GREMLIN Database
YQAK - Uncharacterized protein YqaK
UniProt: P45908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 284 (242)
Sequences: 548 (450)
Seq/√Len: 28.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_E156_A5.4791.00
147_I161_A4.4291.00
96_I103_A3.9261.00
159_G175_Y3.8181.00
114_Q118_R3.5761.00
193_F196_K3.3311.00
165_E171_R3.1461.00
187_K198_D3.1301.00
135_L148_D3.0111.00
55_I77_A2.9681.00
201_A204_L2.8021.00
176_W207_V2.7621.00
131_H157_V2.6951.00
123_K167_I2.6761.00
160_Y181_V2.5970.99
182_E199_W2.5960.99
193_F197_N2.5500.99
93_Y114_Q2.5440.99
129_P157_V2.5050.99
133_G155_D2.4900.99
162_A211_V2.3920.99
178_K182_E2.2970.99
176_W180_Q2.2840.99
95_W108_G2.1900.98
83_L108_G2.1360.98
137_K148_D2.0400.97
157_V200_D2.0390.97
201_A210_A2.0380.97
106_Q209_K1.9160.96
127_C204_L1.9050.96
64_M67_K1.8810.95
94_A105_F1.8540.95
116_A122_Y1.8490.95
252_P255_K1.7740.94
99_Y106_Q1.7190.92
32_S37_I1.7170.92
51_F81_A1.6880.92
243_D248_I1.6780.91
137_K146_E1.6760.91
251_E254_N1.6690.91
123_K165_E1.6500.91
99_Y104_Q1.5620.88
87_I93_Y1.5570.88
160_Y200_D1.5140.87
174_V210_A1.5050.86
122_Y216_G1.4990.86
176_W210_A1.4970.86
97_V106_Q1.4960.86
247_I261_P1.4750.85
134_E140_P1.4740.85
84_D134_E1.4740.85
184_H188_F1.4710.85
182_E185_K1.4480.84
181_V207_V1.4430.84
253_S256_D1.4400.84
184_H210_A1.4110.82
140_P143_E1.3750.81
177_T180_Q1.3680.80
93_Y118_R1.3640.80
174_V201_A1.3570.80
253_S258_T1.3560.80
130_I149_F1.3560.80
188_F198_D1.3300.78
259_E263_A1.3240.78
243_D246_E1.3150.78
39_R42_E1.3040.77
43_V57_S1.2850.76
255_K258_T1.2350.73
186_K191_S1.2350.73
166_L169_G1.2290.73
243_D250_S1.2220.72
51_F80_A1.1930.70
188_F199_W1.1890.70
121_Q166_L1.1880.70
190_K193_F1.1810.69
253_S260_K1.1710.69
187_K197_N1.1670.69
26_T29_G1.1660.68
62_E89_K1.1650.68
69_D72_S1.1570.68
106_Q190_K1.1570.68
110_K218_L1.1550.68
164_F216_G1.1400.67
152_R179_A1.1390.67
212_L218_L1.1350.66
156_A178_K1.1300.66
131_H156_A1.1210.65
136_Q149_F1.1200.65
47_R84_D1.1170.65
73_V103_A1.1030.64
194_G197_N1.0920.63
246_E257_E1.0770.62
180_Q200_D1.0730.62
248_I253_S1.0700.62
140_P161_A1.0550.61
67_K98_P1.0510.60
138_W143_E1.0360.59
109_Y206_T1.0350.59
257_E260_K1.0290.59
254_N263_A1.0160.58
225_A229_E1.0140.57
113_I118_R1.0130.57
21_Q25_A1.0050.57
209_K216_G1.0010.56
64_M98_P1.0000.56
149_F161_A0.9970.56
188_F193_F0.9940.56
233_R236_I0.9940.56
247_I260_K0.9930.56
55_I96_I0.9810.55
85_L107_L0.9760.55
99_Y203_A0.9730.54
250_S256_D0.9700.54
160_Y184_H0.9640.54
67_K100_G0.9630.54
129_P200_D0.9610.53
255_K261_P0.9580.53
48_A175_Y0.9570.53
256_D262_S0.9510.53
125_I145_I0.9470.52
