CLS1 - BACSU - GREMLIN Contacts

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CLS1 - Probable cardiolipin synthase YwiE

UniProt:	P45860	Sequences: MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILFSIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLRKLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRKAESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQAGVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRDTHLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKESMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQYASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVFFTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	500 (469)
Sequences:	3207 (2428)
Seq/√Len:	112.1

ECOLI - CLSA CLSC CLSB
BACSU - CLS1 CLSA CLSB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
159_R	187_E	6.777	1.00
408_E	473_K	5.976	1.00
157_A	254_F	5.684	1.00
188_K	191_Q	5.589	1.00
158_M	184_I	5.545	1.00
377_E	408_E	4.048	1.00
154_I	246_V	3.995	1.00
157_A	280_R	3.756	1.00
253_G	289_L	3.648	1.00
172_F	197_F	3.600	1.00
155_F	184_I	3.344	1.00
187_E	191_Q	3.341	1.00
426_G	461_E	3.080	1.00
155_F	181_M	3.046	1.00
194_E	221_D	2.906	1.00
142_K	153_D	2.806	1.00
138_K	284_E	2.773	1.00
140_N	282_E	2.760	1.00
186_M	218_A	2.706	1.00
150_T	154_I	2.693	1.00
466_E	469_Q	2.661	1.00
150_T	169_Y	2.659	1.00
325_I	449_V	2.627	1.00
253_G	286_V	2.599	1.00
414_K	470_E	2.577	1.00
379_R	408_E	2.570	1.00
157_A	160_K	2.566	1.00
429_A	457_I	2.560	1.00
381_M	471_S	2.448	1.00
254_F	280_R	2.433	1.00
372_A	407_I	2.319	1.00
472_E	478_G	2.311	1.00
156_K	160_K	2.289	1.00
429_A	460_L	2.280	1.00
352_W	379_R	2.261	1.00
157_A	252_T	2.203	1.00
162_E	191_Q	2.189	1.00
162_E	251_K	2.143	1.00
430_S	448_N	2.125	1.00
451_F	456_A	2.117	1.00
386_N	392_Q	2.100	1.00
144_L	153_D	2.096	1.00
215_M	220_V	2.094	1.00
350_S	461_E	2.086	1.00
153_D	254_F	2.066	1.00
182_M	186_M	2.064	1.00
182_M	214_R	2.057	1.00
158_M	165_I	2.055	1.00
343_M	424_I	2.037	1.00
476_P	480_Y	2.034	1.00
410_Y	473_K	2.030	1.00
245_I	289_L	2.027	1.00
381_M	468_M	2.013	1.00
354_A	381_M	2.003	1.00
350_S	426_G	1.990	1.00
167_I	246_V	1.980	1.00
221_D	303_E	1.971	1.00
482_R	490_E	1.954	1.00
379_R	468_M	1.953	1.00
344_I	351_I	1.952	1.00
184_I	188_K	1.951	1.00
153_D	157_A	1.944	1.00
423_I	457_I	1.913	1.00
199_Y	224_P	1.898	1.00
396_R	411_S	1.894	1.00
176_M	267_R	1.884	1.00
384_E	413_Q	1.871	1.00
413_Q	472_E	1.862	1.00
382_V	399_F	1.852	1.00
186_M	190_R	1.846	1.00
281_L	285_I	1.831	1.00
174_S	179_R	1.810	1.00
182_M	211_D	1.807	1.00
