DHBC - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DHBC - Isochorismate synthase DhbC

UniProt:	P45744	Sequences: MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPEADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQFDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPIQTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAGSRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTETMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTGMVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRAMGVDHI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	398 (321)
Sequences:	4938 (3597)
Seq/√Len:	200.8

ECOLI - ENTC MENF PABB TRPE
BACSU - DHBC MENF PABB TRPE
HALSA - Q9HQN2 TRPE2 TRPE1
SULSO - TRPE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
261_C	287_G	4.055	1.00
262_R	288_E	3.658	1.00
309_V	333_T	3.613	1.00
219_S	278_M	3.454	1.00
124_P	128_K	3.139	1.00
374_K	377_D	3.119	1.00
220_R	235_E	3.045	1.00
210_Q	286_K	2.874	1.00
128_K	376_E	2.845	1.00
137_R	142_T	2.661	1.00
127_Y	367_A	2.634	1.00
153_H	362_R	2.622	1.00
316_L	319_E	2.586	1.00
239_S	242_D	2.569	1.00
123_E	126_D	2.513	1.00
230_Q	234_A	2.434	1.00
267_P	286_K	2.410	1.00
223_S	228_E	2.395	1.00
274_K	279_W	2.378	1.00
290_S	293_S	2.332	1.00
137_R	323_S	2.302	1.00
143_L	146_I	2.274	1.00
213_S	253_V	2.233	1.00
124_P	376_E	2.232	1.00
153_H	360_S	2.139	1.00
222_R	229_D	2.099	1.00
143_L	317_A	2.084	1.00
134_G	146_I	2.053	1.00
337_G	347_W	2.027	1.00
234_A	238_S	2.017	1.00
265_E	286_K	1.974	1.00
268_E	271_S	1.963	1.00
262_R	291_D	1.959	1.00
122_P	130_G	1.908	1.00
209_T	288_E	1.907	1.00
294_V	298_E	1.883	1.00
306_T	349_V	1.870	1.00
91_V	94_E	1.869	1.00
202_L	346_E	1.867	1.00
136_A	140_D	1.851	1.00
233_A	274_K	1.833	1.00
376_E	380_Q	1.821	1.00
179_F	197_G	1.778	1.00
195_L	331_F	1.773	1.00
132_E	135_L	1.759	1.00
272_L	281_L	1.758	1.00
233_A	272_L	1.756	1.00
124_P	379_L	1.751	1.00
145_K	368_G	1.746	1.00
210_Q	288_E	1.745	1.00
131_V	375_P	1.737	1.00
162_T	194_T	1.725	1.00
226_P	230_Q	1.725	1.00
137_R	320_A	1.717	1.00
262_R	290_S	1.694	1.00
356_A	361_L	1.689	1.00
156_S	160_I	1.679	1.00
150_R	382_T	1.667	1.00
179_F	336_V	1.659	1.00
143_L	320_A	1.653	1.00
161_Q	164_E	1.650	1.00
132_E	375_P	1.644	1.00
340_D	344_D	1.643	1.00
146_I	321_I	1.633	1.00
129_N	132_E	1.629	1.00
228_E	231_R	1.627	1.00
257_L	261_C	1.627	1.00
155_T	360_S	1.617	1.00
223_S	232_R	1.611	1.00
320_A	324_I	1.592	1.00
228_E	232_R	1.592	1.00
136_A	139_A	1.561	1.00
