GREMLIN Database
UVSE - UV DNA damage endonuclease
UniProt: P45864 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (300)
Sequences: 629 (454)
Seq/√Len: 26.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_E231_R7.9941.00
100_V107_T5.3671.00
7_F58_I5.2471.00
26_A30_K4.7311.00
133_A176_P4.3891.00
151_N184_T3.9311.00
201_C208_F3.6221.00
119_S125_T3.1881.00
115_T128_A3.0061.00
68_F100_V2.9491.00
55_L99_L2.8371.00
121_K124_V2.8071.00
288_A294_A2.6560.99
275_F282_I2.5970.99
157_A191_T2.5850.99
26_A29_S2.5640.99
23_L43_V2.4320.99
94_R98_E2.3550.98
93_F138_M2.3480.98
169_H203_Q2.2550.98
160_N163_T2.2430.98
59_I99_L2.2370.98
165_T200_V2.2330.98
52_M99_L2.1830.97
56_H99_L2.1710.97
21_K46_A2.0880.97
59_I103_H2.0670.96
98_E102_T2.0440.96
140_E182_R2.0180.96
99_L103_H1.9940.95
191_T196_E1.9580.95
176_P179_I1.9220.94
262_Y290_Q1.8690.94
84_D87_T1.8470.93
68_F107_T1.8190.93
90_Q94_R1.8120.92
45_K92_E1.7880.92
193_T218_N1.7780.92
115_T131_D1.7630.91
41_L88_P1.7540.91
77_T134_Y1.6780.89
210_F232_M1.6780.89
120_P158_Y1.6520.88
154_I200_V1.6470.88
52_M95_E1.6160.87
97_G100_V1.6140.87
65_L108_S1.5840.86
51_T66_Y1.5800.86
247_L286_I1.5790.86
295_L299_M1.5730.86
271_L275_F1.5610.85
247_L268_L1.5340.84
152_I184_T1.5210.84
234_K237_E1.4990.83
177_Q181_E1.4870.82
51_T68_F1.4790.82
97_G144_I1.4670.82
244_K285_M1.4510.81
136_Y178_E1.4370.80
48_L96_I1.4360.80
27_R30_K1.4350.80
168_F185_L1.4220.79
132_M179_I1.4180.79
11_A57_Y1.4170.79
28_Y36_R1.4140.79
194_T228_A1.4060.79
243_P282_I1.4040.79
109_F151_N1.4010.78
109_F139_L1.4000.78
157_A161_K1.3760.77
216_Y267_F1.3710.77
112_N128_A1.3710.77
228_A232_M1.3580.76
217_A256_I1.3490.76
92_E96_I1.3320.75
25_F80_D1.3230.74
69_S112_N1.3220.74
24_T27_R1.3120.74
23_L28_Y1.3010.73
71_S112_N1.2910.72
144_I148_S1.2900.72
69_S135_H1.2890.72
124_V194_T1.2870.72
149_V184_T1.2740.71
166_A170_Q1.2720.71
57_Y292_D1.2640.71
123_S127_N1.2610.71
8_V112_N1.2530.70
215_F225_L1.2450.70
127_N130_T1.2430.69
13_S293_K1.2290.69
189_D193_T1.2090.67
12_M293_K1.2080.67
194_T208_F1.2070.67
109_F138_M1.2040.67
249_S292_D1.2030.67
245_V284_F1.2020.67
5_F268_L1.2010.67
120_P160_N1.1960.66
10_N20_A1.1940.66
177_Q180_K1.1930.66
112_N131_D1.1930.66
108_S131_D1.1920.66
52_M56_H1.1870.66
25_F29_S1.1840.66
168_F286_I1.1770.65
233_I243_P1.1680.65
69_S96_I1.1670.64
158_Y164_A1.1460.63
5_F295_L1.1360.62
21_K258_S1.1280.62
