CISY3 - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

CISY3 - 2-methylcitrate synthase

UniProt:	P45858	Sequences: MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSETKSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTGLSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSANFLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASLKGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMMKEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPIFFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	372 (358)
Sequences:	3997 (2006)
Seq/√Len:	106.0

ECOLI - CISY PRPC
BACSU - CISY3 CISY2 CISY
HALSA - Q9HNH4
SULSO - CISY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
200_I	213_G	7.396	1.00
197_A	214_A	3.943	1.00
58_R	64_E	3.550	1.00
62_E	66_E	3.370	1.00
37_D	40_E	3.239	1.00
159_A	175_E	3.125	1.00
171_S	286_K	3.050	1.00
298_A	301_R	3.038	1.00
43_E	278_E	2.883	1.00
156_S	159_A	2.803	1.00
200_I	217_S	2.706	1.00
61_E	64_E	2.672	1.00
49_E	65_M	2.664	1.00
281_Q	297_E	2.652	1.00
250_K	255_E	2.607	1.00
301_R	305_K	2.580	1.00
192_N	203_T	2.538	1.00
205_S	219_K	2.538	1.00
242_D	245_Q	2.499	1.00
235_L	322_W	2.450	1.00
238_K	242_D	2.435	1.00
174_E	324_L	2.409	1.00
244_E	305_K	2.369	1.00
244_E	298_A	2.364	1.00
199_V	357_F	2.316	1.00
103_L	215_V	2.273	1.00
196_A	217_S	2.159	1.00
160_N	164_M	2.134	1.00
12_D	355_R	2.089	1.00
125_A	344_C	2.066	1.00
158_S	179_D	2.000	1.00
278_E	282_Q	1.999	1.00
203_T	217_S	1.993	1.00
46_S	65_M	1.989	1.00
51_V	341_S	1.908	1.00
201_A	210_A	1.866	1.00
244_E	302_L	1.855	1.00
173_L	286_K	1.840	1.00
155_L	159_A	1.821	1.00
52_H	58_R	1.820	1.00
84_R	87_E	1.817	1.00
235_L	328_I	1.805	1.00
296_C	319_P	1.803	1.00
281_Q	285_D	1.795	1.00
298_A	302_L	1.785	1.00
141_R	146_K	1.765	1.00
136_T	337_S	1.763	1.00
156_S	175_E	1.763	1.00
228_E	232_Y	1.755	1.00
248_Q	252_K	1.726	1.00
146_K	149_I	1.724	1.00
245_Q	249_T	1.711	1.00
101_T	104_S	1.692	1.00
102_G	135_L	1.685	1.00
176_Q	179_D	1.682	1.00
117_S	120_A	1.674	1.00
39_I	274_L	1.671	1.00
326_I	334_I	1.671	1.00
145_K	149_I	1.664	1.00
240_T	298_A	1.659	1.00
181_S	321_Y	1.658	1.00
165_M	326_I	1.637	1.00
80_A	84_R	1.634	1.00
132_M	340_T	1.634	1.00
201_A	347_V	1.624	1.00
180_R	279_A	1.619	1.00
100_R	216_A	1.611	1.00
66_E	70_R	1.582	1.00
248_Q	306_E	1.578	1.00
100_R	104_S	1.576	1.00
22_S	187_E	1.575	1.00
171_S	174_E	1.543	1.00
145_K	148_P	1.542	1.00
30_Q	37_D	1.527	1.00
213_G	217_S	1.526	1.00
290_H	322_W	1.523	1.00
152_L	169_L	1.513	1.00
249_T	254_K	1.504	1.00
249_T	253_R	1.501	1.00
50_L	183_V	1.501	1.00
55_L	129_L	1.467	1.00
52_H	64_E	1.445	1.00
63_S	67_T	1.443	1.00
181_S	276_M	1.440	1.00
98_G	139_S	1.428	1.00
70_R	74_S	1.415	1.00