83_L109_Y0.9460.52
22_Q25_A0.9430.52
57_S88_D0.9390.52
138_W176_W0.9320.51
250_S253_S0.9310.51
133_G154_S0.9260.51
53_A57_S0.9180.50
138_W175_Y0.9170.50
76_S137_K0.9170.50
130_I158_I0.9160.50
212_L216_G0.9100.49
83_L88_D0.9100.49
79_V88_D0.9080.49
245_S262_S0.9080.49
245_S249_D0.9060.49
160_Y203_A0.9040.49
99_Y102_K0.9010.49
231_E235_R0.8990.49
185_K193_F0.8990.49
255_K259_E0.8900.48
30_L33_S0.8810.47
247_I252_P0.8800.47
37_I41_E0.8730.47
258_T261_P0.8730.47
184_H198_D0.8680.46
39_R43_V0.8680.46
156_A262_S0.8680.46
188_F191_S0.8670.46
139_N148_D0.8640.46
244_S251_E0.8640.46
112_Y209_K0.8620.46
244_S250_S0.8590.45
254_N258_T0.8550.45
136_Q147_I0.8530.45
158_I175_Y0.8520.45
83_L115_L0.8490.45
68_T103_A0.8480.45
58_L89_K0.8460.44
139_N146_E0.8430.44
157_V160_Y0.8350.44
249_D254_N0.8350.44
184_H187_K0.8350.44
119_T122_Y0.8310.43
58_L88_D0.8280.43
68_T104_Q0.8270.43
129_P204_L0.8220.43
238_I241_E0.8200.42
51_F55_I0.8170.42
99_Y189_S0.8160.42
245_S250_S0.8100.42
245_S251_E0.8100.42
198_D201_A0.8100.42
72_S76_S0.8090.42
136_Q175_Y0.8070.41
130_I159_G0.8020.41
99_Y191_S0.8010.41
84_D147_I0.7990.41
251_E255_K0.7970.41
109_Y113_I0.7940.40
83_L95_W0.7940.40
84_D161_A0.7930.40
256_D261_P0.7920.40
258_T262_S0.7910.40
140_P147_I0.7870.40
25_A33_S0.7830.40
64_M97_V0.7740.39
50_Q86_P0.7730.39
260_K263_A0.7680.39
136_Q140_P0.7630.38
249_D256_D0.7610.38
154_S179_A0.7600.38
139_N144_E0.7590.38
43_V78_M0.7580.38
244_S257_E0.7570.38
31_L59_Y0.7530.37
50_Q95_W0.7500.37
247_I258_T0.7500.37
243_D247_I0.7440.37
77_A114_Q0.7410.37
188_F216_G0.7410.37
84_D87_I0.7360.36
49_T60_N0.7350.36
141_L173_T0.7340.36
122_Y168_N0.7310.36
54_S86_P0.7270.36
48_A159_G0.7250.35
133_G152_R0.7190.35
142_T161_A0.7190.35
114_Q170_F0.7180.35
21_Q24_G0.7160.35
249_D261_P0.7150.35
185_K198_D0.7130.35
185_K196_K0.7130.35
154_S180_Q0.7120.34
100_G192_D0.7100.34
250_S255_K0.7050.34
104_Q229_E0.7040.34
93_Y117_L0.7020.34
180_Q221_E0.6990.34
186_K196_K0.6920.33
33_S52_T0.6900.33
24_G59_Y0.6890.33
83_L110_K0.6880.33
40_F44_L0.6860.33
189_S216_G0.6840.33
256_D263_A0.6790.32
98_P108_G0.6780.32
47_R53_A0.6750.32
46_K166_L0.6740.32
232_T235_R0.6730.32
136_Q158_I0.6700.32
244_S260_K0.6700.32
253_S259_E0.6700.32
95_W109_Y0.6680.31
185_K188_F0.6670.31
47_R50_Q0.6650.31
88_D95_W0.6650.31
105_F110_K0.6620.31
27_M32_S0.6610.31
160_Y199_W0.6600.31
112_Y230_D0.6600.31
116_A120_G0.6590.31
183_K197_N0.6580.31
67_K183_K0.6570.31
129_P177_T0.6570.31
235_R242_A0.6570.31
181_V249_D0.6560.31
252_P260_K0.6550.31
124_S143_E0.6540.31
251_E259_E0.6540.31
153_E258_T0.6510.30
31_L242_A0.6500.30
84_D136_Q0.6470.30
