GREMLIN Database
DHBB - Isochorismatase
UniProt: P45743 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (248)
Sequences: 7509 (6935)
Seq/√Len: 440.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_P217_V3.1201.00
281_T284_E2.9771.00
137_M141_E2.7761.00
132_T167_E2.7391.00
192_Y196_R2.7041.00
225_G253_Q2.5751.00
148_I173_F2.5731.00
115_E118_D2.4341.00
231_T299_T2.4081.00
199_F202_M2.3911.00
255_D258_D2.3131.00
235_I273_W2.3001.00
253_Q292_E2.2521.00
181_F190_L2.2441.00
236_R291_I2.2101.00
131_R167_E2.1811.00
199_F203_T2.1801.00
230_F233_E2.1381.00
238_Q269_L2.0991.00
109_I112_L2.0831.00
126_Y130_K2.0311.00
108_I112_L2.0211.00
255_D289_P1.9971.00
288_R297_L1.9811.00
132_T136_E1.9771.00
241_E272_Q1.9761.00
251_T254_E1.9541.00
74_V78_A1.9251.00
143_R147_I1.8991.00
290_T293_E1.8561.00
143_R170_K1.8521.00
274_R279_E1.8521.00
148_I171_A1.7981.00
151_I162_C1.7911.00
224_T249_D1.7561.00
228_N252_D1.7421.00
252_D291_I1.7371.00
73_P77_T1.7271.00
127_S130_K1.7201.00
125_R130_K1.7071.00
234_N276_E1.6641.00
50_A54_T1.6641.00
119_L122_T1.6261.00
89_A92_T1.6171.00
186_H189_A1.6031.00
192_Y195_G1.5801.00
234_N237_K1.5771.00
227_K299_T1.5581.00
215_A218_Q1.5461.00
107_K111_E1.5431.00
284_E297_L1.5281.00
92_T95_W1.5211.00
74_V77_T1.5101.00
262_D265_R1.5081.00
225_G252_D1.5021.00
239_I291_I1.4961.00
233_E237_K1.4951.00
126_Y129_F1.4811.00
228_N296_K1.4781.00
229_V233_E1.4661.00
92_T96_G1.4651.00
229_V252_D1.4591.00
134_L164_A1.4511.00
237_K276_E1.4451.00
125_R129_F1.4391.00
81_G85_P1.4361.00
116_D120_V1.4281.00
185_K193_A1.4241.00
55_E59_N1.4141.00
77_T81_G1.4011.00
288_R293_E1.3941.00
107_K112_L1.3671.00
56_L59_N1.3561.00
185_K189_A1.3551.00
111_E115_E1.3391.00
232_C252_D1.3271.00
238_Q272_Q1.3271.00
106_E109_I1.3271.00
202_M206_L1.3261.00
214_P218_Q1.3201.00
111_E114_P1.3191.00
269_L285_L1.3061.00
119_L127_S1.2981.00
203_T206_L1.2711.00
72_I76_Y1.2671.00
205_S208_D1.2511.00
70_L73_P1.2481.00
231_T234_N1.2471.00
117_D120_V1.2421.00
283_V287_E1.2241.00
235_I291_I1.2211.00
164_A168_D1.2151.00
239_I261_L1.2131.00
284_E287_E1.2111.00
137_M140_K1.2041.00
188_M192_Y1.2041.00
134_L161_A1.1961.00
136_E139_R1.1931.00
118_D122_T1.1841.00
236_R252_D1.1801.00
256_L261_L1.1761.00
89_A93_D1.1731.00
118_D123_K1.1571.00
119_L123_K1.1481.00
228_N232_C1.1431.00
144_D147_I1.1391.00
238_Q273_W1.1391.00
147_I170_K1.1311.00
116_D123_K1.1241.00
116_D122_T1.1071.00
85_P88_R1.1031.00
228_N292_E1.0941.00
123_K157_C1.0931.00
93_D96_G1.0881.00
109_I113_A1.0771.00
79_Q86_D1.0761.00
91_L95_W1.0631.00
82_S85_P1.0611.00
57_S63_L1.0581.00
90_L93_D1.0561.00
191_E195_G1.0551.00
105_E112_L1.0511.00
242_L269_L1.0351.00
91_L96_G1.0301.00
61_R65_N1.0161.00
