GREMLIN Database
DHBC - Isochorismate synthase DhbC
UniProt: P45744 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (321)
Sequences: 4938 (3597)
Seq/√Len: 200.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_C287_G4.0551.00
262_R288_E3.6581.00
309_V333_T3.6131.00
219_S278_M3.4541.00
124_P128_K3.1391.00
374_K377_D3.1191.00
220_R235_E3.0451.00
210_Q286_K2.8741.00
128_K376_E2.8451.00
137_R142_T2.6611.00
127_Y367_A2.6341.00
153_H362_R2.6221.00
316_L319_E2.5861.00
239_S242_D2.5691.00
123_E126_D2.5131.00
230_Q234_A2.4341.00
267_P286_K2.4101.00
223_S228_E2.3951.00
274_K279_W2.3781.00
290_S293_S2.3321.00
137_R323_S2.3021.00
143_L146_I2.2741.00
213_S253_V2.2331.00
124_P376_E2.2321.00
153_H360_S2.1391.00
222_R229_D2.0991.00
143_L317_A2.0841.00
134_G146_I2.0531.00
337_G347_W2.0271.00
234_A238_S2.0171.00
265_E286_K1.9741.00
268_E271_S1.9631.00
262_R291_D1.9591.00
122_P130_G1.9081.00
209_T288_E1.9071.00
294_V298_E1.8831.00
306_T349_V1.8701.00
91_V94_E1.8691.00
202_L346_E1.8671.00
136_A140_D1.8511.00
233_A274_K1.8331.00
376_E380_Q1.8211.00
179_F197_G1.7781.00
195_L331_F1.7731.00
132_E135_L1.7591.00
272_L281_L1.7581.00
233_A272_L1.7561.00
124_P379_L1.7511.00
145_K368_G1.7461.00
210_Q288_E1.7451.00
131_V375_P1.7371.00
162_T194_T1.7251.00
226_P230_Q1.7251.00
137_R320_A1.7171.00
262_R290_S1.6941.00
356_A361_L1.6891.00
156_S160_I1.6791.00
150_R382_T1.6671.00
179_F336_V1.6591.00
143_L320_A1.6531.00
161_Q164_E1.6501.00
132_E375_P1.6441.00
340_D344_D1.6431.00
146_I321_I1.6331.00
129_N132_E1.6291.00
228_E231_R1.6271.00
257_L261_C1.6271.00
155_T360_S1.6171.00
223_S232_R1.6111.00
320_A324_I1.5921.00
228_E232_R1.5921.00
136_A139_A1.5611.00
134_G148_L1.5461.00
162_T356_A1.5381.00
151_S362_R1.5201.00
244_H248_V1.5041.00
207_M344_D1.4861.00
182_D194_T1.4671.00
224_N228_E1.4631.00
380_Q384_A1.4501.00
216_L282_S1.4241.00
220_R232_R1.4191.00
126_D129_N1.4161.00
273_I282_S1.4001.00
135_L372_G1.3911.00
237_L281_L1.3831.00
242_D377_D1.3721.00
206_R209_T1.3721.00
310_C318_R1.3711.00
212_V286_K1.3661.00
225_D228_E1.3571.00
121_V327_F1.3491.00
290_S294_V1.3391.00
214_N273_I1.3381.00
90_V94_E1.3301.00
142_T316_L1.3251.00
125_E129_N1.3191.00
212_V284_V1.3101.00
379_L383_S1.2951.00
184_S192_R1.2641.00
247_A270_P1.2591.00
87_A90_V1.2551.00
118_I154_L1.2551.00
135_L139_A1.2531.00
260_F302_A1.2531.00
227_V231_R1.2531.00
126_D130_G1.2521.00
119_K155_T1.2471.00
138_I371_A1.2471.00
230_Q233_A1.2331.00
220_R242_D1.2301.00
309_V351_I1.2241.00
367_A382_T1.2231.00
196_L356_A1.2171.00
128_K375_P1.2121.00
133_Q137_R1.2091.00
152_L386_F1.2051.00