461_E	465_E	1.807	1.00
153_D	280_R	1.794	1.00
213_M	217_Q	1.794	1.00
164_Y	290_H	1.790	1.00
159_R	184_I	1.781	1.00
155_F	180_G	1.768	1.00
369_K	401_E	1.760	1.00
223_V	301_S	1.756	1.00
352_W	377_E	1.733	1.00
159_R	180_G	1.731	1.00
468_M	471_S	1.731	1.00
166_H	196_R	1.725	1.00
399_F	409_V	1.719	1.00
139_S	281_L	1.713	1.00
352_W	465_E	1.711	1.00
146_N	273_F	1.708	1.00
148_E	152_P	1.673	1.00
285_I	323_Y	1.667	1.00
152_P	180_G	1.652	1.00
351_I	424_I	1.644	1.00
349_K	426_G	1.620	1.00
146_N	149_E	1.577	1.00
384_E	472_E	1.547	1.00
252_T	282_E	1.543	1.00
251_K	282_E	1.541	1.00
153_D	156_K	1.540	1.00
245_I	447_V	1.535	1.00
166_H	290_H	1.532	1.00
252_T	280_R	1.522	1.00
175_D	178_G	1.507	1.00
183_D	186_M	1.497	1.00
321_G	453_D	1.495	1.00
403_L	476_P	1.489	1.00
195_V	220_V	1.488	1.00
379_R	410_Y	1.486	1.00
402_L	407_I	1.477	1.00
142_K	280_R	1.464	1.00
399_F	411_S	1.460	1.00
404_L	476_P	1.460	1.00
167_I	181_M	1.453	1.00
336_M	434_A	1.453	1.00
255_V	289_L	1.441	1.00
281_L	449_V	1.433	1.00
323_Y	449_V	1.430	1.00
285_I	325_I	1.422	1.00
145_K	463_H	1.418	1.00
69_F	72_V	1.413	1.00
141_I	451_F	1.408	1.00
143_V	463_H	1.390	1.00
142_K	459_T	1.387	1.00
177_L	262_K	1.380	1.00
176_M	262_K	1.377	1.00
379_R	465_E	1.374	1.00
152_P	156_K	1.366	1.00
339_L	450_F	1.365	1.00
157_A	248_I	1.363	1.00
275_R	467_D	1.363	1.00
169_Y	246_V	1.353	1.00
184_I	187_E	1.351	1.00
396_R	486_D	1.350	1.00
156_K	159_R	1.345	1.00
292_I	327_A	1.343	1.00
247_I	289_L	1.337	1.00
181_M	260_V	1.334	1.00
154_I	181_M	1.332	1.00
462_A	466_E	1.325	1.00
411_S	474_L	1.324	1.00
350_S	377_E	1.311	1.00
352_W	461_E	1.310	1.00
141_I	323_Y	1.309	0.99
354_A	417_M	1.292	0.99
173_K	263_E	1.287	0.99
310_E	313_T	1.282	0.99
155_F	159_R	1.279	0.99
186_M	214_R	1.270	0.99
127_S	339_L	1.269	0.99
354_A	421_V	1.266	0.99
150_T	278_H	1.263	0.99
343_M	428_L	1.258	0.99
479_F	482_R	1.253	0.99
164_Y	250_G	1.249	0.99
159_R	188_K	1.246	0.99
255_V	447_V	1.244	0.99
170_Y	444_N	1.244	0.99
201_A	224_P	1.239	0.99
431_V	460_L	1.235	0.99
136_N	288_T	1.231	0.99
135_I	322_I	1.228	0.99
398_Y	494_R	1.217	0.99
167_I	260_V	1.210	0.99
163_S	251_K	1.197	0.99
382_V	395_S	1.196	0.99
320_G	455_E	1.192	0.99
381_M	464_F	1.191	0.99
354_A	464_F	1.186	0.99
168_E	241_N	1.177	0.99
393_Y	490_E	1.173	0.99
183_D	187_E	1.168	0.99
349_K	427_D	1.165	0.99
198_L	300_V	1.162	0.99
390_L	493_A	1.159	0.99
292_I	447_V	1.157	0.99
159_R	162_E	1.156	0.99
182_M	220_V	1.152	0.99
397_S	494_R	1.151	0.99
250_G	290_H	1.147	0.99
350_S	423_I	1.143	0.99
175_D	179_R	1.133	0.99
