GREMLIN Database
CLSB - Minor cardiolipin synthase ClsB
UniProt: P45865 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (344)
Sequences: 7255 (5224)
Seq/√Len: 281.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_K95_A5.1891.00
63_R91_T4.7251.00
61_D158_Y4.1771.00
306_L371_L4.1071.00
157_G193_L3.6031.00
62_I88_L3.4741.00
58_M150_T3.3771.00
275_S306_L3.3431.00
63_R88_L3.2881.00
44_D186_I2.8881.00
61_D184_R2.7251.00
328_I346_N2.6871.00
324_D359_Y2.6431.00
59_M88_L2.6081.00
46_E57_R2.4241.00
277_R306_L2.4161.00
250_T277_R2.3931.00
57_R184_R2.3321.00
327_S358_V2.3161.00
69_V152_I2.2861.00
60_N64_Q2.2841.00
91_T95_A2.2641.00
70_H100_Y2.2591.00
248_R324_D2.1281.00
76_M101_L2.1251.00
54_L58_M2.1181.00
59_M85_M2.1081.00
359_Y363_E2.0671.00
279_I369_S2.0431.00
157_G190_V2.0241.00
62_I69_V2.0041.00
57_R61_D1.9901.00
154_G194_Q1.9711.00
270_R305_C1.9261.00
249_L322_I1.9161.00
248_R359_Y1.9131.00
327_S355_T1.9111.00
78_N83_H1.9061.00
98_S125_H1.8701.00
349_I354_F1.8631.00
364_E367_K1.8461.00
48_I57_R1.8211.00
156_I184_R1.8201.00
242_I249_L1.8081.00
40_K192_D1.8071.00
68_S154_G1.8021.00
42_K188_E1.7871.00
241_N322_I1.7851.00
185_M347_V1.7831.00
57_R60_N1.7791.00
90_K122_A1.7681.00
321_I355_T1.7681.00
61_D156_I1.7491.00
86_Y118_T1.7491.00
79_D82_S1.7401.00
90_K94_Q1.7351.00
370_E376_D1.7301.00
374_M378_S1.7191.00
277_R366_M1.7101.00
185_M189_G1.6741.00
61_D64_Q1.6701.00
103_L128_V1.6651.00
71_M150_T1.6591.00
88_L92_K1.6571.00
311_Y370_E1.6341.00
54_L73_F1.6331.00
86_Y90_K1.6321.00
46_E184_R1.6191.00
88_L91_T1.6171.00
155_K186_I1.6071.00
117_Q121_N1.6031.00
250_T363_E1.6001.00
282_M311_Y1.5971.00
248_R275_S1.5971.00
179_E365_D1.5941.00
250_T275_S1.5921.00
226_I347_V1.5821.00
312_Q368_K1.5761.00
66_A155_K1.5641.00
279_I366_M1.5591.00
308_Y371_L1.5531.00
61_D152_I1.5211.00
68_S194_Q1.4761.00
297_Y307_I1.4741.00
119_M124_V1.4531.00
86_Y115_A1.3791.00
252_C279_I1.3781.00
50_C53_D1.3781.00
57_R158_Y1.3761.00
247_N324_D1.3761.00
252_C315_Y1.3641.00
80_E166_E1.3641.00
52_A56_E1.3601.00
234_L332_A1.3391.00
269_A272_N1.3341.00
267_I299_E1.3341.00
189_G224_H1.3301.00
59_M84_N1.3281.00
158_Y184_R1.3161.00
243_A265_A1.2961.00
245_A322_I1.2951.00
70_H194_Q1.2871.00
63_R84_N1.2871.00
151_V157_G1.2791.00
90_K118_T1.2771.00
284_S290_R1.2731.00
241_N326_L1.2611.00
159_I193_L1.2581.00
181_Y319_A1.2571.00
293_A297_Y1.2541.00
250_T359_Y1.2461.00
100_Y125_H1.2371.00
239_L265_A1.2321.00
335_D342_N1.2311.00
332_A346_N1.2291.00
357_E360_A1.2261.00
377_F380_R1.2061.00
149_I193_L1.2031.00
298_S302_D1.2001.00
280_V297_Y1.1911.00
77_K167_E1.1871.00
87_T90_K1.1791.00
59_M63_R1.1701.00
294_F309_R1.1681.00
49_H361_T1.1481.00
81_V166_E1.1441.00
102_L204_N1.1381.00
297_Y309_R1.1371.00
