GREMLIN Database
ACDB - Acyl-CoA dehydrogenase
UniProt: P45857 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (364)
Sequences: 33798 (19237)
Seq/√Len: 1008.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_K216_E4.0631.00
149_N214_N3.7541.00
289_R327_K3.4451.00
21_E42_K3.2741.00
141_K219_E3.0291.00
111_N116_D2.9361.00
192_T213_D2.9101.00
102_E106_M2.8421.00
28_I32_T2.7921.00
63_D66_S2.7261.00
142_K216_E2.6791.00
15_R73_E2.6461.00
180_S222_L2.4931.00
282_K331_D2.4481.00
111_N117_H2.3991.00
261_D265_Q2.3971.00
151_S211_I2.2931.00
253_E294_R2.2441.00
302_D306_R2.1321.00
16_D20_K2.0931.00
225_K228_D2.0771.00
102_E105_K2.0441.00
272_P275_A2.0381.00
142_K145_K2.0071.00
343_K348_E1.9731.00
228_D231_H1.9471.00
168_A182_F1.9441.00
348_E352_R1.9221.00
164_Y186_K1.8941.00
263_A335_I1.8601.00
54_P97_L1.8451.00
101_N104_Q1.8381.00
256_L290_A1.8331.00
42_K45_K1.8301.00
151_S209_E1.8261.00
72_H294_R1.8041.00
41_K45_K1.8021.00
142_K147_L1.7751.00
76_R257_E1.7451.00
146_Y182_F1.7351.00
323_D364_N1.7091.00
267_V272_P1.7001.00
158_G208_T1.6951.00
188_T215_A1.6731.00
140_I149_N1.6671.00
278_G281_F1.6671.00
253_E257_E1.6621.00
120_A164_Y1.6541.00
147_L216_E1.6421.00
303_L313_E1.6401.00
258_H346_P1.6341.00
73_E76_R1.6251.00
147_L214_N1.6031.00
192_T211_I1.5991.00
263_A279_I1.5911.00
218_P221_N1.5861.00
107_K220_A1.5861.00
55_E61_G1.5861.00
141_K226_E1.5791.00
299_H303_L1.5641.00
185_E221_N1.5571.00
106_M110_P1.5561.00
107_K111_N1.5551.00
146_Y219_E1.5541.00
286_M328_A1.5461.00
8_V11_R1.5351.00
144_G219_E1.5311.00
271_R275_A1.5291.00
292_A320_F1.5131.00
293_A321_A1.5051.00
12_K16_D1.4991.00
194_G211_I1.4881.00
18_A77_I1.4801.00
111_N114_S1.4781.00
149_N213_D1.4761.00
9_M12_K1.4751.00
159_G208_T1.4691.00
194_G209_E1.4681.00
255_A329_A1.4681.00
258_H261_D1.4631.00
222_L226_E1.4541.00
219_E222_L1.4511.00
125_E152_K1.4391.00
339_Y345_Y1.4381.00
124_T154_F1.4341.00
268_Q276_N1.4311.00
260_V264_K1.4231.00
141_K145_K1.4211.00
9_M13_M1.4171.00
327_K331_D1.4131.00
37_F41_K1.4051.00
254_A258_H1.4031.00
103_E107_K1.4001.00
291_E299_H1.3981.00
57_Y105_K1.3971.00
65_V302_D1.3901.00
326_V358_Q1.3881.00
279_I335_I1.3771.00
99_F235_A1.3531.00
286_M331_D1.3411.00
72_H253_E1.3371.00
76_R253_E1.3371.00
104_Q108_Y1.3341.00
198_R343_K1.3231.00
64_V305_N1.3171.00
148_L182_F1.3071.00
139_A182_F1.3011.00
330_L355_K1.2991.00
259_A332_A1.2971.00
51_I70_A1.2951.00
185_E188_T1.2931.00
319_Q364_N1.2931.00
11_R73_E1.2931.00
14_V48_L1.2901.00
72_H298_Y1.2811.00
217_V221_N1.2811.00
122_A155_I1.2611.00
145_K219_E1.2571.00
78_S81_V1.2491.00
252_A290_A1.2471.00
8_V12_K1.2441.00
252_A328_A1.2441.00
31_K198_R1.2441.00
27_E31_K1.2421.00
103_E220_A1.2381.00
110_P114_S1.2301.00
127_H136_R1.2301.00
41_K44_G1.2211.00
285_D368_R1.2151.00
29_M204_G1.2121.00
42_K46_H1.2061.00
105_K109_I1.2001.00
62_A66_S1.1991.00
112_L119_G1.1971.00
186_K191_F1.1951.00
