CLSB - BACSU - GREMLIN Contacts

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CLSB - Minor cardiolipin synthase ClsB

UniProt:	P45865	Sequences: MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSDIELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLLLDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIGGFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQQGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSVRIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANFDKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGRALSYFL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	398 (344)
Sequences:	7255 (5224)
Seq/√Len:	281.6

ECOLI - CLSA CLSB CLSC PSS
BACSU - CLSB CLS1 CLSA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
92_K	95_A	5.189	1.00
63_R	91_T	4.725	1.00
61_D	158_Y	4.177	1.00
306_L	371_L	4.107	1.00
157_G	193_L	3.603	1.00
62_I	88_L	3.474	1.00
58_M	150_T	3.377	1.00
275_S	306_L	3.343	1.00
63_R	88_L	3.288	1.00
44_D	186_I	2.888	1.00
61_D	184_R	2.725	1.00
328_I	346_N	2.687	1.00
324_D	359_Y	2.643	1.00
59_M	88_L	2.608	1.00
46_E	57_R	2.424	1.00
277_R	306_L	2.416	1.00
250_T	277_R	2.393	1.00
57_R	184_R	2.332	1.00
327_S	358_V	2.316	1.00
69_V	152_I	2.286	1.00
60_N	64_Q	2.284	1.00
91_T	95_A	2.264	1.00
70_H	100_Y	2.259	1.00
248_R	324_D	2.128	1.00
76_M	101_L	2.125	1.00
54_L	58_M	2.118	1.00
59_M	85_M	2.108	1.00
359_Y	363_E	2.067	1.00
279_I	369_S	2.043	1.00
157_G	190_V	2.024	1.00
62_I	69_V	2.004	1.00
57_R	61_D	1.990	1.00
154_G	194_Q	1.971	1.00
270_R	305_C	1.926	1.00
249_L	322_I	1.916	1.00
248_R	359_Y	1.913	1.00
327_S	355_T	1.911	1.00
78_N	83_H	1.906	1.00
98_S	125_H	1.870	1.00
349_I	354_F	1.863	1.00
364_E	367_K	1.846	1.00
48_I	57_R	1.821	1.00
156_I	184_R	1.820	1.00
242_I	249_L	1.808	1.00
40_K	192_D	1.807	1.00
68_S	154_G	1.802	1.00
42_K	188_E	1.787	1.00
241_N	322_I	1.785	1.00
185_M	347_V	1.783	1.00
57_R	60_N	1.779	1.00
90_K	122_A	1.768	1.00
321_I	355_T	1.768	1.00
61_D	156_I	1.749	1.00
86_Y	118_T	1.749	1.00
79_D	82_S	1.740	1.00
90_K	94_Q	1.735	1.00
370_E	376_D	1.730	1.00
374_M	378_S	1.719	1.00
277_R	366_M	1.710	1.00
185_M	189_G	1.674	1.00
61_D	64_Q	1.670	1.00
103_L	128_V	1.665	1.00
71_M	150_T	1.659	1.00
88_L	92_K	1.657	1.00
311_Y	370_E	1.634	1.00
54_L	73_F	1.633	1.00
86_Y	90_K	1.632	1.00
46_E	184_R	1.619	1.00
88_L	91_T	1.617	1.00
155_K	186_I	1.607	1.00
117_Q	121_N	1.603	1.00
250_T	363_E	1.600	1.00
282_M	311_Y	1.597	1.00
248_R	275_S	1.597	1.00
179_E	365_D	1.594	1.00
250_T	275_S	1.592	1.00
226_I	347_V	1.582	1.00
312_Q	368_K	1.576	1.00
66_A	155_K	1.564	1.00
279_I	366_M	1.559	1.00
308_Y	371_L	1.553	1.00
61_D	152_I	1.521	1.00