125_R128_A1.0161.00
273_W278_A1.0131.00
181_F189_A1.0131.00
272_Q276_E1.0001.00
116_D121_L0.9991.00
262_D282_F0.9891.00
73_P76_Y0.9881.00
225_G292_E0.9831.00
192_Y197_C0.9821.00
200_T203_T0.9791.00
52_P56_L0.9631.00
158_L161_A0.9621.00
59_N67_C0.9611.00
238_Q276_E0.9491.00
185_K192_Y0.9481.00
193_A196_R0.9471.00
78_A81_G0.9461.00
267_M271_E0.9451.00
171_A174_V0.9441.00
54_T58_A0.9391.00
229_V299_T0.9391.00
63_L67_C0.9371.00
265_R268_T0.9371.00
52_P59_N0.9301.00
135_L147_I0.9271.00
108_I111_E0.9231.00
122_T127_S0.9171.00
183_L189_A0.9101.00
143_R168_D0.9071.00
91_L94_F0.9071.00
75_V79_Q0.9041.00
123_K126_Y0.8981.00
266_I285_L0.8971.00
52_P67_C0.8961.00
187_Q191_E0.8911.00
273_W280_V0.8881.00
109_I131_R0.8871.00
185_K190_L0.8841.00
83_Q87_D0.8821.00
120_V123_K0.8821.00
270_V274_R0.8741.00
222_A230_F0.8731.00
124_W130_K0.8731.00
124_W128_A0.8731.00
181_F186_H0.8731.00
78_A82_S0.8691.00
189_A194_A0.8681.00
268_T272_Q0.8681.00
68_V71_G0.8651.00
204_D207_L0.8621.00
228_N299_T0.8611.00
94_F97_P0.8461.00
284_E288_R0.8451.00
134_L137_M0.8441.00
273_W298_L0.8441.00
274_R278_A0.8331.00
231_T298_L0.8321.00
79_Q82_S0.8201.00
74_V79_Q0.8171.00
90_L94_F0.8161.00
270_V285_L0.8161.00
237_K241_E0.8161.00
124_W129_F0.8101.00
73_P78_A0.8061.00
252_D292_E0.8041.00
186_H193_A0.7991.00
67_C71_G0.7941.00
197_C201_V0.7931.00
264_V282_F0.7891.00
80_P85_P0.7871.00
267_M282_F0.7861.00
70_L77_T0.7861.00
133_N137_M0.7861.00
264_V267_M0.7861.00
186_H190_L0.7801.00
65_N68_V0.7731.00
238_Q241_E0.7711.00
72_I75_V0.7701.00
52_P55_E0.7661.00
102_G105_E0.7621.00
224_T227_K0.7621.00
236_R250_I0.7611.00
60_I67_C0.7561.00
239_I269_L0.7551.00
110_T137_M0.7511.00
202_M205_S0.7501.00
89_A94_F0.7501.00
182_S192_Y0.7491.00
201_V204_D0.7471.00
105_E109_I0.7451.00
297_L301_R0.7411.00
269_L294_W0.7271.00
90_L95_W0.7231.00
182_S185_K0.7221.00
266_I270_V0.7221.00
68_V76_Y0.7201.00
235_I295_Q0.7201.00
55_E58_A0.7181.00
215_A219_K0.7171.00
106_E110_T0.7141.00
78_A85_P0.7131.00
224_T251_T0.7131.00
163_E166_M0.7111.00
64_K67_C0.7111.00
163_E167_E0.7101.00
242_L265_R0.7061.00
194_A197_C0.7061.00
110_T113_A0.7051.00
293_E296_K0.7021.00
170_K174_V0.7011.00
232_C291_I0.6991.00
257_L261_L0.6981.00
214_P219_K0.6941.00
104_Y112_L0.6921.00
102_G110_T0.6921.00
58_A61_R0.6911.00
62_K66_Q0.6881.00
135_L139_R0.6881.00
106_E112_L0.6841.00
121_L157_C0.6831.00
278_A298_L0.6831.00
189_A193_A0.6821.00
117_D121_L0.6781.00
133_N136_E0.6771.00
118_D121_L0.6771.00
75_V78_A0.6771.00
232_C295_Q0.6761.00
132_T139_R0.6741.00
60_I68_V0.6741.00
64_K68_V0.6701.00
51_S55_E0.6701.00
104_Y109_I0.6701.00
202_M209_Q0.6681.00
216_D219_K0.6671.00
71_G76_Y0.6661.00
159_V162_C0.6651.00
