GREMLIN Database
CLS1 - Probable cardiolipin synthase YwiE
UniProt: P45860 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 500 (469)
Sequences: 3207 (2428)
Seq/√Len: 112.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_R187_E6.7771.00
408_E473_K5.9761.00
157_A254_F5.6841.00
188_K191_Q5.5891.00
158_M184_I5.5451.00
377_E408_E4.0481.00
154_I246_V3.9951.00
157_A280_R3.7561.00
253_G289_L3.6481.00
172_F197_F3.6001.00
155_F184_I3.3441.00
187_E191_Q3.3411.00
426_G461_E3.0801.00
155_F181_M3.0461.00
194_E221_D2.9061.00
142_K153_D2.8061.00
138_K284_E2.7731.00
140_N282_E2.7601.00
186_M218_A2.7061.00
150_T154_I2.6931.00
466_E469_Q2.6611.00
150_T169_Y2.6591.00
325_I449_V2.6271.00
253_G286_V2.5991.00
414_K470_E2.5771.00
379_R408_E2.5701.00
157_A160_K2.5661.00
429_A457_I2.5601.00
381_M471_S2.4481.00
254_F280_R2.4331.00
372_A407_I2.3191.00
472_E478_G2.3111.00
156_K160_K2.2891.00
429_A460_L2.2801.00
352_W379_R2.2611.00
157_A252_T2.2031.00
162_E191_Q2.1891.00
162_E251_K2.1431.00
430_S448_N2.1251.00
451_F456_A2.1171.00
386_N392_Q2.1001.00
144_L153_D2.0961.00
215_M220_V2.0941.00
350_S461_E2.0861.00
153_D254_F2.0661.00
182_M186_M2.0641.00
182_M214_R2.0571.00
158_M165_I2.0551.00
343_M424_I2.0371.00
476_P480_Y2.0341.00
410_Y473_K2.0301.00
245_I289_L2.0271.00
381_M468_M2.0131.00
354_A381_M2.0031.00
350_S426_G1.9901.00
167_I246_V1.9801.00
221_D303_E1.9711.00
482_R490_E1.9541.00
379_R468_M1.9531.00
344_I351_I1.9521.00
184_I188_K1.9511.00
153_D157_A1.9441.00
423_I457_I1.9131.00
199_Y224_P1.8981.00
396_R411_S1.8941.00
176_M267_R1.8841.00
384_E413_Q1.8711.00
413_Q472_E1.8621.00
382_V399_F1.8521.00
186_M190_R1.8461.00
281_L285_I1.8311.00
174_S179_R1.8101.00
182_M211_D1.8071.00
461_E465_E1.8071.00
153_D280_R1.7941.00
213_M217_Q1.7941.00
164_Y290_H1.7901.00
159_R184_I1.7811.00
155_F180_G1.7681.00
369_K401_E1.7601.00
223_V301_S1.7561.00
352_W377_E1.7331.00
159_R180_G1.7311.00
468_M471_S1.7311.00
166_H196_R1.7251.00
399_F409_V1.7191.00
139_S281_L1.7131.00
352_W465_E1.7111.00
146_N273_F1.7081.00
148_E152_P1.6731.00
285_I323_Y1.6671.00
152_P180_G1.6521.00
351_I424_I1.6441.00
349_K426_G1.6201.00
146_N149_E1.5771.00
384_E472_E1.5471.00
252_T282_E1.5431.00
251_K282_E1.5411.00
153_D156_K1.5401.00
245_I447_V1.5351.00
166_H290_H1.5321.00
252_T280_R1.5221.00
175_D178_G1.5071.00
183_D186_M1.4971.00
321_G453_D1.4951.00
403_L476_P1.4891.00
195_V220_V1.4881.00
379_R410_Y1.4861.00
402_L407_I1.4771.00
142_K280_R1.4641.00
399_F411_S1.4601.00
