GREMLIN Database
TKT - Transketolase
UniProt: P45694 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 667 (592)
Sequences: 9111 (4965)
Seq/√Len: 204.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
576_E662_K4.5961.00
554_A661_V4.2601.00
204_Q207_E4.2041.00
418_L431_G3.5171.00
214_L240_T3.3621.00
221_N224_E3.1831.00
553_D579_D3.1661.00
290_S294_E3.1531.00
84_S87_D3.1131.00
541_A585_M2.9531.00
600_N605_A2.8911.00
509_S512_H2.8891.00
545_S570_Q2.7821.00
654_V658_V2.7731.00
592_E624_Y2.7601.00
319_K330_E2.6221.00
212_E240_T2.6101.00
201_N204_Q2.6101.00
149_Y180_I2.5281.00
235_N238_K2.5091.00
572_E658_V2.5021.00
308_E312_N2.4871.00
596_D600_N2.4771.00
230_E234_Q2.4371.00
428_R454_P2.4281.00
612_A631_V2.3631.00
491_I502_A2.3141.00
214_L228_A2.2931.00
168_A206_F2.2671.00
165_S209_M2.2511.00
505_L508_Q2.2431.00
557_I585_M2.2291.00
569_A573_L2.2221.00
571_A575_K2.1901.00
630_D660_R2.1751.00
618_S633_G2.1701.00
554_A580_V2.1521.00
568_E571_A2.0961.00
540_G543_V2.0821.00
645_T648_N2.0451.00
154_C181_V2.0331.00
436_V478_Q2.0091.00
86_E89_K1.9921.00
212_E235_N1.9781.00
421_M427_L1.9621.00
489_S587_S1.9591.00
293_Y297_A1.9581.00
155_G158_D1.9561.00
177_G212_E1.9491.00
112_A123_M1.9301.00
445_I488_L1.9281.00
556_L566_A1.9111.00
488_L515_A1.8871.00
214_L231_K1.8841.00
306_K310_E1.8751.00
203_K207_E1.8701.00
519_T523_L1.8581.00
585_M588_M1.8561.00
294_E298_V1.8451.00
656_N660_R1.8441.00
592_E623_K1.8441.00
272_K276_E1.8441.00
489_S512_H1.8361.00
329_L333_I1.8351.00
226_T230_E1.8041.00
572_E654_V1.7951.00
175_Q397_A1.7931.00
478_Q517_V1.7761.00
143_F314_Q1.7731.00
625_T631_V1.7571.00
115_G118_G1.7371.00
283_E287_Y1.7351.00
596_D599_K1.7301.00
219_G246_T1.7281.00
128_A150_T1.7231.00
254_N273_L1.7161.00
185_S243_E1.7001.00
448_A457_Y1.6871.00
566_A613_I1.6831.00
149_Y233_R1.6731.00
572_E575_K1.6721.00
422_A454_P1.6601.00
115_G121_I1.6581.00
298_V302_E1.6551.00
452_G511_D1.6511.00
648_N655_P1.6501.00
302_E306_K1.6441.00
168_A209_M1.6381.00
107_T110_V1.6371.00
77_H293_Y1.6361.00
354_L359_S1.6291.00
572_E655_P1.6281.00
331_L373_F1.6211.00
255_R260_G1.6171.00
535_A538_E1.6161.00
546_K581_S1.6141.00
56_F329_L1.6061.00
247_T256_A1.6051.00
534_L538_E1.6051.00
173_H199_S1.5981.00
146_V329_L1.5961.00
564_G568_E1.5941.00
567_I582_V1.5721.00
203_K243_E1.5711.00
252_S274_T1.5681.00
247_T257_G1.5611.00
170_L174_L1.5361.00
442_R481_S1.5341.00
94_W645_T1.5321.00
182_L229_I1.5311.00
540_G544_V1.5261.00
485_M488_L1.5251.00
479_L517_V1.5231.00
99_P107_T1.5111.00
545_S571_A1.5061.00