134_G	148_L	1.546	1.00
162_T	356_A	1.538	1.00
151_S	362_R	1.520	1.00
244_H	248_V	1.504	1.00
207_M	344_D	1.486	1.00
182_D	194_T	1.467	1.00
224_N	228_E	1.463	1.00
380_Q	384_A	1.450	1.00
216_L	282_S	1.424	1.00
220_R	232_R	1.419	1.00
126_D	129_N	1.416	1.00
273_I	282_S	1.400	1.00
135_L	372_G	1.391	1.00
237_L	281_L	1.383	1.00
242_D	377_D	1.372	1.00
206_R	209_T	1.372	1.00
310_C	318_R	1.371	1.00
212_V	286_K	1.366	1.00
225_D	228_E	1.357	1.00
121_V	327_F	1.349	1.00
290_S	294_V	1.339	1.00
214_N	273_I	1.338	1.00
90_V	94_E	1.330	1.00
142_T	316_L	1.325	1.00
125_E	129_N	1.319	1.00
212_V	284_V	1.310	1.00
379_L	383_S	1.295	1.00
184_S	192_R	1.264	1.00
247_A	270_P	1.259	1.00
87_A	90_V	1.255	1.00
118_I	154_L	1.255	1.00
135_L	139_A	1.253	1.00
260_F	302_A	1.253	1.00
227_V	231_R	1.253	1.00
126_D	130_G	1.252	1.00
119_K	155_T	1.247	1.00
138_I	371_A	1.247	1.00
230_Q	233_A	1.233	1.00
220_R	242_D	1.230	1.00
309_V	351_I	1.224	1.00
367_A	382_T	1.223	1.00
196_L	356_A	1.217	1.00
128_K	375_P	1.212	1.00
133_Q	137_R	1.209	1.00
152_L	386_F	1.205	1.00
237_L	272_L	1.201	1.00
205_S	212_V	1.192	1.00
336_V	350_T	1.183	1.00
214_N	282_S	1.173	1.00
206_R	289_L	1.172	1.00
128_K	379_L	1.166	1.00
132_E	136_A	1.161	1.00
129_N	133_Q	1.155	1.00
211_V	299_L	1.154	1.00
77_G	81_F	1.153	1.00
231_R	235_E	1.153	1.00
263_T	288_E	1.146	1.00
363_L	390_L	1.145	1.00
154_L	361_L	1.141	1.00
131_V	135_L	1.134	1.00
121_V	153_H	1.130	1.00
155_T	359_R	1.122	1.00
365_A	386_F	1.116	1.00
180_A	194_T	1.115	1.00
128_K	132_E	1.112	1.00
119_K	153_H	1.111	1.00
354_A	361_L	1.103	1.00
137_R	316_L	1.094	1.00
89_L	92_P	1.092	1.00
131_V	369_V	1.088	1.00
179_F	353_C	1.084	1.00
165_L	196_L	1.083	1.00
149_S	327_F	1.081	1.00
221_P	232_R	1.069	1.00
354_A	389_M	1.065	1.00
232_R	235_E	1.062	1.00
331_F	350_T	1.062	1.00
124_P	380_Q	1.061	1.00
295_T	298_E	1.055	1.00
87_A	91_V	1.054	1.00
125_E	128_K	1.051	1.00
289_L	299_L	1.044	1.00
193_R	357_E	1.026	1.00
149_S	364_Y	1.024	1.00
148_L	369_V	1.017	1.00
252_A	307_P	1.014	1.00
234_A	237_L	1.010	1.00
68_S	75_V	1.001	1.00
217_A	308_A	0.995	1.00
272_L	279_W	0.995	1.00
214_N	284_V	0.994	1.00
197_G	348_I	0.994	1.00
243_L	269_K	0.991	1.00
363_L	386_F	0.990	1.00
130_G	326_P	0.986	1.00
204_V	345_G	0.984	1.00
133_Q	323_S	0.982	1.00
240_A	244_H	0.979	1.00
332_F	367_A	0.977	1.00
377_D	380_Q	0.974	1.00
90_V	93_E	0.974	1.00
331_F	355_E	0.972	0.99
66_K	69_G	0.971	0.99
135_L	371_A	0.971	0.99
205_S	346_E	0.970	0.99
134_G	143_L	0.969	0.99
97_W	101_L	0.967	0.99
