GREMLIN Database
YWKB - Uncharacterized transporter YwkB
UniProt: P45869 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (293)
Sequences: 6518 (5027)
Seq/√Len: 293.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_I192_L5.3641.00
175_L179_C4.9121.00
257_A267_T4.2571.00
22_F26_F3.3211.00
45_A214_T3.2311.00
278_G303_S2.9401.00
97_N292_Q2.9321.00
51_I188_I2.9281.00
209_D213_S2.8421.00
15_F207_M2.6811.00
40_L214_T2.5261.00
261_G264_A2.5111.00
246_V310_S2.4241.00
24_G225_V2.3001.00
23_A44_Y2.2531.00
114_G276_F2.1311.00
24_G228_G2.0791.00
40_L45_A2.0481.00
171_G175_L2.0301.00
34_A225_V2.0301.00
52_A212_G1.9861.00
104_N299_A1.9501.00
192_L198_F1.9321.00
45_A215_T1.9261.00
185_A189_S1.9191.00
309_I312_P1.9121.00
52_A208_L1.9081.00
30_D33_S1.9041.00
253_M274_V1.8941.00
264_A267_T1.8851.00
242_A246_V1.8621.00
52_A205_V1.8541.00
184_A188_I1.8531.00
261_G267_T1.8371.00
52_A209_D1.7991.00
290_E293_E1.7811.00
35_K39_T1.7801.00
52_A56_T1.7521.00
30_D36_G1.7521.00
242_A303_S1.7471.00
40_L221_F1.7401.00
39_T43_K1.7321.00
23_A221_F1.7121.00
254_F271_I1.6001.00
119_G124_A1.5981.00
202_E206_K1.5961.00
25_H228_G1.5921.00
50_F185_A1.5901.00
243_L247_A1.5871.00
121_L315_I1.5871.00
275_A314_I1.5831.00
19_L207_M1.5501.00
81_I85_L1.5501.00
94_D97_N1.5361.00
39_T288_R1.5351.00
205_V209_D1.5251.00
206_K209_D1.5211.00
265_D269_K1.5141.00
172_K175_L1.5071.00
254_F258_L1.4951.00
48_A208_L1.4931.00
130_P266_Q1.4891.00
226_T283_A1.4771.00
148_I152_V1.4761.00
192_L199_T1.4691.00
100_V296_T1.4541.00
257_A262_L1.4461.00
283_A300_F1.4381.00
72_L134_T1.4071.00
54_I189_S1.4051.00
16_V211_L1.4011.00
48_A185_A1.4001.00
117_V276_F1.4001.00
241_I299_A1.3861.00
263_P266_Q1.3851.00
66_V70_I1.3811.00
55_L192_L1.3791.00
40_L218_V1.3711.00
77_V81_I1.3681.00
105_S244_L1.3671.00
33_S36_G1.3671.00
189_S193_V1.3651.00
11_A15_F1.3651.00
255_L258_L1.3611.00
131_I273_L1.3531.00
264_A268_T1.3521.00
18_V22_F1.3501.00
58_S61_E1.3481.00
118_L131_I1.3431.00
256_I259_A1.3411.00
245_K249_Q1.3391.00
108_P276_F1.3311.00
19_L44_Y1.3231.00
104_N278_G1.3221.00
177_G183_A1.3201.00
176_H179_C1.3061.00
87_C98_S1.3031.00
187_L191_I1.2921.00
11_A203_L1.2841.00
48_A211_L1.2761.00
251_A255_L1.2751.00
223_V280_A1.2741.00
83_I105_S1.2691.00
286_A291_K1.2681.00
265_D268_T1.2621.00
255_L259_A1.2531.00
122_F269_K1.2511.00
41_V219_A1.2451.00
305_I309_I1.2181.00
313_I316_A1.2171.00
196_F199_T1.2151.00
287_T293_E1.2141.00
16_V221_F1.2051.00
267_T271_I1.2051.00
107_Q145_L1.1931.00
192_L200_L1.1831.00
37_V218_V1.1831.00
238_A302_V1.1751.00
56_T205_V1.1711.00
44_Y221_F1.1621.00
118_L122_F1.1581.00
244_L248_V1.1511.00
101_F241_I1.1401.00
208_L212_G1.1361.00
242_A302_V1.1301.00
278_G282_A1.1291.00
16_V210_Q1.1221.00
125_N265_D1.1181.00
239_I243_L1.1171.00
15_F19_L1.1141.00
122_F268_T1.1131.00
204_G207_M1.1041.00
55_L205_V1.1021.00
191_I196_F1.1011.00
86_V91_F1.0861.00
88_R92_K1.0811.00
271_I314_I1.0791.00
32_K36_G1.0721.00
307_S311_L1.0721.00
59_R193_V1.0631.00
307_S310_S1.0551.00
45_A218_V1.0511.00
19_L211_L1.0501.00
263_P267_T1.0461.00
66_V69_M1.0441.00
99_S150_A1.0431.00
41_V45_A1.0411.00
