GREMLIN Database
CCDC - Protein CcdC
UniProt: P45710 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 160 (149)
Sequences: 256 (191)
Seq/√Len: 15.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_L40_F6.7031.00
64_F132_G5.5101.00
56_T59_E3.8341.00
78_S89_M3.7041.00
97_F101_G3.5050.99
29_V145_Y3.0490.98
48_F55_V2.9620.98
118_D122_L2.6150.96
15_V100_V2.4210.93
91_R136_P2.4130.93
69_I73_F2.2100.90
48_F128_I2.1220.87
9_I16_A2.0230.85
79_K144_S1.9660.83
23_K27_K1.9600.83
14_A122_L1.8390.79
62_E125_M1.7700.76
45_A53_F1.7070.73
18_M104_V1.6580.71
54_W145_Y1.6520.70
35_I142_Y1.5930.68
15_V112_I1.5690.66
88_Y105_I1.5500.65
45_A120_G1.5370.65
11_V64_F1.5040.63
40_F59_E1.4940.62
48_F132_G1.4620.61
73_F76_K1.4470.60
50_F120_G1.4420.60
63_A66_L1.4270.59
60_F125_M1.3900.57
57_G60_F1.3900.57
89_M140_A1.3710.56
42_S131_F1.3340.54
11_V151_E1.3200.53
9_I17_V1.3170.53
14_A73_F1.3120.52
27_K33_K1.3040.52
57_G65_T1.2660.50
107_I144_S1.2230.47
61_L85_N1.2220.47
17_V91_R1.2090.46
109_M115_T1.2090.46
84_N104_V1.1850.45
29_V78_S1.1790.45
40_F110_K1.1770.45
64_F135_V1.1560.43
75_I140_A1.1550.43
53_F120_G1.1510.43
96_V100_V1.1490.43
17_V20_V1.1360.42
9_I12_L1.0850.39
95_F134_I1.0790.39
9_I20_V1.0690.39
47_M102_L1.0630.38
102_L141_M1.0610.38
55_V128_I1.0500.38
145_Y148_L1.0450.37
94_A98_I1.0360.37
50_F53_F1.0290.36
72_I76_K1.0250.36
38_P141_M1.0240.36
59_E121_A1.0230.36
49_L60_F1.0170.36
107_I145_Y1.0080.35
48_F127_W1.0020.35
56_T76_K1.0010.35
13_M99_L1.0000.35
36_L117_I0.9820.34
5_V11_V0.9810.34
42_S46_L0.9780.34
16_A107_I0.9760.34
38_P41_M0.9750.34
59_E73_F0.9730.33
49_L52_V0.9640.33
60_F64_F0.9630.33
60_F128_I0.9600.33
65_T119_Y0.9570.33
55_V120_G0.9520.32
133_M141_M0.9450.32
7_S11_V0.9250.31
13_M81_E0.9140.31
65_T68_V0.9140.31
78_S92_S0.9130.30
25_S89_M0.9120.30
58_A112_I0.8900.29
14_A99_L0.8820.29
58_A68_V0.8800.29
47_M129_L0.8740.29
55_V60_F0.8740.29
59_E142_Y0.8720.29
6_S93_K0.8650.28
146_R150_N0.8620.28
29_V89_M0.8570.28
38_P133_M0.8540.28
108_V112_I0.8460.27
62_E120_G0.8450.27
96_V150_N0.8390.27
8_I112_I0.8370.27
143_L146_R0.8330.27
32_K48_F0.8280.27
84_N88_Y0.8270.26
31_P89_M0.8180.26
49_L65_T0.8150.26
10_A13_M0.8100.26
40_F117_I0.8090.26
60_F118_D0.7990.25
36_L81_E0.7980.25
18_M109_M0.7960.25
66_L109_M0.7930.25
122_L132_G0.7920.25
73_F110_K0.7840.25
48_F60_F0.7770.24
55_V127_W0.7750.24
52_V120_G0.7730.24
114_S122_L0.7720.24
73_F121_A0.7710.24
41_M141_M0.7700.24
118_D127_W0.7660.24