116_D119_L0.6641.00
235_I294_W0.6631.00
288_R296_K0.6621.00
223_N226_K0.6601.00
200_T207_L0.6591.00
110_T114_P0.6591.00
82_S87_D0.6571.00
240_A249_D0.6561.00
160_T163_E0.6551.00
165_F168_D0.6551.00
56_L63_L0.6551.00
165_F170_K0.6531.00
161_A164_A0.6500.99
79_Q85_P0.6470.99
284_E294_W0.6460.99
60_I64_K0.6460.99
63_L68_V0.6460.99
78_A83_Q0.6420.99
202_M207_L0.6420.99
57_S67_C0.6370.99
79_Q84_N0.6340.99
76_Y80_P0.6340.99
257_L285_L0.6310.99
152_Y158_L0.6300.99
245_E249_D0.6290.99
197_C202_M0.6280.99
270_V280_V0.6270.99
50_A53_V0.6270.99
71_G75_V0.6240.99
185_K196_R0.6240.99
262_D266_I0.6220.99
203_T207_L0.6180.99
103_P107_K0.6180.99
200_T204_D0.6170.99
166_M170_K0.6150.99
65_N69_Q0.6150.99
53_V59_N0.6140.99
93_D97_P0.6130.99
59_N68_V0.6130.99
132_T135_L0.6120.99
146_L170_K0.6110.99
198_A202_M0.6090.99
245_E250_I0.6070.99
53_V56_L0.6060.99
181_F194_A0.6060.99
115_E123_K0.6050.99
257_L286_A0.6040.99
95_W98_G0.6030.99
59_N63_L0.6010.99
102_G106_E0.6000.99
68_V72_I0.5940.99
231_T295_Q0.5930.99
188_M191_E0.5910.99
68_V75_V0.5900.99
267_M270_V0.5890.99
59_N62_K0.5870.99
121_L160_T0.5870.99
73_P80_P0.5850.99
252_D295_Q0.5840.99
166_M169_I0.5810.99
294_W297_L0.5810.99
109_I167_E0.5810.99
245_E248_E0.5800.99
143_R149_T0.5790.99
164_A170_K0.5780.99
235_I269_L0.5770.99
53_V68_V0.5760.99
182_S189_A0.5750.99
266_I282_F0.5750.99
287_E297_L0.5710.99
128_A161_A0.5700.99
280_V294_W0.5660.99
58_A62_K0.5650.99
115_E120_V0.5650.99
183_L186_H0.5630.99
81_G88_R0.5580.98
262_D267_M0.5570.98
199_F204_D0.5560.98
87_D91_L0.5540.98
206_L209_Q0.5540.98
229_V232_C0.5520.98
66_Q69_Q0.5510.98
240_A248_E0.5510.98
239_I294_W0.5500.98
225_G228_N0.5490.98
101_S104_Y0.5490.98
208_D211_Q0.5460.98
60_I63_L0.5460.98
238_Q242_L0.5430.98
154_H203_T0.5410.98
200_T211_Q0.5380.98
98_G173_F0.5360.98
182_S186_H0.5350.98
67_C70_L0.5340.98
59_N64_K0.5330.98
81_G86_D0.5310.98
82_S86_D0.5290.98
155_I159_V0.5260.98
166_M172_F0.5250.98
79_Q83_Q0.5170.97
162_C165_F0.5140.97
98_G102_G0.5110.97
240_A250_I0.5110.97
236_R240_A0.5110.97
57_S61_R0.5110.97
156_G160_T0.5100.97
71_G78_A0.5100.97
203_T211_Q0.5080.97
244_Q248_E0.5070.97
250_I291_I0.5040.97
272_Q275_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fq1A 2 0.8974 100 0.352 Contact Map
1nf9A 2 0.6603 99.9 0.639 Contact Map
3tg2A 2 0.6571 99.8 0.658 Contact Map
2jgpA 1 0.2885 99.8 0.666 Contact Map
4oqjA 2 0.6058 99.7 0.69 Contact Map
3tejA 1 0.2788 99.7 0.698 Contact Map
3irvA 2 0.6346 99.7 0.704 Contact Map
4pxhB 1 0.2372 99.7 0.705 Contact Map
1dnyA 1 0.2404 99.6 0.712 Contact Map
2cq8A 1 0.3365 99.6 0.712 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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