237_L272_L1.2011.00
205_S212_V1.1921.00
336_V350_T1.1831.00
214_N282_S1.1731.00
206_R289_L1.1721.00
128_K379_L1.1661.00
132_E136_A1.1611.00
129_N133_Q1.1551.00
211_V299_L1.1541.00
77_G81_F1.1531.00
231_R235_E1.1531.00
263_T288_E1.1461.00
363_L390_L1.1451.00
154_L361_L1.1411.00
131_V135_L1.1341.00
121_V153_H1.1301.00
155_T359_R1.1221.00
365_A386_F1.1161.00
180_A194_T1.1151.00
128_K132_E1.1121.00
119_K153_H1.1111.00
354_A361_L1.1031.00
137_R316_L1.0941.00
89_L92_P1.0921.00
131_V369_V1.0881.00
179_F353_C1.0841.00
165_L196_L1.0831.00
149_S327_F1.0811.00
221_P232_R1.0691.00
354_A389_M1.0651.00
232_R235_E1.0621.00
331_F350_T1.0621.00
124_P380_Q1.0611.00
295_T298_E1.0551.00
87_A91_V1.0541.00
125_E128_K1.0511.00
289_L299_L1.0441.00
193_R357_E1.0261.00
149_S364_Y1.0241.00
148_L369_V1.0171.00
252_A307_P1.0141.00
234_A237_L1.0101.00
68_S75_V1.0011.00
217_A308_A0.9951.00
272_L279_W0.9951.00
214_N284_V0.9941.00
197_G348_I0.9941.00
243_L269_K0.9911.00
363_L386_F0.9901.00
130_G326_P0.9861.00
204_V345_G0.9841.00
133_Q323_S0.9821.00
240_A244_H0.9791.00
332_F367_A0.9771.00
377_D380_Q0.9741.00
90_V93_E0.9741.00
331_F355_E0.9720.99
66_K69_G0.9710.99
135_L371_A0.9710.99
205_S346_E0.9700.99
134_G143_L0.9690.99
97_W101_L0.9670.99
77_G80_P0.9630.99
130_G324_I0.9580.99
206_R299_L0.9550.99
221_P384_A0.9540.99
271_S284_V0.9530.99
242_D370_V0.9470.99
179_F195_L0.9460.99
126_D326_P0.9460.99
163_D180_A0.9450.99
173_N277_T0.9440.99
99_G102_Q0.9400.99
354_A363_L0.9390.99
147_V333_T0.9360.99
133_Q136_A0.9330.99
249_V308_A0.9260.99
195_L350_T0.9230.99
243_L270_P0.9200.99
206_R211_V0.9130.99
169_L198_A0.9110.99
192_R357_E0.9090.99
387_R391_R0.9080.99
75_V78_A0.9020.99
254_A266_V0.9020.99
211_V261_C0.9000.99
209_T291_D0.8990.99
91_V95_V0.8970.99
172_H391_R0.8960.99
338_W346_E0.8950.99
147_V309_V0.8910.99
322_L328_D0.8890.99
87_A94_E0.8880.99
139_A371_A0.8850.99
257_L303_L0.8850.99
202_L214_N0.8840.99
231_R234_A0.8810.99
195_L353_C0.8790.99
217_A249_V0.8770.99
147_V366_G0.8710.99
88_R94_E0.8680.99
267_P284_V0.8660.99
390_L394_G0.8650.99
88_R91_V0.8620.99
217_A246_H0.8510.99
209_T262_R0.8500.99
166_L170_A0.8410.99
250_A269_K0.8410.99
72_R76_V0.8410.99
232_R279_W0.8410.99
315_D319_E0.8390.99
297_L339_C0.8370.98
177_Y202_L0.8350.98
300_A339_C0.8340.98
69_G72_R0.8330.98
173_N388_T0.8330.98
243_L247_A0.8310.98
148_L367_A0.8300.98
203_L217_A0.8280.98
74_L81_F0.8250.98
203_L303_L0.8200.98
380_Q383_S0.8190.98
77_G83_Q0.8120.98
213_S303_L0.8110.98
69_G75_V0.8090.98
206_R296_A0.8080.98
77_G82_D0.8070.98
275_T282_S0.8020.98
134_G320_A0.8020.98
97_W102_Q0.8010.98
