GREMLIN Database
YHBH - Stress response UPF0229 protein YhbH
UniProt: P45742 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (371)
Sequences: 652 (325)
Seq/√Len: 16.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_D201_K9.2631.00
264_V295_K5.9821.00
254_E295_K5.4861.00
256_I284_V5.1211.00
266_S269_D4.7831.00
287_K290_E4.5011.00
286_R320_R4.2661.00
291_L295_K3.9491.00
226_G229_E3.8311.00
218_M288_S3.5231.00
282_S313_N3.5011.00
223_G312_D3.3200.99
364_Y378_N3.2970.99
288_S305_P3.2890.99
285_Y307_H3.2750.99
264_V291_L3.2290.99
254_E291_L3.0800.99
166_T200_Y2.8000.98
254_E264_V2.7480.97
218_M305_P2.6370.97
252_E296_Y2.5630.96
145_K333_N2.5060.96
260_T275_E2.4510.95
293_D331_K2.3960.94
352_A355_N2.3450.94
323_K326_N2.2370.92
305_P332_A2.2330.92
292_I298_P2.2220.92
156_E206_I2.1710.91
200_Y292_I2.1290.90
289_L327_D2.0280.87
145_K149_N1.9710.86
179_F200_Y1.9490.85
131_E246_T1.9290.84
125_S263_R1.9280.84
214_V296_Y1.9050.84
378_N381_R1.8410.81
131_E382_N1.8360.81
293_D327_D1.8140.80
256_I288_S1.8140.80
292_I303_I1.8020.80
308_F376_L1.7710.79
308_F338_G1.7310.77
290_E294_E1.7220.77
169_I201_K1.7160.76
35_E39_N1.7020.76
290_E326_N1.6970.76
143_Q237_F1.6770.75
50_I255_F1.6560.74
80_H327_D1.6360.73
68_E243_F1.6350.73
36_A45_V1.6200.72
319_A323_K1.6140.72
111_A114_Q1.5940.71
150_I268_E1.5800.70
34_Q188_P1.5780.70
31_K223_G1.5460.68
136_E149_N1.5290.68
174_T314_L1.5290.68
144_Q333_N1.5190.67
290_E293_D1.5120.67
45_V299_A1.5050.66
132_A200_Y1.4990.66
134_F243_F1.4930.66
259_H287_K1.4900.65
116_G276_S1.4890.65
259_H321_C1.4790.65
216_L288_S1.4750.65
286_R290_E1.4670.64
168_N193_I1.4620.64
34_Q77_K1.4600.64
127_M296_Y1.4600.64
111_A116_G1.4440.63
11_I129_L1.4390.63
116_G282_S1.4350.62
251_V318_N1.4330.62
313_N318_N1.4290.62
238_F365_I1.4230.62
43_D75_Y1.4160.61
260_T283_S1.4030.61
105_P108_G1.4000.60
11_I348_T1.3890.60
219_M230_K1.3840.60
199_K371_D1.3810.59
349_L353_Y1.3770.59
293_D326_N1.3740.59
145_K383_E1.3730.59
328_I332_A1.3580.58
275_E313_N1.3530.58
20_R23_F1.3410.57
112_G116_G1.3410.57
124_V127_M1.3390.57
169_I193_I1.3350.57
168_N203_W1.3270.56
175_M190_F1.3170.56
17_S130_E1.3150.56
232_M371_D1.2970.54
123_E201_K1.2910.54
281_C301_Y1.2900.54
86_G226_G1.2890.54
38_K340_V1.2820.54
187_K259_H1.2810.54
94_V115_A1.2660.53
82_G145_K1.2500.52
45_V381_R1.2360.51
31_K34_Q1.2110.49
149_N215_V1.2010.49
212_K297_N1.2000.49
153_T356_V1.2000.49
183_A372_V1.1940.48
160_I170_D1.1880.48
120_Y273_K1.1760.47
36_A261_E1.1750.47
349_L380_F1.1690.47
264_V366_L1.1660.47
239_W308_F1.1620.46
99_S319_A1.1590.46
111_A115_A1.1530.46
254_E374_Q1.1530.46
223_G313_N1.1490.46
266_S291_L1.1420.45
113_D161_R1.1350.45
141_N211_S1.1290.45
221_T301_Y1.1260.44
256_I291_L1.1230.44
146_E300_R1.1140.44
218_M308_F1.1120.44
177_S199_K1.1110.43
209_P340_V1.1070.43
150_I191_Y1.1010.43
232_M290_E1.1010.43
121_E171_K1.0930.42
85_D214_V1.0920.42
18_L165_L1.0890.42
24_D361_F1.0850.42
16_W168_N1.0840.42