77_G	80_P	0.963	0.99
130_G	324_I	0.958	0.99
206_R	299_L	0.955	0.99
221_P	384_A	0.954	0.99
271_S	284_V	0.953	0.99
242_D	370_V	0.947	0.99
179_F	195_L	0.946	0.99
126_D	326_P	0.946	0.99
163_D	180_A	0.945	0.99
173_N	277_T	0.944	0.99
99_G	102_Q	0.940	0.99
354_A	363_L	0.939	0.99
147_V	333_T	0.936	0.99
133_Q	136_A	0.933	0.99
249_V	308_A	0.926	0.99
195_L	350_T	0.923	0.99
243_L	270_P	0.920	0.99
206_R	211_V	0.913	0.99
169_L	198_A	0.911	0.99
192_R	357_E	0.909	0.99
387_R	391_R	0.908	0.99
75_V	78_A	0.902	0.99
254_A	266_V	0.902	0.99
211_V	261_C	0.900	0.99
209_T	291_D	0.899	0.99
91_V	95_V	0.897	0.99
172_H	391_R	0.896	0.99
338_W	346_E	0.895	0.99
147_V	309_V	0.891	0.99
322_L	328_D	0.889	0.99
87_A	94_E	0.888	0.99
139_A	371_A	0.885	0.99
257_L	303_L	0.885	0.99
202_L	214_N	0.884	0.99
231_R	234_A	0.881	0.99
195_L	353_C	0.879	0.99
217_A	249_V	0.877	0.99
147_V	366_G	0.871	0.99
88_R	94_E	0.868	0.99
267_P	284_V	0.866	0.99
390_L	394_G	0.865	0.99
88_R	91_V	0.862	0.99
217_A	246_H	0.851	0.99
209_T	262_R	0.850	0.99
166_L	170_A	0.841	0.99
250_A	269_K	0.841	0.99
72_R	76_V	0.841	0.99
232_R	279_W	0.841	0.99
315_D	319_E	0.839	0.99
297_L	339_C	0.837	0.98
177_Y	202_L	0.835	0.98
300_A	339_C	0.834	0.98
69_G	72_R	0.833	0.98
173_N	388_T	0.833	0.98
243_L	247_A	0.831	0.98
148_L	367_A	0.830	0.98
203_L	217_A	0.828	0.98
74_L	81_F	0.825	0.98
203_L	303_L	0.820	0.98
380_Q	383_S	0.819	0.98
77_G	83_Q	0.812	0.98
213_S	303_L	0.811	0.98
69_G	75_V	0.809	0.98
206_R	296_A	0.808	0.98
77_G	82_D	0.807	0.98
275_T	282_S	0.802	0.98
134_G	320_A	0.802	0.98
97_W	102_Q	0.801	0.98
90_V	95_V	0.796	0.98
233_A	279_W	0.795	0.98
131_V	148_L	0.795	0.98
195_L	336_V	0.794	0.98
78_A	81_F	0.793	0.98
74_L	77_G	0.790	0.98
260_F	299_L	0.790	0.98
252_A	256_A	0.789	0.98
319_E	323_S	0.785	0.98
184_S	193_R	0.781	0.98
278_M	384_A	0.771	0.97
197_G	336_V	0.769	0.97
160_I	165_L	0.764	0.97
77_G	347_W	0.763	0.97
216_L	351_I	0.761	0.97
114_H	157_P	0.759	0.97
253_V	306_T	0.758	0.97
315_D	318_R	0.757	0.97
178_T	198_A	0.756	0.97
247_A	251_D	0.754	0.97
235_E	238_S	0.752	0.97
214_N	268_E	0.748	0.97
151_S	327_F	0.745	0.97
246_H	249_V	0.744	0.97
208_G	344_D	0.735	0.97
83_Q	86_A	0.732	0.96
122_P	150_R	0.726	0.96
134_G	324_I	0.726	0.96
162_T	180_A	0.725	0.96
147_V	197_G	0.721	0.96
165_L	356_A	0.721	0.96
67_Q	74_L	0.719	0.96
253_V	333_T	0.719	0.96
135_L	370_V	0.719	0.96
211_V	287_G	0.717	0.96
68_S	76_V	0.716	0.96
300_A	347_W	0.716	0.96
265_E	288_E	0.715	0.96
211_V	289_L	0.712	0.96
270_P	281_L	0.712	0.96