225_K229_T1.1221.00
325_H350_D1.1191.00
373_T376_D1.1121.00
46_E357_E1.1101.00
282_M370_E1.1061.00
43_S185_M1.1001.00
302_D374_M1.0961.00
83_H87_T1.0961.00
267_I271_K1.0951.00
80_E171_K1.0861.00
127_H205_T1.0801.00
53_D56_E1.0741.00
151_V193_L1.0721.00
48_I158_Y1.0711.00
260_K264_E1.0681.00
277_R363_E1.0681.00
87_T91_T1.0661.00
235_E259_S1.0641.00
58_M85_M1.0561.00
149_I345_V1.0521.00
66_A95_A1.0321.00
45_I349_I1.0321.00
356_S360_A1.0301.00
54_L162_F1.0291.00
265_A269_A1.0261.00
277_R308_Y1.0221.00
56_E60_N1.0141.00
248_R321_I1.0121.00
172_K175_F1.0111.00
363_E366_M1.0111.00
251_V320_L1.0081.00
328_I348_E1.0051.00
290_R294_F1.0011.00
79_D83_H1.0001.00
115_A118_T0.9991.00
263_Q267_I0.9891.00
54_L182_H0.9881.00
189_G226_I0.9871.00
232_Y235_E0.9821.00
156_I186_I0.9781.00
247_N325_H0.9771.00
252_C319_A0.9761.00
71_M85_M0.9751.00
159_I345_V0.9751.00
293_A296_Y0.9701.00
93_A124_V0.9691.00
237_I348_E0.9651.00
301_L374_M0.9621.00
320_L328_I0.9591.00
321_I359_Y0.9591.00
366_M369_S0.9551.00
283_K287_P0.9551.00
56_E84_N0.9511.00
360_A364_E0.9491.00
267_I303_A0.9431.00
362_I366_M0.9411.00
193_L345_V0.9401.00
324_D356_S0.9401.00
74_F342_N0.9391.00
222_I351_D0.9391.00
76_M164_I0.9321.00
163_N168_Y0.9311.00
225_K228_A0.9281.00
125_H207_I0.9261.00
70_H98_S0.9241.00
289_V293_A0.9221.00
115_A119_M0.9221.00
116_L120_K0.9161.00
288_L291_E0.9161.00
162_F182_H0.9111.00
327_S354_F0.9101.00
308_Y366_M0.9091.00
363_E367_K0.9081.00
73_F150_T0.9041.00
48_I184_R0.9011.00
183_L349_I0.8991.00
364_E368_K0.8961.00
67_S155_K0.8951.00
309_R372_L0.8941.00
240_A244_Q0.8941.00
100_Y201_L0.8911.00
118_T121_N0.8901.00
113_K117_Q0.8901.00
43_S188_E0.8881.00
245_A249_L0.8861.00
214_W217_L0.8811.00
60_N63_R0.8801.00
252_C362_I0.8761.00
46_E186_I0.8751.00
45_I224_H0.8731.00
77_K165_A0.8701.00
330_G346_N0.8691.00
228_A231_G0.8681.00
243_A268_N0.8661.00
249_L269_A0.8661.00
159_I347_V0.8641.00
91_T94_Q0.8621.00
256_Y278_I0.8611.00
152_I158_Y0.8591.00
50_C177_N0.8571.00
337_R342_N0.8561.00
301_L377_F0.8521.00
105_W128_V0.8461.00
290_R293_A0.8461.00
249_L266_L0.8441.00
305_C309_R0.8431.00
196_L228_A0.8431.00
142_Q337_R0.8411.00
69_V89_L0.8391.00
300_L305_C0.8371.00
40_K43_S0.8371.00
72_M145_N0.8371.00
246_K325_H0.8321.00
297_Y301_L0.8311.00
296_Y299_E0.8291.00
183_L329_I0.8281.00
51_G55_V0.8221.00
238_Y328_I0.8221.00
294_F297_Y0.8160.99
298_S378_S0.8140.99
226_I229_T0.8140.99
212_D215_P0.8120.99
191_H195_T0.8070.99
118_T122_A0.8040.99
232_Y340_F0.8010.99
279_I362_I0.8000.99
360_A363_E0.7980.99
76_M103_L0.7920.99
325_H352_E0.7920.99
239_L243_A0.7910.99
79_D166_E0.7880.99
67_S212_D0.7880.99
194_Q198_A0.7860.99
248_R277_R0.7820.99
47_L354_F0.7800.99
93_A99_V0.7790.99
71_M101_L0.7770.99
224_H229_T0.7760.99
