GREMLIN Database
YQAJ - Uncharacterized protein YqaJ
UniProt: P45907 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (290)
Sequences: 706 (565)
Seq/√Len: 33.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
288_I293_L4.9651.00
77_A109_R4.7831.00
117_I158_A4.4671.00
43_K51_D3.9451.00
247_I251_Q3.6591.00
265_M271_G3.6491.00
176_R181_I3.3691.00
30_G147_Y3.3041.00
33_A188_E3.2751.00
146_H188_E3.0411.00
296_Q304_V2.9781.00
80_F159_Y2.8821.00
293_L300_V2.7241.00
116_A157_K2.7031.00
243_I250_L2.5971.00
144_V158_A2.4901.00
157_K173_E2.3520.99
49_W53_T2.3140.99
79_E83_R2.3120.99
292_K296_Q2.3060.99
149_G185_F2.2990.99
103_I185_F2.2250.99
32_D52_K2.2220.99
239_Q253_Q2.2120.99
301_Y305_K2.1790.99
178_D181_I2.1670.99
55_Q199_G2.1430.99
41_K139_S2.1170.99
63_S66_A2.0790.98
34_S40_N2.0200.98
297_F304_V1.9870.98
107_V151_L1.9740.98
103_I146_H1.9670.98
33_A146_H1.9390.97
103_I188_E1.9250.97
60_E66_A1.9020.97
246_Q250_L1.8480.97
192_W196_V1.8420.96
293_L297_F1.8400.96
37_L187_A1.8190.96
116_A159_Y1.7830.96
84_S171_W1.7730.96
37_L184_I1.7480.95
49_W55_Q1.7120.95
258_E262_K1.6930.94
35_I40_N1.6770.94
145_Q181_I1.6770.94
244_K254_A1.6660.94
22_I25_R1.6650.94
291_K295_D1.6440.93
33_A184_I1.6440.93
144_V148_L1.6420.93
62_Q66_A1.6410.93
123_T162_V1.6310.93
236_R260_Q1.6090.93
117_I144_V1.5920.92
119_E147_Y1.5760.92
27_G104_L1.5700.92
74_D78_K1.5570.91
103_I149_G1.5070.90
53_T199_G1.5000.90
148_L158_A1.4990.90
294_K301_Y1.4920.89
247_I254_A1.4840.89
106_N147_Y1.4720.89
49_W199_G1.4700.89
191_F196_V1.4690.89
35_I48_L1.4680.89
29_G32_D1.4600.88
247_I250_L1.4550.88
193_N198_G1.4420.88
288_I300_V1.4410.88
117_I148_L1.4220.87
115_K153_P1.4140.87
243_I257_L1.3940.86
178_D182_D1.3710.85
16_S19_E1.3470.84
62_Q70_S1.3460.84
254_A258_E1.3460.84
296_Q300_V1.3390.84
64_E168_K1.3320.83
29_G52_K1.3320.83
240_Y243_I1.3310.83
235_E239_Q1.3190.83
146_H150_V1.3100.82
149_G181_I1.3090.82
240_Y257_L1.3000.82
292_K304_V1.2990.82
189_I193_N1.2950.81
76_V122_T1.2840.81
34_S139_S1.2840.81
95_L107_V1.2580.79
74_D120_C1.2460.79
33_A36_I1.2380.78
107_V110_M1.2290.78
28_I36_I1.2250.78
142_V180_L1.2040.76
71_L75_I1.2030.76
80_F84_S1.1980.76
15_M106_N1.1880.75
43_K48_L1.1870.75
144_V160_F1.1810.75
288_I297_F1.1800.75
109_R120_C1.1800.75
233_N261_I1.1740.75
29_G147_Y1.1440.73
77_A118_L1.1410.72
76_V120_C1.1210.71
111_I118_L1.1170.71
94_I106_N1.1150.71
251_Q255_K1.1060.70
131_W137_P1.0700.67
64_E83_R1.0670.67
45_P195_K1.0670.67
77_A120_C1.0630.67
233_N257_L1.0610.67
66_A70_S1.0560.66
109_R118_L1.0540.66
68_F163_L1.0500.66
223_N269_E1.0500.66
44_T47_E1.0480.66
243_I254_A1.0420.65
67_Y79_E1.0390.65
25_R54_G1.0370.65
229_L271_G1.0340.65
53_T196_V1.0330.65
161_A169_F1.0330.65
90_R109_R1.0310.64
68_F79_E1.0260.64
164_I170_V1.0260.64
266_K271_G1.0260.64
95_L151_L1.0250.64
37_L142_V1.0110.63
286_N307_E1.0060.63
46_F50_L1.0060.63
233_N264_E1.0050.62
30_G106_N1.0040.62
50_L55_Q0.9960.62
24_R32_D0.9940.62
17_R21_L0.9830.61
271_G278_A0.9810.61
75_I79_E0.9780.60
79_E82_I0.9780.60
67_Y82_I0.9750.60
290_T294_K0.9730.60
297_F300_V0.9630.59
49_W198_G0.9600.59
