YQAK - BACSU - GREMLIN Contacts

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YQAK - Uncharacterized protein YqaK

UniProt:	P45908	Sequences: MATNQSIKNNIQKKQKNVPVQQQGATMKGLLSSPSVIKRFEEVLGKRATQFTASILSLYNSEQMLQKTDPMSVISSAMVAATLDLPIDKNLGYAWIVPYGGKAQFQLGYKGYIQLALRTGQYKSINCIPIHEGELQKWNPLTEEIEIDFEKRESDAVIGYAAYFELINGFRKTVYWTKAQVEKHKKKFSKSDFGWKNDWDAMALKTVLKAVLSKWGILSVEMQKAVIEEDETRERIDITNEADSSEIIDSEPSNKDETEKPSAQETDPFDGKPVDIKDDELPFD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	284 (242)
Sequences:	548 (450)
Seq/√Len:	28.9

ECOLI - RECT
BACSU - YQAK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
132_E	156_A	5.479	1.00
147_I	161_A	4.429	1.00
96_I	103_A	3.926	1.00
159_G	175_Y	3.818	1.00
114_Q	118_R	3.576	1.00
193_F	196_K	3.331	1.00
165_E	171_R	3.146	1.00
187_K	198_D	3.130	1.00
135_L	148_D	3.011	1.00
55_I	77_A	2.968	1.00
201_A	204_L	2.802	1.00
176_W	207_V	2.762	1.00
131_H	157_V	2.695	1.00
123_K	167_I	2.676	1.00
160_Y	181_V	2.597	0.99
182_E	199_W	2.596	0.99
193_F	197_N	2.550	0.99
93_Y	114_Q	2.544	0.99
129_P	157_V	2.505	0.99
133_G	155_D	2.490	0.99
162_A	211_V	2.392	0.99
178_K	182_E	2.297	0.99
176_W	180_Q	2.284	0.99
95_W	108_G	2.190	0.98
83_L	108_G	2.136	0.98
137_K	148_D	2.040	0.97
157_V	200_D	2.039	0.97
201_A	210_A	2.038	0.97
106_Q	209_K	1.916	0.96
127_C	204_L	1.905	0.96
64_M	67_K	1.881	0.95
94_A	105_F	1.854	0.95
116_A	122_Y	1.849	0.95
252_P	255_K	1.774	0.94
99_Y	106_Q	1.719	0.92
32_S	37_I	1.717	0.92
51_F	81_A	1.688	0.92
243_D	248_I	1.678	0.91
137_K	146_E	1.676	0.91
251_E	254_N	1.669	0.91
123_K	165_E	1.650	0.91
99_Y	104_Q	1.562	0.88
87_I	93_Y	1.557	0.88
160_Y	200_D	1.514	0.87
174_V	210_A	1.505	0.86
122_Y	216_G	1.499	0.86
176_W	210_A	1.497	0.86
97_V	106_Q	1.496	0.86
247_I	261_P	1.475	0.85
134_E	140_P	1.474	0.85
84_D	134_E	1.474	0.85
184_H	188_F	1.471	0.85
182_E	185_K	1.448	0.84
181_V	207_V	1.443	0.84
253_S	256_D	1.440	0.84
184_H	210_A	1.411	0.82
140_P	143_E	1.375	0.81
177_T	180_Q	1.368	0.80
93_Y	118_R	1.364	0.80
174_V	201_A	1.357	0.80
253_S	258_T	1.356	0.80
130_I	149_F	1.356	0.80
188_F	198_D	1.330	0.78
259_E	263_A	1.324	0.78
243_D	246_E	1.315	0.78
39_R	42_E	1.304	0.77
43_V	57_S	1.285	0.76
255_K	258_T	1.235	0.73
186_K	191_S	1.235	0.73
166_L	169_G	1.229	0.73
243_D	250_S	1.222	0.72
51_F	80_A	1.193	0.70
188_F	199_W	1.189	0.70
121_Q	166_L	1.188	0.70
190_K	193_F	1.181	0.69