68_S	194_Q	1.476	1.00
297_Y	307_I	1.474	1.00
119_M	124_V	1.453	1.00
86_Y	115_A	1.379	1.00
252_C	279_I	1.378	1.00
50_C	53_D	1.378	1.00
57_R	158_Y	1.376	1.00
247_N	324_D	1.376	1.00
252_C	315_Y	1.364	1.00
80_E	166_E	1.364	1.00
52_A	56_E	1.360	1.00
234_L	332_A	1.339	1.00
269_A	272_N	1.334	1.00
267_I	299_E	1.334	1.00
189_G	224_H	1.330	1.00
59_M	84_N	1.328	1.00
158_Y	184_R	1.316	1.00
243_A	265_A	1.296	1.00
245_A	322_I	1.295	1.00
70_H	194_Q	1.287	1.00
63_R	84_N	1.287	1.00
151_V	157_G	1.279	1.00
90_K	118_T	1.277	1.00
284_S	290_R	1.273	1.00
241_N	326_L	1.261	1.00
159_I	193_L	1.258	1.00
181_Y	319_A	1.257	1.00
293_A	297_Y	1.254	1.00
250_T	359_Y	1.246	1.00
100_Y	125_H	1.237	1.00
239_L	265_A	1.232	1.00
335_D	342_N	1.231	1.00
332_A	346_N	1.229	1.00
357_E	360_A	1.226	1.00
377_F	380_R	1.206	1.00
149_I	193_L	1.203	1.00
298_S	302_D	1.200	1.00
280_V	297_Y	1.191	1.00
77_K	167_E	1.187	1.00
87_T	90_K	1.179	1.00
59_M	63_R	1.170	1.00
294_F	309_R	1.168	1.00
49_H	361_T	1.148	1.00
81_V	166_E	1.144	1.00
102_L	204_N	1.138	1.00
297_Y	309_R	1.137	1.00
225_K	229_T	1.122	1.00
325_H	350_D	1.119	1.00
373_T	376_D	1.112	1.00
46_E	357_E	1.110	1.00
282_M	370_E	1.106	1.00
43_S	185_M	1.100	1.00
302_D	374_M	1.096	1.00
83_H	87_T	1.096	1.00
267_I	271_K	1.095	1.00
80_E	171_K	1.086	1.00
127_H	205_T	1.080	1.00
53_D	56_E	1.074	1.00
151_V	193_L	1.072	1.00
48_I	158_Y	1.071	1.00
260_K	264_E	1.068	1.00
277_R	363_E	1.068	1.00
87_T	91_T	1.066	1.00
235_E	259_S	1.064	1.00
58_M	85_M	1.056	1.00
149_I	345_V	1.052	1.00
66_A	95_A	1.032	1.00
45_I	349_I	1.032	1.00
356_S	360_A	1.030	1.00
54_L	162_F	1.029	1.00
265_A	269_A	1.026	1.00
277_R	308_Y	1.022	1.00
56_E	60_N	1.014	1.00
248_R	321_I	1.012	1.00
172_K	175_F	1.011	1.00
363_E	366_M	1.011	1.00
251_V	320_L	1.008	1.00
328_I	348_E	1.005	1.00
290_R	294_F	1.001	1.00
79_D	83_H	1.000	1.00
115_A	118_T	0.999	1.00
263_Q	267_I	0.989	1.00
54_L	182_H	0.988	1.00
189_G	226_I	0.987	1.00
232_Y	235_E	0.982	1.00
156_I	186_I	0.978	1.00
247_N	325_H	0.977	1.00
252_C	319_A	0.976	1.00
71_M	85_M	0.975	1.00
159_I	345_V	0.975	1.00
293_A	296_Y	0.970	1.00
93_A	124_V	0.969	1.00
237_I	348_E	0.965	1.00
301_L	374_M	0.962	1.00
320_L	328_I	0.959	1.00
321_I	359_Y	0.959	1.00
366_M	369_S	0.955	1.00
283_K	287_P	0.955	1.00
56_E	84_N	0.951	1.00
360_A	364_E	0.949	1.00
267_I	303_A	0.943	1.00
362_I	366_M	0.941	1.00
193_L	345_V	0.940	1.00
324_D	356_S	0.940	1.00
74_F	342_N	0.939	1.00
222_I	351_D	0.939	1.00
76_M	164_I	0.932	1.00
163_N	168_Y	0.931	1.00
225_K	228_A	0.928	1.00
125_H	207_I	0.926	1.00
70_H	98_S	0.924	1.00
289_V	293_A	0.922	1.00
115_A	119_M	0.922	1.00
116_L	120_K	0.916	1.00
