5650.61
241_P244_T0.5650.61
244_T250_Q0.5650.61
167_I227_V0.5650.61
232_D235_K0.5650.61
95_E105_E0.5650.61
96_W103_Q0.5630.61
147_E151_E0.5590.61
60_T255_L0.5550.60
121_I198_Y0.5550.60
178_T186_N0.5550.60
81_D97_K0.5530.60
206_G250_Q0.5520.60
169_L172_Q0.5510.59
173_P209_K0.5500.59
273_I293_D0.5490.59
93_A106_C0.5490.59
266_L290_M0.5480.59
166_S251_I0.5480.59
83_L99_T0.5470.59
94_S99_T0.5460.59
147_E154_K0.5460.59
207_D222_M0.5440.59
257_Y260_L0.5440.59
41_F44_P0.5440.59
104_C108_R0.5430.58
120_G261_N0.5410.58
149_A180_L0.5400.58
119_S122_T0.5400.58
250_Q254_V0.5380.58
170_L272_T0.5370.58
201_Y205_M0.5340.57
276_I300_G0.5340.57
270_E302_R0.5320.57
296_V301_D0.5320.57
37_E74_D0.5300.57
163_R289_Q0.5260.56
93_A99_T0.5250.56
68_L252_Q0.5240.56
97_K103_Q0.5230.56
49_R52_V0.5230.56
205_M243_A0.5210.55
128_L204_G0.5210.55
179_H301_D0.5200.55
256_N260_L0.5200.55
173_P235_K0.5200.55
169_L294_Y0.5190.55
205_M209_K0.5190.55
108_R193_S0.5170.55
164_Q264_P0.5160.55
82_F86_K0.5150.54
125_F218_K0.5150.54
143_K146_Y0.5140.54
144_D148_C0.5130.54
168_A200_P0.5110.54
205_M250_Q0.5110.54
248_V283_L0.5110.54
154_K158_K0.5100.54
230_I287_I0.5080.53
154_K181_L0.5080.53
173_P249_E0.5050.53
103_Q108_R0.5030.53
204_G253_S0.5030.53
106_C112_I0.5030.53
137_G294_Y0.5010.52
241_P258_R0.5010.52
168_A253_S0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m4wJ 3 0.7796 100 0.467 Contact Map
2qgzA 1 0.5623 100 0.496 Contact Map
2w58A 2 0.5815 100 0.587 Contact Map
3ec2A 1 0.5208 100 0.607 Contact Map
2z4sA 1 0.5655 100 0.611 Contact Map
1l8qA 1 0.5655 99.9 0.637 Contact Map
3bosA 2 0.5591 99.9 0.675 Contact Map
2vhjA 3 0.8211 99.9 0.695 Contact Map
2kjqA 1 0.4696 99.7 0.738 Contact Map
1g5tA 2 0.393 99.7 0.745 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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