404_L476_P1.4601.00
167_I181_M1.4531.00
336_M434_A1.4531.00
255_V289_L1.4411.00
281_L449_V1.4331.00
323_Y449_V1.4301.00
285_I325_I1.4221.00
145_K463_H1.4181.00
69_F72_V1.4131.00
141_I451_F1.4081.00
143_V463_H1.3901.00
142_K459_T1.3871.00
177_L262_K1.3801.00
176_M262_K1.3771.00
379_R465_E1.3741.00
152_P156_K1.3661.00
339_L450_F1.3651.00
157_A248_I1.3631.00
275_R467_D1.3631.00
169_Y246_V1.3531.00
184_I187_E1.3511.00
396_R486_D1.3501.00
156_K159_R1.3451.00
292_I327_A1.3431.00
247_I289_L1.3371.00
181_M260_V1.3341.00
154_I181_M1.3321.00
462_A466_E1.3251.00
411_S474_L1.3241.00
350_S377_E1.3111.00
352_W461_E1.3101.00
141_I323_Y1.3090.99
354_A417_M1.2920.99
173_K263_E1.2870.99
310_E313_T1.2820.99
155_F159_R1.2790.99
186_M214_R1.2700.99
127_S339_L1.2690.99
354_A421_V1.2660.99
150_T278_H1.2630.99
343_M428_L1.2580.99
479_F482_R1.2530.99
164_Y250_G1.2490.99
159_R188_K1.2460.99
255_V447_V1.2440.99
170_Y444_N1.2440.99
201_A224_P1.2390.99
431_V460_L1.2350.99
136_N288_T1.2310.99
135_I322_I1.2280.99
398_Y494_R1.2170.99
167_I260_V1.2100.99
163_S251_K1.1970.99
382_V395_S1.1960.99
320_G455_E1.1920.99
381_M464_F1.1910.99
354_A464_F1.1860.99
168_E241_N1.1770.99
393_Y490_E1.1730.99
183_D187_E1.1680.99
349_K427_D1.1650.99
198_L300_V1.1620.99
390_L493_A1.1590.99
292_I447_V1.1570.99
159_R162_E1.1560.99
182_M220_V1.1520.99
397_S494_R1.1510.99
250_G290_H1.1470.99
350_S423_I1.1430.99
175_D179_R1.1330.99
279_L451_F1.1280.98
337_S361_N1.1260.98
492_F496_F1.1260.98
341_Y364_I1.1230.98
364_I441_F1.1220.98
181_M184_I1.1200.98
159_R191_Q1.1130.98
393_Y489_K1.1080.98
255_V449_V1.1080.98
143_V456_A1.1060.98
150_T258_L1.1050.98
380_V409_V1.1040.98
350_S424_I1.0980.98
466_E470_E1.0970.98
241_N296_D1.0930.98
179_R183_D1.0920.98
207_L212_I1.0840.98
351_I368_L1.0820.98
184_I191_Q1.0810.98
381_M417_M1.0680.98
104_L107_K1.0630.98
158_M181_M1.0620.98
459_T462_A1.0600.98
436_M441_F1.0600.98
358_F380_V1.0560.98
46_I67_V1.0480.98
186_M220_V1.0430.97
289_L447_V1.0320.97
157_A282_E1.0320.97
273_F412_Y1.0320.97
246_V260_V1.0270.97
429_A456_A1.0160.97
163_S310_E1.0160.97
173_K261_G1.0100.97
144_L254_F1.0090.97
353_I422_M1.0050.97
384_E411_S1.0040.97
194_E310_E0.9980.97
160_K248_I0.9970.97
434_A448_N0.9920.97
160_K252_T0.9850.96
261_G265_I0.9830.96
385_K389_F0.9800.96
369_K373_T0.9790.96
475_S478_G0.9760.96
189_A218_A0.9750.96
277_T419_Q0.9690.96
172_F260_V0.9640.96
141_I321_G0.9620.96
309_E312_N0.9620.96
334_E442_Q0.9580.96
207_L211_D0.9580.96