172_S	176_Q	1.409	1.00
137_A	161_F	1.409	1.00
152_L	163_Y	1.406	1.00
71_K	126_Y	1.402	1.00
103_L	132_M	1.392	1.00
48_L	72_I	1.390	1.00
75_A	127_Q	1.385	1.00
196_A	213_G	1.378	1.00
147_E	150_L	1.373	1.00
192_N	217_S	1.373	1.00
149_I	164_M	1.372	1.00
176_Q	180_R	1.360	1.00
186_S	341_S	1.352	1.00
83_L	138_A	1.345	0.99
152_L	155_L	1.340	0.99
12_D	263_R	1.336	0.99
76_S	157_Y	1.331	0.99
278_E	281_Q	1.322	0.99
85_L	105_A	1.322	0.99
151_P	160_N	1.310	0.99
280_L	319_P	1.302	0.99
249_T	255_E	1.296	0.99
189_E	360_R	1.276	0.99
196_A	200_I	1.268	0.99
285_D	290_H	1.258	0.99
151_P	164_M	1.254	0.99
257_I	303_M	1.254	0.99
145_K	150_L	1.253	0.99
36_Y	59_L	1.251	0.99
223_H	226_A	1.246	0.99
54_L	341_S	1.235	0.99
240_T	301_R	1.231	0.99
143_I	146_K	1.230	0.99
269_M	274_L	1.227	0.99
146_K	150_L	1.218	0.99
205_S	209_G	1.217	0.99
260_F	303_M	1.216	0.99
237_A	250_K	1.208	0.99
34_R	57_G	1.204	0.99
218_L	336_F	1.203	0.99
76_S	153_Q	1.203	0.99
209_G	219_K	1.200	0.99
207_L	344_C	1.199	0.99
277_K	300_E	1.199	0.99
322_W	328_I	1.196	0.99
239_T	291_R	1.196	0.99
19_T	22_S	1.195	0.99
84_R	88_L	1.185	0.99
71_K	123_E	1.174	0.99
118_P	352_A	1.173	0.99
33_I	186_S	1.171	0.99
18_E	362_S	1.163	0.99
196_A	199_V	1.161	0.98
241_S	245_Q	1.154	0.98
39_I	275_M	1.152	0.98
36_Y	53_L	1.139	0.98
99_L	136_T	1.130	0.98
96_M	227_N	1.129	0.98
53_L	59_L	1.123	0.98
279_A	282_Q	1.119	0.98
124_R	207_L	1.116	0.98
120_A	124_R	1.113	0.98
222_L	256_K	1.113	0.98
66_E	69_E	1.110	0.98
247_L	303_M	1.107	0.98
45_K	49_E	1.096	0.98
46_S	179_D	1.095	0.98
197_A	347_V	1.093	0.98
67_T	71_K	1.090	0.98
166_T	174_E	1.088	0.98
52_H	56_E	1.088	0.98
40_E	44_T	1.087	0.98
277_K	281_Q	1.082	0.98
55_L	344_C	1.081	0.98
232_Y	328_I	1.079	0.98
128_L	211_L	1.075	0.98
239_T	242_D	1.066	0.97
40_E	43_E	1.065	0.97
173_L	282_Q	1.064	0.97
23_Y	26_T	1.060	0.97
302_L	305_K	1.056	0.97
276_M	320_V	1.054	0.97
207_L	347_V	1.050	0.97
303_M	306_E	1.048	0.97
78_L	138_A	1.045	0.97
211_L	340_T	1.036	0.97
211_L	344_C	1.025	0.97
75_A	126_Y	1.022	0.97
122_K	348_I	1.020	0.97
205_S	210_A	1.013	0.96
159_A	172_S	1.009	0.96
233_L	250_K	1.007	0.96
134_A	151_P	1.002	0.96
179_D	183_V	0.997	0.96
69_E	73_N	0.995	0.96
72_I	126_Y	0.995	0.96
26_T	29_S	0.993	0.96
293_Y	297_E	0.993	0.96
240_T	295_M	0.991	0.96
338_A	341_S	0.981	0.96
18_E	364_M	0.979	0.96
47_Y	341_S	0.978	0.96
198_R	350_Q	0.975	0.96
58_R	61_E	0.969	0.95
94_H	228_E	0.962	0.95
9_P	353_N	0.961	0.95
296_C	318_A	0.958	0.95
56_E	122_K	0.958	0.95
234_L	299_G	0.956	0.95
237_A	243_F	0.954	0.95
38_L	275_M	0.950	0.95
251_L	306_E	0.945	0.95
64_E	67_T	0.944	0.95
188_H	265_Y	0.942	0.95
123_E	127_Q	0.941	0.95
246_L	250_K	0.940	0.95
136_T	333_P	0.939	0.95
247_L	302_L	0.939	0.95