104_N282_A1.0411.00
275_A311_L1.0371.00
150_A286_A1.0361.00
251_A314_I1.0321.00
84_L88_R1.0261.00
179_C184_A1.0211.00
214_T217_G1.0191.00
104_N296_T1.0181.00
126_E129_I1.0111.00
71_S75_G1.0001.00
242_A306_L1.0001.00
72_L76_I0.9971.00
43_K288_R0.9961.00
108_P245_K0.9951.00
278_G299_A0.9861.00
214_T218_V0.9811.00
21_W228_G0.9681.00
216_S219_A0.9641.00
55_L189_S0.9531.00
118_L126_E0.9511.00
234_L237_P0.9511.00
24_G229_I0.9461.00
103_L146_A0.9451.00
257_A271_I0.9431.00
29_Y33_S0.9371.00
250_P275_A0.9351.00
88_R98_S0.9311.00
103_L150_A0.9301.00
238_A242_A0.9301.00
143_D147_I0.9281.00
209_D212_G0.9261.00
33_S37_V0.9231.00
258_L267_T0.9231.00
190_M194_L0.9231.00
21_W25_H0.9231.00
65_Q68_L0.9221.00
14_F17_I0.9221.00
192_L196_F0.9191.00
32_K35_K0.9161.00
188_I192_L0.9131.00
115_I128_A0.9121.00
38_S222_A0.9121.00
95_L98_S0.9091.00
191_I194_L0.9091.00
139_N143_D0.9071.00
246_V306_L0.9061.00
93_Y97_N0.8931.00
262_L267_T0.8931.00
27_G30_D0.8901.00
203_L207_M0.8891.00
9_L12_P0.8891.00
75_G253_M0.8871.00
98_S102_S0.8731.00
144_P147_I0.8691.00
292_Q295_E0.8671.00
8_I203_L0.8591.00
143_D146_A0.8481.00
49_H215_T0.8441.00
42_T112_F0.8431.00
80_Y106_A0.8411.00
122_F126_E0.8351.00
275_A310_S0.8351.00
83_I244_L0.8351.00
147_I289_F0.8321.00
252_L256_I0.8311.00
24_G31_A0.8301.00
147_I151_T0.8231.00
126_E265_D0.8171.00
55_L193_V0.8171.00
75_G79_F0.8081.00
278_G300_F0.8061.00
35_K290_E0.8031.00
222_A283_A0.8021.00
55_L200_L0.8021.00
107_Q111_A0.8010.99
23_A28_S0.8010.99
309_I313_I0.8010.99
76_I87_C0.8000.99
170_T174_I0.7860.99
111_A132_A0.7840.99
113_M117_V0.7840.99
247_A250_P0.7800.99
14_F18_V0.7790.99
174_I177_G0.7780.99
103_L107_Q0.7750.99
81_I84_L0.7740.99
117_V272_L0.7670.99
78_G252_L0.7670.99
136_I140_A0.7650.99
41_V215_T0.7650.99
243_L248_V0.7630.99
51_I208_L0.7610.99
24_G27_G0.7600.99
182_L185_A0.7570.99
123_G126_E0.7500.99
168_K171_G0.7470.99
252_L255_L0.7450.99
51_I55_L0.7440.99
246_V303_S0.7430.99
202_E205_V0.7420.99
115_I135_G0.7380.99
276_F282_A0.7370.99
282_A296_T0.7360.99
235_S298_T0.7220.99
79_F249_Q0.7220.99
74_I78_G0.7220.99
286_A293_E0.7210.99
86_V90_I0.7210.99
67_P70_I0.7200.99
239_I242_A0.7200.99
87_C91_F0.7140.99
99_S153_G0.7140.99
210_Q213_S0.7070.99
150_A291_K0.7070.99
44_Y211_L0.7040.99
114_G273_L0.7030.99
287_T290_E0.7000.99
180_E184_A0.6910.99
83_I87_C0.6910.99
48_A212_G0.6890.98
87_C102_S0.6870.98
258_L261_G0.6860.98
29_Y225_V0.6840.98
79_F83_I0.6800.98
118_L269_K0.6790.98
138_V141_I0.6790.98
107_Q143_D0.6780.98
20_G225_V0.6780.98
271_I275_A0.6780.98
85_L88_R0.6750.98
306_L310_S0.6740.98
84_L102_S0.6740.98
248_V290_E0.6740.98
46_L219_A0.6740.98
126_E131_I0.6740.98
250_P310_S0.6730.98
188_I191_I0.6720.98
103_L282_A0.6720.98
108_P114_G0.6720.98
235_S239_I0.6720.98
19_L221_F0.6710.98
184_A187_L0.6670.98
43_K112_F0.6660.98
38_S219_A0.6600.98
100_V150_A0.6590.98
86_V240_G0.6580.98
150_A285_I0.6580.98
13_I138_V0.6560.98
112_F216_S0.6560.98
306_L309_I0.6550.98
6_I10_L0.6550.98
97_N295_E0.6530.98
204_G208_L0.6520.98
70_I74_I0.6500.98
20_G221_F0.6480.98
109_T115_I0.6460.98
73_I137_V0.6450.98
28_S43_K0.6450.98
23_A26_F0.6440.98
247_A313_I0.6420.98