279_L449_V0.9570.96
325_I447_V0.9560.96
124_F135_I0.9550.96
171_M263_E0.9520.96
149_E152_P0.9480.96
344_I368_L0.9470.96
154_I248_I0.9450.95
398_Y497_S0.9450.95
214_R218_A0.9440.95
421_V464_F0.9430.95
144_L280_R0.9430.95
320_G453_D0.9410.95
400_P480_Y0.9380.95
351_I371_A0.9340.95
485_A489_K0.9280.95
358_F402_L0.9240.95
465_E468_M0.9240.95
403_L473_K0.9210.95
396_R399_F0.9210.95
104_L109_E0.9170.95
403_L479_F0.9160.95
377_E473_K0.9090.94
464_F468_M0.9060.94
180_G184_I0.9050.94
151_F177_L0.9050.94
202_A205_M0.9050.94
426_G458_R0.9050.94
61_L65_I0.8990.94
427_D454_A0.8990.94
122_R374_K0.8970.94
274_W415_G0.8970.94
358_F436_M0.8920.94
152_P155_F0.8840.94
160_K163_S0.8830.94
349_K377_E0.8820.94
119_N427_D0.8770.93
323_Y451_F0.8750.93
264_Y274_W0.8720.93
348_Q427_D0.8700.93
403_L474_L0.8680.93
400_P476_P0.8660.93
384_E392_Q0.8640.93
45_S78_L0.8620.93
168_E260_V0.8580.93
189_A220_V0.8540.92
344_I371_A0.8510.92
321_G451_F0.8500.92
340_Y430_S0.8480.92
382_V411_S0.8460.92
277_T421_V0.8390.92
334_E337_S0.8390.92
196_R221_D0.8370.92
422_M430_S0.8340.91
340_Y434_A0.8340.91
169_Y278_H0.8280.91
433_T447_V0.8280.91
142_K282_E0.8280.91
122_R348_Q0.8270.91
392_Q411_S0.8270.91
341_Y345_S0.8270.91
166_H194_E0.8200.91
372_A405_E0.8190.91
400_P404_L0.8180.91
345_S367_A0.8170.91
99_E103_K0.8160.91
456_A459_T0.8160.91
187_E190_R0.8140.90
178_G182_M0.8130.90
358_F409_V0.8130.90
423_I461_E0.8100.90
410_Y468_M0.8090.90
211_D214_R0.8070.90
403_L409_V0.8060.90
465_E469_Q0.8040.90
40_S44_F0.8030.90
328_T336_M0.8020.90
391_T395_S0.8000.90
165_I248_I0.7980.90
238_N257_G0.7970.90
201_A226_S0.7970.90
180_G183_D0.7940.89
136_N139_S0.7880.89
124_F127_S0.7870.89
337_S363_S0.7870.89
326_V339_L0.7860.89
342_E346_S0.7830.89
208_A212_I0.7830.89
484_V487_R0.7820.89
285_I288_T0.7810.89
313_T316_P0.7790.88
351_I376_V0.7780.88
105_F108_E0.7780.88
396_R490_E0.7760.88
486_D489_K0.7720.88
379_R473_K0.7710.88
141_I456_A0.7700.88
248_I254_F0.7700.88
412_Y415_G0.7700.88
225_F238_N0.7670.88
199_Y222_I0.7650.88
211_D215_M0.7640.87
367_A371_A0.7590.87
172_F182_M0.7510.87
93_K97_N0.7500.86
477_V481_K0.7500.86
422_M436_M0.7470.86
400_P479_F0.7460.86
175_D262_K0.7460.86
421_V460_L0.7450.86
139_S284_E0.7440.86
177_L265_I0.7440.86
399_F403_L0.7430.86
402_L409_V0.7420.86
456_A460_L0.7390.86
263_E266_S0.7380.86
358_F365_R0.7370.86
462_A465_E0.7360.85
273_F414_K0.7350.85
113_V116_L0.7350.85
338_D369_K0.7330.85
338_D370_A0.7320.85
186_M189_A0.7290.85
400_P482_R0.7290.85
