GREMLIN Database
THIC - Phosphomethylpyrimidine synthase
UniProt: P45740 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 590 (567)
Sequences: 849 (173)
Seq/√Len: 7.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_M249_V5.4541.00
39_I58_V5.2490.99
577_K580_E5.0510.99
341_M348_F4.9260.99
150_I165_V4.8970.99
165_V172_I4.8430.99
469_R519_R4.7900.99
171_I347_A4.7860.99
470_E519_R4.7280.99
372_E407_K4.1970.97
335_E383_K4.1560.97
335_E380_I3.8930.96
131_N342_K3.5190.92
22_K66_T3.4610.92
339_E384_H3.2530.89
92_V124_L3.2410.89
29_S88_E3.1820.88
464_N526_E2.9150.83
402_K406_D2.8650.82
102_P106_G2.8270.81
470_E474_T2.8110.80
194_I472_V2.7990.80
21_K38_E2.7770.79
335_E384_H2.7660.79
508_R521_L2.7620.79
106_G236_T2.6990.77
398_M442_M2.6970.77
492_Q496_D2.6420.76
95_Y106_G2.6250.75
277_L337_I2.6200.75
53_N500_K2.6100.75
288_F337_I2.5950.74
136_H385_D2.5750.74
98_R104_D2.5700.74
264_V267_D2.5620.73
35_P149_F2.5550.73
328_S332_T2.5050.72
277_L288_F2.4730.71
98_R106_G2.4640.70
306_T360_A2.4630.70
474_T477_I2.4620.70
326_Q332_T2.4090.69
44_T53_N2.4040.68
407_K411_I2.3840.68
295_L328_S2.3430.66
342_K384_H2.3410.66
530_A533_A2.3090.65
437_A448_T2.2430.63
95_Y104_D2.2400.63
131_N136_H2.2290.62
555_I558_Y2.2040.61
100_I106_G2.1980.61
196_A217_A2.1690.60
264_V545_K2.1440.59
95_Y100_I2.1380.59
296_L325_H2.1250.58
150_I185_I2.0960.57
95_Y102_P2.0760.56
112_P116_Y2.0550.56
174_S181_S2.0550.56
31_D88_E2.0240.54
374_L390_I2.0220.54
398_M401_I2.0180.54
28_S88_E2.0170.54
512_N521_L1.9980.53
359_I492_Q1.9880.53
106_G109_K1.9570.52
98_R105_N1.9420.51
80_P121_R1.9390.51
163_D167_S1.9310.51
181_S347_A1.8980.49
95_Y99_A1.8850.49
100_I104_D1.8800.49
563_D569_A1.8700.48
167_S414_E1.8600.48
405_V409_M1.8450.47
131_N384_H1.8400.47
95_Y98_R1.8260.47
191_H476_K1.8240.47
469_R473_I1.8170.46
207_I237_T1.8140.46
136_H342_K1.7920.45
39_I494_R1.7870.45
409_M414_E1.7870.45
103_E106_G1.7670.44
372_E411_I1.7620.44
217_A222_A1.7550.44
334_F350_L1.7500.44
196_A225_M1.7300.43
106_G116_Y1.7090.42
188_R409_M1.7090.42
100_I105_N1.7040.42
317_M328_S1.7040.42
27_G152_I1.6970.42
191_H488_H1.6890.41
574_L578_A1.6810.41
148_E152_I1.6790.41
160_F189_N1.6700.41
365_E372_E1.6670.41
269_T272_I1.6410.40
350_L374_L1.6390.40
136_H140_K1.6160.39
466_D470_E1.6150.39
171_I389_M1.6110.39
315_A551_I1.6080.38
498_L514_S1.6050.38
225_M245_C1.6040.38
519_R522_E1.5970.38
38_E57_R1.5960.38
28_S32_I1.5850.38
95_Y105_N1.5760.37
301_L365_E1.5750.37
22_K149_F1.5740.37
95_Y236_T1.5690.37
358_S424_T1.5540.36
27_G148_E1.5540.36
