GREMLIN Database
THL - Acetyl-CoA acetyltransferase
UniProt: P45855 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (375)
Sequences: 15155 (8312)
Seq/√Len: 429.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_R185_R3.5321.00
3_K262_E3.4941.00
174_E329_K3.4011.00
264_K268_L3.3611.00
107_A110_L2.9981.00
180_L226_L2.9161.00
36_E39_Q2.8511.00
95_V359_L2.8451.00
362_L374_G2.6991.00
262_E266_A2.6791.00
181_R184_A2.6761.00
188_K192_E2.6741.00
264_K267_E2.6631.00
175_Q241_S2.6461.00
166_K237_A2.6461.00
9_A360_M2.4311.00
5_V265_A2.4211.00
300_L304_N2.4121.00
102_I259_L2.4101.00
34_M111_V2.3711.00
300_L389_L2.3631.00
191_D222_R2.3521.00
10_A40_Q2.3241.00
37_A258_V2.2571.00
196_Q215_D2.2521.00
109_I260_M2.1541.00
98_C110_L2.1131.00
274_A363_V2.1081.00
171_S174_E2.1021.00
278_G304_N2.0591.00
313_L340_V2.0311.00
366_L371_G2.0291.00
30_G53_M2.0271.00
44_S47_D2.0151.00
219_A249_G1.9911.00
190_A220_I1.9791.00
102_I261_S1.9761.00
7_V260_M1.9701.00
32_I202_V1.9551.00
3_K275_T1.9531.00
273_L367_K1.9211.00
275_T391_Q1.9001.00
306_L373_L1.8751.00
173_R177_E1.8661.00
187_A220_I1.8421.00
181_R335_L1.8181.00
164_A170_I1.8151.00
278_G300_L1.8121.00
255_G356_A1.8111.00
47_D268_L1.8051.00
328_E335_L1.8001.00
229_L245_G1.7631.00
20_V214_V1.7481.00
196_Q216_K1.7461.00
190_A199_I1.7251.00
297_I377_A1.7251.00
260_M264_K1.7081.00
108_D261_S1.7071.00
328_E338_V1.6781.00
260_M265_A1.6771.00
312_D371_G1.6771.00
298_N302_K1.6681.00
341_N365_E1.6571.00
167_E288_E1.6431.00
308_V314_F1.6351.00
365_E369_R1.6341.00
190_A216_K1.6321.00
187_A191_D1.6291.00
194_K341_N1.6241.00
108_D264_K1.6221.00
228_Q231_K1.6191.00
261_S264_K1.6181.00
306_L311_I1.6181.00
158_A236_Y1.6121.00
37_A41_A1.6041.00
101_M107_A1.5991.00
100_Q106_D1.5991.00
53_M113_G1.5941.00
180_L184_A1.5941.00
257_F356_A1.5851.00
82_E97_L1.5841.00
311_I314_F1.5781.00
8_S41_A1.5731.00
32_I200_V1.5711.00
117_S120_N1.5501.00
311_I389_L1.5461.00
28_E72_L1.5421.00
36_E200_V1.5371.00
98_C259_L1.5321.00
30_G69_A1.5241.00
197_D367_K1.5191.00
306_L389_L1.4921.00
35_K39_Q1.4801.00
313_L365_E1.4721.00
177_E181_R1.4711.00
194_K365_E1.4531.00
34_M69_A1.4501.00
177_E226_L1.4501.00
5_V275_T1.4341.00
365_E368_R1.4321.00
184_A188_K1.4151.00
109_I264_K1.4051.00
33_V256_A1.4031.00
33_V254_A1.3961.00
184_A223_D1.3941.00
277_L391_Q1.3941.00
314_F375_V1.3891.00
359_L390_V1.3831.00
301_L308_V1.3711.00
21_L214_V1.3681.00
372_G391_Q1.3611.00
96_T388_V1.3551.00
280_S299_K1.3481.00
36_E40_Q1.3381.00
280_S300_L1.3211.00
295_F298_N1.3151.00
334_D337_K1.3081.00
8_S37_A1.3071.00
77_W285_P1.3041.00
14_F353_A1.2981.00
299_K302_K1.2971.00
263_E267_E1.2881.00
65_P115_M1.2861.00
194_K368_R1.2831.00
174_E177_E1.2761.00
124_A142_L1.2691.00
24_V32_I1.2621.00
375_V389_L1.2581.00
172_R243_T1.2411.00
187_A223_D1.2411.00
89_A386_D1.2311.00
4_T259_L1.2301.00
49_E107_A1.2281.00
297_I375_V1.2271.00
291_A294_G1.2261.00
296_A387_A1.2261.00
340_V365_E1.2191.00
48_V109_I1.2181.00