48_L51_D0.9570.59
17_R70_S0.9490.58
195_K203_A0.9480.58
242_L246_Q0.9450.58
132_E172_K0.9360.57
152_G181_I0.9330.57
300_V304_V0.9310.56
262_K280_W0.9300.56
118_L161_A0.9290.56
193_N197_L0.9250.56
24_R52_K0.9220.56
239_Q243_I0.9200.56
49_W195_K0.9180.55
123_T127_N0.9110.55
296_Q303_K0.9020.54
250_L254_A0.9020.54
49_W201_A0.8960.54
232_A260_Q0.8910.53
293_L301_Y0.8880.53
86_K114_E0.8860.53
61_S66_A0.8810.52
64_E79_E0.8810.52
246_Q249_E0.8770.52
73_E119_E0.8750.52
105_A147_Y0.8740.52
159_Y173_E0.8730.52
31_S38_G0.8700.51
284_V307_E0.8620.51
47_E51_D0.8620.51
149_G176_R0.8550.50
77_A90_R0.8490.50
134_E172_K0.8380.49
85_G105_A0.8360.49
67_Y71_L0.8330.48
257_L264_E0.8310.48
297_F303_K0.8280.48
160_F174_I0.8250.48
68_F167_N0.8230.47
245_E252_S0.8220.47
68_F166_G0.8200.47
131_W160_F0.8190.47
162_V169_F0.8180.47
163_L166_G0.8150.47
184_I187_A0.8120.47
108_D143_Q0.8100.46
240_Y258_E0.8090.46
60_E63_S0.8080.46
253_Q257_L0.8070.46
21_L25_R0.8060.46
108_D121_K0.8020.46
121_K143_Q0.8020.46
102_F188_E0.8000.46
80_F116_A0.8000.46
236_R257_L0.8000.46
255_K259_N0.7990.45
76_V161_A0.7990.45
48_L54_G0.7960.45
92_K109_R0.7950.45
46_F210_A0.7940.45
250_L253_Q0.7900.45
97_H101_N0.7900.45
103_I150_V0.7880.45
205_D271_G0.7820.44
131_W164_I0.7810.44
240_Y244_K0.7780.44
286_N300_V0.7780.44
289_D306_K0.7770.44
88_V111_I0.7770.44
240_Y254_A0.7740.43
97_H185_F0.7730.43
30_G140_Y0.7730.43
257_L261_I0.7720.43
288_I304_V0.7690.43
41_K209_A0.7670.43
59_S66_A0.7640.43
272_F277_Q0.7620.42
111_I160_F0.7610.42
96_R99_E0.7580.42
103_I107_V0.7570.42
64_E68_F0.7560.42
58_V63_S0.7560.42
162_V209_A0.7520.42
75_I83_R0.7520.42
125_A145_Q0.7500.41
27_G80_F0.7490.41
22_I26_K0.7480.41
286_N305_K0.7380.41
87_K90_R0.7370.40
122_T163_L0.7320.40
247_I265_M0.7310.40
21_L27_G0.7300.40
34_S66_A0.7300.40
43_K47_E0.7290.40
51_D56_V0.7290.40
100_Y103_I0.7290.40
125_A168_K0.7270.40
183_M186_K0.7260.40
23_E104_L0.7250.39
249_E253_Q0.7240.39
35_I49_W0.7210.39
299_D302_E0.7190.39
36_I187_A0.7150.39
140_Y147_Y0.7150.39
286_N293_L0.7140.39
52_K165_G0.7140.39
269_E281_K0.7110.38
131_W166_G0.7090.38
148_L176_R0.7060.38
45_P48_L0.7060.38
58_V287_R0.7040.38
73_E143_Q0.7040.38
73_E108_D0.7040.38
261_I264_E0.7030.38
177_D180_L0.7000.37
253_Q256_E0.6950.37
146_H192_W0.6950.37
34_S142_V0.6940.37
142_V187_A0.6920.37
203_A245_E0.6910.37
131_W202_P0.6890.37
49_W202_P0.6890.37
73_E121_K0.6880.37
109_R113_G0.6870.36
145_Q174_I0.6860.36
226_A229_L0.6780.36
20_W24_R0.6760.36
72_L122_T0.6750.36
244_K258_E0.6730.35
83_R167_N0.6720.35
141_I177_D0.6710.35
107_V158_A0.6680.35
286_N290_T0.6670.35
115_K154_E0.6640.35
80_F147_Y0.6630.35
44_T207_S0.6610.34
23_E93_A0.6590.34
222_E269_E0.6590.34
69_G143_Q0.6560.34
69_G108_D0.6560.34
255_K279_C0.6550.34
132_E170_V0.6540.34
240_Y250_L0.6540.34
239_Q260_Q0.6540.34
223_N267_D0.6530.34
301_Y306_K0.6500.34
50_L53_T0.6470.33
18_D22_I0.6470.33
161_A201_A0.6460.33
240_Y247_I0.6440.33
131_W136_I0.6440.33
96_R104_L0.6440.33
59_S170_V0.6420.33
69_G121_K0.6420.33
244_K248_S0.6400.33
302_E307_E0.6400.33
77_A92_K0.6390.33
87_K92_K0.6380.33