171_I515_L1.5460.36
295_L298_Y1.5250.35
102_P116_Y1.5240.35
20_S37_R1.5200.35
469_R518_E1.5140.35
102_P105_N1.5010.35
378_T382_W1.4880.34
135_M342_K1.4840.34
25_V152_I1.4700.33
290_I337_I1.4690.33
500_K504_E1.4660.33
428_A435_T1.4560.33
189_N409_M1.4510.33
80_P83_Q1.4390.32
91_D137_Y1.4320.32
28_S31_D1.4310.32
295_L369_A1.4240.32
334_F374_L1.4190.32
437_A474_T1.4080.31
442_M446_Y1.4060.31
508_R512_N1.4040.31
100_I116_Y1.4020.31
306_T358_S1.4020.31
196_A222_A1.3970.31
102_P236_T1.3950.31
579_K583_D1.3890.31
408_Q488_H1.3850.31
578_A582_V1.3840.31
348_F384_H1.3640.30
44_T55_P1.3530.29
407_K410_D1.3490.29
97_G104_D1.3460.29
12_S15_S1.3400.29
16_S219_R1.3370.29
525_D534_K1.3340.29
524_H540_S1.3260.29
104_D236_T1.3250.29
473_I477_I1.3240.29
368_F407_K1.3190.28
41_L54_A1.3150.28
273_Y472_V1.3120.28
150_I172_I1.3100.28
41_L55_P1.3060.28
191_H469_R1.3060.28
98_R102_P1.2930.28
23_V36_M1.2880.27
174_S347_A1.2820.27
102_P109_K1.2780.27
440_A475_Y1.2630.27
112_P115_S1.2600.27
100_I236_T1.2560.26
266_E319_Q1.2550.26
328_S474_T1.2520.26
105_N236_T1.2500.26
126_A145_P1.2470.26
323_A332_T1.2460.26
273_Y332_T1.2430.26
245_C249_V1.2360.26
359_I484_L1.2310.26
41_L56_V1.2280.26
106_G112_P1.2240.25
196_A245_C1.2240.25
242_I359_I1.2190.25
132_V136_H1.2180.25
113_N116_Y1.2140.25
469_R522_E1.2080.25
552_S558_Y1.2060.25
396_V408_Q1.2000.25
93_E125_R1.2000.25
401_I424_T1.1970.25
379_Q413_K1.1970.25
109_K116_Y1.1950.25
12_S472_V1.1940.25
206_S237_T1.1940.25
303_A553_Q1.1930.25
473_I519_R1.1910.25
99_A106_G1.1840.24
525_D540_S1.1750.24
100_I109_K1.1730.24
135_M442_M1.1720.24
73_N76_E1.1640.24
214_M448_T1.1620.24
335_E342_K1.1570.24
408_Q413_K1.1540.23
86_I91_D1.1540.23
189_N414_E1.1510.23
58_V494_R1.1480.23
97_G123_P1.1320.23
136_H384_H1.1290.23
306_T500_K1.1250.23
101_K104_D1.1250.23
131_N383_K1.1170.22
342_K385_D1.1120.22
294_V348_F1.1080.22
192_V482_A1.1080.22
444_G473_I1.1060.22
581_F589_Y1.1060.22
99_A102_P1.1060.22
334_F390_I1.1050.22
399_H408_Q1.1030.22
155_H319_Q1.1020.22
131_N385_D1.1010.22
297_R328_S1.1010.22
95_Y103_E1.1010.22
559_A569_A1.0960.22
472_V530_A1.0950.22
99_A104_D1.0950.22
98_R103_E1.0930.22
212_E465_R1.0880.22
165_V444_G1.0880.22
341_M437_A1.0820.22
472_V514_S1.0820.22
171_I388_V1.0810.21
136_H386_V1.0810.21
525_D536_A1.0790.21
319_Q587_N1.0780.21
217_A400_K1.0780.21
237_T504_E1.0770.21
225_M247_V1.0760.21
519_R523_Y1.0730.21
585_G589_Y1.0680.21
347_A437_A1.0640.21
553_Q557_D1.0610.21
103_E109_K1.0600.21
399_H496_D1.0590.21
534_K540_S1.0550.21
