GREMLIN Database
YQAL - Uncharacterized protein YqaL
UniProt: P45909 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (199)
Sequences: 871 (732)
Seq/√Len: 51.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_V13_R5.0241.00
190_R196_G5.0171.00
188_Q199_Q4.5611.00
136_R142_E4.1171.00
164_T200_S3.5921.00
190_R199_Q3.3461.00
157_K196_G3.1261.00
191_K195_Y2.9231.00
94_Y98_I2.8671.00
96_D100_L2.8351.00
190_R195_Y2.7201.00
165_A178_V2.6601.00
160_E163_K2.5991.00
94_Y97_Y2.3611.00
145_R179_Q2.3201.00
198_K201_S2.2441.00
18_E21_D2.1761.00
161_A182_L2.1041.00
130_Y166_F2.0891.00
149_M179_Q2.0541.00
133_K166_F2.0361.00
130_Y162_I1.9350.99
157_K190_R1.8970.99
154_G157_K1.8570.99
162_I178_V1.8470.99
157_K193_K1.8110.99
147_G151_D1.7770.99
129_L159_M1.7740.99
126_A162_I1.5840.98
127_F138_V1.5450.97
25_Y28_L1.5350.97
94_Y100_L1.5330.97
196_G200_S1.5290.97
52_L63_I1.5140.97
27_H30_K1.5120.97
127_F151_D1.5120.97
28_L31_R1.5090.97
131_E138_V1.5000.97
194_Q197_Y1.4960.97
160_E164_T1.4690.97
169_K176_S1.4030.95
172_A180_A1.3930.95
98_I101_G1.3850.95
31_R52_L1.3790.95
180_A183_S1.3770.95
141_M175_L1.3580.95
99_Q109_L1.3560.95
130_Y178_V1.3520.94
130_Y133_K1.3430.94
139_G144_Q1.3430.94
23_K28_L1.3390.94
135_A142_E1.3370.94
49_V67_L1.3360.94
28_L66_S1.3320.94
17_K38_Q1.3220.94
142_E175_L1.3090.93
50_V60_A1.2890.93
53_A59_S1.2830.93
160_E193_K1.2600.92
162_I166_F1.2590.92
130_Y136_R1.2440.92
128_E131_E1.2360.91
184_N188_Q1.2350.91
116_H119_V1.2030.90
24_I75_Y1.1920.90
164_T182_L1.1870.90
79_H93_H1.1830.89
136_R175_L1.1750.89
148_Y152_D1.1610.88
48_K51_E1.1580.88
164_T180_A1.1570.88
161_A165_A1.1560.88
130_Y142_E1.1530.88
146_I184_N1.1500.88
150_V153_Y1.1370.87
135_A162_I1.1350.87
197_Y201_S1.1060.86
48_K90_T1.1020.86
69_R73_Q1.1000.86
96_D101_G1.0880.85
143_A176_S1.0870.85
70_M182_L1.0720.84
47_I92_L1.0590.83
9_V33_E1.0400.82
133_K139_G1.0370.82
68_D72_K1.0360.82
136_R179_Q1.0350.82
29_F33_E1.0310.82
43_G67_L1.0160.81
10_V13_R1.0110.80
11_I16_F1.0110.80
104_M107_K1.0060.80
141_M174_S0.9980.80
164_T181_I0.9890.79
76_I84_K0.9860.79
130_Y175_L0.9740.78
156_E196_G0.9680.77
23_K27_H0.9640.77
26_D30_K0.9640.77
176_S179_Q0.9620.77
130_Y165_A0.9600.77
105_K108_A0.9560.77
52_L55_D0.9560.77
145_R175_L0.9540.76
143_A147_G0.9420.75
86_G91_I0.9410.75
15_P29_F0.9320.75
150_V158_V0.9290.74
117_Q120_D0.9260.74
136_R149_M0.9110.73
134_V142_E0.9070.73
37_N41_E0.9020.72
115_E119_V0.8980.72
19_F26_D0.8960.72
28_L33_E0.8960.72
14_L17_K0.8860.71
50_V54_K0.8800.70
98_I104_M0.8760.70
53_A60_A0.8750.70
126_A159_M0.8720.70
193_K197_Y0.8650.69
195_Y207_I0.8600.69
115_E120_D0.8500.68
113_Q116_H0.8500.68
100_L104_M0.8490.68
129_L133_K0.8460.67
174_S178_V0.8430.67
153_Y164_T0.8400.67
56_F66_S0.8390.67
171_K184_N0.8380.67
13_R17_K0.8360.66
161_A181_I0.8320.66
195_Y199_Q0.8310.66
155_E159_M0.8300.66
142_E162_I0.8260.65
149_M186_F0.8190.65
110_E114_I0.8190.65
116_H120_D0.8190.65
113_Q117_Q0.8160.65
184_N190_R0.8150.64
20_R57_N0.8100.64
22_E29_F0.8050.63
157_K205_H0.8050.63
208_S212_A0.8010.63
126_A150_V0.8000.63
172_A175_L0.7980.63
204_R207_I0.7930.62
130_Y139_G0.7870.62
9_V16_F0.7810.61
192_E202_Q0.7750.60
145_R196_G0.7660.60
162_I172_A0.7660.60
18_E81_L0.7610.59
149_M181_I0.7600.59
99_Q104_M0.7580.59
24_I28_L0.7540.58