338_D373_T0.7270.85
147_G177_L0.7270.85
381_M467_D0.7250.85
33_G37_C0.7250.85
111_P114_T0.7240.85
347_A424_I0.7240.85
166_H247_I0.7230.84
362_E366_T0.7230.84
268_D272_G0.7210.84
127_S326_V0.7190.84
321_G456_A0.7150.84
243_R296_D0.7130.84
257_G264_Y0.7120.84
197_F222_I0.7090.83
458_R462_A0.7090.83
145_K466_E0.7090.83
472_E475_S0.7080.83
430_S450_F0.7050.83
341_Y367_A0.7050.83
147_G257_G0.7040.83
266_S388_S0.7040.83
263_E271_I0.7040.83
46_I63_I0.7030.83
473_K476_P0.6990.82
189_A194_E0.6990.82
43_L47_Y0.6990.82
368_L407_I0.6990.82
140_N320_G0.6980.82
160_K251_K0.6960.82
258_L278_H0.6950.82
94_R98_R0.6950.82
64_H68_F0.6940.82
476_P483_G0.6930.82
104_L108_E0.6910.82
413_Q470_E0.6910.82
64_H67_V0.6900.82
155_F177_L0.6900.82
230_Y234_N0.6890.81
151_F260_V0.6890.81
388_S392_Q0.6880.81
166_H294_M0.6880.81
42_I46_I0.6840.81
177_L180_G0.6840.81
173_K260_V0.6820.81
108_E112_E0.6810.81
394_A500_L0.6800.81
298_E304_V0.6800.81
365_R369_K0.6790.81
144_L150_T0.6790.81
350_S379_R0.6780.80
145_K149_E0.6770.80
423_I429_A0.6770.80
321_G454_A0.6740.80
210_R213_M0.6730.80
421_V431_V0.6730.80
328_T332_M0.6720.80
103_K106_D0.6720.80
53_N491_S0.6710.80
172_F199_Y0.6690.80
399_F474_L0.6690.80
172_F211_D0.6680.79
214_R217_Q0.6660.79
274_W387_D0.6660.79
345_S436_M0.6650.79
423_I468_M0.6650.79
411_S472_E0.6610.79
353_I436_M0.6610.79
488_T492_F0.6600.79
225_F257_G0.6600.79
35_L39_I0.6600.79
404_L480_Y0.6590.79
484_V488_T0.6590.79
139_S453_D0.6560.78
463_H467_D0.6520.78
493_A496_F0.6510.78
298_E301_S0.6500.78
239_F443_L0.6480.77
437_D444_N0.6480.77
330_P445_F0.6480.77
277_T467_D0.6470.77
179_R214_R0.6470.77
65_I69_F0.6460.77
307_D311_Y0.6460.77
159_R195_V0.6460.77
421_V463_H0.6460.77
100_K104_L0.6420.77
189_A195_V0.6380.76
255_V279_L0.6380.76
170_Y388_S0.6370.76
412_Y470_E0.6360.76
32_Y35_L0.6350.76
261_G264_Y0.6350.76
480_Y483_G0.6340.76
174_S211_D0.6330.76
190_R217_Q0.6330.76
427_D453_D0.6320.76
358_F407_I0.6320.76
216_K222_I0.6310.76
247_I286_V0.6310.76
151_F155_F0.6260.75
107_K111_P0.6250.75
328_T335_S0.6240.75
179_R182_M0.6240.75
228_L231_G0.6220.74
55_T58_H0.6210.74
324_Q452_T0.6210.74
483_G488_T0.6210.74
136_N285_I0.6200.74
166_H250_G0.6200.74
146_N152_P0.6180.74
257_G464_F0.6180.74
51_L484_V0.6170.74
393_Y482_R0.6160.74
343_M350_S0.6160.74
123_F343_M0.6150.74
311_Y315_V0.6150.74
167_I197_F0.6150.74
343_M351_I0.6130.73
266_S272_G0.6110.73
155_F188_K0.6110.73
296_D329_G0.6080.73
144_L157_A0.6060.73
49_L59_T0.6060.73