279_L	451_F	1.128	0.98
337_S	361_N	1.126	0.98
492_F	496_F	1.126	0.98
341_Y	364_I	1.123	0.98
364_I	441_F	1.122	0.98
181_M	184_I	1.120	0.98
159_R	191_Q	1.113	0.98
393_Y	489_K	1.108	0.98
255_V	449_V	1.108	0.98
143_V	456_A	1.106	0.98
150_T	258_L	1.105	0.98
380_V	409_V	1.104	0.98
350_S	424_I	1.098	0.98
466_E	470_E	1.097	0.98
241_N	296_D	1.093	0.98
179_R	183_D	1.092	0.98
207_L	212_I	1.084	0.98
351_I	368_L	1.082	0.98
184_I	191_Q	1.081	0.98
381_M	417_M	1.068	0.98
104_L	107_K	1.063	0.98
158_M	181_M	1.062	0.98
459_T	462_A	1.060	0.98
436_M	441_F	1.060	0.98
358_F	380_V	1.056	0.98
46_I	67_V	1.048	0.98
186_M	220_V	1.043	0.97
289_L	447_V	1.032	0.97
157_A	282_E	1.032	0.97
273_F	412_Y	1.032	0.97
246_V	260_V	1.027	0.97
429_A	456_A	1.016	0.97
163_S	310_E	1.016	0.97
173_K	261_G	1.010	0.97
144_L	254_F	1.009	0.97
353_I	422_M	1.005	0.97
384_E	411_S	1.004	0.97
194_E	310_E	0.998	0.97
160_K	248_I	0.997	0.97
434_A	448_N	0.992	0.97
160_K	252_T	0.985	0.96
261_G	265_I	0.983	0.96
385_K	389_F	0.980	0.96
369_K	373_T	0.979	0.96
475_S	478_G	0.976	0.96
189_A	218_A	0.975	0.96
277_T	419_Q	0.969	0.96
172_F	260_V	0.964	0.96
141_I	321_G	0.962	0.96
309_E	312_N	0.962	0.96
334_E	442_Q	0.958	0.96
207_L	211_D	0.958	0.96
279_L	449_V	0.957	0.96
325_I	447_V	0.956	0.96
124_F	135_I	0.955	0.96
171_M	263_E	0.952	0.96
149_E	152_P	0.948	0.96
344_I	368_L	0.947	0.96
154_I	248_I	0.945	0.95
398_Y	497_S	0.945	0.95
214_R	218_A	0.944	0.95
421_V	464_F	0.943	0.95
144_L	280_R	0.943	0.95
320_G	453_D	0.941	0.95
400_P	480_Y	0.938	0.95
351_I	371_A	0.934	0.95
485_A	489_K	0.928	0.95
358_F	402_L	0.924	0.95
465_E	468_M	0.924	0.95
403_L	473_K	0.921	0.95
396_R	399_F	0.921	0.95
104_L	109_E	0.917	0.95
403_L	479_F	0.916	0.95
377_E	473_K	0.909	0.94
464_F	468_M	0.906	0.94
180_G	184_I	0.905	0.94
151_F	177_L	0.905	0.94
202_A	205_M	0.905	0.94
426_G	458_R	0.905	0.94
61_L	65_I	0.899	0.94
427_D	454_A	0.899	0.94
122_R	374_K	0.897	0.94
274_W	415_G	0.897	0.94
358_F	436_M	0.892	0.94
152_P	155_F	0.884	0.94
160_K	163_S	0.883	0.94
349_K	377_E	0.882	0.94
119_N	427_D	0.877	0.93
323_Y	451_F	0.875	0.93
264_Y	274_W	0.872	0.93
348_Q	427_D	0.870	0.93
403_L	474_L	0.868	0.93
400_P	476_P	0.866	0.93
384_E	392_Q	0.864	0.93
45_S	78_L	0.862	0.93
168_E	260_V	0.858	0.93
189_A	220_V	0.854	0.92
344_I	371_A	0.851	0.92
321_G	451_F	0.850	0.92
340_Y	430_S	0.848	0.92
382_V	411_S	0.846	0.92
277_T	421_V	0.839	0.92
334_E	337_S	0.839	0.92
196_R	221_D	0.837	0.92
422_M	430_S	0.834	0.91
340_Y	434_A	0.834	0.91
169_Y	278_H	0.828	0.91
433_T	447_V	0.828	0.91