325_A354_A1.1911.00
141_K146_Y1.1901.00
191_F215_A1.1901.00
287_A291_E1.1841.00
25_A29_M1.1841.00
238_N311_G1.1831.00
68_I301_A1.1821.00
107_K221_N1.1821.00
299_H302_D1.1811.00
256_L260_V1.1751.00
246_A297_V1.1751.00
271_R276_N1.1721.00
258_H336_Y1.1721.00
330_L358_Q1.1641.00
290_A328_A1.1581.00
188_T221_N1.1531.00
117_H162_D1.1521.00
144_G216_E1.1491.00
170_T180_S1.1471.00
63_D305_N1.1431.00
303_L308_L1.1421.00
13_M46_H1.1411.00
140_I147_L1.1401.00
53_V113_A1.1401.00
315_S367_Q1.1341.00
167_F181_A1.1311.00
282_K365_E1.1301.00
326_V330_L1.1291.00
240_G361_E1.1281.00
186_K193_V1.1261.00
68_I246_A1.1261.00
254_A350_L1.1251.00
138_T149_N1.1151.00
332_A347_V1.1101.00
108_Y163_I1.1091.00
293_A324_A1.1061.00
11_R69_L1.1061.00
230_F234_M1.1041.00
44_G49_M1.1031.00
355_K358_Q1.0951.00
289_R331_D1.0921.00
137_T148_L1.0891.00
122_A164_Y1.0871.00
103_E106_M1.0731.00
41_K116_D1.0731.00
75_S82_G1.0561.00
167_F179_I1.0521.00
289_R324_A1.0481.00
100_G104_Q1.0461.00
56_Q106_M1.0441.00
38_Q41_K1.0401.00
146_Y170_T1.0361.00
166_T184_V1.0351.00
249_L290_A1.0311.00
119_G163_I1.0281.00
139_A168_A1.0281.00
216_E219_E1.0281.00
25_A28_I1.0261.00
13_M48_L1.0221.00
140_I214_N1.0211.00
288_T316_M1.0201.00
358_Q364_N1.0191.00
148_L166_T1.0141.00
171_A178_G1.0141.00
190_G215_A1.0101.00
323_D327_K1.0051.00
122_A212_F1.0011.00
264_K274_A1.0001.00
295_H299_H0.9911.00
104_Q183_I0.9911.00
98_Y235_A0.9911.00
131_D134_S0.9851.00
92_G119_G0.9841.00
191_F210_L0.9791.00
326_V351_L0.9791.00
324_A327_K0.9771.00
319_Q368_R0.9761.00
166_T212_F0.9721.00
14_V18_A0.9701.00
249_L297_V0.9701.00
17_F42_K0.9641.00
146_Y226_E0.9641.00
248_A357_T0.9601.00
260_V283_L0.9591.00
285_D289_R0.9551.00
15_R19_R0.9541.00
164_Y191_F0.9541.00
329_A354_A0.9521.00
143_N216_E0.9421.00
107_K185_E0.9411.00
104_Q221_N0.9351.00
182_F222_L0.9351.00
263_A273_I0.9311.00
164_Y210_L0.9251.00
263_A274_A0.9241.00
180_S226_E0.9211.00
255_A350_L0.9191.00
140_I171_A0.9191.00
202_L356_V0.9161.00
154_F339_Y0.9151.00
153_I209_E0.9131.00
31_K343_K0.9111.00
14_V70_A0.9091.00
200_L351_L0.9061.00
323_D358_Q0.9011.00
322_S364_N0.9011.00
158_G193_V0.8991.00
189_P216_E0.8951.00
300_A317_A0.8911.00
53_V93_T0.8891.00
148_L217_V0.8871.00
257_E261_D0.8861.00
188_T191_F0.8831.00
163_I185_E0.8811.00
333_V351_L0.8811.00
99_F232_I0.8741.00
364_N368_R0.8731.00
25_A38_Q0.8721.00
261_D264_K0.8701.00
287_A316_M0.8691.00
17_F46_H0.8681.00
65_V305_N0.8671.00
101_N105_K0.8661.00
56_Q102_E0.8651.00
54_P57_Y0.8651.00
323_D368_R0.8641.00
65_V69_L0.8631.00
148_L168_A0.8631.00
80_A204_G0.8581.00
356_V360_Y0.8521.00
171_A174_Q0.8511.00
154_F342_M0.8491.00
65_V298_Y0.8481.00
357_T360_Y0.8471.00
289_R320_F0.8461.00
120_A186_K0.8451.00
92_G165_I0.8441.00
165_I181_A0.8431.00
169_L179_I0.8421.00
251_I350_L0.8411.00
11_R15_R0.8401.00
18_A74_I0.8391.00
37_F162_D0.8381.00
38_Q42_K0.8361.00
117_H163_I0.8341.00
30_E352_R0.8321.00