109_L114_I0.7510.58
201_S205_H0.7490.58
35_R39_E0.7400.57
24_I30_K0.7380.57
133_K169_K0.7360.57
70_M161_A0.7340.56
23_K29_F0.7330.56
122_K154_G0.7290.56
15_P22_E0.7250.55
126_A131_E0.7240.55
16_F20_R0.7210.55
127_F146_I0.7200.55
22_E31_R0.7150.54
139_G166_F0.7130.54
193_K196_G0.7110.54
145_R160_E0.7100.54
130_Y146_I0.7080.54
115_E118_E0.7050.53
81_L89_V0.7000.53
114_I117_Q0.6980.53
76_I194_Q0.6950.52
63_I93_H0.6940.52
46_I78_L0.6940.52
135_A138_V0.6930.52
118_E121_D0.6930.52
21_D27_H0.6920.52
13_R16_F0.6910.52
127_F147_G0.6900.52
47_I52_L0.6850.51
126_A146_I0.6770.50
110_E117_Q0.6750.50
161_A164_T0.6750.50
165_A182_L0.6740.50
24_I29_F0.6690.50
170_G200_S0.6640.49
12_P76_I0.6630.49
27_H33_E0.6630.49
48_K78_L0.6630.49
165_A181_I0.6620.49
146_I204_R0.6610.49
175_L193_K0.6580.48
11_I29_F0.6580.48
134_V179_Q0.6570.48
53_A63_I0.6570.48
15_P19_F0.6520.48
173_A180_A0.6490.47
73_Q93_H0.6490.47
28_L69_R0.6480.47
143_A170_G0.6470.47
97_Y101_G0.6450.47
141_M169_K0.6430.47
144_Q163_K0.6410.47
62_Q65_Y0.6410.47
33_E38_Q0.6400.47
85_R90_T0.6370.46
35_R38_Q0.6340.46
72_K194_Q0.6340.46
177_Y181_I0.6310.46
127_F174_S0.6290.45
23_K30_K0.6280.45
99_Q108_A0.6280.45
40_L63_I0.6210.45
146_I150_V0.6200.44
25_Y32_A0.6180.44
76_I107_K0.6180.44
29_F32_A0.6150.44
138_V145_R0.6150.44
145_R176_S0.6100.43
37_N53_A0.6090.43
95_A99_Q0.6040.43
80_R89_V0.6020.43
159_M174_S0.5990.42
163_K192_E0.5970.42
94_Y101_G0.5950.42
121_D205_H0.5930.42
11_I106_N0.5920.42
28_L32_A0.5900.41
157_K185_P0.5890.41
110_E113_Q0.5880.41
153_Y179_Q0.5880.41
171_K189_K0.5880.41
129_L198_K0.5850.41
152_D198_K0.5840.41
138_V180_A0.5820.41
189_K196_G0.5810.40
65_Y193_K0.5800.40
19_F136_R0.5740.40
169_K179_Q0.5710.39
134_V145_R0.5700.39
95_A98_I0.5690.39
95_A102_N0.5690.39
176_S204_R0.5670.39
131_E136_R0.5630.39
136_R178_V0.5610.38
75_Y93_H0.5600.38
195_Y198_K0.5590.38
110_E122_K0.5560.38
174_S187_T0.5520.38
59_S69_R0.5490.37
146_I170_G0.5490.37
78_L90_T0.5480.37
137_S183_S0.5460.37
179_Q186_F0.5440.37
207_I210_D0.5420.37
130_Y137_S0.5410.37
179_Q183_S0.5410.37
149_M182_L0.5400.36
153_Y171_K0.5390.36
40_L67_L0.5380.36
183_S197_Y0.5380.36
159_M189_K0.5360.36
103_Y107_K0.5360.36
153_Y157_K0.5350.36
176_S196_G0.5340.36
14_L18_E0.5310.36
124_K132_N0.5310.36
121_D125_N0.5300.35
42_L47_I0.5280.35
85_R94_Y0.5250.35
208_S211_H0.5240.35
26_D29_F0.5210.35
202_Q205_H0.5200.35
129_L132_N0.5190.34
126_A158_V0.5190.34
105_K109_L0.5180.34
144_Q172_A0.5170.34
172_A176_S0.5120.34
39_E55_D0.5120.34
138_V162_I0.5110.34
131_E187_T0.5100.34
99_Q106_N0.5080.33
162_I179_Q0.5060.33
149_M175_L0.5050.33
31_R66_S0.5050.33
160_E173_A0.5040.33
133_K163_K0.5040.33
138_V155_E0.5040.33
83_Q89_V0.5030.33
48_K87_L0.5030.33
36_P39_E0.5020.33
120_D156_E0.5000.33
146_I166_F0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i5uA 1 0.2918 99.8 0.603 Contact Map
2zc2A 1 0.3133 99.8 0.608 Contact Map
2v79A 4 0.4764 99.4 0.726 Contact Map
2vn2A 4 0.4464 98.7 0.794 Contact Map
4ptaD 3 0.4506 97.4 0.852 Contact Map
4pt7A 3 0.4807 97.3 0.855 Contact Map
3jw4A 2 0.515 96 0.876 Contact Map
4mnuA 2 0.6266 95.7 0.878 Contact Map
3u2rA 4 0.5408 95.6 0.879 Contact Map
3broA 2 0.5708 95.6 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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