130_G	134_G	0.711	0.96
149_S	332_F	0.708	0.96
96_R	101_L	0.705	0.96
355_E	362_R	0.701	0.96
335_M	347_W	0.700	0.95
211_V	257_L	0.700	0.95
150_R	383_S	0.698	0.95
251_D	254_A	0.698	0.95
306_T	348_I	0.696	0.95
120_P	150_R	0.695	0.95
220_R	384_A	0.694	0.95
222_R	279_W	0.692	0.95
254_A	258_R	0.691	0.95
233_A	237_L	0.683	0.95
152_L	390_L	0.681	0.95
146_I	317_A	0.680	0.95
223_S	229_D	0.678	0.95
156_S	356_A	0.676	0.95
316_L	320_A	0.675	0.95
81_F	84_V	0.671	0.94
144_S	255_A	0.670	0.94
235_E	242_D	0.670	0.94
150_R	317_A	0.667	0.94
268_E	284_V	0.666	0.94
174_S	276_E	0.656	0.94
147_V	217_A	0.656	0.94
244_H	372_G	0.656	0.94
104_D	107_E	0.655	0.94
82_D	86_A	0.653	0.93
246_H	333_T	0.653	0.93
113_G	116_Y	0.651	0.93
296_A	345_G	0.650	0.93
129_N	136_A	0.650	0.93
229_D	279_W	0.650	0.93
196_L	354_A	0.649	0.93
150_R	379_L	0.647	0.93
134_G	369_V	0.646	0.93
202_L	212_V	0.644	0.93
98_S	101_L	0.641	0.93
239_S	377_D	0.641	0.93
300_A	345_G	0.641	0.93
184_S	194_T	0.639	0.93
181_A	336_V	0.639	0.93
196_L	389_M	0.638	0.93
255_A	314_T	0.638	0.93
247_A	269_K	0.635	0.93
257_L	287_G	0.635	0.93
88_R	92_P	0.633	0.92
154_L	393_M	0.627	0.92
320_A	323_S	0.625	0.92
246_H	250_A	0.625	0.92
246_H	283_S	0.625	0.92
202_L	205_S	0.623	0.92
149_S	382_T	0.622	0.92
82_D	322_L	0.622	0.92
92_P	95_V	0.619	0.92
203_L	308_A	0.618	0.92
249_V	307_P	0.618	0.92
144_S	254_A	0.617	0.91
246_H	308_A	0.616	0.91
357_E	360_S	0.614	0.91
72_R	77_G	0.612	0.91
175_H	178_T	0.609	0.91
147_V	308_A	0.608	0.91
88_R	95_V	0.607	0.91
152_L	365_A	0.607	0.91
128_K	374_K	0.607	0.91
254_A	312_T	0.605	0.91
354_A	392_A	0.604	0.91
122_P	148_L	0.604	0.91
143_L	316_L	0.604	0.91
253_V	285_I	0.603	0.91
204_V	299_L	0.603	0.91
248_V	312_T	0.600	0.90
350_T	353_C	0.597	0.90
149_S	217_A	0.597	0.90
164_E	168_H	0.596	0.90
134_G	147_V	0.596	0.90
147_V	310_C	0.594	0.90
160_I	361_L	0.594	0.90
335_M	348_I	0.590	0.90
74_L	78_A	0.590	0.90
146_I	320_A	0.589	0.89
127_Y	382_T	0.589	0.89
137_R	140_D	0.589	0.89
309_V	350_T	0.587	0.89
99_G	104_D	0.587	0.89
249_V	253_V	0.587	0.89
217_A	280_H	0.585	0.89
225_D	231_R	0.585	0.89
249_V	349_V	0.584	0.89
165_L	354_A	0.584	0.89
197_G	333_T	0.582	0.89
298_E	302_A	0.581	0.89
168_H	171_Q	0.581	0.89
253_V	349_V	0.580	0.89
101_L	108_K	0.580	0.89
70_Q	73_P	0.579	0.89
199_S	348_I	0.579	0.89
251_D	255_A	0.578	0.89
162_T	196_L	0.577	0.89
121_V	151_S	0.574	0.88
203_L	246_H	0.574	0.88
173_N	198_A	0.574	0.88
221_P	380_Q	0.574	0.88
65_A	79_V	0.574	0.88