250_P257_R1.1180.61
25_F28_Y1.1140.61
25_F77_T1.1060.60
154_I292_D1.1030.60
52_M96_I1.0970.60
44_T89_F1.0910.59
194_T232_M1.0830.59
292_D295_L1.0710.58
172_I180_K1.0670.57
213_H250_P1.0630.57
205_D238_R1.0620.57
126_K174_Q1.0600.57
195_E223_A1.0570.57
65_L285_M1.0550.57
75_L217_A1.0480.56
11_A293_K1.0450.56
70_S291_K1.0440.56
213_H257_R1.0400.55
166_A203_Q1.0350.55
116_L125_T1.0350.55
151_N244_K1.0350.55
151_N197_T1.0340.55
294_A298_L1.0330.55
195_E206_V1.0270.54
180_K206_V1.0260.54
297_R301_E1.0240.54
94_R101_K1.0170.54
140_E178_E1.0150.54
196_E218_N1.0120.53
9_S71_S1.0110.53
44_T73_V1.0100.53
8_V11_A1.0080.53
44_T48_L0.9990.52
290_Q293_K0.9950.52
97_G101_K0.9940.52
49_R92_E0.9930.52
224_D227_V0.9850.51
91_K102_T0.9840.51
286_I295_L0.9820.51
271_L284_F0.9810.51
70_S111_P0.9730.50
195_E221_D0.9620.50
9_S20_A0.9620.50
55_L177_Q0.9620.50
172_I204_E0.9610.50
77_T131_D0.9550.49
108_S115_T0.9540.49
296_L300_D0.9470.49
23_L75_L0.9440.48
122_E154_I0.9430.48
158_Y161_K0.9420.48
144_I182_R0.9420.48
59_I105_L0.9380.48
75_L78_H0.9370.48
49_R91_K0.9340.48
147_R175_L0.9340.48
90_Q101_K0.9330.47
213_H288_A0.9260.47
72_I138_M0.9240.47
14_L73_V0.9220.47
246_H288_A0.9190.46
23_L36_R0.9180.46
156_G192_Y0.9170.46
165_T199_Q0.9090.46
168_F206_V0.9040.45
32_S35_E0.8970.45
21_K25_F0.8900.44
31_L77_T0.8860.44
22_T27_R0.8860.44
185_L200_V0.8840.44
98_E101_K0.8780.43
265_A301_E0.8780.43
35_E38_E0.8730.43
197_T208_F0.8690.43
205_D300_D0.8630.42
152_I197_T0.8630.42
76_A134_Y0.8590.42
260_A302_L0.8550.42
215_F221_D0.8550.42
55_L96_I0.8470.41
10_N36_R0.8460.41
44_T83_W0.8450.41
117_F132_M0.8440.41
117_F125_T0.8420.41
73_V124_V0.8380.41
141_A175_L0.8370.40
24_T28_Y0.8340.40
160_N164_A0.8300.40
208_F229_L0.8190.39
33_K37_K0.8190.39
22_T26_A0.8120.39
215_F220_D0.8110.39
161_K218_N0.8110.39
224_D270_P0.8090.39
259_H263_V0.8080.38
48_L73_V0.8060.38
157_A196_E0.8030.38
118_T200_V0.7970.38
290_Q297_R0.7970.38
157_A192_Y0.7970.38
19_P142_M0.7950.38
7_F283_D0.7930.37
199_Q203_Q0.7930.37
133_A179_I0.7920.37
136_Y179_I0.7920.37
83_W213_H0.7910.37
16_D42_T0.7890.37
7_F285_M0.7880.37
91_K177_Q0.7860.37
6_G9_S0.7850.37
233_I282_I0.7840.37
213_H294_A0.7840.37
149_V239_I0.7830.37
251_K258_S0.7800.36
191_T218_N0.7780.36
151_N246_H0.7780.36
272_L275_F0.7770.36
102_T173_K0.7730.36
78_H83_W0.7700.36
111_P291_K0.7690.36
172_I239_I0.7690.36
55_L139_L0.7690.36
