GREMLIN Database
HBD - Probable 3-hydroxybutyryl-CoA dehydrogenase
UniProt: P45856 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (279)
Sequences: 8916 (5399)
Seq/√Len: 323.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_E103_T3.1911.00
270_W277_R2.9671.00
36_P40_E2.7921.00
7_M80_A2.7331.00
219_K230_A2.7191.00
105_D131_N2.5471.00
90_I100_M2.4841.00
76_T79_E2.4251.00
277_R281_D2.3821.00
210_K213_A2.3601.00
91_A96_A2.3401.00
5_Q28_Y2.2161.00
137_I167_V2.2101.00
23_A71_I2.1961.00
168_M180_E2.1721.00
134_Q160_S2.1721.00
161_E165_L2.1421.00
61_E65_K2.1231.00
245_E263_R2.1061.00
6_I22_A2.0861.00
105_D130_T2.0641.00
151_V171_A2.0611.00
84_D109_P2.0091.00
43_L73_I1.9481.00
7_M83_A1.9391.00
132_R135_R1.9291.00
204_V214_I1.9221.00
94_M125_E1.9041.00
265_Y270_W1.8941.00
90_I96_A1.8921.00
5_Q82_H1.8621.00
22_A170_L1.8541.00
271_L275_S1.8331.00
160_S163_T1.8281.00
153_V168_M1.8201.00
86_V108_C1.8051.00
54_A64_V1.8031.00
98_T129_V1.8031.00
155_R161_E1.7851.00
168_M172_E1.7241.00
111_H135_R1.7231.00
103_T106_R1.7201.00
39_A73_I1.6671.00
5_Q30_R1.6641.00
139_M171_A1.6521.00
27_F173_K1.6471.00
51_A55_E1.6441.00
22_A174_M1.6281.00
264_K268_A1.6251.00
108_C112_T1.6231.00
28_Y70_R1.6211.00
116_S123_I1.6101.00
13_Q239_T1.6061.00
66_S70_R1.5971.00
60_T63_E1.5801.00
74_S79_E1.5721.00
238_D274_K1.5661.00
47_K68_I1.5631.00
139_M167_V1.5591.00
133_P158_A1.5461.00
47_K51_A1.5361.00
43_L47_K1.4981.00
209_A214_I1.4891.00
6_I27_F1.4881.00
181_V188_V1.4711.00
11_A31_M1.4681.00
177_T216_E1.4591.00
124_T157_L1.4541.00
94_M121_L1.4481.00
102_K129_V1.4441.00
155_R164_A1.4321.00
241_L263_R1.4301.00
63_E66_S1.4301.00
85_I167_V1.4271.00
20_Q49_Q1.4191.00
101_F114_L1.4141.00
106_R131_N1.4121.00
164_A180_E1.4101.00
232_A240_C1.3961.00
40_E44_K1.3951.00
11_A33_D1.3851.00
16_S45_R1.3801.00
95_A98_T1.3731.00
35_N38_A1.3731.00
108_C114_L1.3661.00
51_A64_V1.3651.00
130_T136_V1.3471.00
165_L169_A1.3451.00
263_R267_K1.3401.00
95_A99_E1.3371.00
65_K69_N1.3361.00
124_T183_D1.3291.00
99_E102_K1.3181.00
169_A173_K1.3161.00
30_R74_S1.3141.00
32_Y77_L1.3101.00
169_A172_E1.3081.00
20_Q24_D1.3061.00
44_K48_K1.2981.00
36_P75_Q1.2891.00
78_E103_T1.2761.00
109_P112_T1.2751.00
241_L266_V1.2621.00
171_A178_A1.2591.00
85_I170_L1.2551.00
125_E128_A1.2541.00
204_V211_P1.2471.00
19_A31_M1.2461.00
50_L67_V1.2451.00
245_E249_S1.2391.00
102_K106_R1.2341.00
94_M98_T1.2281.00
64_V68_I1.2241.00
260_P264_K1.2221.00
28_Y72_S1.2221.00
241_L245_E1.2211.00
24_D67_V1.2021.00
101_F104_L1.2011.00
156_G159_T1.1931.00
30_R72_S1.1831.00
98_T102_K1.1741.00
54_A59_R1.1661.00
113_I163_T1.1611.00
82_H109_P1.1611.00
126_I136_V1.1571.00
38_A41_A1.1391.00
61_E64_V1.1331.00
78_E107_I1.1311.00
115_A137_I1.1251.00
123_I138_G1.1221.00
41_A45_R1.1171.00
96_A99_E1.1161.00
203_C208_V1.1131.00
39_A75_Q1.1131.00
137_I163_T1.1041.00
138_G154_I1.1031.00
37_E40_E1.0941.00
47_K64_V1.0921.00
179_V217_V1.0901.00
11_A42_G1.0861.00
62_T66_S1.0821.00