142_K	282_E	0.828	0.91
122_R	348_Q	0.827	0.91
392_Q	411_S	0.827	0.91
341_Y	345_S	0.827	0.91
166_H	194_E	0.820	0.91
372_A	405_E	0.819	0.91
400_P	404_L	0.818	0.91
345_S	367_A	0.817	0.91
99_E	103_K	0.816	0.91
456_A	459_T	0.816	0.91
187_E	190_R	0.814	0.90
178_G	182_M	0.813	0.90
358_F	409_V	0.813	0.90
423_I	461_E	0.810	0.90
410_Y	468_M	0.809	0.90
211_D	214_R	0.807	0.90
403_L	409_V	0.806	0.90
465_E	469_Q	0.804	0.90
40_S	44_F	0.803	0.90
328_T	336_M	0.802	0.90
391_T	395_S	0.800	0.90
165_I	248_I	0.798	0.90
238_N	257_G	0.797	0.90
201_A	226_S	0.797	0.90
180_G	183_D	0.794	0.89
136_N	139_S	0.788	0.89
124_F	127_S	0.787	0.89
337_S	363_S	0.787	0.89
326_V	339_L	0.786	0.89
342_E	346_S	0.783	0.89
208_A	212_I	0.783	0.89
484_V	487_R	0.782	0.89
285_I	288_T	0.781	0.89
313_T	316_P	0.779	0.88
351_I	376_V	0.778	0.88
105_F	108_E	0.778	0.88
396_R	490_E	0.776	0.88
486_D	489_K	0.772	0.88
379_R	473_K	0.771	0.88
141_I	456_A	0.770	0.88
248_I	254_F	0.770	0.88
412_Y	415_G	0.770	0.88
225_F	238_N	0.767	0.88
199_Y	222_I	0.765	0.88
211_D	215_M	0.764	0.87
367_A	371_A	0.759	0.87
172_F	182_M	0.751	0.87
93_K	97_N	0.750	0.86
477_V	481_K	0.750	0.86
422_M	436_M	0.747	0.86
400_P	479_F	0.746	0.86
175_D	262_K	0.746	0.86
421_V	460_L	0.745	0.86
139_S	284_E	0.744	0.86
177_L	265_I	0.744	0.86
399_F	403_L	0.743	0.86
402_L	409_V	0.742	0.86
456_A	460_L	0.739	0.86
263_E	266_S	0.738	0.86
358_F	365_R	0.737	0.86
462_A	465_E	0.736	0.85
273_F	414_K	0.735	0.85
113_V	116_L	0.735	0.85
338_D	369_K	0.733	0.85
338_D	370_A	0.732	0.85
186_M	189_A	0.729	0.85
400_P	482_R	0.729	0.85
338_D	373_T	0.727	0.85
147_G	177_L	0.727	0.85
381_M	467_D	0.725	0.85
33_G	37_C	0.725	0.85
111_P	114_T	0.724	0.85
347_A	424_I	0.724	0.85
166_H	247_I	0.723	0.84
362_E	366_T	0.723	0.84
268_D	272_G	0.721	0.84
127_S	326_V	0.719	0.84
321_G	456_A	0.715	0.84
243_R	296_D	0.713	0.84
257_G	264_Y	0.712	0.84
197_F	222_I	0.709	0.83
458_R	462_A	0.709	0.83
145_K	466_E	0.709	0.83
472_E	475_S	0.708	0.83
430_S	450_F	0.705	0.83
341_Y	367_A	0.705	0.83
147_G	257_G	0.704	0.83
266_S	388_S	0.704	0.83
263_E	271_I	0.704	0.83
46_I	63_I	0.703	0.83
473_K	476_P	0.699	0.82
189_A	194_E	0.699	0.82
43_L	47_Y	0.699	0.82
368_L	407_I	0.699	0.82
140_N	320_G	0.698	0.82
160_K	251_K	0.696	0.82
258_L	278_H	0.695	0.82
94_R	98_R	0.695	0.82
64_H	68_F	0.694	0.82
476_P	483_G	0.693	0.82
104_L	108_E	0.691	0.82
413_Q	470_E	0.691	0.82
64_H	67_V	0.690	0.82
155_F	177_L	0.690	0.82
230_Y	234_N	0.689	0.81
151_F	260_V	0.689	0.81
388_S	392_Q	0.688	0.81
166_H	294_M	0.688	0.81
42_I	46_I	0.684	0.81
