GREMLIN Database
PRMC - Release factor glutamine methyltransferase
UniProt: P45873 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (268)
Sequences: 5732 (4405)
Seq/√Len: 269.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_M67_V4.7961.00
84_M157_A3.9371.00
75_K82_E3.6921.00
130_A144_A2.9561.00
171_G176_P2.5941.00
271_K277_D2.5931.00
88_D150_E2.5821.00
149_K170_Q2.4991.00
147_I213_H2.4751.00
185_D237_K2.3261.00
49_G52_E2.2741.00
159_A168_F2.1461.00
120_V184_A2.1381.00
26_E37_R2.1341.00
130_A142_V2.1051.00
77_F82_E2.0931.00
81_R135_L2.0901.00
79_Y136_E2.0651.00
36_E39_K2.0581.00
143_S184_A2.0451.00
220_D226_K2.0371.00
229_M258_I2.0311.00
83_F132_T2.0201.00
218_G223_K2.0161.00
143_S169_Y2.0021.00
59_H72_I1.9721.00
244_F258_I1.9711.00
133_L188_V1.9581.00
11_A60_V1.8841.00
196_E216_T1.8711.00
86_N154_V1.8711.00
124_T155_A1.8601.00
71_Y210_E1.8371.00
131_V164_A1.8191.00
232_I242_V1.7981.00
236_M240_V1.7801.00
84_M161_K1.7781.00
32_D59_H1.7781.00
118_E141_S1.7661.00
7_A48_I1.7651.00
102_H270_L1.7581.00
29_L56_F1.7471.00
66_G204_E1.7321.00
103_L243_V1.7301.00
134_A165_N1.7301.00
251_G269_V1.7101.00
81_R132_T1.6911.00
74_G84_M1.6901.00
43_S46_E1.6831.00
81_R136_E1.6641.00
95_E98_E1.6641.00
258_I282_A1.6501.00
89_V126_S1.6451.00
104_L137_N1.5611.00
199_M216_T1.5431.00
251_G277_D1.5261.00
70_Q76_E1.5111.00
173_L224_F1.5101.00
134_A142_V1.5071.00
35_M39_K1.4841.00
31_Y73_I1.4841.00
106_K241_F1.4711.00
96_T129_I1.4461.00
11_A56_F1.4421.00
174_L235_V1.4411.00
212_L216_T1.4361.00
103_L186_I1.4361.00
39_K43_S1.4121.00
172_D227_R1.3981.00
79_Y101_F1.3911.00
225_Y244_F1.3881.00
77_F80_G1.3871.00
67_V87_D1.3841.00
152_L168_F1.3821.00
195_S249_K1.3571.00
248_W276_K1.3501.00
106_K243_V1.3501.00
172_D175_E1.3381.00
102_H105_E1.3361.00
99_V243_V1.3311.00
144_A166_V1.3201.00
255_K269_V1.3071.00
227_R231_D1.3061.00
103_L188_V1.2981.00
255_K259_L1.2621.00
83_F128_A1.2601.00
131_V159_A1.2581.00
137_N140_F1.2531.00
31_Y59_H1.2391.00
246_I280_I1.2381.00
14_Y64_K1.2371.00
124_T130_A1.2191.00
256_D260_K1.2051.00
31_Y75_K1.2041.00
243_V281_C1.1941.00
67_V72_I1.1921.00
79_Y132_T1.1881.00
229_M257_L1.1801.00
195_S198_E1.1791.00
148_S213_H1.1751.00
270_L281_C1.1741.00
118_E182_K1.1651.00
83_F131_V1.1581.00
122_V228_F1.1581.00
152_L170_Q1.1551.00
82_E161_K1.1531.00
98_E273_I1.1521.00
231_D234_L1.1461.00
119_V140_F1.1461.00
88_D154_V1.1441.00
217_D225_Y1.1391.00
219_G226_K1.1381.00
148_S151_A1.1361.00
145_V177_F1.1351.00
70_Q91_I1.1341.00
183_K237_K1.1331.00
222_L253_A1.1331.00
85_V154_V1.1281.00
53_L57_K1.1251.00
10_W57_K1.1171.00
98_E279_T1.1151.00
247_G250_Q1.1141.00
48_I52_E1.1051.00
222_L257_L1.1031.00
189_S244_F1.0951.00
141_S167_R1.0901.00
114_D117_L1.0861.00
198_E249_K1.0761.00
100_V132_T1.0741.00
144_A168_F1.0691.00
246_I251_G1.0641.00
85_V89_V1.0621.00
38_S42_A1.0531.00
155_A168_F1.0441.00