143_I	329_P	0.938	0.95
33_I	50_L	0.937	0.94
237_A	246_L	0.933	0.94
244_E	248_Q	0.930	0.94
348_I	352_A	0.929	0.94
236_E	255_E	0.926	0.94
140_Y	144_N	0.921	0.94
243_F	298_A	0.921	0.94
144_N	148_P	0.909	0.94
226_A	312_N	0.906	0.93
160_N	163_Y	0.906	0.93
63_S	66_E	0.905	0.93
36_Y	41_L	0.905	0.93
20_H	364_M	0.903	0.93
149_I	163_Y	0.903	0.93
17_A	190_M	0.902	0.93
290_H	294_E	0.898	0.93
54_L	186_S	0.896	0.93
22_S	189_E	0.891	0.93
100_R	212_T	0.891	0.93
86_L	139_S	0.891	0.93
124_R	208_Y	0.887	0.93
87_E	147_E	0.885	0.93
185_Y	313_L	0.885	0.93
89_L	108_G	0.883	0.93
294_E	297_E	0.879	0.92
52_H	68_L	0.878	0.92
296_C	315_Y	0.873	0.92
78_L	135_L	0.871	0.92
143_I	147_E	0.870	0.92
48_L	158_S	0.869	0.92
36_Y	58_R	0.868	0.92
229_A	232_Y	0.866	0.92
176_Q	279_A	0.866	0.92
235_L	292_L	0.859	0.91
65_M	69_E	0.857	0.91
155_L	175_E	0.857	0.91
215_V	336_F	0.856	0.91
134_A	164_M	0.855	0.91
204_H	222_L	0.854	0.91
277_K	297_E	0.846	0.91
115_D	120_A	0.846	0.91
155_L	160_N	0.845	0.91
49_E	59_L	0.842	0.91
86_L	142_I	0.837	0.90
182_L	337_S	0.836	0.90
297_E	301_R	0.831	0.90
238_K	291_R	0.828	0.90
224_G	335_F	0.824	0.90
85_L	89_L	0.822	0.90
193_S	223_H	0.816	0.89
280_L	296_C	0.815	0.89
190_M	360_R	0.814	0.89
223_H	314_D	0.814	0.89
260_F	311_P	0.813	0.89
83_L	87_E	0.813	0.89
240_T	294_E	0.811	0.89
86_L	102_G	0.808	0.89
158_S	178_F	0.807	0.89
41_L	50_L	0.806	0.89
227_N	314_D	0.805	0.89
203_T	356_L	0.805	0.89
195_F	357_F	0.803	0.89
77_S	150_L	0.802	0.88
245_Q	248_Q	0.797	0.88
294_E	298_A	0.796	0.88
218_L	335_F	0.796	0.88
71_K	75_A	0.796	0.88
87_E	142_I	0.795	0.88
125_A	348_I	0.795	0.88
121_N	124_R	0.792	0.88
193_S	224_G	0.790	0.88
46_S	49_E	0.788	0.88
269_M	277_K	0.788	0.88
176_Q	282_Q	0.786	0.87
25_D	28_S	0.782	0.87
158_S	182_L	0.781	0.87
104_S	216_A	0.781	0.87
143_I	148_P	0.778	0.87
195_F	199_V	0.777	0.87
41_L	59_L	0.777	0.87
75_A	123_E	0.774	0.87
218_L	224_G	0.773	0.87
32_L	368_Y	0.773	0.87
158_S	175_E	0.773	0.87
55_L	341_S	0.771	0.86
77_S	153_Q	0.770	0.86
174_E	283_L	0.769	0.86
129_L	157_Y	0.767	0.86
23_Y	363_Y	0.764	0.86
11_L	14_V	0.763	0.86
210_A	347_V	0.762	0.86
33_I	53_L	0.762	0.86
238_K	241_S	0.757	0.85
120_A	123_E	0.755	0.85
223_H	335_F	0.754	0.85
230_V	234_L	0.752	0.85
189_E	361_V	0.749	0.85
237_A	299_G	0.749	0.85
23_Y	28_S	0.747	0.85
227_N	332_T	0.743	0.84
155_L	170_P	0.743	0.84
45_K	183_V	0.739	0.84
156_S	179_D	0.738	0.84
85_L	88_L	0.735	0.84
82_H	105_A	0.730	0.83
16_A	195_F	0.729	0.83
51_V	68_L	0.727	0.83
42_S	183_V	0.724	0.83
236_E	250_K	0.724	0.83
279_A	320_V	0.721	0.83
112_Q	127_Q	0.720	0.82
82_H	85_L	0.720	0.82
185_Y	227_N	0.719	0.82
185_Y	317_A	0.717	0.82
99_L	215_V	0.716	0.82
173_L	177_I	0.713	0.82
127_Q	131_K	0.712	0.82