177_L	180_G	0.684	0.81
173_K	260_V	0.682	0.81
108_E	112_E	0.681	0.81
394_A	500_L	0.680	0.81
298_E	304_V	0.680	0.81
365_R	369_K	0.679	0.81
144_L	150_T	0.679	0.81
350_S	379_R	0.678	0.80
145_K	149_E	0.677	0.80
423_I	429_A	0.677	0.80
321_G	454_A	0.674	0.80
210_R	213_M	0.673	0.80
421_V	431_V	0.673	0.80
328_T	332_M	0.672	0.80
103_K	106_D	0.672	0.80
53_N	491_S	0.671	0.80
172_F	199_Y	0.669	0.80
399_F	474_L	0.669	0.80
172_F	211_D	0.668	0.79
214_R	217_Q	0.666	0.79
274_W	387_D	0.666	0.79
345_S	436_M	0.665	0.79
423_I	468_M	0.665	0.79
411_S	472_E	0.661	0.79
353_I	436_M	0.661	0.79
488_T	492_F	0.660	0.79
225_F	257_G	0.660	0.79
35_L	39_I	0.660	0.79
404_L	480_Y	0.659	0.79
484_V	488_T	0.659	0.79
139_S	453_D	0.656	0.78
463_H	467_D	0.652	0.78
493_A	496_F	0.651	0.78
298_E	301_S	0.650	0.78
239_F	443_L	0.648	0.77
437_D	444_N	0.648	0.77
330_P	445_F	0.648	0.77
277_T	467_D	0.647	0.77
179_R	214_R	0.647	0.77
65_I	69_F	0.646	0.77
307_D	311_Y	0.646	0.77
159_R	195_V	0.646	0.77
421_V	463_H	0.646	0.77
100_K	104_L	0.642	0.77
189_A	195_V	0.638	0.76
255_V	279_L	0.638	0.76
170_Y	388_S	0.637	0.76
412_Y	470_E	0.636	0.76
32_Y	35_L	0.635	0.76
261_G	264_Y	0.635	0.76
480_Y	483_G	0.634	0.76
174_S	211_D	0.633	0.76
190_R	217_Q	0.633	0.76
427_D	453_D	0.632	0.76
358_F	407_I	0.632	0.76
216_K	222_I	0.631	0.76
247_I	286_V	0.631	0.76
151_F	155_F	0.626	0.75
107_K	111_P	0.625	0.75
328_T	335_S	0.624	0.75
179_R	182_M	0.624	0.75
228_L	231_G	0.622	0.74
55_T	58_H	0.621	0.74
324_Q	452_T	0.621	0.74
483_G	488_T	0.621	0.74
136_N	285_I	0.620	0.74
166_H	250_G	0.620	0.74
146_N	152_P	0.618	0.74
257_G	464_F	0.618	0.74
51_L	484_V	0.617	0.74
393_Y	482_R	0.616	0.74
343_M	350_S	0.616	0.74
123_F	343_M	0.615	0.74
311_Y	315_V	0.615	0.74
167_I	197_F	0.615	0.74
343_M	351_I	0.613	0.73
266_S	272_G	0.611	0.73
155_F	188_K	0.611	0.73
296_D	329_G	0.608	0.73
144_L	157_A	0.606	0.73
49_L	59_T	0.606	0.73
199_Y	204_S	0.604	0.72
454_A	458_R	0.604	0.72
118_D	122_R	0.604	0.72
190_R	219_G	0.604	0.72
383_P	395_S	0.603	0.72
147_G	276_D	0.602	0.72
223_V	300_V	0.602	0.72
333_K	373_T	0.601	0.72
394_A	398_Y	0.601	0.72
147_G	151_F	0.601	0.72
45_S	48_S	0.600	0.72
144_L	149_E	0.599	0.72
248_I	282_E	0.598	0.72
383_P	391_T	0.596	0.71
383_P	445_F	0.596	0.71
113_V	124_F	0.595	0.71
264_Y	415_G	0.594	0.71
262_K	267_R	0.594	0.71
59_T	494_R	0.592	0.71
64_H	428_L	0.592	0.71
438_M	442_Q	0.591	0.71
254_F	286_V	0.591	0.71
398_Y	401_E	0.591	0.71
113_V	117_K	0.590	0.71
53_N	56_S	0.590	0.71
426_G	457_I	0.588	0.70
363_S	493_A	0.588	0.70
119_N	348_Q	0.588	0.70