199_Y204_S0.6040.72
454_A458_R0.6040.72
118_D122_R0.6040.72
190_R219_G0.6040.72
383_P395_S0.6030.72
147_G276_D0.6020.72
223_V300_V0.6020.72
333_K373_T0.6010.72
394_A398_Y0.6010.72
147_G151_F0.6010.72
45_S48_S0.6000.72
144_L149_E0.5990.72
248_I282_E0.5980.72
383_P391_T0.5960.71
383_P445_F0.5960.71
113_V124_F0.5950.71
264_Y415_G0.5940.71
262_K267_R0.5940.71
59_T494_R0.5920.71
64_H428_L0.5920.71
438_M442_Q0.5910.71
254_F286_V0.5910.71
398_Y401_E0.5910.71
113_V117_K0.5900.71
53_N56_S0.5900.71
426_G457_I0.5880.70
363_S493_A0.5880.70
119_N348_Q0.5880.70
394_A493_A0.5880.70
225_F445_F0.5880.70
150_T246_V0.5870.70
337_S364_I0.5870.70
66_L74_Y0.5860.70
415_G445_F0.5860.70
268_D271_I0.5830.70
352_W468_M0.5820.70
205_M224_P0.5820.70
190_R218_A0.5820.70
100_K103_K0.5810.69
165_I195_V0.5810.69
38_Y46_I0.5810.69
164_Y294_M0.5810.69
70_P73_G0.5800.69
102_R106_D0.5800.69
482_R487_R0.5800.69
209_R212_I0.5800.69
332_M335_S0.5800.69
60_L63_I0.5790.69
326_V331_D0.5790.69
369_K405_E0.5790.69
85_V89_L0.5790.69
158_M167_I0.5790.69
109_E115_G0.5780.69
397_S490_E0.5770.69
257_G467_D0.5770.69
341_Y370_A0.5770.69
257_G261_G0.5740.68
212_I222_I0.5730.68
208_A211_D0.5730.68
154_I433_T0.5730.68
139_S323_Y0.5720.68
118_D121_E0.5720.68
324_Q354_A0.5710.68
177_L260_V0.5710.68
238_N467_D0.5710.68
457_I460_L0.5700.68
257_G263_E0.5670.68
389_F392_Q0.5670.68
483_G486_D0.5660.67
150_T254_F0.5650.67
149_E273_F0.5650.67
148_E273_F0.5620.67
239_F286_V0.5610.67
382_V407_I0.5610.67
113_V281_L0.5600.67
365_R401_E0.5600.67
360_P365_R0.5600.67
106_D109_E0.5580.66
69_F76_F0.5580.66
212_I220_V0.5570.66
176_M180_G0.5560.66
165_I185_M0.5550.66
180_G267_R0.5550.66
164_Y211_D0.5550.66
493_A500_L0.5540.66
384_E389_F0.5540.66
170_Y268_D0.5540.66
58_H239_F0.5540.66
164_Y311_Y0.5540.66
147_G238_N0.5530.66
85_V239_F0.5530.66
282_E318_E0.5520.66
110_T116_L0.5520.66
254_F278_H0.5510.65
332_M336_M0.5510.65
364_I436_M0.5500.65
147_G278_H0.5500.65
390_L393_Y0.5490.65
251_K315_V0.5480.65
263_E388_S0.5460.65
433_T444_N0.5460.65
326_V450_F0.5450.65
344_I424_I0.5450.65
154_I157_A0.5440.64
312_N315_V0.5440.64
147_G258_L0.5440.64
121_E125_T0.5430.64
259_N264_Y0.5420.64
264_Y416_F0.5420.64
213_M216_K0.5410.64
480_Y485_A0.5400.64
186_M193_V0.5400.64
298_E302_N0.5400.64
428_L450_F0.5390.64
389_F489_K0.5390.64
393_Y493_A0.5390.64
363_S367_A0.5380.64
423_I464_F0.5370.63
359_V438_M0.5360.63
389_F393_Y0.5360.63
180_G187_E0.5350.63
344_I364_I0.5340.63
53_N400_P0.5330.63
245_I325_I0.5330.63