63_R95_A0.7720.99
82_S164_I0.7690.99
151_V190_V0.7690.99
289_V296_Y0.7660.99
202_K205_T0.7650.99
85_M164_I0.7650.99
226_I345_V0.7640.99
262_L339_L0.7620.99
254_P335_D0.7620.99
47_L361_T0.7620.99
196_L345_V0.7620.99
281_P314_F0.7610.99
90_K124_V0.7610.99
235_E261_P0.7600.99
224_H347_V0.7600.99
331_T345_V0.7580.99
307_I310_Y0.7580.99
362_I365_D0.7560.99
62_I92_K0.7540.99
172_K176_G0.7530.99
68_S98_S0.7480.99
189_G192_D0.7460.99
242_I269_A0.7410.99
202_K208_E0.7400.99
76_M86_Y0.7400.99
261_P265_A0.7400.99
63_R66_A0.7390.99
49_H364_E0.7390.99
62_I85_M0.7390.99
39_S223_S0.7360.99
56_E59_M0.7290.99
222_I229_T0.7280.99
324_D355_T0.7270.99
64_Q67_S0.7240.99
371_L374_M0.7230.99
352_E356_S0.7180.99
289_V292_A0.7180.99
90_K93_A0.7170.99
250_T362_I0.7150.99
67_S98_S0.7150.99
70_H198_A0.7150.99
86_Y124_V0.7140.99
356_S359_Y0.7140.99
161_G168_Y0.7130.99
277_R371_L0.7130.99
276_V305_C0.7130.99
78_N112_K0.7120.99
170_G177_N0.7090.99
171_K174_K0.7060.99
224_H349_I0.7060.99
378_S381_T0.7040.98
72_M147_R0.7030.98
145_N200_D0.7030.98
78_N115_A0.7030.98
326_L348_E0.7020.98
165_A168_Y0.6980.98
197_F201_L0.6960.98
268_N272_N0.6950.98
283_K286_H0.6950.98
269_A274_V0.6950.98
43_S189_G0.6940.98
101_L126_V0.6940.98
99_V124_V0.6930.98
108_C111_I0.6920.98
234_L238_Y0.6910.98
282_M309_R0.6900.98
331_T342_N0.6890.98
105_W130_N0.6890.98
370_E374_M0.6870.98
63_R92_K0.6860.98
137_F140_H0.6840.98
62_I150_T0.6820.98
351_D354_F0.6780.98
114_T121_N0.6760.98
319_A358_V0.6750.98
279_I315_Y0.6750.98
250_T321_I0.6750.98
88_L95_A0.6740.98
93_A122_A0.6720.98
358_V362_I0.6720.98
288_L292_A0.6710.98
190_V194_Q0.6680.98
279_I365_D0.6660.98
376_D380_R0.6660.98
64_Q155_K0.6660.98
111_I115_A0.6660.98
211_S214_W0.6630.98
116_L126_V0.6620.98
84_N88_L0.6600.98
247_N275_S0.6590.98
222_I354_F0.6590.98
298_S377_F0.6590.98
62_I89_L0.6590.98
73_F182_H0.6590.98
311_Y368_K0.6580.98
158_Y182_H0.6570.98
55_V85_M0.6540.98
270_R303_A0.6530.98
353_A356_S0.6530.98
84_N87_T0.6450.97
70_H151_V0.6430.97
374_M380_R0.6430.97
222_I226_I0.6420.97
75_I167_E0.6420.97
73_F163_N0.6390.97
245_A274_V0.6360.97
69_V97_V0.6340.97
103_L126_V0.6340.97
326_L350_D0.6330.97
275_S363_E0.6320.97
71_M164_I0.6320.97
227_Y231_G0.6310.97
282_M287_P0.6300.97
161_G180_D0.6280.97
167_E170_G0.6270.97
301_L307_I0.6260.97
76_M82_S0.6250.97
70_H154_G0.6250.97
280_V309_R0.6240.97
223_S226_I0.6210.97
321_I327_S0.6170.97
55_V81_V0.6160.97
301_L372_L0.6140.96
375_E379_K0.6110.96
222_I349_I0.6110.96
354_F358_V0.6090.96
255_Y285_D0.6070.96
328_I332_A0.6060.96
82_S86_Y0.6040.96
291_E294_F0.6030.96
81_V169_L0.6030.96
298_S374_M0.6020.96
246_K274_V0.6020.96
227_Y237_I0.6000.96
58_M164_I0.6000.96
299_E302_D0.6000.96
262_L334_F0.6000.96
305_C308_Y0.5970.96
193_L226_I0.5960.96
