GREMLIN Database
YNEK - Uncharacterized protein YneK
UniProt: P45711 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (138)
Sequences: 165 (101)
Seq/√Len: 8.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_D83_K3.8340.97
16_M20_L3.5510.96
45_L48_Q3.4350.95
97_E109_K3.3430.94
56_R68_D2.9080.88
124_K138_Q2.7970.86
56_R83_K2.7720.85
6_F10_I2.5650.80
52_I84_A2.4790.78
69_E130_K2.4550.77
124_K141_L2.4280.76
4_G7_L2.3520.74
89_K92_E2.3450.74
45_L49_D2.0120.61
99_V106_L1.9660.59
9_F17_M1.9470.59
12_F16_M1.9170.57
50_Y54_N1.9100.57
92_E96_K1.8850.56
4_G14_V1.8440.54
7_L11_L1.8290.54
93_L106_L1.7830.52
98_K103_D1.7210.49
49_D84_A1.7070.48
17_M21_L1.6460.46
49_D53_E1.6350.45
48_Q52_I1.6290.45
10_I13_W1.6250.45
97_E106_L1.5800.43
15_I55_S1.5100.40
52_I139_T1.4590.38
105_Q109_K1.4410.37
126_H129_D1.4390.37
60_N63_N1.4250.37
45_L52_I1.3900.35
122_F125_R1.3860.35
35_R39_E1.3730.35
11_L15_I1.3690.35
14_V17_M1.3490.34
5_W8_W1.3390.33
131_K138_Q1.3000.32
19_V22_S1.3000.32
18_V21_L1.2770.31
7_L14_V1.2620.31
6_F13_W1.2310.29
49_D52_I1.2050.29
45_L84_A1.2000.28
42_R61_D1.1570.27
69_E77_L1.1420.26
61_D65_Q1.1370.26
20_L100_A1.1360.26
122_F141_L1.1330.26
48_Q84_A1.1200.26
105_Q129_D1.1050.25
26_F124_K1.1040.25
11_L14_V1.0850.25
125_R141_L1.0710.24
51_Y95_L1.0690.24
36_L39_E1.0550.24
81_A120_H1.0410.23
104_Q130_K1.0350.23
10_I14_V1.0310.23
50_Y53_E1.0110.22
55_S121_T1.0080.22
7_L21_L0.9830.21
35_R77_L0.9770.21
22_S135_E0.9750.21
44_E55_S0.9660.21
84_A126_H0.9540.21
7_L101_K0.9450.20
53_E56_R0.9270.20
44_E48_Q0.9260.20
60_N96_K0.9200.20
7_L26_F0.9180.20
19_V23_I0.9170.20
55_S91_G0.9060.19
26_F139_T0.9020.19
93_L97_E0.8910.19
50_Y131_K0.8900.19
63_N102_I0.8840.19
84_A139_T0.8740.19
42_R138_Q0.8700.18
21_L126_H0.8670.18
39_E51_Y0.8660.18
91_G123_L0.8650.18
45_L83_K0.8550.18
69_E107_M0.8440.18
35_R106_L0.8370.18
99_V109_K0.8340.18
8_W97_E0.8250.17
58_L97_E0.8250.17
4_G11_L0.8220.17
104_Q139_T0.8160.17
35_R45_L0.8120.17
124_K134_L0.8100.17
65_Q135_E0.8070.17
100_A103_D0.8000.17
69_E126_H0.8000.17
54_N100_A0.7950.17
6_F105_Q0.7930.17
26_F62_E0.7930.17
54_N108_I0.7790.16
14_V138_Q0.7780.16
108_I123_L0.7730.16
56_R84_A0.7580.16
6_F14_V0.7560.16
108_I131_K0.7530.16
16_M105_Q0.7520.16
126_H134_L0.7480.16
35_R52_I0.7420.15
55_S106_L0.7400.15
126_H130_K0.7370.15
106_L109_K0.7360.15
57_H91_G0.7340.15
22_S26_F0.7270.15
72_A126_H0.7210.15
4_G22_S0.7210.15
26_F44_E0.7200.15
97_E117_K0.7140.15
72_A131_K0.7080.15
74_V82_A0.7040.15
89_K106_L0.6990.14
57_H95_L0.6960.14
58_L117_K0.6940.14
8_W57_H0.6890.14
33_L120_H0.6860.14
53_E81_A0.6860.14
17_M93_L0.6850.14
33_L38_K0.6780.14
35_R44_E0.6770.14
54_N81_A0.6700.14
19_V62_E0.6700.14
12_F19_V0.6670.14
5_W122_F0.6670.14
109_K113_L0.6670.14
95_L102_I0.6620.14
36_L84_A0.6600.14
129_D134_L0.6550.14
80_D109_K0.6530.14
12_F68_D0.6520.13
62_E132_I0.6480.13
76_E125_R0.6450.13
11_L50_Y0.6440.13
35_R140_L0.6370.13
95_L130_K0.6370.13
51_Y97_E0.6360.13
19_V131_K0.6360.13
102_I140_L0.6310.13
89_K124_K0.6310.13
58_L109_K0.6300.13
93_L113_L0.6260.13
84_A100_A0.6220.13
76_E85_K0.6220.13
101_K104_Q0.6220.13
11_L26_F0.6200.13
4_G44_E0.6180.13
102_I107_M0.6170.13
9_F100_A0.6150.13
49_D139_T0.6150.13
66_F81_A0.6080.13
11_L21_L0.6080.13
50_Y65_Q0.6080.13
125_R129_D0.6030.13
42_R89_K0.5990.12
15_I107_M0.5960.12
55_S108_I0.5900.12
64_K84_A0.5870.12
22_S138_Q0.5850.12
20_L131_K0.5850.12
81_A98_K0.5790.12
24_G27_F0.5780.12
45_L99_V0.5770.12
69_E120_H0.5760.12
35_R49_D0.5740.12
7_L58_L0.5730.12
8_W11_L0.5730.12
55_S102_I0.5710.12
4_G122_F0.5690.12
16_M53_E0.5670.12
17_M81_A0.5660.12
52_I140_L0.5630.12
64_K68_D0.5620.12
48_Q85_K0.5610.12
63_N134_L0.5570.12
77_L120_H0.5520.12
77_L126_H0.5500.12
76_E122_F0.5460.12
99_V104_Q0.5390.11
9_F15_I0.5320.11
16_M19_V0.5310.11
60_N134_L0.5290.11
6_F9_F0.5280.11
81_A131_K0.5270.11
8_W22_S0.5220.11
26_F61_D0.5210.11
20_L72_A0.5210.11
39_E49_D0.5210.11
64_K83_K0.5190.11
56_R107_M0.5170.11
26_F122_F0.5170.11
4_G21_L0.5160.11
68_D109_K0.5150.11
63_N88_G0.5090.11
26_F65_Q0.5090.11
15_I54_N0.5080.11
38_K121_T0.5040.11
101_K131_K0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pc9A 1 0.6972 29.8 0.96 Contact Map
2kruA 1 0.4437 13.3 0.966 Contact Map
2l09A 1 0.4366 10.5 0.967 Contact Map
4pf6A 1 0.7183 9.8 0.968 Contact Map
2xwvA 1 0.7676 9.8 0.968 Contact Map
1fexA 1 0.3521 9.6 0.968 Contact Map
4uybA 1 0.4014 9.5 0.968 Contact Map
4m8oA 1 0.5986 8.8 0.968 Contact Map
2eqrA 1 0.4296 8.6 0.969 Contact Map
1d4oA 1 0.3873 8.6 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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