86_I137_Y1.0550.21
551_I555_I1.0540.21
87_T92_V1.0530.21
27_G32_I1.0520.21
86_I181_S1.0380.20
400_K448_T1.0360.20
288_F341_M1.0330.20
525_D529_P1.0300.20
216_W220_W1.0260.20
131_N341_M1.0230.20
558_Y569_A1.0230.20
25_V36_M1.0230.20
129_G145_P1.0220.20
176_I494_R1.0200.20
33_Q125_R1.0190.20
13_I465_R1.0180.20
307_T358_S1.0170.20
100_I103_E1.0080.20
157_S215_T1.0050.20
44_T500_K1.0030.20
204_T214_M1.0020.19
296_L322_L1.0010.19
342_K383_K0.9980.19
37_R65_Y0.9950.19
470_E518_E0.9940.19
322_L325_H0.9920.19
38_E55_P0.9890.19
302_T556_R0.9880.19
529_P534_K0.9870.19
396_V405_V0.9790.19
150_I437_A0.9780.19
43_P53_N0.9770.19
102_P112_P0.9730.19
301_L369_A0.9720.19
555_I559_A0.9710.19
116_Y236_T0.9710.19
135_M172_I0.9700.19
32_I64_P0.9680.19
191_H399_H0.9680.19
95_Y123_P0.9670.19
319_Q554_D0.9650.19
294_V298_Y0.9630.19
140_K342_K0.9570.18
23_V57_R0.9550.18
550_R555_I0.9550.18
101_K105_N0.9500.18
126_A386_V0.9480.18
157_S409_M0.9450.18
101_K106_G0.9420.18
434_I448_T0.9380.18
98_R236_T0.9380.18
332_T384_H0.9380.18
408_Q496_D0.9360.18
508_R550_R0.9350.18
574_L577_K0.9330.18
65_Y72_I0.9320.18
442_M445_W0.9310.18
350_L390_I0.9290.18
135_M382_W0.9280.18
185_I206_S0.9270.18
254_I294_V0.9260.18
399_H442_M0.9230.18
583_D588_L0.9230.18
137_Y385_D0.9220.18
16_S66_T0.9210.18
578_A588_L0.9200.18
131_N348_F0.9200.18
277_L290_I0.9200.18
335_E348_F0.9150.17
294_V498_L0.9150.17
529_P536_A0.9140.17
171_I382_W0.9120.17
21_K40_A0.9100.17
448_T555_I0.9090.17
104_D109_K0.9080.17
43_P273_Y0.9080.17
140_K339_E0.9080.17
72_I336_E0.9050.17
27_G31_D0.9040.17
158_P401_I0.9030.17
400_K496_D0.9020.17
528_L540_S0.9020.17
551_I559_A0.9010.17
135_M434_I0.9000.17
145_P148_E0.8980.17
572_K575_K0.8970.17
29_S33_Q0.8970.17
411_I448_T0.8970.17
380_I390_I0.8940.17
473_I526_E0.8930.17
265_A319_Q0.8880.17
206_S209_E0.8880.17
27_G145_P0.8790.17
319_Q409_M0.8790.17
124_L272_I0.8780.17
91_D181_S0.8780.17
298_Y373_T0.8770.17
464_N559_A0.8750.17
532_G535_T0.8740.17
273_Y341_M0.8730.17
194_I214_M0.8700.16
550_R554_D0.8680.16
45_T53_N0.8680.16
498_L552_S0.8630.16
294_V341_M0.8610.16
235_H279_E0.8600.16
26_E33_Q0.8560.16
525_D538_F0.8540.16
86_I92_V0.8530.16
172_I427_I0.8510.16
429_P498_L0.8500.16
296_L537_H0.8500.16
325_H581_F0.8490.16
414_E445_W0.8450.16
296_L551_I0.8440.16
135_M150_I0.8420.16
156_V550_R0.8410.16
191_H299_V0.8370.16
466_D519_R0.8350.16
336_E339_E0.8340.16
472_V532_G0.8280.16
204_T332_T0.8270.16
429_P435_T0.8260.16
126_A385_D0.8230.15
83_Q87_T0.8190.15
106_G115_S0.8190.15
343_M347_A0.8170.15