31_G72_L1.2161.00
298_N330_I1.2161.00
55_M58_Q1.2141.00
53_M256_A1.2141.00
363_V367_K1.2121.00
18_G130_W1.2111.00
111_V258_V1.2111.00
10_A200_V1.2091.00
360_M364_Y1.2051.00
95_V257_F1.1961.00
96_T279_F1.1911.00
197_D368_R1.1891.00
5_V262_E1.1821.00
14_F347_L1.1631.00
170_I175_Q1.1581.00
311_I373_L1.1541.00
159_V237_A1.1481.00
307_T310_D1.1321.00
304_N389_L1.1141.00
198_E361_T1.0991.00
178_W324_V1.0981.00
49_E108_D1.0921.00
282_T295_F1.0891.00
9_A364_Y1.0881.00
32_I36_E1.0871.00
52_V110_L1.0871.00
158_A235_I1.0861.00
162_N237_A1.0851.00
98_C112_A1.0841.00
47_D264_K1.0831.00
284_M291_A1.0821.00
92_L359_L1.0811.00
168_Y291_A1.0741.00
187_A222_R1.0721.00
163_T167_E1.0711.00
5_V260_M1.0711.00
34_M75_M1.0701.00
103_R106_D1.0701.00
178_W325_L1.0651.00
204_W214_V1.0651.00
89_A380_S1.0641.00
106_D303_K1.0611.00
170_I325_L1.0591.00
312_D337_K1.0511.00
288_E291_A1.0501.00
226_L230_A1.0451.00
93_R97_L1.0441.00
197_D364_Y1.0371.00
278_G303_K1.0211.00
100_Q104_A1.0161.00
313_L369_R1.0151.00
95_V259_L1.0071.00
308_V311_I1.0071.00
312_D366_L1.0071.00
54_G90_S1.0061.00
13_P214_V1.0061.00
224_T229_L1.0051.00
51_N70_A1.0031.00
6_I390_V1.0011.00
10_A36_E0.9991.00
373_L391_Q0.9971.00
9_A363_V0.9951.00
232_L245_G0.9911.00
276_I388_V0.9901.00
340_V369_R0.9881.00
192_E218_E0.9881.00
277_L373_L0.9781.00
357_R361_T0.9731.00
167_E287_H0.9701.00
282_T299_K0.9671.00
47_D267_E0.9651.00
38_L75_M0.9641.00
162_N166_K0.9631.00
262_E275_T0.9561.00
33_V36_E0.9461.00
180_L229_L0.9461.00
8_S40_Q0.9461.00
273_L363_V0.9441.00
25_K28_E0.9441.00
255_G353_A0.9411.00
341_N368_R0.9371.00
180_L223_D0.9321.00
278_G389_L0.9281.00
184_A187_A0.9281.00
31_G35_K0.9271.00
181_R336_E0.9241.00
314_F333_F0.9231.00
75_M79_V0.9181.00
362_L376_A0.9141.00
299_K303_K0.9131.00
311_I375_V0.9111.00
313_L362_L0.9101.00
4_T261_S0.9051.00
192_E368_R0.9041.00
7_V270_K0.9021.00
333_F338_V0.8991.00
3_K103_R0.8961.00
12_T33_V0.8921.00
38_L43_V0.8921.00
168_Y330_I0.8921.00
358_I376_A0.8911.00
14_F251_N0.8891.00
99_D276_I0.8851.00
16_K219_A0.8801.00
225_S228_Q0.8771.00
291_A326_T0.8761.00
71_R77_W0.8681.00
316_V377_A0.8681.00
165_A322_S0.8671.00
164_A326_T0.8671.00
297_I331_V0.8661.00
186_A220_I0.8661.00
232_L243_T0.8661.00
12_T29_L0.8651.00
52_V98_C0.8641.00
86_K93_R0.8641.00
373_L389_L0.8591.00
15_G218_E0.8581.00
13_P32_I0.8561.00
291_A330_I0.8561.00
164_A291_A0.8531.00
190_A196_Q0.8531.00
260_M270_K0.8491.00
173_R230_A0.8471.00
233_A244_A0.8471.00
276_I279_F0.8451.00
52_V82_E0.8431.00
112_A257_F0.8421.00
47_D109_I0.8411.00
294_G298_N0.8391.00
99_D103_R0.8371.00
52_V94_A0.8361.00
176_D246_N0.8351.00
255_G360_M0.8351.00
378_I381_G0.8341.00
37_A111_V0.8311.00
289_L293_P0.8261.00
139_L142_L0.8211.00
363_V390_V0.8211.00
321_A345_I0.8201.00
149_T154_E0.8181.00
4_T99_D0.8151.00
190_A222_R0.8131.00
344_A354_S0.8121.00
359_L388_V0.8081.00
12_T32_I0.8061.00
9_A257_F0.8021.00
163_T166_K0.8011.00
284_M295_F0.8001.00
324_V328_E0.7981.00