234_E256_D0.6440.30
117_L217_I0.6410.30
244_S247_I0.6400.30
69_D244_S0.6370.29
137_K150_E0.6360.29
23_Q29_G0.6350.29
190_K198_D0.6350.29
80_A94_A0.6340.29
228_E233_R0.6320.29
243_D252_P0.6320.29
250_S257_E0.6310.29
246_E255_K0.6300.29
80_A212_L0.6300.29
227_I231_E0.6220.28
185_K191_S0.6220.28
113_I208_L0.6200.28
224_K237_D0.6200.28
27_M59_Y0.6190.28
44_L214_K0.6190.28
105_F109_Y0.6180.28
195_W205_K0.6150.28
102_K261_P0.6150.28
127_C208_L0.6080.28
119_T217_I0.6080.28
51_F77_A0.6060.27
254_N257_E0.6060.27
184_H189_S0.6060.27
252_P259_E0.6060.27
239_T242_A0.6040.27
48_A181_V0.6030.27
40_F50_Q0.6010.27
255_K262_S0.6000.27
57_S82_T0.5960.27
256_D260_K0.5950.27
134_E137_K0.5940.27
192_D197_N0.5930.27
247_I253_S0.5890.26
184_H209_K0.5880.26
136_Q163_Y0.5860.26
98_P109_Y0.5860.26
250_S260_K0.5850.26
145_I234_E0.5840.26
50_Q81_A0.5770.26
85_L114_Q0.5760.26
128_I141_L0.5740.26
72_S103_A0.5720.25
38_K150_E0.5690.25
176_W201_A0.5670.25
43_V53_A0.5670.25
254_N262_S0.5650.25
19_P23_Q0.5630.25
117_L216_G0.5620.25
193_F218_L0.5620.25
51_F54_S0.5610.25
222_M225_A0.5600.25
78_M97_V0.5530.24
46_K162_A0.5520.24
80_A87_I0.5500.24
39_R198_D0.5500.24
248_I251_E0.5480.24
108_G115_L0.5480.24
162_A208_L0.5460.24
257_E262_S0.5450.24
145_I173_T0.5430.24
121_Q167_I0.5430.24
73_V164_F0.5420.24
178_K257_E0.5410.24
40_F53_A0.5410.24
57_S79_V0.5410.24
80_A86_P0.5410.24
95_W98_P0.5390.23
69_D172_K0.5390.23
244_S248_I0.5380.23
169_G195_W0.5370.23
87_I134_E0.5350.23
179_A237_D0.5350.23
188_F212_L0.5340.23
33_S41_E0.5330.23
58_L61_S0.5330.23
140_P163_Y0.5310.23
36_V45_G0.5310.23
83_L105_F0.5300.23
143_E176_W0.5290.23
185_K209_K0.5290.23
237_D241_E0.5280.23
20_V32_S0.5280.23
53_A75_S0.5280.23
114_Q121_Q0.5270.23
180_Q210_A0.5270.23
129_P160_Y0.5230.23
100_G181_V0.5230.23
20_V29_G0.5220.23
113_I164_F0.5220.23
245_S255_K0.5210.22
86_P108_G0.5190.22
89_K96_I0.5190.22
62_E74_I0.5190.22
59_Y77_A0.5170.22
19_P102_K0.5160.22
24_G150_E0.5160.22
182_E186_K0.5160.22
43_V201_A0.5120.22
92_G108_G0.5090.22
47_R221_E0.5070.22
67_K258_T0.5070.22
43_V81_A0.5050.22
233_R240_N0.5030.22
76_S79_V0.5020.21
200_D203_A0.5000.21
131_H152_R0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e6pL 1 0.4507 16.8 0.965 Contact Map
4u7aA 1 0 14.1 0.966 Contact Map
3m9dG 1 0.1021 9.8 0.968 Contact Map
1p0zA 4 0.4577 5.3 0.972 Contact Map
3eaqA 2 0.257 5.1 0.972 Contact Map
3m91B 1 0.1092 4.6 0.973 Contact Map
4a8xB 1 0.0951 4 0.974 Contact Map
4ci2B 1 0.0176 3.7 0.974 Contact Map
1hjrA 2 0.5211 3.6 0.974 Contact Map
3sbxA 2 0.5317 3.4 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.