119_S	123_E	0.705	0.81
51_V	129_L	0.704	0.81
280_L	320_V	0.704	0.81
234_L	296_C	0.703	0.81
112_Q	123_E	0.703	0.81
188_H	224_G	0.702	0.81
82_H	102_G	0.701	0.81
241_S	244_E	0.697	0.80
14_V	17_A	0.696	0.80
104_S	212_T	0.696	0.80
281_Q	293_Y	0.696	0.80
243_F	302_L	0.694	0.80
143_I	149_I	0.693	0.80
130_G	133_P	0.691	0.80
336_F	343_L	0.691	0.80
47_Y	51_V	0.690	0.80
226_A	261_G	0.689	0.80
231_M	328_I	0.687	0.79
240_T	244_E	0.687	0.79
231_M	331_Y	0.686	0.79
32_L	37_D	0.685	0.79
13_G	16_A	0.680	0.79
141_R	149_I	0.679	0.79
242_D	249_T	0.678	0.79
155_L	163_Y	0.677	0.78
276_M	317_A	0.675	0.78
230_V	295_M	0.675	0.78
292_L	322_W	0.674	0.78
11_L	195_F	0.673	0.78
200_I	210_A	0.670	0.78
83_L	150_L	0.670	0.78
26_T	268_K	0.669	0.78
218_L	227_N	0.669	0.78
233_L	246_L	0.668	0.77
11_L	15_I	0.666	0.77
170_P	175_E	0.665	0.77
110_D	127_Q	0.664	0.77
194_T	332_T	0.662	0.77
250_K	254_K	0.662	0.77
81_D	109_Y	0.661	0.77
180_R	183_V	0.659	0.77
181_S	185_Y	0.658	0.76
193_S	314_D	0.655	0.76
87_E	138_A	0.654	0.76
38_L	184_L	0.653	0.76
50_L	186_S	0.653	0.76
17_A	24_L	0.651	0.76
89_L	105_A	0.650	0.76
230_V	313_L	0.650	0.76
176_Q	183_V	0.649	0.75
28_S	268_K	0.649	0.75
289_D	294_E	0.646	0.75
250_K	253_R	0.645	0.75
229_A	258_M	0.645	0.75
121_N	125_A	0.643	0.75
194_T	346_H	0.642	0.75
244_E	247_L	0.638	0.74
81_D	84_R	0.638	0.74
346_H	354_N	0.638	0.74
17_A	22_S	0.637	0.74
21_I	34_R	0.636	0.74
204_H	351_H	0.633	0.74
247_L	295_M	0.632	0.74
75_A	131_K	0.631	0.73
125_A	207_L	0.631	0.73
47_Y	179_D	0.631	0.73
294_E	305_K	0.630	0.73
204_H	221_N	0.630	0.73
138_A	164_M	0.627	0.73
75_A	214_A	0.623	0.72
67_T	70_R	0.623	0.72
223_H	261_G	0.623	0.72
232_Y	235_L	0.622	0.72
45_K	179_D	0.621	0.72
31_I	38_L	0.621	0.72
280_L	293_Y	0.618	0.72
13_G	24_L	0.617	0.72
174_E	287_A	0.616	0.72
261_G	312_N	0.614	0.71
188_H	335_F	0.612	0.71
179_D	355_R	0.611	0.71
257_I	307_K	0.611	0.71
81_D	91_E	0.610	0.71
34_R	51_V	0.607	0.70
291_R	294_E	0.605	0.70
182_L	338_A	0.605	0.70
283_L	320_V	0.604	0.70
237_A	247_L	0.603	0.70
112_Q	115_D	0.600	0.70
188_H	191_P	0.600	0.70
168_K	174_E	0.600	0.70
32_L	367_R	0.598	0.69
11_L	16_A	0.596	0.69
77_S	123_E	0.596	0.69
277_K	316_Y	0.595	0.69
340_T	344_C	0.595	0.69
189_E	309_L	0.592	0.69
74_S	153_Q	0.592	0.69
326_I	330_L	0.592	0.69
89_L	101_T	0.590	0.68
46_S	69_E	0.589	0.68
73_N	153_Q	0.589	0.68
206_D	209_G	0.588	0.68
121_N	351_H	0.587	0.68
144_N	327_P	0.587	0.68
22_S	32_L	0.586	0.68
134_A	137_A	0.585	0.68
107_A	206_D	0.585	0.68
36_Y	40_E	0.584	0.68
248_Q	251_L	0.584	0.68
206_D	219_K	0.581	0.67
158_S	162_L	0.581	0.67
85_L	102_G	0.581	0.67
184_L	275_M	0.576	0.67
132_M	215_V	0.575	0.66
194_T	198_R	0.575	0.66
185_Y	314_D	0.575	0.66