422_A429_V1.5051.00
289_P292_V1.4991.00
227_A231_K1.4991.00
418_L432_G1.4971.00
476_V634_I1.4951.00
504_K508_Q1.4951.00
87_D90_G1.4911.00
391_N396_T1.4881.00
203_K213_V1.4871.00
558_A566_A1.4861.00
118_G121_I1.4841.00
656_N659_N1.4831.00
94_W641_A1.4741.00
574_A580_V1.4731.00
392_A396_T1.4651.00
505_L509_S1.4631.00
489_S509_S1.4591.00
598_Y603_L1.4461.00
124_A152_S1.4451.00
312_N316_A1.4431.00
489_S590_R1.4421.00
599_K603_L1.4401.00
565_L654_V1.4351.00
187_D245_K1.4331.00
519_T561_S1.4291.00
647_I652_F1.4261.00
85_I89_K1.4251.00
552_P579_D1.4221.00
163_I412_F1.4211.00
618_S622_G1.4181.00
422_A453_L1.4181.00
418_L455_V1.4181.00
148_H424_H1.4181.00
354_L362_E1.4131.00
144_N147_D1.4121.00
646_I650_Y1.4121.00
376_G430_F1.4091.00
618_S635_D1.4041.00
558_A563_V1.4011.00
76_L109_G1.4011.00
447_L488_L1.4011.00
645_T649_E1.4001.00
568_E654_V1.3961.00
438_S481_S1.3841.00
353_S522_N1.3791.00
566_A582_V1.3741.00
62_V127_M1.3691.00
358_A522_N1.3611.00
494_A563_V1.3581.00
533_A538_E1.3571.00
435_F482_L1.3571.00
556_L661_V1.3531.00
572_E576_E1.3491.00
258_T261_V1.3481.00
273_L276_E1.3471.00
499_T518_L1.3471.00
642_P645_T1.3441.00
415_G441_L1.3411.00
203_K215_Y1.3331.00
358_A386_K1.3331.00
215_Y243_E1.3311.00
354_L358_A1.3281.00
305_E309_Q1.3231.00
177_G237_K1.3151.00
556_L604_P1.3071.00
94_W649_E1.3001.00
541_A545_S1.3001.00
643_G647_I1.2961.00
124_A181_V1.2921.00
538_E541_A1.2861.00
182_L244_V1.2861.00
480_A616_G1.2851.00
392_A395_F1.2851.00
435_F517_V1.2841.00
276_E280_W1.2821.00
100_G103_E1.2821.00
578_I662_K1.2761.00
212_E231_K1.2741.00
309_Q313_A1.2731.00
512_H593_K1.2701.00
549_N579_D1.2621.00
533_A536_G1.2611.00
631_V634_I1.2521.00
536_G540_G1.2491.00
330_E334_K1.2481.00
543_V546_K1.2441.00
114_T118_G1.2421.00
541_A544_V1.2391.00
365_N390_K1.2391.00
249_G261_V1.2341.00
535_A539_K1.2321.00
98_T101_H1.2301.00
95_G649_E1.2301.00
588_M592_E1.2281.00
307_K310_E1.2241.00
169_S198_F1.2141.00
150_T178_R1.2081.00
626_G629_G1.2031.00
328_Q331_L1.2011.00
537_V540_G1.2001.00
449_A452_G1.1961.00
133_H375_V1.1961.00
570_Q582_V1.1901.00
366_G369_K1.1861.00
611_L660_R1.1841.00
491_I514_T1.1801.00
391_N394_D1.1801.00
116_P121_I1.1751.00
132_R400_Y1.1711.00
637_F642_P1.1701.00
362_E390_K1.1691.00
144_N314_Q1.1571.00
558_A562_E1.1511.00
83_L87_D1.1491.00
151_Y180_I1.1481.00
113_T118_G1.1471.00
206_F241_L1.1471.00
415_G458_V1.1431.00
445_I459_F1.1421.00
367_L374_F1.1391.00
359_S496_G1.1361.00
596_D605_A1.1361.00
129_I174_L1.1351.00
524_P564_G1.1331.00
122_A167_A1.1311.00