42_P252_E1.0830.42
232_M366_L1.0830.42
161_R167_G1.0800.42
153_T205_D1.0790.42
169_I383_E1.0790.42
289_L293_D1.0760.41
260_T347_S1.0700.41
129_L143_Q1.0650.41
71_I135_K1.0630.41
230_K243_F1.0530.40
141_N303_I1.0500.40
28_R282_S1.0500.40
340_V371_D1.0460.40
255_F271_F1.0390.39
132_A371_D1.0330.39
118_D243_F1.0310.39
340_V366_L1.0290.39
162_K199_K1.0290.39
127_M130_E1.0240.38
293_D355_N1.0230.38
295_K374_Q1.0200.38
32_K349_L1.0200.38
18_L82_G1.0170.38
66_L109_Q1.0170.38
218_M239_W1.0170.38
66_L117_E1.0160.38
34_Q61_I1.0080.38
175_M191_Y1.0010.37
237_F263_R0.9950.37
36_A168_N0.9930.37
283_S287_K0.9930.37
251_V292_I0.9920.37
276_S312_D0.9910.37
227_V280_I0.9900.37
289_L322_V0.9890.36
169_I226_G0.9880.36
143_Q333_N0.9850.36
227_V342_Q0.9780.36
223_G314_L0.9690.35
208_K328_I0.9670.35
126_L245_R0.9650.35
198_L373_F0.9650.35
335_F340_V0.9620.35
316_S319_A0.9570.35
309_S335_F0.9550.35
287_K332_A0.9540.35
16_W20_R0.9520.34
233_A236_F0.9490.34
151_I326_N0.9470.34
170_D176_M0.9340.34
38_K51_I0.9320.33
31_K45_V0.9320.33
187_K202_T0.9320.33
94_V325_V0.9290.33
338_G369_K0.9280.33
257_A273_K0.9280.33
58_V123_E0.9270.33
17_S339_E0.9270.33
161_R170_D0.9260.33
264_V374_Q0.9210.33
103_Q109_Q0.9210.33
226_G276_S0.9210.33
318_N369_K0.9200.33
187_K287_K0.9190.33
154_D208_K0.9190.33
179_F188_P0.9170.33
61_I208_K0.9150.33
306_F333_N0.9140.32
260_T361_F0.9140.32
71_I333_N0.9140.32
281_C380_F0.9140.32
121_E369_K0.9110.32
155_I211_S0.9070.32
141_N333_N0.9020.32
49_S320_R0.9020.32
33_V212_K0.9010.32
161_R211_S0.8940.31
110_G237_F0.8940.31
112_G145_K0.8930.31
23_F174_T0.8870.31
187_K232_M0.8740.30
61_I98_G0.8720.30
263_R273_K0.8720.30
29_H36_A0.8710.30
75_Y105_P0.8710.30
298_P331_K0.8690.30
232_M259_H0.8670.30
268_E348_T0.8660.30
18_L23_F0.8640.30
14_E281_C0.8620.30
126_L188_P0.8600.30
235_S306_F0.8590.30
127_M147_R0.8560.30
218_M284_V0.8540.29
27_Q131_E0.8530.29
24_D67_D0.8520.29
154_D250_T0.8490.29
346_H364_Y0.8470.29
174_T195_P0.8460.29
52_M380_F0.8460.29
169_I251_V0.8450.29
38_K49_S0.8390.29
154_D382_N0.8390.29
98_G109_Q0.8390.29
38_K141_N0.8380.29
96_R284_V0.8370.29
154_D327_D0.8360.29
98_G292_I0.8340.28
11_I228_W0.8340.28
84_G256_I0.8330.28
64_R108_G0.8330.28
217_A239_W0.8330.28
67_D355_N0.8310.28
215_V334_L0.8310.28
68_E134_F0.8300.28
34_Q132_A0.8290.28
61_I116_G0.8290.28
134_F217_A0.8230.28
27_Q31_K0.8210.28
215_V371_D0.8210.28
108_G112_G0.8140.27
135_K200_Y0.8090.27
90_V272_S0.8070.27
161_R174_T0.8050.27
34_Q58_V0.8010.27
150_I297_N0.7980.27
179_F286_R0.7950.27
162_K177_S0.7940.27
320_R323_K0.7920.26
373_F378_N0.7890.26
212_K319_A0.7890.26
43_D72_R0.7880.26
171_K265_V0.7860.26
11_I329_M0.7850.26
263_R366_L0.7790.26
221_T347_S0.7790.26
16_W19_H0.7780.26
63_I86_G0.7770.26
239_W307_H0.7770.26
33_V37_I0.7750.26
138_E382_N0.7740.26
80_H95_A0.7720.26
188_P195_P0.7680.25
282_S318_N0.7680.25
100_D104_G0.7670.25
135_K273_K0.7660.25
256_I335_F0.7620.25
95_A382_N0.7580.25
125_S187_K0.7570.25