300_V303_K0.6370.33
205_D278_A0.6330.32
205_D210_A0.6320.32
140_Y160_F0.6300.32
27_G32_D0.6300.32
30_G80_F0.6300.32
289_D296_Q0.6250.32
141_I180_L0.6250.32
84_S146_H0.6240.32
79_E184_I0.6230.32
230_T264_E0.6220.32
99_E185_F0.6190.31
89_R109_R0.6190.31
33_A142_V0.6190.31
26_K96_R0.6190.31
31_S36_I0.6180.31
293_L296_Q0.6180.31
295_D300_V0.6160.31
102_F146_H0.6160.31
297_F301_Y0.6160.31
20_W106_N0.6150.31
91_K110_M0.6120.31
187_A190_E0.6100.31
30_G40_N0.6090.31
37_L177_D0.6090.31
206_G209_A0.6050.30
285_S307_E0.6050.30
279_C283_V0.6050.30
67_Y166_G0.6040.30
72_L163_L0.6030.30
195_K200_Q0.6020.30
30_G52_K0.6020.30
42_W123_T0.6010.30
150_V188_E0.5960.30
297_F302_E0.5960.30
95_L152_G0.5950.30
76_V163_L0.5940.30
213_Y217_R0.5920.29
159_Y171_W0.5890.29
68_F165_G0.5880.29
32_D165_G0.5880.29
210_A259_N0.5860.29
185_F188_E0.5840.29
205_D214_L0.5840.29
260_Q264_E0.5830.29
102_F185_F0.5820.29
40_N139_S0.5820.29
293_L298_P0.5810.29
111_I116_A0.5790.29
109_R112_V0.5780.29
265_M278_A0.5770.28
73_E140_Y0.5770.28
160_F163_L0.5760.28
239_Q294_K0.5740.28
295_D303_K0.5720.28
77_A111_I0.5710.28
64_E167_N0.5700.28
39_L142_V0.5700.28
225_K269_E0.5700.28
252_S255_K0.5670.28
32_D43_K0.5660.28
86_K159_Y0.5640.28
102_F189_I0.5620.27
90_R267_D0.5620.27
235_E246_Q0.5610.27
54_G57_P0.5580.27
105_A150_V0.5580.27
57_P175_E0.5560.27
80_F161_A0.5560.27
61_S174_I0.5530.27
25_R303_K0.5520.27
250_L257_L0.5510.27
56_V61_S0.5500.27
36_I48_L0.5500.27
26_K190_E0.5490.27
204_L209_A0.5480.27
68_F160_F0.5480.27
27_G150_V0.5470.26
206_G259_N0.5470.26
235_E238_Q0.5450.26
30_G43_K0.5440.26
118_L144_V0.5430.26
161_A166_G0.5420.26
186_K190_E0.5420.26
14_E18_D0.5380.26
292_K306_K0.5380.26
46_F49_W0.5360.26
68_F71_L0.5360.26
195_K198_G0.5350.26
290_T306_K0.5340.26
64_E166_G0.5330.26
246_Q253_Q0.5290.25
97_H100_Y0.5290.25
134_E182_D0.5280.25
255_K258_E0.5280.25
69_G73_E0.5280.25
39_L184_I0.5260.25
74_D90_R0.5260.25
162_V166_G0.5250.25
274_G278_A0.5240.25
62_Q83_R0.5240.25
99_E152_G0.5240.25
290_T301_Y0.5220.25
148_L160_F0.5220.25
114_E162_V0.5210.25
106_N150_V0.5190.25
29_G165_G0.5180.25
243_I279_C0.5180.25
224_N227_I0.5170.25
47_E268_A0.5160.24
134_E168_K0.5160.24
44_T209_A0.5150.24
28_I192_W0.5140.24
116_A173_E0.5130.24
236_R264_E0.5120.24
91_K271_G0.5100.24
23_E44_T0.5100.24
190_E195_K0.5100.24
119_E140_Y0.5070.24
36_I111_I0.5050.24
287_R290_T0.5040.24
236_R291_K0.5040.24
42_W136_I0.5040.24
96_R151_L0.5040.24
165_G168_K0.5030.24
154_E157_K0.5020.24
71_L79_E0.5020.24
124_S127_N0.5020.24
184_I188_E0.5010.24
219_A224_N0.5000.24
182_D220_E0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3syyA 3 0.5768 100 0.488 Contact Map
3sm4A 3 0.6458 100 0.498 Contact Map
3k93A 3 0.5674 100 0.55 Contact Map
2w45A 1 0.7868 99.9 0.701 Contact Map
3fhdA 1 0.7555 99.7 0.788 Contact Map
4r5qA 1 0.5768 96.5 0.919 Contact Map
4ic1A 5 0.6082 95.1 0.927 Contact Map
3l0aA 3 0.6708 93.3 0.933 Contact Map
3h4rA 3 0.5705 79.9 0.946 Contact Map
4r8aA 1 0.442 39.5 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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