157_A251_K0.5330.63
227_P300_V0.5330.63
383_P388_S0.5320.63
263_E273_F0.5320.63
453_D456_A0.5310.63
105_F112_E0.5300.62
108_E111_P0.5300.62
455_E458_R0.5300.62
39_I43_L0.5290.62
186_M215_M0.5290.62
99_E424_I0.5280.62
106_D117_K0.5280.62
142_K149_E0.5280.62
38_Y42_I0.5280.62
69_F105_F0.5270.62
201_A227_P0.5260.62
172_F181_M0.5250.62
156_K162_E0.5250.62
294_M305_L0.5240.62
90_F331_D0.5240.62
163_S194_E0.5240.62
80_S237_L0.5240.62
176_M265_I0.5240.62
423_I426_G0.5210.61
102_R105_F0.5210.61
34_G76_F0.5210.61
155_F165_I0.5210.61
475_S479_F0.5200.61
337_S366_T0.5200.61
135_I324_Q0.5200.61
384_E474_L0.5190.61
60_L64_H0.5190.61
194_E311_Y0.5190.61
395_S398_Y0.5190.61
99_E104_L0.5180.61
343_M430_S0.5180.61
146_N258_L0.5170.60
105_F110_T0.5170.60
371_A374_K0.5160.60
112_E316_P0.5160.60
289_L404_L0.5160.60
135_I452_T0.5150.60
309_E317_V0.5150.60
275_R463_H0.5150.60
349_K486_D0.5140.60
85_V235_Q0.5140.60
159_R310_E0.5140.60
164_Y312_N0.5140.60
266_S273_F0.5130.60
363_S366_T0.5130.60
394_A444_N0.5130.60
181_M246_V0.5130.60
45_S74_Y0.5120.60
351_I377_E0.5120.60
179_R211_D0.5120.60
105_F109_E0.5120.60
259_N437_D0.5110.60
309_E313_T0.5110.60
380_V458_R0.5110.60
32_Y36_L0.5100.59
82_Q85_V0.5100.59
154_I345_S0.5100.59
470_E473_K0.5100.59
59_T491_S0.5100.59
257_G278_H0.5090.59
482_R486_D0.5090.59
329_G332_M0.5090.59
326_V430_S0.5090.59
415_G498_G0.5090.59
342_E374_K0.5090.59
172_F208_A0.5090.59
199_Y211_D0.5090.59
451_F457_I0.5090.59
473_K477_V0.5090.59
50_I76_F0.5080.59
51_L488_T0.5080.59
200_D259_N0.5080.59
383_P416_F0.5080.59
198_L223_V0.5070.59
179_R262_K0.5070.59
155_F191_Q0.5070.59
328_T447_V0.5070.59
42_I74_Y0.5070.59
110_T217_Q0.5070.59
290_H312_N0.5060.59
58_H443_L0.5050.59
139_S321_G0.5050.59
74_Y78_L0.5050.59
314_P485_A0.5040.59
336_M339_L0.5040.59
34_G110_T0.5040.59
393_Y486_D0.5030.58
110_T113_V0.5030.58
291_A295_L0.5020.58
137_T284_E0.5020.58
352_W423_I0.5020.58
282_E455_E0.5010.58
86_K90_F0.5010.58
88_K92_T0.5010.58
496_F500_L0.5000.58
372_A406_G0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v0wA 1 0.77 100 0.52 Contact Map
3hsiA 2 0.754 100 0.531 Contact Map
2o8rA 2 0.756 100 0.641 Contact Map
1xdpA 4 0.792 100 0.642 Contact Map
4urjA 1 0.328 100 0.805 Contact Map
2c1lA 2 0.354 100 0.817 Contact Map
1byrA 2 0.3 100 0.82 Contact Map
4gelA 2 0.342 99.9 0.826 Contact Map
4ggjA 2 0.328 99.9 0.832 Contact Map
4rctA 2 0.35 99.4 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0292 seconds.