212_K333_N0.7550.25
261_E274_G0.7510.25
213_A311_G0.7500.25
138_E175_M0.7500.25
134_F380_F0.7480.24
14_E301_Y0.7450.24
92_D109_Q0.7440.24
63_I212_K0.7440.24
82_G344_N0.7440.24
34_Q373_F0.7430.24
342_Q351_S0.7420.24
174_T213_A0.7410.24
243_F271_F0.7380.24
294_E299_A0.7360.24
175_M376_L0.7350.24
203_W226_G0.7320.24
145_K148_D0.7310.24
150_I319_A0.7290.24
252_E360_K0.7290.24
28_R313_N0.7280.24
136_E382_N0.7280.24
219_M273_K0.7270.24
332_A347_S0.7260.23
218_M292_I0.7260.23
43_D60_K0.7230.23
236_F243_F0.7220.23
263_R269_D0.7220.23
36_A48_E0.7210.23
55_G132_A0.7210.23
141_N336_C0.7180.23
259_H269_D0.7170.23
321_C325_V0.7160.23
323_K327_D0.7150.23
263_R275_E0.7110.23
257_A281_C0.7070.23
160_I163_T0.7030.23
129_L274_G0.7010.22
286_R366_L0.6980.22
299_A335_F0.6970.22
215_V308_F0.6970.22
175_M351_S0.6940.22
182_N218_M0.6940.22
38_K361_F0.6920.22
50_I356_V0.6920.22
318_N321_C0.6900.22
159_D217_A0.6900.22
145_K226_G0.6900.22
78_N109_Q0.6890.22
203_W229_E0.6880.22
60_K377_K0.6880.22
255_F360_K0.6870.22
167_G345_R0.6850.22
131_E351_S0.6840.22
71_I301_Y0.6840.22
55_G226_G0.6830.22
364_Y383_E0.6810.22
118_D273_K0.6790.22
221_T235_S0.6790.22
315_T348_T0.6780.22
272_S276_S0.6770.21
120_Y372_V0.6750.21
90_V379_F0.6740.21
99_S322_V0.6730.21
127_M132_A0.6720.21
270_F317_D0.6710.21
362_K378_N0.6710.21
144_Q149_N0.6700.21
150_I286_R0.6690.21
294_E326_N0.6690.21
137_L377_K0.6670.21
96_R99_S0.6660.21
119_Y273_K0.6660.21
47_E371_D0.6650.21
13_E194_Y0.6650.21
66_L142_L0.6640.21
158_N215_V0.6630.21
60_K319_A0.6630.21
331_K358_D0.6610.21
211_S372_V0.6590.21
340_V364_Y0.6590.21
226_G348_T0.6590.21
106_G291_L0.6590.21
11_I191_Y0.6580.21
29_H235_S0.6580.21
47_E63_I0.6550.21
68_E118_D0.6540.21
174_T283_S0.6540.21
11_I356_V0.6540.21
60_K94_V0.6520.20
260_T263_R0.6500.20
179_F190_F0.6490.20
133_L280_I0.6490.20
154_D290_E0.6480.20
29_H242_R0.6480.20
131_E286_R0.6450.20
21_K166_T0.6450.20
229_E336_C0.6450.20
315_T344_N0.6450.20
59_V103_Q0.6440.20
85_D128_D0.6440.20
137_L207_T0.6440.20
141_N351_S0.6430.20
20_R154_D0.6430.20
305_P335_F0.6430.20
180_K264_V0.6410.20
61_I228_W0.6410.20
183_A226_G0.6390.20
236_F339_E0.6370.20
141_N144_Q0.6350.20
77_K80_H0.6350.20
22_G241_T0.6320.20
373_F380_F0.6310.20
68_E236_F0.6300.20
132_A135_K0.6300.20
319_A328_I0.6280.20
168_N201_K0.6270.20
318_N347_S0.6260.19
217_A240_M0.6260.19
53_S212_K0.6260.19
219_M233_A0.6230.19
328_I356_V0.6230.19
100_D209_P0.6230.19
200_Y274_G0.6220.19
124_V346_H0.6210.19
230_K275_E0.6210.19
211_S250_T0.6210.19
79_K384_E0.6190.19
42_P378_N0.6180.19
338_G356_V0.6170.19
329_M356_V0.6170.19
255_F373_F0.6150.19
177_S180_K0.6150.19
150_I206_I0.6150.19
121_E290_E0.6140.19
45_V246_T0.6130.19
32_K380_F0.6130.19
68_E230_K0.6120.19
320_R370_S0.6110.19
169_I315_T0.6110.19
104_G381_R0.6110.19
237_F354_K0.6100.19
237_F251_V0.6100.19
44_L318_N0.6100.19
208_K356_V0.6090.19
136_E280_I0.6090.19
289_L299_A0.6090.19
64_R98_G0.6090.19
70_K200_Y0.6080.19
