GREMLIN Database
ACDA - Acyl-CoA dehydrogenase
UniProt: P45867 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (365)
Sequences: 33869 (19267)
Seq/√Len: 1008.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_D218_V3.9681.00
151_N216_D3.9011.00
291_M329_K3.3691.00
23_E44_E3.2461.00
144_I218_V2.9181.00
194_F215_E2.8971.00
113_Q118_E2.8451.00
143_R221_A2.7981.00
104_E108_T2.7941.00
182_T224_R2.7391.00
17_R75_E2.7081.00
65_D68_A2.7001.00
30_E34_Q2.6231.00
284_K333_E2.3461.00
263_Q267_E2.3261.00
113_Q119_K2.2241.00
153_S213_M2.1931.00
255_Q296_R2.1801.00
170_A184_F2.1141.00
304_W308_S2.0841.00
104_E107_K2.0691.00
227_E230_E2.0281.00
144_I147_D2.0251.00
18_D22_H2.0211.00
274_S277_E2.0141.00
103_T106_Q2.0041.00
265_A337_I1.9781.00
345_K350_E1.9401.00
74_E296_R1.9111.00
350_E354_R1.8571.00
56_P99_F1.8561.00
230_E233_K1.8551.00
166_Y188_K1.8201.00
148_Y184_F1.7991.00
325_D366_Q1.7651.00
44_E47_N1.7541.00
258_L292_I1.7511.00
78_K259_D1.7311.00
153_S211_E1.7191.00
9_H68_A1.7151.00
255_Q259_D1.7131.00
43_R47_N1.6951.00
143_R228_E1.6871.00
160_G210_T1.6661.00
144_I149_V1.6571.00
142_E151_N1.6421.00
269_K274_S1.6401.00
220_P223_K1.6291.00
122_A166_Y1.6261.00
75_E78_K1.6251.00
265_A281_I1.6081.00
280_G283_F1.5991.00
305_L315_A1.5891.00
149_V218_V1.5871.00
146_D218_V1.5791.00
190_F217_C1.5721.00
109_E222_S1.5661.00
288_M330_V1.5531.00
149_V216_D1.5411.00
148_Y221_A1.5411.00
126_T156_F1.5351.00
109_E113_Q1.5281.00
224_R228_E1.5261.00
127_E154_K1.5221.00
151_N215_E1.5171.00
260_A348_P1.5171.00
187_E223_K1.5111.00
273_K277_E1.5091.00
294_A322_M1.5051.00
194_F213_M1.4941.00
10_E13_R1.4941.00
146_D221_A1.4761.00
57_E63_G1.4751.00
301_Q305_L1.4741.00
113_Q116_L1.4701.00
11_M14_K1.4681.00
9_H65_D1.4681.00
281_I337_I1.4641.00
59_Y107_K1.4631.00
257_A331_T1.4611.00
14_K18_D1.4521.00
20_A79_V1.4511.00
143_R147_D1.4511.00
141_A184_F1.4391.00
270_Q278_Q1.4301.00
161_G210_T1.4211.00
221_A224_R1.4121.00
150_L184_F1.4121.00
295_S323_A1.4111.00
196_G211_E1.4111.00
108_T112_T1.4051.00
341_Y347_Y1.4051.00
9_H71_I1.3951.00
293_E301_Q1.3851.00
260_A263_Q1.3841.00
106_Q110_Y1.3811.00
196_G213_M1.3601.00
11_M15_L1.3551.00
80_C83_T1.3541.00
105_E109_E1.3541.00
321_L366_Q1.3501.00
187_E190_F1.3491.00
262_L266_K1.3471.00
256_G260_A1.3451.00
328_M360_Q1.3371.00
74_E300_Y1.3311.00
13_R75_E1.3311.00
78_K255_Q1.3271.00
67_L304_W1.3181.00
288_M333_E1.3181.00
332_T357_K1.3141.00
16_V50_L1.3121.00
329_K333_E1.3071.00
219_V223_K1.2981.00
147_D221_A1.2971.00
53_I72_A1.2961.00
101_F237_K1.2951.00
105_E222_S1.2851.00
66_Y307_S1.2801.00
200_K345_K1.2691.00
173_D176_K1.2611.00
114_L121_G1.2551.00
33_E200_K1.2531.00
74_E255_Q1.2481.00
107_K111_L1.2471.00
39_R43_R1.2451.00
254_A292_I1.2431.00
287_D370_R1.2411.00
193_F217_C1.2351.00
292_I330_V1.2331.00
31_R206_S1.2211.00
254_A330_V1.2151.00
261_A334_A1.2121.00
188_K193_F1.2101.00
124_A157_I1.2081.00