394_A	493_A	0.588	0.70
225_F	445_F	0.588	0.70
150_T	246_V	0.587	0.70
337_S	364_I	0.587	0.70
66_L	74_Y	0.586	0.70
415_G	445_F	0.586	0.70
268_D	271_I	0.583	0.70
352_W	468_M	0.582	0.70
205_M	224_P	0.582	0.70
190_R	218_A	0.582	0.70
100_K	103_K	0.581	0.69
165_I	195_V	0.581	0.69
38_Y	46_I	0.581	0.69
164_Y	294_M	0.581	0.69
70_P	73_G	0.580	0.69
102_R	106_D	0.580	0.69
482_R	487_R	0.580	0.69
209_R	212_I	0.580	0.69
332_M	335_S	0.580	0.69
60_L	63_I	0.579	0.69
326_V	331_D	0.579	0.69
369_K	405_E	0.579	0.69
85_V	89_L	0.579	0.69
158_M	167_I	0.579	0.69
109_E	115_G	0.578	0.69
397_S	490_E	0.577	0.69
257_G	467_D	0.577	0.69
341_Y	370_A	0.577	0.69
257_G	261_G	0.574	0.68
212_I	222_I	0.573	0.68
208_A	211_D	0.573	0.68
154_I	433_T	0.573	0.68
139_S	323_Y	0.572	0.68
118_D	121_E	0.572	0.68
324_Q	354_A	0.571	0.68
177_L	260_V	0.571	0.68
238_N	467_D	0.571	0.68
457_I	460_L	0.570	0.68
257_G	263_E	0.567	0.68
389_F	392_Q	0.567	0.68
483_G	486_D	0.566	0.67
150_T	254_F	0.565	0.67
149_E	273_F	0.565	0.67
148_E	273_F	0.562	0.67
239_F	286_V	0.561	0.67
382_V	407_I	0.561	0.67
113_V	281_L	0.560	0.67
365_R	401_E	0.560	0.67
360_P	365_R	0.560	0.67
106_D	109_E	0.558	0.66
69_F	76_F	0.558	0.66
212_I	220_V	0.557	0.66
176_M	180_G	0.556	0.66
165_I	185_M	0.555	0.66
180_G	267_R	0.555	0.66
164_Y	211_D	0.555	0.66
493_A	500_L	0.554	0.66
384_E	389_F	0.554	0.66
170_Y	268_D	0.554	0.66
58_H	239_F	0.554	0.66
164_Y	311_Y	0.554	0.66
147_G	238_N	0.553	0.66
85_V	239_F	0.553	0.66
282_E	318_E	0.552	0.66
110_T	116_L	0.552	0.66
254_F	278_H	0.551	0.65
332_M	336_M	0.551	0.65
364_I	436_M	0.550	0.65
147_G	278_H	0.550	0.65
390_L	393_Y	0.549	0.65
251_K	315_V	0.548	0.65
263_E	388_S	0.546	0.65
433_T	444_N	0.546	0.65
326_V	450_F	0.545	0.65
344_I	424_I	0.545	0.65
154_I	157_A	0.544	0.64
312_N	315_V	0.544	0.64
147_G	258_L	0.544	0.64
121_E	125_T	0.543	0.64
259_N	264_Y	0.542	0.64
264_Y	416_F	0.542	0.64
213_M	216_K	0.541	0.64
480_Y	485_A	0.540	0.64
186_M	193_V	0.540	0.64
298_E	302_N	0.540	0.64
428_L	450_F	0.539	0.64
389_F	489_K	0.539	0.64
393_Y	493_A	0.539	0.64
363_S	367_A	0.538	0.64
423_I	464_F	0.537	0.63
359_V	438_M	0.536	0.63
389_F	393_Y	0.536	0.63
180_G	187_E	0.535	0.63
344_I	364_I	0.534	0.63
53_N	400_P	0.533	0.63
245_I	325_I	0.533	0.63
157_A	251_K	0.533	0.63
227_P	300_V	0.533	0.63
383_P	388_S	0.532	0.63
263_E	273_F	0.532	0.63
453_D	456_A	0.531	0.63
105_F	112_E	0.530	0.62
108_E	111_P	0.530	0.62
455_E	458_R	0.530	0.62
39_I	43_L	0.529	0.62
186_M	215_M	0.529	0.62
99_E	424_I	0.528	0.62
106_D	117_K	0.528	0.62
142_K	149_E	0.528	0.62