193_V210_L0.8311.00
281_F369_L0.8311.00
28_I31_K0.8301.00
146_Y222_L0.8261.00
326_V355_K0.8251.00
52_P67_Y0.8251.00
281_F285_D0.8231.00
123_L237_L0.8231.00
145_K218_P0.8221.00
122_A166_T0.8211.00
324_A328_A0.8201.00
19_R76_R0.8181.00
280_S369_L0.8161.00
329_A350_L0.8151.00
251_I325_A0.8131.00
13_M16_D0.8121.00
120_A161_A0.8111.00
130_S366_I0.8101.00
263_A283_L0.8061.00
163_I183_I0.8061.00
200_L348_E0.8031.00
212_F215_A0.7961.00
330_L351_L0.7921.00
291_E294_R0.7921.00
259_A335_I0.7901.00
285_D331_D0.7871.00
259_A336_Y0.7851.00
249_L293_A0.7851.00
37_F160_A0.7841.00
17_F43_M0.7831.00
291_E295_H0.7831.00
256_L287_A0.7821.00
258_H350_L0.7791.00
252_A324_A0.7781.00
201_G353_D0.7771.00
69_L298_Y0.7771.00
244_I361_E0.7761.00
135_L167_F0.7751.00
43_M48_L0.7741.00
182_F217_V0.7731.00
310_C313_E0.7731.00
27_E349_R0.7701.00
69_L73_E0.7701.00
288_T320_F0.7671.00
286_M332_A0.7671.00
251_I354_A0.7641.00
180_S227_G0.7631.00
351_L355_K0.7631.00
245_A317_A0.7631.00
139_A146_Y0.7601.00
17_F21_E0.7591.00
329_A351_L0.7571.00
56_Q59_G0.7561.00
137_T152_K0.7551.00
333_V347_V0.7541.00
253_E287_A0.7521.00
285_D327_K0.7491.00
19_R23_A0.7481.00
162_D187_N0.7481.00
202_L360_Y0.7481.00
135_L179_I0.7471.00
320_F324_A0.7461.00
139_A170_T0.7431.00
262_Y339_Y0.7421.00
57_Y102_E0.7391.00
171_A227_G0.7381.00
122_A210_L0.7341.00
245_A297_V0.7331.00
145_K220_A0.7321.00
255_A332_A0.7311.00
259_A263_A0.7301.00
222_L225_K0.7291.00
56_Q105_K0.7291.00
39_L81_V0.7281.00
108_Y183_I0.7281.00
174_Q177_H0.7271.00
296_L317_A0.7241.00
282_K335_I0.7231.00
277_Q281_F0.7211.00
327_K330_L0.7191.00
369_L373_K0.7191.00
16_D19_R0.7181.00
296_L316_M0.7161.00
19_R77_I0.7151.00
162_D186_K0.7141.00
288_T319_Q0.7121.00
292_A296_L0.7101.00
108_Y221_N0.7031.00
349_R353_D0.6971.00
76_R254_A0.6961.00
273_I276_N0.6961.00
125_E137_T0.6951.00
22_I39_L0.6951.00
93_T112_L0.6941.00
18_A22_I0.6921.00
203_Y343_K0.6921.00
367_Q370_I0.6901.00
228_D232_I0.6891.00
312_K374_Y0.6891.00
159_G206_N0.6841.00
248_A322_S0.6831.00
187_N191_F0.6811.00
334_Q355_K0.6751.00
170_T178_G0.6731.00
108_Y117_H0.6711.00
51_I62_A0.6711.00
301_A305_N0.6701.00
276_N280_S0.6701.00
336_Y347_V0.6691.00
151_S194_G0.6661.00
329_A347_V0.6651.00
280_S372_S0.6641.00
198_R203_Y0.6631.00
333_V340_G0.6621.00
11_R72_H0.6621.00
144_G220_A0.6611.00
325_A329_A0.6611.00
141_K147_L0.6571.00
53_V57_Y0.6561.00
121_F233_A0.6551.00
180_S224_G0.6551.00
297_V321_A0.6531.00
104_Q107_K0.6531.00
289_R292_A0.6521.00
165_I223_L0.6521.00
245_A321_A0.6491.00
155_I210_L0.6451.00
169_L178_G0.6451.00
56_Q61_G0.6441.00
39_L42_K0.6431.00
123_L132_A0.6431.00
95_P236_N0.6421.00
135_L169_L0.6411.00
246_A250_G0.6411.00
15_R76_R0.6381.00
296_L320_F0.6371.00
259_A286_M0.6351.00
10_M66_S0.6351.00
112_L163_I0.6351.00
282_K334_Q0.6341.00
282_K285_D0.6341.00
201_G341_Y0.6331.00
37_F118_L0.6331.00
100_G105_K0.6301.00
294_R298_Y0.6291.00