143_R148_Y1.2071.00
43_R46_A1.2021.00
258_L262_L1.1981.00
77_S84_G1.1951.00
65_D307_S1.1941.00
248_A299_T1.1861.00
10_E14_K1.1841.00
112_T116_L1.1811.00
172_T182_T1.1741.00
332_T360_Q1.1741.00
70_V303_A1.1701.00
242_G363_E1.1681.00
327_A356_A1.1661.00
190_F223_K1.1641.00
256_G352_Y1.1601.00
273_K278_Q1.1581.00
64_S68_A1.1511.00
129_G138_K1.1491.00
301_Q304_W1.1491.00
232_F236_M1.1451.00
55_W115_A1.1451.00
142_E149_V1.1441.00
240_D313_G1.1441.00
13_R71_I1.1421.00
44_E48_L1.1411.00
334_A349_V1.1381.00
70_V248_A1.1341.00
109_E223_K1.1341.00
102_G106_Q1.1321.00
289_A293_E1.1311.00
148_Y228_E1.1291.00
15_L48_L1.1231.00
284_K367_E1.1171.00
305_L310_L1.1111.00
169_F183_A1.1061.00
260_A338_F1.1031.00
119_K164_D1.1031.00
110_Y165_I1.1001.00
27_T31_R1.1001.00
139_T150_L1.0931.00
140_T151_N1.0931.00
106_Q185_I1.0891.00
295_S326_T1.0891.00
357_K360_Q1.0861.00
168_V186_V1.0831.00
192_G217_C1.0781.00
150_L168_V1.0761.00
317_A369_Q1.0751.00
251_V292_I1.0751.00
188_K195_T1.0721.00
193_F212_I1.0711.00
105_E108_T1.0701.00
328_M332_T1.0611.00
290_T318_M1.0601.00
148_Y172_T1.0591.00
16_V20_A1.0581.00
291_M333_E1.0561.00
46_A51_T1.0541.00
43_R118_E1.0511.00
15_L50_L1.0411.00
58_D108_T1.0401.00
142_E216_D1.0331.00
124_A166_Y1.0311.00
169_F181_V1.0281.00
360_Q366_Q1.0281.00
29_A33_E1.0191.00
121_G165_I1.0181.00
150_L170_A1.0121.00
141_A170_A1.0111.00
133_D136_S1.0081.00
168_V214_F0.9931.00
218_V221_A0.9911.00
27_T30_E0.9901.00
251_V299_T0.9891.00
331_T356_A0.9841.00
94_C121_G0.9801.00
182_T228_E0.9791.00
39_R164_D0.9771.00
40_E43_R0.9731.00
19_F44_E0.9721.00
325_D329_K0.9701.00
291_M326_T0.9701.00
265_A275_I0.9551.00
173_D180_G0.9551.00
328_M353_M0.9541.00
142_E173_D0.9531.00
166_Y193_F0.9511.00
266_K276_A0.9491.00
250_A359_T0.9471.00
100_A237_K0.9471.00
325_D360_Q0.9451.00
166_Y212_I0.9411.00
109_E187_E0.9411.00
160_G195_T0.9381.00
321_L370_R0.9381.00
124_A214_F0.9371.00
257_A352_Y0.9361.00
94_C167_I0.9361.00
184_F224_R0.9331.00
262_L285_L0.9291.00
366_Q370_R0.9281.00
156_F341_Y0.9281.00
150_L219_V0.9231.00
16_V72_A0.9211.00
204_I358_I0.9191.00
145_G218_V0.9171.00
297_L301_Q0.9161.00
106_Q223_K0.9091.00
326_T329_K0.9001.00
202_L353_M0.8991.00
302_A319_S0.8981.00
324_G366_Q0.8931.00
55_W95_S0.8931.00
32_D354_R0.8931.00
103_T107_K0.8861.00
56_P59_Y0.8831.00
358_I362_Y0.8821.00
265_A276_A0.8821.00
287_D291_M0.8821.00
17_R21_K0.8791.00
165_I187_E0.8771.00
289_A318_M0.8741.00
58_D104_E0.8731.00
155_V211_E0.8731.00
191_E218_V0.8721.00
33_E345_K0.8711.00
122_A163_A0.8711.00
122_A188_K0.8681.00
19_F48_L0.8661.00
259_D263_Q0.8601.00
20_A76_L0.8601.00
67_L307_S0.8591.00
263_Q266_K0.8571.00
45_M50_L0.8571.00
325_D370_R0.8571.00
101_F234_I0.8431.00
335_V353_M0.8421.00
156_F344_T0.8421.00
132_S368_I0.8411.00
125_L239_L0.8381.00
261_A337_I0.8371.00
164_D189_D0.8341.00
59_Y104_E0.8311.00
171_V181_V0.8291.00
265_A285_L0.8281.00
19_F45_M0.8281.00