214_M470_E0.8150.15
319_Q550_R0.8150.15
142_I337_I0.8130.15
12_S17_F0.8120.15
273_Y290_I0.8120.15
390_I408_Q0.8110.15
39_I466_D0.8100.15
39_I217_A0.8070.15
582_V587_N0.8060.15
563_D570_I0.8060.15
434_I470_E0.8050.15
103_E236_T0.8050.15
559_A563_D0.8040.15
56_V490_G0.8040.15
97_G106_G0.8040.15
86_I89_R0.8030.15
135_M448_T0.8030.15
427_I515_L0.7980.15
167_S192_V0.7960.15
19_G219_R0.7940.15
135_M165_V0.7940.15
401_I414_E0.7930.15
579_K582_V0.7930.15
409_M445_W0.7930.15
235_H276_T0.7920.15
524_H534_K0.7910.15
66_T219_R0.7890.15
143_I333_H0.7860.15
35_P107_Y0.7850.15
524_H528_L0.7840.15
242_I347_A0.7830.15
102_P117_P0.7820.15
100_I117_P0.7820.15
140_K267_D0.7810.15
220_W270_W0.7800.15
105_N109_K0.7780.15
575_K583_D0.7760.15
95_Y116_Y0.7740.14
529_P540_S0.7740.14
341_M472_V0.7740.14
273_Y488_H0.7700.14
103_E110_A0.7700.14
103_E496_D0.7660.14
95_Y112_P0.7650.14
581_F585_G0.7650.14
191_H519_R0.7640.14
109_K112_P0.7620.14
202_A472_V0.7610.14
427_I476_K0.7600.14
401_I405_V0.7590.14
155_H496_D0.7590.14
434_I437_A0.7580.14
100_I112_P0.7570.14
222_A318_A0.7540.14
37_R60_D0.7530.14
87_T124_L0.7510.14
43_P55_P0.7500.14
296_L315_A0.7490.14
189_N405_V0.7480.14
358_S552_S0.7460.14
16_S19_G0.7430.14
407_K514_S0.7380.14
214_M225_M0.7380.14
102_P115_S0.7360.14
524_H536_A0.7340.14
358_S555_I0.7330.14
74_I152_I0.7330.14
108_K236_T0.7330.14
150_I442_M0.7310.14
171_I242_I0.7300.14
212_E333_H0.7290.14
374_L384_H0.7290.14
53_N236_T0.7260.14
131_N386_V0.7260.14
235_H256_Q0.7260.14
348_F396_V0.7260.14
104_D108_K0.7240.14
437_A472_V0.7240.14
17_F574_L0.7230.14
372_E413_K0.7200.13
385_D545_K0.7200.13
536_A540_S0.7190.13
342_K348_F0.7170.13
386_V490_G0.7160.13
444_G484_L0.7150.13
388_V408_Q0.7140.13
476_K557_D0.7140.13
95_Y109_K0.7110.13
102_P107_Y0.7080.13
281_A346_I0.7080.13
577_K581_F0.7060.13
160_F409_M0.7050.13
91_D385_D0.7050.13
30_S33_Q0.7030.13
382_W413_K0.7030.13
26_E57_R0.7030.13
132_V385_D0.7030.13
92_V343_M0.7010.13
104_D112_P0.6970.13
498_L577_K0.6970.13
414_E444_G0.6970.13
215_T365_E0.6970.13
12_S194_I0.6970.13
269_T274_R0.6940.13
163_D328_S0.6940.13
18_S58_V0.6940.13
56_V493_I0.6930.13
167_S204_T0.6920.13
176_I288_F0.6910.13
498_L513_L0.6900.13
106_G117_P0.6890.13
36_M148_E0.6880.13
33_Q379_Q0.6880.13
181_S328_S0.6880.13
484_L497_A0.6870.13
143_I465_R0.6830.13
574_L580_E0.6830.13
297_R369_A0.6830.13
81_L514_S0.6820.13
41_L498_L0.6800.13
172_I333_H0.6800.13
155_H532_G0.6790.13
328_S535_T0.6790.13
405_V430_G0.6790.13
380_I384_H0.6790.13
27_G36_M0.6790.13
317_M574_L0.6780.13