288_L	291_E	0.916	1.00
162_F	182_H	0.911	1.00
327_S	354_F	0.910	1.00
308_Y	366_M	0.909	1.00
363_E	367_K	0.908	1.00
73_F	150_T	0.904	1.00
48_I	184_R	0.901	1.00
183_L	349_I	0.899	1.00
364_E	368_K	0.896	1.00
67_S	155_K	0.895	1.00
309_R	372_L	0.894	1.00
240_A	244_Q	0.894	1.00
100_Y	201_L	0.891	1.00
118_T	121_N	0.890	1.00
113_K	117_Q	0.890	1.00
43_S	188_E	0.888	1.00
245_A	249_L	0.886	1.00
214_W	217_L	0.881	1.00
60_N	63_R	0.880	1.00
252_C	362_I	0.876	1.00
46_E	186_I	0.875	1.00
45_I	224_H	0.873	1.00
77_K	165_A	0.870	1.00
330_G	346_N	0.869	1.00
228_A	231_G	0.868	1.00
243_A	268_N	0.866	1.00
249_L	269_A	0.866	1.00
159_I	347_V	0.864	1.00
91_T	94_Q	0.862	1.00
256_Y	278_I	0.861	1.00
152_I	158_Y	0.859	1.00
50_C	177_N	0.857	1.00
337_R	342_N	0.856	1.00
301_L	377_F	0.852	1.00
105_W	128_V	0.846	1.00
290_R	293_A	0.846	1.00
249_L	266_L	0.844	1.00
305_C	309_R	0.843	1.00
196_L	228_A	0.843	1.00
142_Q	337_R	0.841	1.00
69_V	89_L	0.839	1.00
300_L	305_C	0.837	1.00
40_K	43_S	0.837	1.00
72_M	145_N	0.837	1.00
246_K	325_H	0.832	1.00
297_Y	301_L	0.831	1.00
296_Y	299_E	0.829	1.00
183_L	329_I	0.828	1.00
51_G	55_V	0.822	1.00
238_Y	328_I	0.822	1.00
294_F	297_Y	0.816	0.99
298_S	378_S	0.814	0.99
226_I	229_T	0.814	0.99
212_D	215_P	0.812	0.99
191_H	195_T	0.807	0.99
118_T	122_A	0.804	0.99
232_Y	340_F	0.801	0.99
279_I	362_I	0.800	0.99
360_A	363_E	0.798	0.99
76_M	103_L	0.792	0.99
325_H	352_E	0.792	0.99
239_L	243_A	0.791	0.99
79_D	166_E	0.788	0.99
67_S	212_D	0.788	0.99
194_Q	198_A	0.786	0.99
248_R	277_R	0.782	0.99
47_L	354_F	0.780	0.99
93_A	99_V	0.779	0.99
71_M	101_L	0.777	0.99
224_H	229_T	0.776	0.99
63_R	95_A	0.772	0.99
82_S	164_I	0.769	0.99
151_V	190_V	0.769	0.99
289_V	296_Y	0.766	0.99
202_K	205_T	0.765	0.99
85_M	164_I	0.765	0.99
226_I	345_V	0.764	0.99
262_L	339_L	0.762	0.99
254_P	335_D	0.762	0.99
47_L	361_T	0.762	0.99
196_L	345_V	0.762	0.99
281_P	314_F	0.761	0.99
90_K	124_V	0.761	0.99
235_E	261_P	0.760	0.99
224_H	347_V	0.760	0.99
331_T	345_V	0.758	0.99
307_I	310_Y	0.758	0.99
362_I	365_D	0.756	0.99
62_I	92_K	0.754	0.99
172_K	176_G	0.753	0.99
68_S	98_S	0.748	0.99
189_G	192_D	0.746	0.99
242_I	269_A	0.741	0.99
202_K	208_E	0.740	0.99
76_M	86_Y	0.740	0.99
261_P	265_A	0.740	0.99
63_R	66_A	0.739	0.99
49_H	364_E	0.739	0.99
62_I	85_M	0.739	0.99
39_S	223_S	0.736	0.99
56_E	59_M	0.729	0.99
222_I	229_T	0.728	0.99
324_D	355_T	0.727	0.99
64_Q	67_S	0.724	0.99
371_L	374_M	0.723	0.99
352_E	356_S	0.718	0.99
289_V	292_A	0.718	0.99
90_K	93_A	0.717	0.99
250_T	362_I	0.715	0.99
67_S	98_S	0.715	0.99
70_H	198_A	0.715	0.99
86_Y	124_V	0.714	0.99
356_S	359_Y	0.714	0.99
161_G	168_Y	0.713	0.99
277_R	371_L	0.713	0.99