220_D224_D0.7670.36
69_S161_K0.7660.36
120_P269_L0.7640.35
195_E220_D0.7620.35
11_A14_L0.7610.35
109_F150_I0.7610.35
10_N128_A0.7610.35
149_V247_L0.7590.35
129_V183_M0.7550.35
41_L150_I0.7540.35
184_T209_V0.7520.35
33_K36_R0.7520.35
4_R78_H0.7510.35
142_M192_Y0.7500.34
31_L36_R0.7490.34
9_S112_N0.7480.34
154_I197_T0.7480.34
13_S57_Y0.7450.34
132_M183_M0.7440.34
70_S135_H0.7420.34
109_F184_T0.7420.34
154_I196_E0.7410.34
23_L26_A0.7400.34
113_Q119_S0.7360.34
202_E234_K0.7360.34
92_E98_E0.7350.33
104_Q282_I0.7330.33
97_G258_S0.7330.33
45_K49_R0.7320.33
164_A249_S0.7260.33
54_T58_I0.7260.33
151_N209_V0.7240.33
55_L59_I0.7210.33
119_S124_V0.7200.32
163_T166_A0.7200.32
98_E173_K0.7190.32
151_N185_L0.7150.32
38_E262_Y0.7110.32
163_T167_Q0.7100.32
38_E41_L0.7080.32
209_V215_F0.7070.32
159_G243_P0.7060.32
247_L288_A0.7020.31
149_V182_R0.6990.31
241_L294_A0.6990.31
121_K154_I0.6990.31
20_A28_Y0.6990.31
122_E126_K0.6940.31
288_A298_L0.6910.31
96_I141_A0.6900.31
71_S125_T0.6840.30
98_E237_E0.6830.30
100_V168_F0.6810.30
68_F142_M0.6780.30
128_A131_D0.6780.30
40_L90_Q0.6720.29
247_L262_Y0.6720.29
261_D298_L0.6670.29
112_N115_T0.6660.29
54_T285_M0.6650.29
65_L162_D0.6640.29
102_T304_S0.6640.29
9_S113_Q0.6620.29
195_E224_D0.6610.29
118_T268_L0.6580.29
114_F135_H0.6570.28
123_S162_D0.6540.28
82_M183_M0.6530.28
191_T197_T0.6510.28
117_F183_M0.6490.28
61_H96_I0.6480.28
69_S109_F0.6470.28
174_Q178_E0.6460.28
155_G158_Y0.6440.28
69_S192_Y0.6440.28
71_S113_Q0.6440.28
55_L105_L0.6440.28
58_I65_L0.6420.28
148_S278_W0.6400.27
121_K191_T0.6400.27
261_D290_Q0.6390.27
60_G205_D0.6360.27
90_Q141_A0.6360.27
159_G164_A0.6350.27
157_A218_N0.6330.27
53_R60_G0.6320.27
36_R39_A0.6310.27
151_N191_T0.6310.27
118_T132_M0.6280.27
45_K124_V0.6270.27
77_T80_D0.6260.27
30_K34_T0.6260.27
262_Y297_R0.6240.27
171_N174_Q0.6190.26
29_S237_E0.6190.26
109_F250_P0.6180.26
224_D297_R0.6120.26
269_L302_L0.6110.26
139_L144_I0.6110.26
174_Q274_R0.6100.26
104_Q130_T0.6070.26
68_F96_I0.6070.26
150_I153_H0.6060.26
101_K178_E0.6050.25
45_K203_Q0.6030.25
164_A192_Y0.6000.25
123_S164_A0.5990.25
251_K255_A0.5950.25
66_Y69_S0.5950.25
118_T169_H0.5950.25
95_E98_E0.5940.25
52_M105_L0.5930.25
213_H298_L0.5920.25
169_H204_E0.5880.25
8_V71_S0.5860.24
95_E167_Q0.5850.24
197_T254_Q0.5850.24
10_N204_E0.5830.24
19_P50_N0.5820.24
109_F208_F0.5810.24
112_N118_T0.5780.24
118_T184_T0.5750.24