369_S372_L0.5950.96
236_N268_N0.5950.96
321_I324_D0.5950.96
271_K303_A0.5940.96
234_L346_N0.5930.96
223_S350_D0.5900.96
49_H53_D0.5870.95
357_E361_T0.5850.95
332_A339_L0.5850.95
235_E239_L0.5850.95
265_A268_N0.5800.95
68_S100_Y0.5780.95
104_D144_R0.5780.95
213_V217_L0.5770.95
92_K97_V0.5760.95
205_T208_E0.5760.95
61_D186_I0.5750.95
94_Q123_G0.5710.95
221_T353_A0.5690.95
54_L150_T0.5690.95
297_Y372_L0.5680.95
185_M224_H0.5670.95
45_I354_F0.5670.95
270_R276_V0.5670.95
374_M381_T0.5670.95
168_Y178_W0.5660.94
41_K223_S0.5650.94
69_V92_K0.5620.94
80_E83_H0.5610.94
292_A296_Y0.5610.94
306_L309_R0.5600.94
267_I270_R0.5590.94
222_I225_K0.5550.94
290_R309_R0.5540.94
336_K340_F0.5540.94
242_I320_L0.5520.94
114_T118_T0.5520.94
354_F357_E0.5510.94
111_I116_L0.5500.94
194_Q197_F0.5480.93
281_P286_H0.5480.93
241_N328_I0.5480.93
87_T118_T0.5480.93
159_I183_L0.5470.93
58_M62_I0.5470.93
143_K230_D0.5460.93
264_E268_N0.5460.93
226_I230_D0.5460.93
361_T365_D0.5450.93
202_K206_G0.5440.93
192_D195_T0.5430.93
256_Y263_Q0.5430.93
198_A202_K0.5420.93
245_A323_D0.5420.93
227_Y230_D0.5410.93
300_L307_I0.5410.93
361_T364_E0.5390.93
58_M182_H0.5380.93
119_M123_G0.5380.93
232_Y236_N0.5380.93
78_N86_Y0.5380.93
358_V361_T0.5370.93
48_I182_H0.5370.93
231_G343_E0.5360.93
250_T366_M0.5360.93
319_A362_I0.5360.93
80_E84_N0.5350.93
143_K341_L0.5340.93
359_Y362_I0.5320.92
248_R322_I0.5310.92
287_P291_E0.5300.92
245_A269_A0.5290.92
45_I222_I0.5290.92
185_M193_L0.5270.92
214_W220_G0.5260.92
293_A301_L0.5230.92
227_Y348_E0.5220.92
242_I266_L0.5210.92
195_T199_S0.5200.92
212_D216_K0.5200.92
298_S301_L0.5200.92
290_R297_Y0.5190.92
352_E355_T0.5180.91
290_R300_L0.5180.91
178_W314_F0.5160.91
188_E191_H0.5160.91
100_Y197_F0.5150.91
284_S314_F0.5150.91
196_L199_S0.5130.91
61_D155_K0.5120.91
48_I54_L0.5120.91
183_L347_V0.5090.91
289_V297_Y0.5080.91
148_K163_N0.5080.91
104_D107_G0.5080.91
81_V164_I0.5060.90
181_Y317_V0.5050.90
334_F339_L0.5050.90
148_K318_K0.5050.90
242_I262_L0.5040.90
94_Q121_N0.5030.90
322_I326_L0.5030.90
285_D289_V0.5030.90
319_A329_I0.5020.90
289_V301_L0.5020.90
98_S213_V0.5020.90
373_T377_F0.5020.90
90_K119_M0.5010.90
223_S229_T0.5010.90
47_L327_S0.5000.90
298_S380_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v0wA 1 0.9196 100 0.356 Contact Map
3hsiA 2 0.9296 100 0.374 Contact Map
2o8rA 2 0.8693 100 0.512 Contact Map
1xdpA 4 0.8693 100 0.518 Contact Map
4urjA 1 0.407 99.9 0.731 Contact Map
1byrA 2 0.3769 99.9 0.734 Contact Map
4gelA 2 0.4472 99.9 0.75 Contact Map
4ggjA 2 0.4121 99.9 0.753 Contact Map
2c1lA 2 0.4246 99.8 0.775 Contact Map
4rctA 2 0.4372 99.5 0.834 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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