188_K194_K0.7951.00
14_F357_R0.7921.00
262_E265_A0.7901.00
173_R226_L0.7881.00
106_D279_F0.7861.00
51_N79_V0.7861.00
26_A115_M0.7841.00
136_D140_R0.7821.00
48_V111_V0.7821.00
263_E266_A0.7791.00
297_I387_A0.7751.00
341_N369_R0.7751.00
271_R367_K0.7721.00
49_E299_K0.7711.00
328_E333_F0.7661.00
185_R188_K0.7651.00
94_A356_A0.7641.00
61_S120_N0.7631.00
284_M292_A0.7621.00
4_T103_R0.7611.00
234_P237_A0.7601.00
246_N321_A0.7601.00
185_R335_L0.7581.00
380_S386_D0.7581.00
125_V139_L0.7571.00
24_V28_E0.7571.00
33_V37_A0.7531.00
38_L48_V0.7511.00
12_T202_V0.7491.00
50_G101_M0.7481.00
294_G330_I0.7461.00
174_E325_L0.7461.00
224_T228_Q0.7441.00
237_A240_G0.7411.00
37_A256_A0.7371.00
298_N331_V0.7351.00
30_G113_G0.7351.00
161_G322_S0.7341.00
96_T386_D0.7321.00
119_S252_D0.7281.00
97_L100_Q0.7281.00
92_L388_V0.7231.00
49_E110_L0.7221.00
111_V256_A0.7201.00
306_L310_D0.7141.00
191_D216_K0.7131.00
27_A61_S0.7131.00
180_L224_T0.7121.00
309_Q332_G0.7121.00
186_A190_A0.7111.00
309_Q337_K0.7091.00
55_M61_S0.7071.00
50_G281_T0.7061.00
316_V327_C0.7051.00
183_H219_A0.7021.00
101_M106_D0.7011.00
97_L101_M0.7001.00
100_Q103_R0.6991.00
188_K191_D0.6991.00
127_A132_A0.6971.00
281_T386_D0.6961.00
132_A137_G0.6961.00
75_M111_V0.6961.00
308_V333_F0.6951.00
183_H187_A0.6921.00
301_L306_L0.6911.00
32_I35_K0.6901.00
10_A33_V0.6881.00
52_V97_L0.6861.00
53_M66_S0.6861.00
224_T245_G0.6831.00
4_T102_I0.6831.00
273_L364_Y0.6821.00
38_L45_G0.6801.00
86_K281_T0.6791.00
326_T330_I0.6771.00
297_I316_V0.6761.00
55_M65_P0.6751.00
227_D231_K0.6741.00
108_D303_K0.6721.00
35_K45_G0.6721.00
277_L304_N0.6691.00
41_A258_V0.6671.00
180_L228_Q0.6631.00
380_S384_Q0.6621.00
366_L374_G0.6611.00
289_L292_A0.6590.99
20_V218_E0.6570.99
300_L375_V0.6570.99
156_H159_V0.6520.99
180_L225_S0.6510.99
38_L42_G0.6490.99
48_V75_M0.6490.99
101_M110_L0.6480.99
242_I247_A0.6460.99
168_Y288_E0.6460.99
6_I363_V0.6450.99
176_D226_L0.6440.99
6_I259_L0.6430.99
109_I268_L0.6430.99
25_K120_N0.6420.99
186_A346_A0.6410.99
28_E31_G0.6410.99
183_H220_I0.6390.99
10_A37_A0.6350.99
98_C107_A0.6340.99
56_V351_I0.6310.99
45_G76_P0.6300.99
5_V261_S0.6300.99
24_V120_N0.6290.99
29_L202_V0.6290.99
170_I329_K0.6290.99
160_H289_L0.6290.99
84_L97_L0.6280.99
257_F360_M0.6280.99
108_D267_E0.6270.99
164_A168_Y0.6270.99
170_I174_E0.6270.99
46_D78_S0.6260.99
285_P288_E0.6260.99
70_A81_S0.6260.99
133_R137_G0.6250.99
297_I308_V0.6220.99
34_M73_A0.6220.99
35_K74_G0.6220.99
155_V159_V0.6210.99
50_G86_K0.6200.99
95_V356_A0.6190.99
277_L306_L0.6190.99
138_E141_D0.6180.99
377_A380_S0.6170.99
162_N240_G0.6150.99
8_S273_L0.6130.99
276_I390_V0.6120.99
18_G119_S0.6110.99
161_G242_I0.6100.99
272_P275_T0.6090.99
128_G132_A0.6090.99
53_M69_A0.6090.99
324_V338_V0.6080.99
354_S358_I0.6070.99
370_G373_L0.6070.99
5_V264_K0.6050.99
159_V163_T0.6020.99
34_M38_L0.6000.99
80_P281_T0.5990.99
259_L276_I0.5990.99
82_E93_R0.5980.99
183_H345_I0.5970.99
92_L376_A0.5950.99