136_H171_I0.6760.13
572_K583_D0.6730.13
569_A576_E0.6730.13
92_V194_I0.6730.13
441_A445_W0.6720.13
143_I427_I0.6710.13
390_I411_I0.6700.13
281_A341_M0.6700.13
254_I552_S0.6700.13
273_Y336_E0.6700.13
413_K488_H0.6690.13
143_I304_K0.6690.13
167_S326_Q0.6690.13
398_M446_Y0.6690.13
527_T540_S0.6690.13
572_K576_E0.6680.13
70_V79_K0.6680.13
112_P117_P0.6680.13
281_A343_M0.6670.13
155_H490_G0.6670.13
123_P237_T0.6660.13
44_T469_R0.6650.13
22_K65_Y0.6650.13
131_N335_E0.6640.12
25_V96_E0.6630.12
95_Y117_P0.6610.12
114_V117_P0.6590.12
113_N117_P0.6570.12
140_K385_D0.6570.12
167_S466_D0.6570.12
150_I472_V0.6570.12
53_N237_T0.6560.12
99_A236_T0.6550.12
212_E281_A0.6550.12
181_S336_E0.6530.12
155_H191_H0.6530.12
20_S58_V0.6530.12
148_E267_D0.6500.12
157_S496_D0.6490.12
74_I466_D0.6490.12
237_T500_K0.6480.12
13_I215_T0.6470.12
326_Q407_K0.6470.12
325_H545_K0.6460.12
435_T474_T0.6450.12
111_K114_V0.6440.12
534_K538_F0.6440.12
64_P69_E0.6430.12
332_T490_G0.6430.12
347_A552_S0.6400.12
437_A578_A0.6400.12
301_L437_A0.6390.12
37_R62_S0.6380.12
277_L560_K0.6380.12
170_A190_F0.6370.12
214_M218_I0.6370.12
472_V523_Y0.6370.12
53_N496_D0.6370.12
401_I442_M0.6360.12
277_L405_V0.6350.12
53_N207_I0.6340.12
18_S37_R0.6340.12
109_K236_T0.6330.12
484_L496_D0.6330.12
27_G33_Q0.6320.12
56_V136_H0.6320.12
103_E448_T0.6320.12
100_I496_D0.6310.12
126_A343_M0.6300.12
508_R530_A0.6300.12
578_A584_T0.6280.12
114_V118_G0.6270.12
105_N108_K0.6260.12
88_E587_N0.6260.12
219_R518_E0.6250.12
19_G508_R0.6250.12
65_Y208_E0.6240.12
338_C348_F0.6240.12
62_S66_T0.6230.12
65_Y334_F0.6230.12
203_V294_V0.6230.12
66_T149_F0.6220.12
117_P239_E0.6210.12
249_V424_T0.6210.12
518_E521_L0.6190.12
33_Q69_E0.6190.12
522_E557_D0.6190.12
74_I208_E0.6170.12
145_P152_I0.6160.12
124_L127_K0.6150.12
514_S522_E0.6140.12
325_H589_Y0.6130.12
25_V341_M0.6130.12
17_F578_A0.6120.12
56_V156_V0.6100.12
214_M472_V0.6100.12
334_F380_I0.6090.12
13_I17_F0.6090.12
508_R531_E0.6080.12
298_Y322_L0.6080.12
137_Y148_E0.6070.12
202_A232_K0.6060.12
259_E270_W0.6050.12
136_H145_P0.6030.11
218_I262_N0.6020.11
99_A105_N0.6020.11
341_M384_H0.6020.11
17_F219_R0.6010.11
158_P518_E0.6010.11
405_V408_Q0.6000.11
296_L581_F0.6000.11
56_V317_M0.6000.11
54_A514_S0.6000.11
165_V410_D0.5980.11
42_S55_P0.5980.11
39_I174_S0.5970.11
234_I329_F0.5970.11
233_D469_R0.5970.11
129_G339_E0.5950.11
341_M445_W0.5940.11
139_K521_L0.5940.11
405_V577_K0.5930.11
103_E116_Y0.5920.11
100_I107_Y0.5920.11
191_H273_Y0.5910.11
99_A103_E0.5910.11
378_T389_M0.5900.11