82_H	86_L	0.575	0.66
15_I	22_S	0.574	0.66
137_A	164_M	0.574	0.66
313_L	317_A	0.574	0.66
193_S	335_F	0.572	0.66
231_M	322_W	0.572	0.66
304_E	308_G	0.572	0.66
103_L	128_L	0.572	0.66
13_G	17_A	0.571	0.66
128_L	207_L	0.570	0.66
244_E	281_Q	0.569	0.66
287_A	323_M	0.568	0.65
191_P	313_L	0.567	0.65
181_S	334_I	0.566	0.65
243_F	295_M	0.565	0.65
78_L	83_L	0.565	0.65
144_N	147_E	0.563	0.65
11_L	357_F	0.562	0.65
44_T	49_E	0.560	0.64
188_H	193_S	0.559	0.64
245_Q	252_K	0.558	0.64
364_M	367_R	0.558	0.64
256_K	356_L	0.557	0.64
79_P	106_L	0.555	0.64
198_R	234_L	0.555	0.64
312_N	318_A	0.554	0.64
79_P	82_H	0.553	0.63
163_Y	167_G	0.553	0.63
287_A	290_H	0.552	0.63
89_L	93_T	0.551	0.63
117_S	121_N	0.550	0.63
106_L	135_L	0.550	0.63
152_L	160_N	0.550	0.63
71_K	74_S	0.549	0.63
269_M	310_Y	0.547	0.63
136_T	215_V	0.547	0.63
309_L	315_Y	0.546	0.62
113_I	124_R	0.546	0.62
134_A	160_N	0.545	0.62
162_L	175_E	0.545	0.62
46_S	51_V	0.544	0.62
110_D	124_R	0.543	0.62
132_M	136_T	0.540	0.62
177_I	279_A	0.539	0.61
177_I	283_L	0.538	0.61
51_V	55_L	0.538	0.61
138_A	142_I	0.538	0.61
110_D	351_H	0.537	0.61
191_P	262_H	0.532	0.60
191_P	335_F	0.532	0.60
141_R	145_K	0.532	0.60
51_V	198_R	0.531	0.60
41_L	53_L	0.530	0.60
138_A	148_P	0.529	0.60
235_L	331_Y	0.529	0.60
190_M	198_R	0.529	0.60
198_R	204_H	0.528	0.60
303_M	315_Y	0.528	0.60
313_L	320_V	0.527	0.60
233_L	237_A	0.526	0.60
17_A	21_I	0.525	0.59
19_T	346_H	0.524	0.59
73_N	76_S	0.524	0.59
281_Q	301_R	0.524	0.59
288_G	294_E	0.523	0.59
143_I	150_L	0.523	0.59
48_L	157_Y	0.523	0.59
347_V	361_V	0.522	0.59
300_E	304_E	0.521	0.59
25_D	32_L	0.520	0.59
86_L	148_P	0.519	0.59
121_N	348_I	0.518	0.58
284_C	293_Y	0.518	0.58
256_K	296_C	0.518	0.58
92_D	111_R	0.516	0.58
104_S	107_A	0.515	0.58
318_A	335_F	0.514	0.58
250_K	307_K	0.512	0.58
201_A	351_H	0.511	0.57
227_N	331_Y	0.511	0.57
13_G	22_S	0.510	0.57
193_S	218_L	0.510	0.57
328_I	331_Y	0.510	0.57
17_A	364_M	0.509	0.57
18_E	22_S	0.509	0.57
81_D	85_L	0.508	0.57
133_P	136_T	0.508	0.57
308_G	311_P	0.508	0.57
46_S	176_Q	0.506	0.57
29_S	271_P	0.506	0.57
144_N	149_I	0.506	0.57
180_R	282_Q	0.505	0.57
280_L	284_C	0.503	0.56
31_I	35_G	0.503	0.56
118_P	121_N	0.501	0.56
131_K	134_A	0.500	0.56
45_K	65_M	0.500	0.56
129_L	341_S	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hwkA	5	0.9785	100	0.047	Contact Map
2h12A	4	0.9973	100	0.055	Contact Map
1a59A	2	0.9892	100	0.056	Contact Map
4xghA	5	0.914	100	0.056	Contact Map
2ibpA	2	0.9946	100	0.057	Contact Map
1iomA	2	0.9812	100	0.06	Contact Map
3msuA	2	0.9892	100	0.062	Contact Map
1o7xA	2	0.9785	100	0.064	Contact Map
1vgpA	2	0.9758	100	0.068	Contact Map
1vgmA	2	0.9785	100	0.069	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.