73_I77_V0.6400.98
73_I76_I0.6380.98
107_Q289_F0.6380.98
13_I41_V0.6370.97
106_A146_A0.6360.97
126_E130_P0.6350.97
59_R194_L0.6340.97
71_S256_I0.6340.97
46_L182_L0.6340.97
262_L266_Q0.6320.97
41_V218_V0.6320.97
174_I178_L0.6310.97
37_V222_A0.6290.97
198_F201_P0.6290.97
236_M239_I0.6290.97
170_T173_S0.6290.97
200_L205_V0.6280.97
68_L270_A0.6250.97
109_T279_S0.6250.97
29_Y36_G0.6250.97
54_I191_I0.6240.97
49_H217_G0.6240.97
119_G126_E0.6240.97
51_I185_A0.6230.97
42_T281_V0.6220.97
128_A132_A0.6170.97
31_A229_I0.6160.97
26_F30_D0.6150.97
140_A143_D0.6130.97
20_G220_L0.6120.97
210_Q214_T0.6120.97
223_V283_A0.6110.97
253_M271_I0.6090.97
65_Q80_Y0.6080.97
206_K210_Q0.6080.97
200_L204_G0.6070.97
314_I317_L0.6060.97
111_A131_I0.6040.97
139_N142_L0.6040.97
286_A296_T0.6020.96
137_V148_I0.5990.96
42_T180_E0.5990.96
114_G304_A0.5970.96
237_P317_L0.5970.96
227_V301_V0.5960.96
65_Q69_M0.5960.96
174_I179_C0.5890.96
110_F138_V0.5880.96
83_I106_A0.5870.96
258_L263_P0.5850.96
115_I131_I0.5850.96
15_F18_V0.5850.96
53_G132_A0.5840.96
140_A144_P0.5830.96
34_A222_A0.5820.96
138_V279_S0.5810.96
74_I77_V0.5800.96
279_S282_A0.5790.96
300_F304_A0.5780.96
75_G80_Y0.5760.95
87_C101_F0.5760.95
230_R301_V0.5760.95
207_M210_Q0.5740.95
49_H245_K0.5740.95
80_Y84_L0.5730.95
14_F305_I0.5720.95
240_G243_L0.5690.95
172_K176_H0.5690.95
247_A310_S0.5680.95
80_Y102_S0.5670.95
146_A150_A0.5670.95
78_G82_I0.5640.95
243_L246_V0.5620.95
75_G252_L0.5620.95
86_V244_L0.5610.95
10_L308_L0.5600.95
237_P295_E0.5600.95
310_S314_I0.5590.95
141_I144_P0.5580.95
23_A211_L0.5580.95
74_I256_I0.5570.95
57_T193_V0.5520.94
132_A135_G0.5520.94
222_A225_V0.5500.94
41_V112_F0.5480.94
24_G29_Y0.5470.94
136_I139_N0.5460.94
220_L278_G0.5460.94
283_A287_T0.5430.94
112_F280_A0.5430.94
247_A251_A0.5410.94
33_S225_V0.5410.94
223_V301_V0.5400.94
26_F29_Y0.5400.94
37_V273_L0.5360.93
137_V141_I0.5360.93
212_G215_T0.5360.93
102_S106_A0.5340.93
273_L301_V0.5340.93
38_S283_A0.5340.93
101_F295_E0.5300.93
99_S152_V0.5290.93
135_G279_S0.5270.93
171_G174_I0.5240.93
199_T203_L0.5240.93
9_L111_A0.5230.93
180_E185_A0.5220.93
169_M172_K0.5200.92
241_I278_G0.5200.92
138_V142_L0.5190.92
67_P71_S0.5180.92
65_Q266_Q0.5150.92
48_A188_I0.5150.92
199_T202_E0.5150.92
173_S177_G0.5140.92
282_A300_F0.5110.92
46_L49_H0.5100.92
70_I96_T0.5100.92
246_V275_A0.5080.92
233_K294_E0.5080.92
111_A139_N0.5070.91
240_G244_L0.5070.91
234_L294_E0.5050.91
12_P223_V0.5040.91
119_G128_A0.5040.91
143_D289_F0.5040.91
7_L11_A0.5030.91
29_Y40_L0.5030.91
286_A290_E0.5030.91
88_R91_F0.5020.91
223_V300_F0.5020.91
68_L72_L0.5010.91
7_L10_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.4577 99.7 0.686 Contact Map
4n7wA 2 0.442 99.7 0.693 Contact Map
2cfqA 1 0.9592 89.3 0.913 Contact Map
4czbA 2 0.5204 81.5 0.922 Contact Map
3o7qA 1 0.931 81.3 0.922 Contact Map
4cz8A 2 0.5172 79.2 0.924 Contact Map
4bwzA 2 0.4765 61.7 0.933 Contact Map
4m64A 1 0.953 50.5 0.937 Contact Map
2gfpA 2 0.9279 48.8 0.938 Contact Map
3wdoA 1 0.9216 46.8 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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