114_S127_W0.7620.24
68_V91_R0.7610.24
21_R95_F0.7580.24
65_T84_N0.7570.23
83_K111_S0.7560.23
54_W116_S0.7530.23
13_M133_M0.7490.23
18_M103_L0.7450.23
30_S147_K0.7430.23
13_M117_I0.7390.23
11_V113_L0.7380.23
110_K124_G0.7340.23
69_I104_V0.7310.22
36_L39_I0.7190.22
22_I127_W0.7120.22
88_Y109_M0.7100.22
104_V121_A0.7090.22
112_I143_L0.7080.22
4_I145_Y0.7010.21
35_I117_I0.6970.21
39_I42_S0.6910.21
38_P92_S0.6900.21
12_L143_L0.6900.21
8_I15_V0.6880.21
65_T86_E0.6870.21
38_P47_M0.6860.21
70_F142_Y0.6850.21
31_P84_N0.6840.21
71_S75_I0.6780.20
17_V115_T0.6770.20
18_M96_V0.6760.20
80_F89_M0.6740.20
113_L128_I0.6720.20
19_V66_L0.6710.20
55_V124_G0.6710.20
20_V128_I0.6640.20
31_P142_Y0.6590.20
131_F135_V0.6580.20
25_S121_A0.6540.20
55_V104_V0.6460.19
60_F73_F0.6450.19
41_M133_M0.6440.19
136_P140_A0.6440.19
7_S10_A0.6420.19
38_P102_L0.6370.19
16_A113_L0.6350.19
52_V127_W0.6350.19
22_I88_Y0.6340.19
105_I109_M0.6330.19
10_A62_E0.6320.19
35_I65_T0.6230.18
122_L125_M0.6220.18
145_Y149_H0.6220.18
6_S148_L0.6170.18
25_S96_V0.6160.18
11_V104_V0.6110.18
73_F125_M0.6090.18
41_M102_L0.6040.18
41_M47_M0.6040.18
36_L57_G0.6030.18
35_I145_Y0.6000.18
4_I29_V0.5990.18
89_M123_S0.5990.18
26_D144_S0.5980.18
55_V119_Y0.5950.17
39_I61_L0.5900.17
32_K39_I0.5820.17
15_V119_Y0.5800.17
48_F141_M0.5770.17
93_K145_Y0.5750.17
35_I82_I0.5740.17
4_I149_H0.5740.17
135_V142_Y0.5700.17
45_A123_S0.5660.17
72_I101_G0.5630.16
22_I91_R0.5610.16
17_V136_P0.5610.16
48_F63_A0.5600.16
75_I78_S0.5590.16
18_M113_L0.5570.16
27_K58_A0.5560.16
110_K114_S0.5500.16
11_V16_A0.5490.16
11_V86_E0.5460.16
45_A114_S0.5450.16
26_D82_I0.5440.16
26_D86_E0.5430.16
43_T47_M0.5340.16
45_A131_F0.5340.16
12_L61_L0.5320.15
47_M141_M0.5300.15
4_I139_I0.5280.15
85_N151_E0.5270.15
111_S140_A0.5250.15
60_F121_A0.5240.15
55_V107_I0.5180.15
26_D134_I0.5160.15
45_A64_F0.5160.15
66_L97_F0.5130.15
85_N105_I0.5130.15
92_S141_M0.5120.15
16_A58_A0.5100.15
110_K120_G0.5080.15
105_I145_Y0.5050.15
102_L126_F0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xnjA 1 0.875 34.3 0.948 Contact Map
1pi7A 1 0.1125 10.8 0.959 Contact Map
4ikvA 1 0.9062 10.3 0.959 Contact Map
4j05A 3 0.9187 8.7 0.961 Contact Map
4bwzA 2 0.875 8.2 0.961 Contact Map
4w6vA 1 0.8562 5.7 0.964 Contact Map
4tphA 2 0.7562 5.4 0.964 Contact Map
3wdoA 1 0.95 5.1 0.965 Contact Map
5a2fA 1 0 5 0.965 Contact Map
4uvmA 1 0.9125 4.6 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0065 seconds.