269_V280_I1.0411.00
230_E261_A1.0401.00
108_R137_N1.0401.00
107_Y186_I1.0341.00
145_V171_G1.0341.00
100_V129_I1.0131.00
135_L164_A1.0111.00
14_Y57_K1.0111.00
104_L136_E1.0101.00
66_G205_I1.0071.00
7_A56_F0.9951.00
131_V162_L0.9951.00
118_E143_S0.9931.00
121_D130_A0.9861.00
173_L227_R0.9811.00
20_R23_N0.9801.00
119_V133_L0.9781.00
19_G23_N0.9761.00
24_A63_H0.9661.00
62_M65_E0.9621.00
119_V142_V0.9591.00
199_M212_L0.9561.00
122_V173_L0.9551.00
143_S167_R0.9541.00
130_A134_A0.9541.00
28_L56_F0.9521.00
232_I264_G0.9431.00
130_A166_V0.9431.00
32_D52_E0.9351.00
102_H281_C0.9301.00
157_A161_K0.9261.00
159_A164_A0.9231.00
174_L231_D0.9231.00
146_D152_L0.9191.00
10_W14_Y0.9151.00
15_L20_R0.9111.00
15_L60_V0.9101.00
101_F105_E0.9071.00
217_D224_F0.9011.00
258_I280_I0.8971.00
184_A187_I0.8951.00
35_M43_S0.8941.00
118_E184_A0.8911.00
27_L69_V0.8911.00
135_L162_L0.8891.00
167_R182_K0.8861.00
251_G255_K0.8841.00
55_R58_R0.8751.00
252_A256_D0.8711.00
269_V277_D0.8701.00
57_K61_E0.8691.00
63_H205_I0.8691.00
117_L140_F0.8621.00
134_A166_V0.8611.00
217_D223_K0.8571.00
14_Y18_A0.8561.00
50_E53_L0.8561.00
61_E64_K0.8521.00
118_E237_K0.8451.00
196_E218_G0.8451.00
124_T146_D0.8441.00
270_L279_T0.8431.00
271_K275_G0.8411.00
30_L33_T0.8360.99
102_H279_T0.8340.99
256_D259_L0.8280.99
199_M202_L0.8270.99
268_E281_C0.8250.99
24_A69_V0.8240.99
132_T136_E0.8230.99
80_G136_E0.8200.99
86_N157_A0.8140.99
157_A160_E0.8130.99
229_M282_A0.8100.99
246_I254_V0.8050.99
20_R66_G0.8040.99
46_E52_E0.7990.99
28_L59_H0.7980.99
196_E199_M0.7960.99
75_K161_K0.7960.99
106_K268_E0.7850.99
123_G173_L0.7830.99
267_V282_A0.7830.99
156_S160_E0.7820.99
194_I215_L0.7800.99
220_D223_K0.7790.99
71_Y91_I0.7780.99
80_G135_L0.7730.99
89_V154_V0.7730.99
8_L29_L0.7690.99
156_S159_A0.7660.99
122_V174_L0.7610.99
150_E153_Q0.7610.99
222_L226_K0.7590.99
81_R162_L0.7580.99
50_E54_Y0.7430.99
121_D124_T0.7420.99
100_V104_L0.7400.99
264_G282_A0.7360.99
95_E279_T0.7330.99
251_G276_K0.7320.99
246_I269_V0.7310.99
71_Y88_D0.7290.99
100_V133_L0.7280.99
107_Y137_N0.7280.99
255_K277_D0.7210.98
116_K141_S0.7180.98
86_N150_E0.7180.98
55_R59_H0.7170.98
7_A53_L0.7110.98
119_V137_N0.7080.98
224_F227_R0.7070.98
252_A277_D0.7010.98
255_K267_V0.7000.98
95_E274_N0.6970.98
9_K13_S0.6960.98
102_H106_K0.6960.98
233_P264_G0.6940.98
123_G224_F0.6920.98
228_F242_V0.6890.98
143_S182_K0.6890.98
8_L26_E0.6880.98
119_V186_I0.6840.98
229_M244_F0.6830.98
103_L107_Y0.6830.98
91_I214_A0.6800.98
195_S217_D0.6790.98
91_I210_E0.6780.98
102_H243_V0.6770.98
67_V209_H0.6750.98
171_G177_F0.6740.98
225_Y254_V0.6730.98
198_E248_W0.6710.98
129_I188_V0.6710.98
131_V135_L0.6710.98
148_S152_L0.6700.98
58_R61_E0.6690.98
227_R230_E0.6680.98
169_Y182_K0.6670.98
159_A162_L0.6670.98
19_G22_E0.6630.97
153_Q156_S0.6620.97
124_T144_A0.6600.97
142_V166_V0.6590.97
134_A159_A0.6570.97
259_L267_V0.6550.97