90_V95_V0.7960.98
233_A279_W0.7950.98
131_V148_L0.7950.98
195_L336_V0.7940.98
78_A81_F0.7930.98
74_L77_G0.7900.98
260_F299_L0.7900.98
252_A256_A0.7890.98
319_E323_S0.7850.98
184_S193_R0.7810.98
278_M384_A0.7710.97
197_G336_V0.7690.97
160_I165_L0.7640.97
77_G347_W0.7630.97
216_L351_I0.7610.97
114_H157_P0.7590.97
253_V306_T0.7580.97
315_D318_R0.7570.97
178_T198_A0.7560.97
247_A251_D0.7540.97
235_E238_S0.7520.97
214_N268_E0.7480.97
151_S327_F0.7450.97
246_H249_V0.7440.97
208_G344_D0.7350.97
83_Q86_A0.7320.96
122_P150_R0.7260.96
134_G324_I0.7260.96
162_T180_A0.7250.96
147_V197_G0.7210.96
165_L356_A0.7210.96
67_Q74_L0.7190.96
253_V333_T0.7190.96
135_L370_V0.7190.96
211_V287_G0.7170.96
68_S76_V0.7160.96
300_A347_W0.7160.96
265_E288_E0.7150.96
211_V289_L0.7120.96
270_P281_L0.7120.96
130_G134_G0.7110.96
149_S332_F0.7080.96
96_R101_L0.7050.96
355_E362_R0.7010.96
335_M347_W0.7000.95
211_V257_L0.7000.95
150_R383_S0.6980.95
251_D254_A0.6980.95
306_T348_I0.6960.95
120_P150_R0.6950.95
220_R384_A0.6940.95
222_R279_W0.6920.95
254_A258_R0.6910.95
233_A237_L0.6830.95
152_L390_L0.6810.95
146_I317_A0.6800.95
223_S229_D0.6780.95
156_S356_A0.6760.95
316_L320_A0.6750.95
81_F84_V0.6710.94
144_S255_A0.6700.94
235_E242_D0.6700.94
150_R317_A0.6670.94
268_E284_V0.6660.94
174_S276_E0.6560.94
147_V217_A0.6560.94
244_H372_G0.6560.94
104_D107_E0.6550.94
82_D86_A0.6530.93
246_H333_T0.6530.93
113_G116_Y0.6510.93
296_A345_G0.6500.93
129_N136_A0.6500.93
229_D279_W0.6500.93
196_L354_A0.6490.93
150_R379_L0.6470.93
134_G369_V0.6460.93
202_L212_V0.6440.93
98_S101_L0.6410.93
239_S377_D0.6410.93
300_A345_G0.6410.93
184_S194_T0.6390.93
181_A336_V0.6390.93
196_L389_M0.6380.93
255_A314_T0.6380.93
247_A269_K0.6350.93
257_L287_G0.6350.93
88_R92_P0.6330.92
154_L393_M0.6270.92
320_A323_S0.6250.92
246_H250_A0.6250.92
246_H283_S0.6250.92
202_L205_S0.6230.92
149_S382_T0.6220.92
82_D322_L0.6220.92
92_P95_V0.6190.92
203_L308_A0.6180.92
249_V307_P0.6180.92
144_S254_A0.6170.91
246_H308_A0.6160.91
357_E360_S0.6140.91
72_R77_G0.6120.91
175_H178_T0.6090.91
147_V308_A0.6080.91
88_R95_V0.6070.91
152_L365_A0.6070.91
128_K374_K0.6070.91
254_A312_T0.6050.91
354_A392_A0.6040.91
122_P148_L0.6040.91
143_L316_L0.6040.91
253_V285_I0.6030.91
204_V299_L0.6030.91
248_V312_T0.6000.90
350_T353_C0.5970.90
149_S217_A0.5970.90
164_E168_H0.5960.90
134_G147_V0.5960.90
147_V310_C0.5940.90
160_I361_L0.5940.90
335_M348_I0.5900.90
74_L78_A0.5900.90
146_I320_A0.5890.89
127_Y382_T0.5890.89
137_R140_D0.5890.89
309_V350_T0.5870.89
99_G104_D0.5870.89
249_V253_V0.5870.89
217_A280_H0.5850.89