38_Y	42_I	0.528	0.62
69_F	105_F	0.527	0.62
201_A	227_P	0.526	0.62
172_F	181_M	0.525	0.62
156_K	162_E	0.525	0.62
294_M	305_L	0.524	0.62
90_F	331_D	0.524	0.62
163_S	194_E	0.524	0.62
80_S	237_L	0.524	0.62
176_M	265_I	0.524	0.62
423_I	426_G	0.521	0.61
102_R	105_F	0.521	0.61
34_G	76_F	0.521	0.61
155_F	165_I	0.521	0.61
475_S	479_F	0.520	0.61
337_S	366_T	0.520	0.61
135_I	324_Q	0.520	0.61
384_E	474_L	0.519	0.61
60_L	64_H	0.519	0.61
194_E	311_Y	0.519	0.61
395_S	398_Y	0.519	0.61
99_E	104_L	0.518	0.61
343_M	430_S	0.518	0.61
146_N	258_L	0.517	0.60
105_F	110_T	0.517	0.60
371_A	374_K	0.516	0.60
112_E	316_P	0.516	0.60
289_L	404_L	0.516	0.60
135_I	452_T	0.515	0.60
309_E	317_V	0.515	0.60
275_R	463_H	0.515	0.60
349_K	486_D	0.514	0.60
85_V	235_Q	0.514	0.60
159_R	310_E	0.514	0.60
164_Y	312_N	0.514	0.60
266_S	273_F	0.513	0.60
363_S	366_T	0.513	0.60
394_A	444_N	0.513	0.60
181_M	246_V	0.513	0.60
45_S	74_Y	0.512	0.60
351_I	377_E	0.512	0.60
179_R	211_D	0.512	0.60
105_F	109_E	0.512	0.60
259_N	437_D	0.511	0.60
309_E	313_T	0.511	0.60
380_V	458_R	0.511	0.60
32_Y	36_L	0.510	0.59
82_Q	85_V	0.510	0.59
154_I	345_S	0.510	0.59
470_E	473_K	0.510	0.59
59_T	491_S	0.510	0.59
257_G	278_H	0.509	0.59
482_R	486_D	0.509	0.59
329_G	332_M	0.509	0.59
326_V	430_S	0.509	0.59
415_G	498_G	0.509	0.59
342_E	374_K	0.509	0.59
172_F	208_A	0.509	0.59
199_Y	211_D	0.509	0.59
451_F	457_I	0.509	0.59
473_K	477_V	0.509	0.59
50_I	76_F	0.508	0.59
51_L	488_T	0.508	0.59
200_D	259_N	0.508	0.59
383_P	416_F	0.508	0.59
198_L	223_V	0.507	0.59
179_R	262_K	0.507	0.59
155_F	191_Q	0.507	0.59
328_T	447_V	0.507	0.59
42_I	74_Y	0.507	0.59
110_T	217_Q	0.507	0.59
290_H	312_N	0.506	0.59
58_H	443_L	0.505	0.59
139_S	321_G	0.505	0.59
74_Y	78_L	0.505	0.59
314_P	485_A	0.504	0.59
336_M	339_L	0.504	0.59
34_G	110_T	0.504	0.59
393_Y	486_D	0.503	0.58
110_T	113_V	0.503	0.58
291_A	295_L	0.502	0.58
137_T	284_E	0.502	0.58
352_W	423_I	0.502	0.58
282_E	455_E	0.501	0.58
86_K	90_F	0.501	0.58
88_K	92_T	0.501	0.58
496_F	500_L	0.500	0.58
372_A	406_G	0.500	0.58

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1v0wA	1	0.77	100	0.52	Contact Map
3hsiA	2	0.754	100	0.531	Contact Map
2o8rA	2	0.756	100	0.641	Contact Map
1xdpA	4	0.792	100	0.642	Contact Map
4urjA	1	0.328	100	0.805	Contact Map
2c1lA	2	0.354	100	0.817	Contact Map
1byrA	2	0.3	100	0.82	Contact Map
4gelA	2	0.342	99.9	0.826	Contact Map
4ggjA	2	0.328	99.9	0.832	Contact Map
4rctA	2	0.35	99.4	0.902	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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