299_H313_E0.6271.00
23_A26_A0.6271.00
268_Q273_I0.6221.00
126_P151_S0.6171.00
319_Q371_I0.6161.00
363_T366_I0.6151.00
148_L184_V0.6141.00
83_V202_L0.6131.00
10_M70_A0.6131.00
79_A251_I0.6131.00
279_I283_L0.6131.00
27_E346_P0.6111.00
30_E203_Y0.6111.00
289_R323_D0.6101.00
184_V212_F0.6061.00
137_T212_F0.6041.00
97_L105_K0.6031.00
167_F233_A0.5991.00
254_A257_E0.5981.00
316_M371_I0.5981.00
252_A293_A0.5981.00
175_G178_G0.5961.00
242_I301_A0.5951.00
138_T171_A0.5941.00
80_A84_I0.5931.00
54_P59_G0.5891.00
293_A320_F0.5891.00
304_H310_C0.5891.00
254_A346_P0.5871.00
26_A349_R0.5851.00
142_K219_E0.5841.00
238_N314_A0.5831.00
253_E290_A0.5821.00
169_L176_R0.5811.00
67_Y243_G0.5791.00
158_G210_L0.5791.00
64_V304_H0.5771.00
219_E226_E0.5751.00
269_F276_N0.5741.00
200_L352_R0.5741.00
170_T226_E0.5691.00
296_L300_A0.5691.00
21_E24_P0.5671.00
199_K207_T0.5671.00
33_D198_R0.5661.00
143_N147_L0.5651.00
288_T292_A0.5651.00
225_K232_I0.5631.00
182_F219_E0.5621.00
291_E296_L0.5621.00
326_V354_A0.5611.00
57_Y110_P0.5611.00
279_I282_K0.5611.00
137_T150_G0.5581.00
338_G341_Y0.5571.00
346_P350_L0.5541.00
249_L253_E0.5541.00
92_G95_P0.5531.00
33_D203_Y0.5511.00
322_S357_T0.5511.00
171_A175_G0.5491.00
69_L72_H0.5491.00
43_M81_V0.5481.00
346_P349_R0.5471.00
10_M14_V0.5471.00
15_R77_I0.5471.00
93_T109_I0.5461.00
123_L167_F0.5461.00
163_I221_N0.5451.00
266_R269_F0.5441.00
90_S93_T0.5441.00
191_F212_F0.5431.00
319_Q323_D0.5431.00
166_T215_A0.5431.00
50_G113_A0.5401.00
94_N98_Y0.5401.00
184_V215_A0.5391.00
13_M60_A0.5381.00
137_T166_T0.5371.00
160_A206_N0.5361.00
252_A255_A0.5331.00
242_I297_V0.5331.00
286_M335_I0.5331.00
231_H235_A0.5331.00
50_G60_A0.5321.00
293_A317_A0.5321.00
267_V275_A0.5321.00
276_N279_I0.5311.00
95_P232_I0.5311.00
355_K359_I0.5311.00
92_G112_L0.5311.00
285_D323_D0.5311.00
262_Y345_Y0.5301.00
293_A328_A0.5291.00
137_T168_A0.5291.00
182_F221_N0.5281.00
95_P99_F0.5281.00
156_T207_T0.5281.00
29_M34_E0.5281.00
273_I279_I0.5251.00
187_N190_G0.5231.00
366_I369_L0.5221.00
34_E37_F0.5181.00
183_I223_L0.5171.00
141_K144_G0.5151.00
289_R293_A0.5141.00
262_Y265_Q0.5141.00
68_I298_Y0.5141.00
193_V208_T0.5131.00
96_I100_G0.5131.00
170_T182_F0.5131.00
266_R338_G0.5121.00
128_S136_R0.5111.00
285_D288_T0.5101.00
196_K209_E0.5091.00
169_L174_Q0.5061.00
107_K110_P0.5031.00
120_A155_I0.5011.00
23_A254_A0.5001.00
48_L70_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l1fA 4 0.9974 100 0.074 Contact Map
2jifA 4 0.9974 100 0.074 Contact Map
2d29A 4 1 100 0.075 Contact Map
4u83A 2 0.9683 100 0.076 Contact Map
1bucA 4 0.9947 100 0.079 Contact Map
1ivhA 4 0.9974 100 0.079 Contact Map
2dvlA 4 0.9763 100 0.081 Contact Map
2vigA 6 0.9947 100 0.082 Contact Map
1rx0A 4 0.9921 100 0.082 Contact Map
3pfdA 4 0.9736 100 0.083 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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