101_F126_I1.0741.00
32_Y74_S1.0561.00
205_Y259_C1.0421.00
40_E43_L1.0401.00
84_D111_H1.0391.00
218_M222_M1.0391.00
202_Y206_E1.0381.00
103_T107_I1.0331.00
85_I139_M1.0301.00
31_M42_G1.0221.00
77_L107_I1.0121.00
22_A87_I1.0101.00
124_T156_G1.0071.00
211_P229_L0.9971.00
72_S79_E0.9951.00
172_E178_A0.9921.00
218_M228_P0.9811.00
9_A104_L0.9781.00
6_I85_I0.9751.00
196_M224_H0.9701.00
9_A100_M0.9581.00
77_L103_T0.9531.00
163_T166_D0.9471.00
134_Q158_A0.9391.00
120_S243_I0.9381.00
32_Y103_T0.9371.00
50_L64_V0.9361.00
122_P125_E0.9361.00
201_I279_F0.9331.00
189_S217_V0.9301.00
115_A139_M0.9291.00
271_L274_K0.9221.00
158_A270_W0.9211.00
44_K47_K0.9201.00
225_P231_L0.9151.00
47_K65_K0.9041.00
155_R180_E0.9031.00
80_A83_A0.9001.00
23_A67_V0.8981.00
52_R55_E0.8981.00
137_I153_V0.8971.00
230_A234_F0.8921.00
31_M73_I0.8871.00
39_A43_L0.8841.00
45_R48_K0.8821.00
30_R82_H0.8791.00
51_A54_A0.8781.00
116_S126_I0.8731.00
98_T126_I0.8711.00
149_K177_T0.8641.00
116_S138_G0.8571.00
33_D38_A0.8561.00
104_L108_C0.8511.00
63_E70_R0.8491.00
192_V196_M0.8481.00
4_K84_D0.8481.00
85_I115_A0.8471.00
45_R49_Q0.8471.00
198_N259_C0.8431.00
49_Q53_D0.8361.00
162_E166_D0.8291.00
78_E81_E0.8291.00
203_C214_I0.8261.00
7_M30_R0.8231.00
27_F170_L0.8221.00
94_M126_I0.8221.00
127_A136_V0.8201.00
105_D132_R0.8181.00
202_Y259_C0.8151.00
93_N242_S0.8111.00
113_I137_I0.8011.00
165_L168_M0.7991.00
9_A32_Y0.7971.00
237_L240_C0.7951.00
8_V19_A0.7921.00
216_E219_K0.7891.00
96_A100_M0.7881.00
34_V38_A0.7871.00
142_M189_S0.7841.00
16_S42_G0.7821.00
245_E258_P0.7821.00
21_T25_A0.7821.00
141_F174_M0.7811.00
167_V171_A0.7811.00
67_V70_R0.7781.00
20_Q146_P0.7731.00
197_I232_A0.7671.00
189_S222_M0.7671.00
121_L125_E0.7671.00
118_T138_G0.7661.00
232_A237_L0.7661.00
199_E206_E0.7630.99
54_A61_E0.7620.99
139_M153_V0.7600.99
202_Y205_Y0.7580.99
269_G275_S0.7570.99
5_Q83_A0.7570.99
21_T174_M0.7550.99
249_S252_G0.7500.99
77_L80_A0.7480.99
177_T220_L0.7450.99
165_L180_E0.7450.99
101_F130_T0.7440.99
235_I240_C0.7430.99
150_L179_V0.7380.99
168_M178_A0.7370.99
30_R83_A0.7360.99
14_M117_N0.7360.99
237_L266_V0.7350.99
179_V188_V0.7270.99
98_T128_A0.7260.99
142_M150_L0.7240.99
53_D59_R0.7210.99
139_M170_L0.7200.99
6_I170_L0.7190.99
261_L279_F0.7190.99
34_V91_A0.7180.99
85_I113_I0.7180.99
248_H252_G0.7130.99
16_S41_A0.7130.99
153_V178_A0.7100.99
30_R79_E0.7050.99
53_D58_K0.7030.99
170_L174_M0.7020.99
213_A216_E0.7020.99
17_G146_P0.7010.99
93_N96_A0.7010.99
200_A229_L0.7000.99
194_L240_C0.6990.99
105_D136_V0.6980.99
62_T65_K0.6960.99
53_D147_V0.6960.99
159_T163_T0.6960.99
21_T176_K0.6960.99
32_Y80_A0.6950.99
77_L100_M0.6950.99
25_A175_G0.6940.99
98_T125_E0.6930.99
14_M18_I0.6910.99
135_R160_S0.6910.99
64_V67_V0.6900.99
226_M234_F0.6830.99
46_L71_I0.6830.99
110_P131_N0.6790.99
212_E216_E0.6750.99
75_Q79_E0.6730.99
161_E180_E0.6730.99
252_G255_K0.6730.99
122_P183_D0.6720.99
164_A168_M0.6720.99
211_P280_Y0.6710.99
93_N99_E0.6700.99
193_L197_I0.6700.99