253_S	260_K	1.171	0.69
187_K	197_N	1.167	0.69
26_T	29_G	1.166	0.68
62_E	89_K	1.165	0.68
69_D	72_S	1.157	0.68
106_Q	190_K	1.157	0.68
110_K	218_L	1.155	0.68
164_F	216_G	1.140	0.67
152_R	179_A	1.139	0.67
212_L	218_L	1.135	0.66
156_A	178_K	1.130	0.66
131_H	156_A	1.121	0.65
136_Q	149_F	1.120	0.65
47_R	84_D	1.117	0.65
73_V	103_A	1.103	0.64
194_G	197_N	1.092	0.63
246_E	257_E	1.077	0.62
180_Q	200_D	1.073	0.62
248_I	253_S	1.070	0.62
140_P	161_A	1.055	0.61
67_K	98_P	1.051	0.60
138_W	143_E	1.036	0.59
109_Y	206_T	1.035	0.59
257_E	260_K	1.029	0.59
254_N	263_A	1.016	0.58
225_A	229_E	1.014	0.57
113_I	118_R	1.013	0.57
21_Q	25_A	1.005	0.57
209_K	216_G	1.001	0.56
64_M	98_P	1.000	0.56
149_F	161_A	0.997	0.56
188_F	193_F	0.994	0.56
233_R	236_I	0.994	0.56
247_I	260_K	0.993	0.56
55_I	96_I	0.981	0.55
85_L	107_L	0.976	0.55
99_Y	203_A	0.973	0.54
250_S	256_D	0.970	0.54
160_Y	184_H	0.964	0.54
67_K	100_G	0.963	0.54
129_P	200_D	0.961	0.53
255_K	261_P	0.958	0.53
48_A	175_Y	0.957	0.53
256_D	262_S	0.951	0.53
125_I	145_I	0.947	0.52
83_L	109_Y	0.946	0.52
22_Q	25_A	0.943	0.52
57_S	88_D	0.939	0.52
138_W	176_W	0.932	0.51
250_S	253_S	0.931	0.51
133_G	154_S	0.926	0.51
53_A	57_S	0.918	0.50
138_W	175_Y	0.917	0.50
76_S	137_K	0.917	0.50
130_I	158_I	0.916	0.50
212_L	216_G	0.910	0.49
83_L	88_D	0.910	0.49
79_V	88_D	0.908	0.49
245_S	262_S	0.908	0.49
245_S	249_D	0.906	0.49
160_Y	203_A	0.904	0.49
99_Y	102_K	0.901	0.49
231_E	235_R	0.899	0.49
185_K	193_F	0.899	0.49
255_K	259_E	0.890	0.48
30_L	33_S	0.881	0.47
247_I	252_P	0.880	0.47
37_I	41_E	0.873	0.47
258_T	261_P	0.873	0.47
184_H	198_D	0.868	0.46
39_R	43_V	0.868	0.46
156_A	262_S	0.868	0.46
188_F	191_S	0.867	0.46
139_N	148_D	0.864	0.46
244_S	251_E	0.864	0.46
112_Y	209_K	0.862	0.46
244_S	250_S	0.859	0.45
254_N	258_T	0.855	0.45
136_Q	147_I	0.853	0.45
158_I	175_Y	0.852	0.45
83_L	115_L	0.849	0.45
68_T	103_A	0.848	0.45
58_L	89_K	0.846	0.44
139_N	146_E	0.843	0.44
157_V	160_Y	0.835	0.44
249_D	254_N	0.835	0.44
184_H	187_K	0.835	0.44
119_T	122_Y	0.831	0.43
58_L	88_D	0.828	0.43
68_T	104_Q	0.827	0.43
129_P	204_L	0.822	0.43
238_I	241_E	0.820	0.42
51_F	55_I	0.817	0.42
99_Y	189_S	0.816	0.42
245_S	250_S	0.810	0.42
245_S	251_E	0.810	0.42
198_D	201_A	0.810	0.42
72_S	76_S	0.809	0.42
136_Q	175_Y	0.807	0.41
130_I	159_G	0.802	0.41
99_Y	191_S	0.801	0.41
84_D	147_I	0.799	0.41
251_E	255_K	0.797	0.41