225_D231_R0.5850.89
249_V349_V0.5840.89
165_L354_A0.5840.89
197_G333_T0.5820.89
298_E302_A0.5810.89
168_H171_Q0.5810.89
253_V349_V0.5800.89
101_L108_K0.5800.89
70_Q73_P0.5790.89
199_S348_I0.5790.89
251_D255_A0.5780.89
162_T196_L0.5770.89
121_V151_S0.5740.88
203_L246_H0.5740.88
173_N198_A0.5740.88
221_P380_Q0.5740.88
65_A79_V0.5740.88
206_R345_G0.5720.88
147_V348_I0.5700.88
193_R355_E0.5690.88
367_A373_S0.5690.88
149_S280_H0.5680.88
363_L389_M0.5670.88
208_G288_E0.5670.88
69_G77_G0.5650.87
69_G73_P0.5640.87
116_Y155_T0.5640.87
261_C264_L0.5640.87
87_A92_P0.5640.87
252_A314_T0.5640.87
102_Q105_H0.5630.87
203_L249_V0.5620.87
144_S248_V0.5620.87
122_P326_P0.5570.87
87_A95_V0.5550.87
337_G345_G0.5530.86
253_V308_A0.5520.86
82_D85_K0.5510.86
260_F298_E0.5500.86
128_K131_V0.5500.86
100_P104_D0.5500.86
367_A377_D0.5500.86
217_A368_G0.5490.86
335_M350_T0.5490.86
65_A69_G0.5470.86
147_V150_R0.5460.86
259_P315_D0.5440.85
222_R274_K0.5440.85
176_G388_T0.5430.85
69_G76_V0.5410.85
145_K308_A0.5400.85
379_L382_T0.5380.85
217_A370_V0.5370.85
179_F196_L0.5360.85
314_T318_R0.5350.84
66_K75_V0.5350.84
177_Y348_I0.5350.84
133_Q324_I0.5350.84
64_Q67_Q0.5350.84
253_V303_L0.5340.84
97_W100_P0.5330.84
147_V280_H0.5290.84
204_V303_L0.5290.84
298_E301_A0.5280.84
256_A314_T0.5280.84
144_S251_D0.5280.84
390_L393_M0.5280.84
78_A82_D0.5270.84
64_Q69_G0.5270.84
179_F348_I0.5270.84
96_R119_K0.5250.83
120_P152_L0.5240.83
203_L253_V0.5210.83
183_V193_R0.5200.83
87_A93_E0.5200.83
178_T348_I0.5190.83
197_G350_T0.5190.83
157_P359_R0.5180.83
97_W105_H0.5180.83
246_H270_P0.5180.83
216_L350_T0.5170.82
198_A338_W0.5160.82
137_R143_L0.5160.82
79_V82_D0.5150.82
215_P282_S0.5150.82
223_S226_P0.5140.82
365_A382_T0.5140.82
369_V377_D0.5140.82
240_A372_G0.5130.82
235_E239_S0.5120.82
155_T358_E0.5120.82
176_G275_T0.5120.82
204_V347_W0.5100.82
297_L300_A0.5100.82
194_T356_A0.5100.82
327_F364_Y0.5090.81
256_A259_P0.5090.81
238_S243_L0.5090.81
145_K333_T0.5070.81
119_K123_E0.5050.81
145_K317_A0.5040.81
306_T310_C0.5030.81
110_Q114_H0.5030.81
100_P103_F0.5030.81
127_Y199_S0.5010.80
152_L382_T0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3os6A 3 0.9422 100 0.15 Contact Map
3hwoA 1 0.9397 100 0.154 Contact Map
3bzmA 1 0.9322 100 0.202 Contact Map
3gseA 1 0.9171 100 0.209 Contact Map
1qdlA 1 0.9598 100 0.223 Contact Map
3h9mA 1 0.8693 100 0.224 Contact Map
3logA 1 0.9698 100 0.234 Contact Map
2fn0A 2 0.9322 100 0.239 Contact Map
1k0eA 1 0.9246 100 0.242 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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