223_G282_S0.6060.19
135_K331_K0.6040.19
133_L227_V0.6020.19
229_E341_N0.6020.19
83_Q240_M0.6000.19
16_W22_G0.5980.18
377_K382_N0.5970.18
59_V384_E0.5960.18
211_S327_D0.5950.18
112_G369_K0.5950.18
188_P193_I0.5940.18
38_K94_V0.5930.18
210_E371_D0.5920.18
73_Y132_A0.5900.18
197_D278_G0.5880.18
20_R65_S0.5870.18
44_L48_E0.5870.18
57_D261_E0.5860.18
64_R292_I0.5850.18
37_I134_F0.5850.18
125_S323_K0.5840.18
233_A339_E0.5830.18
46_T371_D0.5820.18
299_A326_N0.5820.18
57_D272_S0.5820.18
138_E284_V0.5810.18
83_Q308_F0.5800.18
33_V229_E0.5790.18
314_L318_N0.5780.18
108_G319_A0.5760.18
196_E253_I0.5760.18
345_R369_K0.5750.18
33_V121_E0.5750.18
200_Y216_L0.5730.18
63_I256_I0.5710.18
97_D295_K0.5710.18
229_E340_V0.5710.18
59_V231_Y0.5680.17
46_T61_I0.5670.17
126_L227_V0.5670.17
43_D78_N0.5660.17
269_D290_E0.5660.17
240_M243_F0.5650.17
148_D152_H0.5630.17
51_I61_I0.5630.17
36_A238_F0.5610.17
173_R282_S0.5610.17
260_T314_L0.5590.17
129_L235_S0.5580.17
112_G260_T0.5570.17
140_P213_A0.5560.17
233_A243_F0.5560.17
132_A333_N0.5550.17
43_D323_K0.5550.17
37_I323_K0.5530.17
54_N361_F0.5530.17
138_E329_M0.5530.17
160_I193_I0.5520.17
287_K291_L0.5480.17
75_Y135_K0.5480.17
368_Q371_D0.5480.17
307_H336_C0.5450.17
322_V384_E0.5450.17
46_T211_S0.5440.17
215_V244_L0.5440.17
79_K200_Y0.5430.17
169_I198_L0.5420.17
57_D70_K0.5410.17
59_V240_M0.5410.17
59_V325_V0.5400.16
26_Q376_L0.5380.16
63_I357_K0.5370.16
170_D259_H0.5370.16
48_E233_A0.5360.16
74_N110_G0.5350.16
263_R355_N0.5350.16
94_V107_K0.5350.16
104_G114_Q0.5350.16
150_I300_R0.5340.16
175_M196_E0.5330.16
112_G115_A0.5310.16
112_G201_K0.5310.16
272_S346_H0.5300.16
73_Y322_V0.5280.16
334_L338_G0.5280.16
231_Y235_S0.5280.16
235_S255_F0.5280.16
155_I345_R0.5280.16
259_H275_E0.5270.16
64_R165_L0.5270.16
21_K24_D0.5240.16
194_Y264_V0.5240.16
186_G189_S0.5220.16
140_P311_G0.5190.16
81_V355_N0.5190.16
29_H69_Y0.5190.16
146_E152_H0.5190.16
109_Q358_D0.5190.16
38_K193_I0.5180.16
82_G121_E0.5180.16
34_Q200_Y0.5170.16
83_Q129_L0.5160.16
293_D322_V0.5160.16
51_I153_T0.5160.16
247_K383_E0.5130.16
111_A293_D0.5110.16
55_G86_G0.5100.16
22_G259_H0.5100.16
94_V98_G0.5100.16
175_M268_E0.5090.15
151_I209_P0.5080.15
286_R381_R0.5080.15
55_G253_I0.5070.15
160_I338_G0.5060.15
31_K299_A0.5060.15
42_P340_V0.5040.15
284_V335_F0.5040.15
350_M372_V0.5040.15
134_F198_L0.5020.15
303_I332_A0.5010.15
66_L370_S0.5010.15
322_V352_A0.5000.15
305_P328_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2odpA 1 0.4796 98.6 0.935 Contact Map
1q0pA 1 0.3929 98.4 0.94 Contact Map
2x31A 2 0.4286 98.4 0.94 Contact Map
1atzA 1 0.4311 98.2 0.943 Contact Map
4hqfA 1 0.4464 98.2 0.943 Contact Map
1ijbA 1 0.4566 98.1 0.944 Contact Map
1rrkA 1 0.4541 98.1 0.944 Contact Map
4fx5A 1 0.5357 98.1 0.944 Contact Map
1n3yA 1 0.4362 98.1 0.945 Contact Map
4jduA 1 0.4005 98 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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