276_V	305_C	0.713	0.99
78_N	112_K	0.712	0.99
170_G	177_N	0.709	0.99
171_K	174_K	0.706	0.99
224_H	349_I	0.706	0.99
378_S	381_T	0.704	0.98
72_M	147_R	0.703	0.98
145_N	200_D	0.703	0.98
78_N	115_A	0.703	0.98
326_L	348_E	0.702	0.98
165_A	168_Y	0.698	0.98
197_F	201_L	0.696	0.98
268_N	272_N	0.695	0.98
283_K	286_H	0.695	0.98
269_A	274_V	0.695	0.98
43_S	189_G	0.694	0.98
101_L	126_V	0.694	0.98
99_V	124_V	0.693	0.98
108_C	111_I	0.692	0.98
234_L	238_Y	0.691	0.98
282_M	309_R	0.690	0.98
331_T	342_N	0.689	0.98
105_W	130_N	0.689	0.98
370_E	374_M	0.687	0.98
63_R	92_K	0.686	0.98
137_F	140_H	0.684	0.98
62_I	150_T	0.682	0.98
351_D	354_F	0.678	0.98
114_T	121_N	0.676	0.98
319_A	358_V	0.675	0.98
279_I	315_Y	0.675	0.98
250_T	321_I	0.675	0.98
88_L	95_A	0.674	0.98
93_A	122_A	0.672	0.98
358_V	362_I	0.672	0.98
288_L	292_A	0.671	0.98
190_V	194_Q	0.668	0.98
279_I	365_D	0.666	0.98
376_D	380_R	0.666	0.98
64_Q	155_K	0.666	0.98
111_I	115_A	0.666	0.98
211_S	214_W	0.663	0.98
116_L	126_V	0.662	0.98
84_N	88_L	0.660	0.98
247_N	275_S	0.659	0.98
222_I	354_F	0.659	0.98
298_S	377_F	0.659	0.98
62_I	89_L	0.659	0.98
73_F	182_H	0.659	0.98
311_Y	368_K	0.658	0.98
158_Y	182_H	0.657	0.98
55_V	85_M	0.654	0.98
270_R	303_A	0.653	0.98
353_A	356_S	0.653	0.98
84_N	87_T	0.645	0.97
70_H	151_V	0.643	0.97
374_M	380_R	0.643	0.97
222_I	226_I	0.642	0.97
75_I	167_E	0.642	0.97
73_F	163_N	0.639	0.97
245_A	274_V	0.636	0.97
69_V	97_V	0.634	0.97
103_L	126_V	0.634	0.97
326_L	350_D	0.633	0.97
275_S	363_E	0.632	0.97
71_M	164_I	0.632	0.97
227_Y	231_G	0.631	0.97
282_M	287_P	0.630	0.97
161_G	180_D	0.628	0.97
167_E	170_G	0.627	0.97
301_L	307_I	0.626	0.97
76_M	82_S	0.625	0.97
70_H	154_G	0.625	0.97
280_V	309_R	0.624	0.97
223_S	226_I	0.621	0.97
321_I	327_S	0.617	0.97
55_V	81_V	0.616	0.97
301_L	372_L	0.614	0.96
375_E	379_K	0.611	0.96
222_I	349_I	0.611	0.96
354_F	358_V	0.609	0.96
255_Y	285_D	0.607	0.96
328_I	332_A	0.606	0.96
82_S	86_Y	0.604	0.96
291_E	294_F	0.603	0.96
81_V	169_L	0.603	0.96
298_S	374_M	0.602	0.96
246_K	274_V	0.602	0.96
227_Y	237_I	0.600	0.96
58_M	164_I	0.600	0.96
299_E	302_D	0.600	0.96
262_L	334_F	0.600	0.96
305_C	308_Y	0.597	0.96
193_L	226_I	0.596	0.96
369_S	372_L	0.595	0.96
236_N	268_N	0.595	0.96
321_I	324_D	0.595	0.96
271_K	303_A	0.594	0.96
234_L	346_N	0.593	0.96
223_S	350_D	0.590	0.96
49_H	53_D	0.587	0.95
357_E	361_T	0.585	0.95
332_A	339_L	0.585	0.95
235_E	239_L	0.585	0.95
265_A	268_N	0.580	0.95
68_S	100_Y	0.578	0.95
104_D	144_R	0.578	0.95
213_V	217_L	0.577	0.95
92_K	97_V	0.576	0.95
205_T	208_E	0.576	0.95
61_D	186_I	0.575	0.95
94_Q	123_G	0.571	0.95
221_T	353_A	0.569	0.95
54_L	150_T	0.569	0.95