118_M351_I0.5950.99
374_G390_V0.5940.99
7_V264_K0.5920.99
347_L357_R0.5920.99
219_A251_N0.5910.99
35_K73_A0.5900.99
137_G142_L0.5900.99
38_L41_A0.5880.99
7_V265_A0.5880.99
302_K307_T0.5880.99
23_E120_N0.5850.99
223_D228_Q0.5840.99
69_A73_A0.5840.99
95_V112_A0.5840.99
325_L329_K0.5840.99
31_G73_A0.5830.99
24_V117_S0.5820.99
34_M256_A0.5820.99
93_R96_T0.5800.99
187_A221_R0.5790.99
235_I244_A0.5790.99
298_N332_G0.5780.99
319_A349_H0.5760.99
27_A72_L0.5750.99
64_I384_Q0.5740.99
183_H223_D0.5740.99
133_R136_D0.5740.99
135_G138_E0.5730.99
168_Y326_T0.5720.99
227_D230_A0.5720.99
312_D372_G0.5710.99
155_V287_H0.5700.99
280_S303_K0.5700.99
323_V327_C0.5700.99
30_G115_M0.5690.99
311_I380_S0.5690.99
57_V121_I0.5670.98
179_A183_H0.5660.98
193_G196_Q0.5660.98
93_R281_T0.5660.98
301_L304_N0.5640.98
306_L380_S0.5640.98
69_A115_M0.5640.98
198_E364_Y0.5640.98
260_M268_L0.5640.98
70_A75_M0.5620.98
161_G165_A0.5620.98
194_K369_R0.5620.98
67_R71_R0.5610.98
103_R279_F0.5610.98
113_G256_A0.5590.98
186_A347_L0.5550.98
362_L381_G0.5550.98
353_A356_A0.5540.98
22_K130_W0.5540.98
226_L229_L0.5530.98
328_E334_D0.5520.98
312_D373_L0.5500.98
359_L376_A0.5500.98
34_M51_N0.5490.98
123_Y127_A0.5490.98
314_F377_A0.5480.98
286_A290_A0.5460.98
201_P215_D0.5450.98
60_G124_A0.5450.98
50_G107_A0.5450.98
13_P199_I0.5450.98
137_G141_D0.5440.98
329_K332_G0.5440.98
316_V324_V0.5410.98
177_E335_L0.5400.98
289_L294_G0.5400.98
297_I327_C0.5380.98
58_Q83_T0.5370.98
377_A381_G0.5370.98
94_A112_A0.5370.98
32_I203_N0.5370.98
121_I142_L0.5370.98
51_N111_V0.5360.98
43_V258_V0.5360.98
49_E79_V0.5350.98
13_P215_D0.5350.98
92_L386_D0.5330.98
155_V163_T0.5310.98
93_R101_M0.5300.98
137_G140_R0.5290.98
179_A229_L0.5290.98
343_G346_A0.5280.98
367_K370_G0.5280.98
269_G272_P0.5270.98
187_A190_A0.5270.98
5_V268_L0.5260.98
176_D230_A0.5230.97
297_I301_L0.5220.97
136_D141_D0.5210.97
125_V128_G0.5210.97
179_A321_A0.5200.97
292_A295_F0.5190.97
10_A41_A0.5170.97
128_G137_G0.5170.97
290_A293_P0.5140.97
319_A323_V0.5140.97
300_L311_I0.5130.97
158_A240_G0.5120.97
123_Y128_G0.5120.97
62_G68_Q0.5120.97
322_S326_T0.5110.97
165_A241_S0.5090.97
188_K372_G0.5090.97
166_K239_D0.5090.97
178_W343_G0.5080.97
101_M104_A0.5080.97
273_L277_L0.5060.97
13_P216_K0.5050.97
203_N214_V0.5050.97
15_G21_L0.5030.97
21_L24_V0.5030.97
216_K222_R0.5030.97
162_N242_I0.5020.97
376_A379_C0.5010.97
164_A322_S0.5010.97
52_V101_M0.5010.97
56_V87_V0.5000.97
24_V202_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ulqA 4 0.9949 100 0.234 Contact Map
4n46A 4 0.9975 100 0.24 Contact Map
3ss6A 4 0.9949 100 0.242 Contact Map
2vu1A 4 0.9949 100 0.242 Contact Map
4e1lA 4 0.9822 100 0.243 Contact Map
2wu9A 2 0.972 100 0.249 Contact Map
2ib8A 4 0.9873 100 0.253 Contact Map
1wl4A 4 0.9949 100 0.255 Contact Map
4o9aA 4 0.9975 100 0.256 Contact Map
4c2jA 4 0.9847 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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