326_T330_V0.8271.00
82_S206_S0.8261.00
328_M357_K0.8261.00
21_K78_K0.8231.00
203_G355_D0.8221.00
335_V349_V0.8221.00
283_F371_L0.8221.00
291_M322_M0.8171.00
202_L350_E0.8161.00
359_T362_Y0.8161.00
27_T40_E0.8151.00
214_F217_C0.8131.00
19_F23_E0.8121.00
165_I185_I0.8111.00
253_I356_A0.8111.00
282_A371_L0.8081.00
141_A148_Y0.8081.00
9_H67_L0.8081.00
261_A338_F0.8071.00
67_L71_I0.8061.00
253_I327_A0.8031.00
13_R17_R0.8021.00
67_L300_Y0.8001.00
184_F219_V0.7971.00
182_T229_G0.7961.00
253_I352_Y0.7961.00
124_A168_V0.7951.00
119_K165_I0.7921.00
195_T212_I0.7911.00
261_A265_A0.7911.00
148_Y224_R0.7901.00
29_A351_R0.7891.00
283_F287_D0.7881.00
58_D61_G0.7861.00
141_A172_T0.7861.00
190_F193_F0.7851.00
254_A326_T0.7841.00
147_D220_P0.7841.00
150_L186_V0.7831.00
331_T352_Y0.7801.00
71_I75_E0.7791.00
293_E296_R0.7771.00
167_I183_A0.7761.00
147_D222_S0.7761.00
293_E297_L0.7751.00
15_L18_D0.7741.00
332_T353_M0.7731.00
284_K337_I0.7721.00
246_I363_E0.7681.00
290_T322_M0.7671.00
137_M169_F0.7661.00
331_T353_M0.7661.00
247_A319_S0.7651.00
275_I278_Q0.7621.00
54_P69_Y0.7611.00
110_Y185_I0.7531.00
288_M334_A0.7521.00
251_V295_S0.7501.00
258_L289_A0.7491.00
137_M181_V0.7481.00
41_L83_T0.7471.00
58_D107_K0.7461.00
260_A352_Y0.7401.00
268_R271_F0.7381.00
124_A212_I0.7371.00
95_S114_L0.7351.00
164_D188_K0.7331.00
336_Q357_K0.7301.00
351_R355_D0.7291.00
353_M357_K0.7261.00
204_I362_Y0.7241.00
279_Q283_F0.7211.00
287_D333_E0.7211.00
139_T154_K0.7201.00
264_Y341_Y0.7191.00
173_D229_G0.7171.00
298_L318_M0.7151.00
171_V174_P0.7121.00
294_A298_L0.7111.00
30_E33_E0.7111.00
21_K79_V0.7101.00
71_I300_Y0.7101.00
78_K256_G0.7101.00
182_T226_G0.7091.00
255_Q289_A0.7091.00
224_R227_E0.7071.00
40_E44_E0.7071.00
322_M326_T0.7061.00
287_D329_K0.7051.00
24_V41_L0.7051.00
189_D193_F0.7041.00
257_A334_A0.7041.00
172_T180_G0.7031.00
127_E139_T0.6991.00
298_L319_S0.6991.00
39_R162_V0.6981.00
250_A324_G0.6981.00
312_Y315_A0.6971.00
331_T349_V0.6961.00
110_Y223_K0.6931.00
167_I225_L0.6911.00
290_T321_L0.6891.00
278_Q282_A0.6871.00
20_A24_V0.6861.00
247_A299_T0.6861.00
123_F235_A0.6841.00
13_R74_E0.6841.00
329_K332_T0.6831.00
56_P61_G0.6831.00
53_I64_S0.6821.00
371_L375_R0.6791.00
137_M171_V0.6771.00
369_Q372_V0.6741.00
114_L165_I0.6731.00
145_G149_V0.6721.00
303_A307_S0.6711.00
200_K205_R0.6701.00
125_L134_A0.6701.00
282_A374_S0.6701.00
327_A331_T0.6681.00
247_A323_A0.6661.00
58_D63_G0.6651.00
171_V180_G0.6651.00
110_Y119_K0.6631.00
335_V342_G0.6621.00
161_G208_P0.6601.00
12_I72_A0.6601.00
230_E234_I0.6591.00
365_T368_I0.6571.00
106_Q109_E0.6571.00
144_I221_A0.6521.00
21_K25_A0.6461.00
143_R149_V0.6441.00
102_G107_K0.6431.00
338_F349_V0.6431.00
291_M294_A0.6421.00
299_T323_A0.6411.00
41_L44_E0.6401.00
176_K179_K0.6381.00
296_R300_Y0.6381.00
281_I285_L0.6381.00
18_D21_K0.6371.00
298_L322_M0.6361.00
157_I212_I0.6351.00
28_A351_R0.6321.00
153_S196_G0.6291.00