63_E67_V0.6680.99
266_V271_L0.6670.99
48_K51_A0.6650.99
241_L267_K0.6640.99
76_T103_T0.6600.99
198_N202_Y0.6590.99
18_I89_A0.6570.99
191_R199_E0.6560.98
86_V104_L0.6530.98
37_E41_A0.6510.98
162_E165_L0.6490.98
216_E220_L0.6420.98
201_I232_A0.6420.98
239_T243_I0.6410.98
201_I261_L0.6390.98
127_A156_G0.6380.98
166_D173_K0.6350.98
66_S69_N0.6350.98
153_V171_A0.6310.98
42_G46_L0.6280.98
205_Y260_P0.6280.98
150_L217_V0.6260.98
234_F273_K0.6260.98
264_K267_K0.6260.98
21_T145_V0.6230.98
217_V222_M0.6220.98
204_V229_L0.6210.98
270_W275_S0.6200.98
273_K282_Y0.6170.98
195_P198_N0.6170.98
261_L265_Y0.6160.98
106_R109_P0.6150.98
194_L197_I0.6130.98
48_K52_R0.6110.98
123_I183_D0.6100.98
229_L279_F0.6090.98
209_A213_A0.6030.97
46_L49_Q0.6020.97
51_A61_E0.6000.97
143_N235_I0.5970.97
42_G73_I0.5950.97
242_S245_E0.5950.97
128_A158_A0.5950.97
138_G183_D0.5930.97
197_I240_C0.5920.97
13_Q143_N0.5910.97
143_N231_L0.5910.97
30_R80_A0.5900.97
115_A167_V0.5890.97
242_S246_V0.5880.97
7_M32_Y0.5870.97
204_V261_L0.5870.97
80_A107_I0.5830.97
226_M230_A0.5790.97
113_I166_D0.5780.97
34_V90_I0.5760.97
190_N195_P0.5750.97
4_K173_K0.5740.97
104_L107_I0.5670.96
119_S190_N0.5670.96
231_L235_I0.5650.96
114_L136_V0.5600.96
109_P135_R0.5600.96
114_L130_T0.5600.96
33_D39_A0.5570.96
166_D169_A0.5570.96
46_L73_I0.5570.96
6_I87_I0.5560.96
193_L235_I0.5540.96
238_D271_L0.5520.96
22_A27_F0.5510.96
11_A19_A0.5490.96
185_P246_V0.5480.95
65_K68_I0.5470.95
5_Q84_D0.5460.95
172_E177_T0.5460.95
20_Q53_D0.5450.95
258_P262_L0.5450.95
260_P263_R0.5430.95
154_I187_F0.5360.95
54_A57_G0.5350.95
236_G239_T0.5340.95
59_R67_V0.5330.95
110_P132_R0.5320.95
24_D53_D0.5310.95
248_H258_P0.5290.95
196_M218_M0.5280.94
202_Y257_R0.5260.94
83_A86_V0.5250.94
111_H166_D0.5240.94
121_L246_V0.5240.94
170_L173_K0.5220.94
193_L232_A0.5220.94
21_T146_P0.5210.94
178_A181_V0.5200.94
205_Y261_L0.5200.94
34_V93_N0.5200.94
41_A44_K0.5200.94
198_N244_M0.5200.94
78_E106_R0.5180.94
133_P156_G0.5180.94
193_L225_P0.5170.94
35_N41_A0.5160.94
93_N98_T0.5140.94
130_T133_P0.5140.94
118_T187_F0.5120.94
236_G274_K0.5120.94
265_Y277_R0.5120.94
237_L241_L0.5100.93
197_I201_I0.5100.93
123_I156_G0.5080.93
4_K27_F0.5080.93
51_A68_I0.5070.93
102_K131_N0.5070.93
198_N256_Y0.5060.93
235_I239_T0.5050.93
237_L265_Y0.5040.93
189_S195_P0.5040.93
193_L231_L0.5030.93
101_F108_C0.5030.93
104_L114_L0.5030.93
213_A221_G0.5030.93
188_V209_A0.5020.93
137_I164_A0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wdkA 2 0.9826 100 0.234 Contact Map
2wtbA 1 0.9129 100 0.242 Contact Map
4b3hA 1 0.9895 100 0.245 Contact Map
3zwcA 1 0.9861 100 0.261 Contact Map
3k6jA 1 0.9582 100 0.266 Contact Map
4j0eA 2 0.9826 100 0.272 Contact Map
1zcjA 1 0.9861 100 0.272 Contact Map
1f0yA 2 0.9861 100 0.296 Contact Map
4r1nA 2 0.9826 100 0.301 Contact Map
3mogA 3 1 100 0.318 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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