15_S207_I0.5890.11
580_E584_T0.5870.11
25_V38_E0.5870.11
559_A562_N0.5860.11
116_Y119_L0.5850.11
434_I498_L0.5850.11
41_L496_D0.5830.11
117_P236_T0.5820.11
155_H530_A0.5820.11
98_R109_K0.5820.11
470_E473_I0.5820.11
245_C265_A0.5820.11
180_E329_F0.5810.11
339_E385_D0.5810.11
61_T514_S0.5810.11
295_L500_K0.5800.11
337_I341_M0.5790.11
126_A129_G0.5780.11
12_S215_T0.5780.11
399_H406_D0.5780.11
25_V57_R0.5770.11
341_M407_K0.5770.11
108_K118_G0.5770.11
254_I317_M0.5760.11
329_F419_T0.5760.11
135_M444_G0.5750.11
26_E31_D0.5750.11
127_K242_I0.5750.11
380_I383_K0.5750.11
208_E441_A0.5750.11
294_V353_G0.5750.11
100_I115_S0.5740.11
555_I570_I0.5740.11
243_R329_F0.5730.11
466_D469_R0.5730.11
39_I192_V0.5720.11
578_A581_F0.5710.11
236_T496_D0.5700.11
534_K537_H0.5690.11
322_L554_D0.5690.11
136_H464_N0.5690.11
319_Q405_V0.5690.11
12_S465_R0.5690.11
32_I494_R0.5680.11
165_V202_A0.5670.11
398_M441_A0.5670.11
35_P532_G0.5670.11
158_P571_N0.5670.11
525_D528_L0.5670.11
165_V278_I0.5670.11
465_R470_E0.5660.11
325_H585_G0.5660.11
208_E477_I0.5660.11
84_K88_E0.5660.11
31_D214_M0.5660.11
232_K533_A0.5650.11
115_S236_T0.5650.11
299_V427_I0.5650.11
98_R496_D0.5640.11
167_S399_H0.5640.11
160_F405_V0.5640.11
204_T474_T0.5640.11
236_T386_V0.5630.11
107_Y112_P0.5630.11
171_I522_E0.5630.11
62_S423_L0.5630.11
300_P552_S0.5620.11
339_E383_K0.5620.11
56_V383_K0.5620.11
398_M438_I0.5610.11
22_K62_S0.5600.11
573_G581_F0.5600.11
65_Y70_V0.5590.11
17_F466_D0.5590.11
94_E122_K0.5580.11
104_D110_A0.5570.11
486_K509_D0.5570.11
341_M530_A0.5570.11
181_S218_I0.5570.11
470_E477_I0.5560.11
118_G532_G0.5550.11
400_K472_V0.5540.11
105_N116_Y0.5540.11
194_I514_S0.5530.11
577_K582_V0.5530.11
270_W274_R0.5530.11
332_T341_M0.5530.11
104_D107_Y0.5520.11
135_M385_D0.5520.11
374_L411_I0.5520.11
209_E217_A0.5520.11
302_T540_S0.5510.11
407_K413_K0.5510.11
306_T317_M0.5510.11
271_E466_D0.5510.11
109_K115_S0.5500.11
53_N492_Q0.5500.11
234_I443_I0.5500.11
60_D65_Y0.5500.11
80_P117_P0.5500.11
273_Y408_Q0.5490.11
53_N504_E0.5490.11
242_I522_E0.5490.11
571_N575_K0.5490.11
405_V411_I0.5490.11
29_S35_P0.5480.11
29_S155_H0.5470.11
403_E410_D0.5460.11
262_N267_D0.5450.11
220_W259_E0.5450.11
156_V191_H0.5440.11
135_M341_M0.5440.11
148_E328_S0.5440.11
33_Q88_E0.5440.11
275_D496_D0.5430.11
494_R500_K0.5430.11
152_I176_I0.5430.11
573_G585_G0.5420.11
157_S319_Q0.5400.11
27_G158_P0.5400.11
276_T279_E0.5390.11
271_E403_E0.5380.10
133_T383_K0.5370.10
524_H527_T0.5360.10
18_S87_T0.5360.10
19_G70_V0.5360.10
584_T587_N0.5360.10