55_W59_Y0.6261.00
32_D205_R0.6241.00
244_N303_A0.6231.00
270_Q275_I0.6211.00
248_A252_G0.6181.00
85_V204_I0.6151.00
160_G212_I0.6111.00
171_V176_K0.6111.00
254_A295_S0.6081.00
340_G343_Y0.6071.00
205_R345_K0.6071.00
261_A288_M0.6061.00
97_P238_T0.6051.00
172_T228_E0.6031.00
240_D316_S0.6031.00
321_L373_I0.6031.00
203_G343_Y0.5991.00
17_R79_V0.5971.00
12_I68_A0.5971.00
256_G259_D0.5921.00
139_T214_F0.5921.00
29_A348_P0.5911.00
254_A257_A0.5891.00
143_R146_D0.5881.00
318_M373_I0.5881.00
271_F278_Q0.5861.00
95_S111_L0.5861.00
35_E200_K0.5851.00
140_T174_P0.5831.00
139_T152_G0.5821.00
169_F235_A0.5811.00
295_S319_S0.5811.00
256_G348_P0.5811.00
186_V214_F0.5811.00
17_R78_K0.5791.00
39_R120_I0.5791.00
177_K180_G0.5781.00
306_E312_Y0.5751.00
221_A228_E0.5751.00
128_A153_S0.5741.00
201_K209_T0.5731.00
281_I284_K0.5721.00
284_K287_D0.5711.00
295_S322_M0.5691.00
348_P351_R0.5691.00
293_E298_L0.5681.00
291_M325_D0.5681.00
69_Y245_G0.5651.00
290_T294_A0.5641.00
59_Y112_T0.5641.00
94_C97_P0.5591.00
284_K336_Q0.5591.00
12_I16_V0.5591.00
25_A28_A0.5591.00
98_L102_G0.5581.00
202_L354_R0.5581.00
264_Y347_Y0.5571.00
251_V255_Q0.5541.00
184_F223_K0.5541.00
301_Q315_A0.5521.00
109_E112_T0.5511.00
189_D192_G0.5511.00
324_G359_T0.5501.00
168_V217_C0.5491.00
368_I371_L0.5481.00
140_T173_D0.5461.00
52_G62_I0.5451.00
94_C114_L0.5441.00
184_F221_A0.5431.00
81_A253_I0.5421.00
288_M337_I0.5411.00
193_F214_F0.5401.00
269_K277_E0.5381.00
158_T209_T0.5381.00
165_I223_K0.5371.00
143_R184_F0.5371.00
99_F107_K0.5371.00
205_R355_D0.5371.00
287_D290_T0.5361.00
66_Y306_E0.5351.00
321_L325_D0.5341.00
357_K361_I0.5341.00
244_N299_T0.5331.00
15_L62_I0.5321.00
31_R80_C0.5311.00
45_M83_T0.5311.00
328_M356_A0.5301.00
59_Y108_T0.5301.00
143_R218_V0.5281.00
268_R340_G0.5281.00
295_S330_V0.5281.00
139_T168_V0.5281.00
125_L169_F0.5281.00
255_Q292_I0.5271.00
287_D325_D0.5261.00
298_L302_A0.5261.00
348_P352_Y0.5261.00
97_P101_F0.5261.00
147_D223_K0.5251.00
24_V83_T0.5241.00
35_E205_R0.5241.00
172_T184_F0.5241.00
288_M326_T0.5231.00
71_I74_E0.5231.00
97_P234_I0.5211.00
148_Y219_V0.5201.00
70_V300_Y0.5201.00
275_I281_I0.5181.00
264_Y267_E0.5171.00
162_V208_P0.5171.00
239_L242_G0.5141.00
278_Q281_I0.5141.00
291_M295_S0.5121.00
189_D195_T0.5111.00
186_V217_C0.5101.00
50_L72_A0.5091.00
336_Q367_E0.5091.00
369_Q373_I0.5081.00
141_A150_L0.5081.00
57_E60_G0.5071.00
110_Y187_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d29A 4 1 100 0.069 Contact Map
4l1fA 4 1 100 0.069 Contact Map
1bucA 4 1 100 0.071 Contact Map
1ukwA 4 0.9974 100 0.075 Contact Map
4m9aA 4 0.9921 100 0.076 Contact Map
2jifA 4 0.9974 100 0.077 Contact Map
3pfdA 4 0.9736 100 0.078 Contact Map
1ivhA 4 1 100 0.078 Contact Map
4irnA 4 0.9894 100 0.08 Contact Map
4p13A 4 0.9974 100 0.082 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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