206_R	345_G	0.572	0.88
147_V	348_I	0.570	0.88
193_R	355_E	0.569	0.88
367_A	373_S	0.569	0.88
149_S	280_H	0.568	0.88
363_L	389_M	0.567	0.88
208_G	288_E	0.567	0.88
69_G	77_G	0.565	0.87
69_G	73_P	0.564	0.87
116_Y	155_T	0.564	0.87
261_C	264_L	0.564	0.87
87_A	92_P	0.564	0.87
252_A	314_T	0.564	0.87
102_Q	105_H	0.563	0.87
203_L	249_V	0.562	0.87
144_S	248_V	0.562	0.87
122_P	326_P	0.557	0.87
87_A	95_V	0.555	0.87
337_G	345_G	0.553	0.86
253_V	308_A	0.552	0.86
82_D	85_K	0.551	0.86
260_F	298_E	0.550	0.86
128_K	131_V	0.550	0.86
100_P	104_D	0.550	0.86
367_A	377_D	0.550	0.86
217_A	368_G	0.549	0.86
335_M	350_T	0.549	0.86
65_A	69_G	0.547	0.86
147_V	150_R	0.546	0.86
259_P	315_D	0.544	0.85
222_R	274_K	0.544	0.85
176_G	388_T	0.543	0.85
69_G	76_V	0.541	0.85
145_K	308_A	0.540	0.85
379_L	382_T	0.538	0.85
217_A	370_V	0.537	0.85
179_F	196_L	0.536	0.85
314_T	318_R	0.535	0.84
66_K	75_V	0.535	0.84
177_Y	348_I	0.535	0.84
133_Q	324_I	0.535	0.84
64_Q	67_Q	0.535	0.84
253_V	303_L	0.534	0.84
97_W	100_P	0.533	0.84
147_V	280_H	0.529	0.84
204_V	303_L	0.529	0.84
298_E	301_A	0.528	0.84
256_A	314_T	0.528	0.84
144_S	251_D	0.528	0.84
390_L	393_M	0.528	0.84
78_A	82_D	0.527	0.84
64_Q	69_G	0.527	0.84
179_F	348_I	0.527	0.84
96_R	119_K	0.525	0.83
120_P	152_L	0.524	0.83
203_L	253_V	0.521	0.83
183_V	193_R	0.520	0.83
87_A	93_E	0.520	0.83
178_T	348_I	0.519	0.83
197_G	350_T	0.519	0.83
157_P	359_R	0.518	0.83
97_W	105_H	0.518	0.83
246_H	270_P	0.518	0.83
216_L	350_T	0.517	0.82
198_A	338_W	0.516	0.82
137_R	143_L	0.516	0.82
79_V	82_D	0.515	0.82
215_P	282_S	0.515	0.82
223_S	226_P	0.514	0.82
365_A	382_T	0.514	0.82
369_V	377_D	0.514	0.82
240_A	372_G	0.513	0.82
235_E	239_S	0.512	0.82
155_T	358_E	0.512	0.82
176_G	275_T	0.512	0.82
204_V	347_W	0.510	0.82
297_L	300_A	0.510	0.82
194_T	356_A	0.510	0.82
327_F	364_Y	0.509	0.81
256_A	259_P	0.509	0.81
238_S	243_L	0.509	0.81
145_K	333_T	0.507	0.81
119_K	123_E	0.505	0.81
145_K	317_A	0.504	0.81
306_T	310_C	0.503	0.81
110_Q	114_H	0.503	0.81
100_P	103_F	0.503	0.81
127_Y	199_S	0.501	0.80
152_L	382_T	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3os6A	3	0.9422	100	0.15	Contact Map
3hwoA	1	0.9397	100	0.154	Contact Map
3bzmA	1	0.9322	100	0.202	Contact Map
3gseA	1	0.9171	100	0.209	Contact Map
1qdlA	1	0.9598	100	0.223	Contact Map
3h9mA	1	0.8693	100	0.224	Contact Map
3logA	1	0.9698	100	0.234	Contact Map
2fn0A	2	0.9322	100	0.239	Contact Map
1k0eA	1	0.9246	100	0.242	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0108 seconds.