14_Y17_E0.6510.97
249_K276_K0.6510.97
120_V174_L0.6500.97
56_F60_V0.6500.97
225_Y246_I0.6490.97
223_K226_K0.6460.97
14_Y61_E0.6460.97
195_S199_M0.6420.97
196_E219_G0.6420.97
254_V257_L0.6400.97
97_E100_V0.6390.97
25_A56_F0.6370.97
120_V177_F0.6370.97
13_S17_E0.6360.97
199_M217_D0.6360.97
123_G189_S0.6330.97
26_E41_L0.6320.97
226_K257_L0.6300.96
199_M207_R0.6290.96
30_L35_M0.6290.96
159_A166_V0.6280.96
7_A11_A0.6250.96
32_D55_R0.6240.96
229_M261_A0.6220.96
242_V258_I0.6220.96
75_K84_M0.6200.96
8_L12_S0.6200.96
186_I241_F0.6190.96
149_K153_Q0.6190.96
174_L177_F0.6130.96
132_T135_L0.6110.96
229_M254_V0.6110.96
145_V169_Y0.6110.96
124_T168_F0.6100.96
106_K281_C0.6070.96
196_E217_D0.6060.96
228_F232_I0.6060.96
128_A132_T0.6050.96
74_G157_A0.6050.96
105_E270_L0.6030.96
217_D220_D0.5980.95
242_V282_A0.5970.95
156_S168_F0.5960.95
241_F281_C0.5920.95
35_M46_E0.5920.95
27_L73_I0.5880.95
230_E233_P0.5850.95
122_V145_V0.5850.95
39_K46_E0.5820.95
11_A25_A0.5800.94
52_E55_R0.5780.94
26_E30_L0.5780.94
18_A21_E0.5780.94
98_E102_H0.5770.94
115_G139_S0.5770.94
131_V166_V0.5760.94
88_D211_P0.5760.94
126_S154_V0.5730.94
51_D55_R0.5720.94
198_E247_G0.5720.94
146_D155_A0.5720.94
117_L137_N0.5710.94
60_V64_K0.5680.94
187_I235_V0.5670.94
83_F162_L0.5660.94
63_H72_I0.5660.94
202_L215_L0.5660.94
187_I232_I0.5620.94
130_A168_F0.5610.93
33_T52_E0.5590.93
221_G250_Q0.5570.93
12_S16_T0.5550.93
133_L137_N0.5540.93
213_H224_F0.5530.93
108_R114_D0.5500.93
255_K280_I0.5480.93
147_I170_Q0.5470.93
27_L31_Y0.5470.93
30_L37_R0.5470.93
58_R62_M0.5460.93
233_P261_A0.5400.92
116_K139_S0.5400.92
71_Y85_V0.5390.92
148_S154_V0.5380.92
253_A256_D0.5370.92
181_G234_L0.5370.92
107_Y140_F0.5360.92
152_L156_S0.5350.92
11_A15_L0.5350.92
204_E207_R0.5320.92
66_G203_S0.5300.91
243_V279_T0.5300.91
10_W60_V0.5290.91
39_K42_A0.5280.91
120_V145_V0.5250.91
120_V187_I0.5240.91
254_V280_I0.5240.91
202_L217_D0.5230.91
189_S228_F0.5210.91
195_S220_D0.5210.91
117_L185_D0.5190.91
197_E219_G0.5190.91
133_L140_F0.5180.90
198_E201_D0.5170.90
18_A22_E0.5170.90
85_V126_S0.5150.90
79_Y135_L0.5120.90
169_Y176_P0.5120.90
232_I236_M0.5120.90
199_M203_S0.5110.90
7_A57_K0.5090.90
86_N89_V0.5080.90
194_I206_V0.5070.90
207_R216_T0.5070.90
246_I277_D0.5060.89
145_V176_P0.5050.89
37_R41_L0.5030.89
244_F254_V0.5020.89
78_F132_T0.5020.89
134_A164_A0.5010.89
103_L133_L0.5010.89
18_A23_N0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b3tA 1 0.9549 100 0.36 Contact Map
1nv8A 1 0.9306 100 0.364 Contact Map
4dzrA 2 0.5451 100 0.629 Contact Map
3c6kA 2 0.8542 100 0.664 Contact Map
3tm4A 1 0.8958 100 0.665 Contact Map
1uwvA 1 0.8403 100 0.666 Contact Map
4dcmA 1 0.809 100 0.669 Contact Map
3evzA 1 0.6632 100 0.672 Contact Map
4mtlA 4 0.7049 100 0.693 Contact Map
1uirA 4 0.7708 100 0.694 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0187 seconds.