109_Y	113_I	0.794	0.40
83_L	95_W	0.794	0.40
84_D	161_A	0.793	0.40
256_D	261_P	0.792	0.40
258_T	262_S	0.791	0.40
140_P	147_I	0.787	0.40
25_A	33_S	0.783	0.40
64_M	97_V	0.774	0.39
50_Q	86_P	0.773	0.39
260_K	263_A	0.768	0.39
136_Q	140_P	0.763	0.38
249_D	256_D	0.761	0.38
154_S	179_A	0.760	0.38
139_N	144_E	0.759	0.38
43_V	78_M	0.758	0.38
244_S	257_E	0.757	0.38
31_L	59_Y	0.753	0.37
50_Q	95_W	0.750	0.37
247_I	258_T	0.750	0.37
243_D	247_I	0.744	0.37
77_A	114_Q	0.741	0.37
188_F	216_G	0.741	0.37
84_D	87_I	0.736	0.36
49_T	60_N	0.735	0.36
141_L	173_T	0.734	0.36
122_Y	168_N	0.731	0.36
54_S	86_P	0.727	0.36
48_A	159_G	0.725	0.35
133_G	152_R	0.719	0.35
142_T	161_A	0.719	0.35
114_Q	170_F	0.718	0.35
21_Q	24_G	0.716	0.35
249_D	261_P	0.715	0.35
185_K	198_D	0.713	0.35
185_K	196_K	0.713	0.35
154_S	180_Q	0.712	0.34
100_G	192_D	0.710	0.34
250_S	255_K	0.705	0.34
104_Q	229_E	0.704	0.34
93_Y	117_L	0.702	0.34
180_Q	221_E	0.699	0.34
186_K	196_K	0.692	0.33
33_S	52_T	0.690	0.33
24_G	59_Y	0.689	0.33
83_L	110_K	0.688	0.33
40_F	44_L	0.686	0.33
189_S	216_G	0.684	0.33
256_D	263_A	0.679	0.32
98_P	108_G	0.678	0.32
47_R	53_A	0.675	0.32
46_K	166_L	0.674	0.32
232_T	235_R	0.673	0.32
136_Q	158_I	0.670	0.32
244_S	260_K	0.670	0.32
253_S	259_E	0.670	0.32
95_W	109_Y	0.668	0.31
185_K	188_F	0.667	0.31
47_R	50_Q	0.665	0.31
88_D	95_W	0.665	0.31
105_F	110_K	0.662	0.31
27_M	32_S	0.661	0.31
160_Y	199_W	0.660	0.31
112_Y	230_D	0.660	0.31
116_A	120_G	0.659	0.31
183_K	197_N	0.658	0.31
67_K	183_K	0.657	0.31
129_P	177_T	0.657	0.31
235_R	242_A	0.657	0.31
181_V	249_D	0.656	0.31
252_P	260_K	0.655	0.31
124_S	143_E	0.654	0.31
251_E	259_E	0.654	0.31
153_E	258_T	0.651	0.30
31_L	242_A	0.650	0.30
84_D	136_Q	0.647	0.30
234_E	256_D	0.644	0.30
117_L	217_I	0.641	0.30
244_S	247_I	0.640	0.30
69_D	244_S	0.637	0.29
137_K	150_E	0.636	0.29
23_Q	29_G	0.635	0.29
190_K	198_D	0.635	0.29
80_A	94_A	0.634	0.29
228_E	233_R	0.632	0.29
243_D	252_P	0.632	0.29
250_S	257_E	0.631	0.29
246_E	255_K	0.630	0.29
80_A	212_L	0.630	0.29
227_I	231_E	0.622	0.28
185_K	191_S	0.622	0.28
113_I	208_L	0.620	0.28
224_K	237_D	0.620	0.28
27_M	59_Y	0.619	0.28
44_L	214_K	0.619	0.28
105_F	109_Y	0.618	0.28
195_W	205_K	0.615	0.28
102_K	261_P	0.615	0.28
127_C	208_L	0.608	0.28
119_T	217_I	0.608	0.28
51_F	77_A	0.606	0.27
254_N	257_E	0.606	0.27
184_H	189_S	0.606	0.27
252_P	259_E	0.606	0.27