56_V552_S0.5350.10
235_H321_C0.5340.10
319_Q559_A0.5340.10
408_Q411_I0.5340.10
23_V498_L0.5340.10
115_S496_D0.5330.10
286_D424_T0.5320.10
135_M378_T0.5310.10
218_I540_S0.5310.10
527_T534_K0.5300.10
328_S369_A0.5300.10
157_S160_F0.5300.10
437_A555_I0.5290.10
142_I155_H0.5290.10
329_F443_I0.5290.10
437_A470_E0.5290.10
185_I190_F0.5290.10
22_K35_P0.5290.10
380_I402_K0.5280.10
36_M86_I0.5280.10
140_K369_A0.5260.10
156_V445_W0.5260.10
469_R577_K0.5260.10
496_D578_A0.5250.10
38_E41_L0.5250.10
20_S288_F0.5250.10
295_L527_T0.5250.10
171_I407_K0.5250.10
300_P318_A0.5240.10
299_V514_S0.5240.10
574_L588_L0.5240.10
581_F588_L0.5240.10
54_A399_H0.5230.10
326_Q465_R0.5230.10
95_Y115_S0.5230.10
575_K588_L0.5230.10
424_T492_Q0.5230.10
222_A225_M0.5230.10
13_I16_S0.5230.10
334_F411_I0.5220.10
171_I384_H0.5220.10
112_P236_T0.5220.10
266_E550_R0.5220.10
180_E243_R0.5210.10
332_T342_K0.5210.10
83_Q92_V0.5200.10
304_K557_D0.5200.10
191_H578_A0.5190.10
131_N135_M0.5190.10
586_S589_Y0.5190.10
273_Y348_F0.5180.10
321_C553_Q0.5180.10
218_I529_P0.5180.10
189_N319_Q0.5170.10
577_K589_Y0.5170.10
365_E413_K0.5160.10
555_I560_K0.5150.10
557_D561_K0.5150.10
203_V222_A0.5150.10
465_R496_D0.5140.10
427_I526_E0.5140.10
14_M17_F0.5130.10
216_W270_W0.5130.10
165_V484_L0.5120.10
139_K298_Y0.5120.10
29_S76_E0.5110.10
369_A410_D0.5110.10
157_S405_V0.5110.10
386_V500_K0.5110.10
97_G105_N0.5110.10
265_A474_T0.5100.10
44_T442_M0.5100.10
106_G389_M0.5090.10
145_P578_A0.5080.10
192_V378_T0.5080.10
131_N472_V0.5080.10
180_E234_I0.5070.10
188_R319_Q0.5070.10
474_T494_R0.5070.10
275_D333_H0.5070.10
109_K217_A0.5070.10
277_L341_M0.5070.10
518_E522_E0.5070.10
322_L537_H0.5070.10
217_A523_Y0.5070.10
214_M332_T0.5060.10
155_H409_M0.5050.10
204_T527_T0.5040.10
150_I335_E0.5040.10
497_A506_R0.5040.10
339_E342_K0.5030.10
27_G68_P0.5030.10
249_V552_S0.5020.10
272_I575_K0.5020.10
215_T219_R0.5010.10
343_M514_S0.5010.10
552_S578_A0.5010.10
383_K588_L0.5010.10
156_V165_V0.5000.10
262_N328_S0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3epoA 2 0.8508 100 0.175 Contact Map
4s28A 2 0.8729 100 0.234 Contact Map
3wqoA 2 0.3915 40.5 0.99 Contact Map
1qtwA 1 0.3983 36.2 0.99 Contact Map
1icpA 1 0.4508 33.9 0.99 Contact Map
3fysA 1 0.0678 33 0.99 Contact Map
3s4oA 1 0.2593 21.3 0.991 Contact Map
2yciX 2 0.3949 20.9 0.991 Contact Map
3p6lA 2 0.378 18.1 0.991 Contact Map
1i60A 1 0.4051 15.2 0.992 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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