78_H244_K0.5740.24
154_I208_F0.5740.24
242_Q281_N0.5740.24
217_A267_F0.5740.24
20_A286_I0.5730.24
96_I100_V0.5730.24
91_K130_T0.5700.24
142_M210_F0.5700.24
162_D302_L0.5690.23
128_A164_A0.5690.23
58_I285_M0.5680.23
55_L103_H0.5680.23
34_T38_E0.5660.23
163_T303_S0.5660.23
152_I160_N0.5650.23
49_R230_P0.5650.23
58_I161_K0.5650.23
91_K234_K0.5600.23
136_Y176_P0.5580.23
128_A223_A0.5570.23
30_K200_V0.5560.23
32_S36_R0.5550.23
172_I284_F0.5540.23
113_Q125_T0.5540.23
15_W99_L0.5530.23
23_L31_L0.5520.23
169_H200_V0.5520.23
51_T115_T0.5490.22
26_A39_A0.5470.22
135_H139_L0.5470.22
250_P256_I0.5440.22
75_L85_F0.5440.22
67_R110_H0.5440.22
114_F175_L0.5440.22
17_A124_V0.5430.22
115_T156_G0.5430.22
251_K257_R0.5420.22
19_P51_T0.5410.22
168_F172_I0.5390.22
4_R208_F0.5390.22
113_Q159_G0.5380.22
139_L285_M0.5370.22
51_T136_Y0.5360.22
127_N152_I0.5360.22
184_T191_T0.5360.22
215_F219_P0.5350.22
169_H205_D0.5350.22
292_D301_E0.5350.22
208_F232_M0.5320.22
176_P263_V0.5310.22
67_R186_E0.5310.22
224_D235_T0.5290.21
98_E126_K0.5280.21
11_A40_L0.5280.21
96_I151_N0.5270.21
52_M142_M0.5260.21
213_H262_Y0.5250.21
268_L272_L0.5250.21
123_S126_K0.5250.21
20_A24_T0.5240.21
194_T260_A0.5240.21
200_V204_E0.5230.21
9_S279_G0.5230.21
152_I157_A0.5210.21
182_R239_I0.5200.21
48_L259_H0.5200.21
57_Y89_F0.5180.21
199_Q208_F0.5180.21
252_S255_A0.5180.21
164_A167_Q0.5170.21
136_Y221_D0.5170.21
50_N57_Y0.5170.21
8_V285_M0.5170.21
98_E229_L0.5150.21
31_L73_V0.5140.21
38_E205_D0.5130.21
54_T63_I0.5120.21
246_H298_L0.5120.21
47_N187_N0.5120.21
106_R283_D0.5120.21
27_R39_A0.5110.21
149_V209_V0.5100.20
97_G143_G0.5090.20
124_V292_D0.5070.20
97_G142_M0.5050.20
101_K143_G0.5050.20
93_F148_S0.5040.20
157_A164_A0.5040.20
120_P131_D0.5030.20
188_D215_F0.5020.20
115_T201_C0.5020.20
68_F144_I0.5020.20
116_L256_I0.5010.20
181_E274_R0.5000.20
95_E216_Y0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tc3A 1 0.9062 100 0.536 Contact Map
2j6vA 1 0.8688 100 0.582 Contact Map
3kwsA 2 0.7625 99.6 0.863 Contact Map
4hnoA 1 0.825 99.5 0.87 Contact Map
3p14A 2 0.8969 99.5 0.872 Contact Map
1qtwA 1 0.8063 99.5 0.872 Contact Map
3aamA 1 0.7719 99.5 0.874 Contact Map
3wqoA 2 0.7875 99.5 0.875 Contact Map
3aalA 1 0.8375 99.4 0.878 Contact Map
3ayvA 2 0.7188 99.4 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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