239_T	242_A	0.604	0.27
48_A	181_V	0.603	0.27
40_F	50_Q	0.601	0.27
255_K	262_S	0.600	0.27
57_S	82_T	0.596	0.27
256_D	260_K	0.595	0.27
134_E	137_K	0.594	0.27
192_D	197_N	0.593	0.27
247_I	253_S	0.589	0.26
184_H	209_K	0.588	0.26
136_Q	163_Y	0.586	0.26
98_P	109_Y	0.586	0.26
250_S	260_K	0.585	0.26
145_I	234_E	0.584	0.26
50_Q	81_A	0.577	0.26
85_L	114_Q	0.576	0.26
128_I	141_L	0.574	0.26
72_S	103_A	0.572	0.25
38_K	150_E	0.569	0.25
176_W	201_A	0.567	0.25
43_V	53_A	0.567	0.25
254_N	262_S	0.565	0.25
19_P	23_Q	0.563	0.25
117_L	216_G	0.562	0.25
193_F	218_L	0.562	0.25
51_F	54_S	0.561	0.25
222_M	225_A	0.560	0.25
78_M	97_V	0.553	0.24
46_K	162_A	0.552	0.24
80_A	87_I	0.550	0.24
39_R	198_D	0.550	0.24
248_I	251_E	0.548	0.24
108_G	115_L	0.548	0.24
162_A	208_L	0.546	0.24
257_E	262_S	0.545	0.24
145_I	173_T	0.543	0.24
121_Q	167_I	0.543	0.24
73_V	164_F	0.542	0.24
178_K	257_E	0.541	0.24
40_F	53_A	0.541	0.24
57_S	79_V	0.541	0.24
80_A	86_P	0.541	0.24
95_W	98_P	0.539	0.23
69_D	172_K	0.539	0.23
244_S	248_I	0.538	0.23
169_G	195_W	0.537	0.23
87_I	134_E	0.535	0.23
179_A	237_D	0.535	0.23
188_F	212_L	0.534	0.23
33_S	41_E	0.533	0.23
58_L	61_S	0.533	0.23
140_P	163_Y	0.531	0.23
36_V	45_G	0.531	0.23
83_L	105_F	0.530	0.23
143_E	176_W	0.529	0.23
185_K	209_K	0.529	0.23
237_D	241_E	0.528	0.23
20_V	32_S	0.528	0.23
53_A	75_S	0.528	0.23
114_Q	121_Q	0.527	0.23
180_Q	210_A	0.527	0.23
129_P	160_Y	0.523	0.23
100_G	181_V	0.523	0.23
20_V	29_G	0.522	0.23
113_I	164_F	0.522	0.23
245_S	255_K	0.521	0.22
86_P	108_G	0.519	0.22
89_K	96_I	0.519	0.22
62_E	74_I	0.519	0.22
59_Y	77_A	0.517	0.22
19_P	102_K	0.516	0.22
24_G	150_E	0.516	0.22
182_E	186_K	0.516	0.22
43_V	201_A	0.512	0.22
92_G	108_G	0.509	0.22
47_R	221_E	0.507	0.22
67_K	258_T	0.507	0.22
43_V	81_A	0.505	0.22
233_R	240_N	0.503	0.22
76_S	79_V	0.502	0.21
200_D	203_A	0.500	0.21
131_H	152_R	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3e6pL	1	0.4507	16.8	0.965	Contact Map
4u7aA	1	0	14.1	0.966	Contact Map
3m9dG	1	0.1021	9.8	0.968	Contact Map
1p0zA	4	0.4577	5.3	0.972	Contact Map
3eaqA	2	0.257	5.1	0.972	Contact Map
3m91B	1	0.1092	4.6	0.973	Contact Map
4a8xB	1	0.0951	4	0.974	Contact Map
4ci2B	1	0.0176	3.7	0.974	Contact Map
1hjrA	2	0.5211	3.6	0.974	Contact Map
3sbxA	2	0.5317	3.4	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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