297_Y	372_L	0.568	0.95
185_M	224_H	0.567	0.95
45_I	354_F	0.567	0.95
270_R	276_V	0.567	0.95
374_M	381_T	0.567	0.95
168_Y	178_W	0.566	0.94
41_K	223_S	0.565	0.94
69_V	92_K	0.562	0.94
80_E	83_H	0.561	0.94
292_A	296_Y	0.561	0.94
306_L	309_R	0.560	0.94
267_I	270_R	0.559	0.94
222_I	225_K	0.555	0.94
290_R	309_R	0.554	0.94
336_K	340_F	0.554	0.94
242_I	320_L	0.552	0.94
114_T	118_T	0.552	0.94
354_F	357_E	0.551	0.94
111_I	116_L	0.550	0.94
194_Q	197_F	0.548	0.93
281_P	286_H	0.548	0.93
241_N	328_I	0.548	0.93
87_T	118_T	0.548	0.93
159_I	183_L	0.547	0.93
58_M	62_I	0.547	0.93
143_K	230_D	0.546	0.93
264_E	268_N	0.546	0.93
226_I	230_D	0.546	0.93
361_T	365_D	0.545	0.93
202_K	206_G	0.544	0.93
192_D	195_T	0.543	0.93
256_Y	263_Q	0.543	0.93
198_A	202_K	0.542	0.93
245_A	323_D	0.542	0.93
227_Y	230_D	0.541	0.93
300_L	307_I	0.541	0.93
361_T	364_E	0.539	0.93
58_M	182_H	0.538	0.93
119_M	123_G	0.538	0.93
232_Y	236_N	0.538	0.93
78_N	86_Y	0.538	0.93
358_V	361_T	0.537	0.93
48_I	182_H	0.537	0.93
231_G	343_E	0.536	0.93
250_T	366_M	0.536	0.93
319_A	362_I	0.536	0.93
80_E	84_N	0.535	0.93
143_K	341_L	0.534	0.93
359_Y	362_I	0.532	0.92
248_R	322_I	0.531	0.92
287_P	291_E	0.530	0.92
245_A	269_A	0.529	0.92
45_I	222_I	0.529	0.92
185_M	193_L	0.527	0.92
214_W	220_G	0.526	0.92
293_A	301_L	0.523	0.92
227_Y	348_E	0.522	0.92
242_I	266_L	0.521	0.92
195_T	199_S	0.520	0.92
212_D	216_K	0.520	0.92
298_S	301_L	0.520	0.92
290_R	297_Y	0.519	0.92
352_E	355_T	0.518	0.91
290_R	300_L	0.518	0.91
178_W	314_F	0.516	0.91
188_E	191_H	0.516	0.91
100_Y	197_F	0.515	0.91
284_S	314_F	0.515	0.91
196_L	199_S	0.513	0.91
61_D	155_K	0.512	0.91
48_I	54_L	0.512	0.91
183_L	347_V	0.509	0.91
289_V	297_Y	0.508	0.91
148_K	163_N	0.508	0.91
104_D	107_G	0.508	0.91
81_V	164_I	0.506	0.90
181_Y	317_V	0.505	0.90
334_F	339_L	0.505	0.90
148_K	318_K	0.505	0.90
242_I	262_L	0.504	0.90
94_Q	121_N	0.503	0.90
322_I	326_L	0.503	0.90
285_D	289_V	0.503	0.90
319_A	329_I	0.502	0.90
289_V	301_L	0.502	0.90
98_S	213_V	0.502	0.90
373_T	377_F	0.502	0.90
90_K	119_M	0.501	0.90
223_S	229_T	0.501	0.90
47_L	327_S	0.500	0.90
298_S	380_R	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1v0wA	1	0.9196	100	0.356	Contact Map
3hsiA	2	0.9296	100	0.374	Contact Map
2o8rA	2	0.8693	100	0.512	Contact Map
1xdpA	4	0.8693	100	0.518	Contact Map
4urjA	1	0.407	99.9	0.731	Contact Map
1byrA	2	0.3769	99.9	0.734	Contact Map
4gelA	2	0.4472	99.9	0.75	Contact Map
4ggjA	2	0.4121	99.9	0.753	Contact Map
2c1lA	2	0.4246	99.8	0.775	Contact Map
4rctA	2	0.4372	99.5	0.834	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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