116_P120_G1.1301.00
612_A618_S1.1261.00
611_L632_L1.1261.00
340_D344_E1.1261.00
622_G631_V1.1251.00
121_I168_A1.1251.00
157_G189_S1.1231.00
376_G404_N1.1231.00
177_G236_E1.1231.00
131_E150_T1.1211.00
549_N574_A1.1161.00
489_S589_D1.1091.00
121_I181_V1.1081.00
441_L445_I1.1081.00
415_G457_Y1.1051.00
112_A115_G1.1051.00
643_G646_I1.1011.00
310_E313_A1.1001.00
501_A537_V1.0991.00
502_A516_L1.0981.00
655_P659_N1.0971.00
65_A155_G1.0961.00
480_A620_G1.0961.00
539_K543_V1.0941.00
465_A647_I1.0931.00
385_N432_G1.0921.00
506_A509_S1.0891.00
122_A413_A1.0811.00
183_Y203_K1.0811.00
553_D578_I1.0791.00
214_L232_A1.0771.00
540_G546_K1.0771.00
636_R643_G1.0751.00
562_E565_L1.0691.00
382_A406_W1.0691.00
422_A455_V1.0661.00
309_Q312_N1.0641.00
394_D406_W1.0641.00
213_V243_E1.0641.00
364_L430_F1.0531.00
304_G307_K1.0501.00
536_G539_K1.0491.00
207_E215_Y1.0461.00
356_S523_L1.0381.00
318_Y322_Y1.0361.00
375_V421_M1.0361.00
230_E233_R1.0341.00
267_G270_E1.0311.00
189_S409_V1.0311.00
216_V224_E1.0311.00
122_A416_A1.0291.00
152_S181_V1.0291.00
533_A539_K1.0291.00
313_A317_K1.0291.00
390_K393_G1.0261.00
569_A572_E1.0261.00
98_T103_E1.0261.00
329_L332_A1.0241.00
548_K574_A1.0231.00
568_E572_E1.0191.00
555_L604_P1.0181.00
303_S306_K1.0171.00
86_E90_G1.0171.00
533_A540_G1.0151.00
115_G120_G1.0151.00
588_M624_Y1.0131.00
360_S503_W1.0111.00
99_P103_E1.0101.00
65_A153_I1.0071.00
56_F146_V1.0061.00
291_E294_E1.0061.00
177_G240_T1.0041.00
96_S99_P1.0021.00
326_A330_E1.0021.00
489_S514_T1.0001.00
160_M189_S0.9991.00
115_G119_Q0.9991.00
113_T116_P0.9981.00
600_N604_P0.9971.00
117_L120_G0.9961.00
162_G166_E0.9961.00
149_Y178_R0.9961.00
215_Y245_K0.9941.00
637_F643_G0.9931.00
652_F656_N0.9921.00
226_T233_R0.9901.00
600_N606_D0.9901.00
133_H427_L0.9841.00
358_A362_E0.9791.00
636_R642_P0.9781.00
598_Y601_E0.9731.00
361_G386_K0.9721.00
458_V518_L0.9721.00
132_R178_R0.9681.00
553_D599_K0.9681.00
641_A645_T0.9681.00
541_A602_V0.9671.00
125_V167_A0.9671.00
574_A579_D0.9640.99
504_K538_E0.9620.99
322_Y325_L0.9610.99
252_S273_L0.9550.99
114_T117_L0.9550.99
117_L121_I0.9530.99
556_L613_I0.9520.99
442_R458_V0.9500.99
636_R649_E0.9490.99
506_A514_T0.9470.99
540_G545_S0.9470.99
478_Q613_I0.9440.99
555_L583_V0.9430.99
417_A420_G0.9400.99
114_T121_I0.9390.99
254_N270_E0.9370.99
479_L484_A0.9350.99
56_F333_I0.9340.99
328_Q333_I0.9330.99
314_Q317_K0.9330.99
443_P448_A0.9330.99
482_L515_A0.9330.99
393_G396_T0.9310.99
552_P607_V0.9310.99
597_E600_N0.9300.99
205_R209_M0.9280.99
223_E227_A0.9250.99
175_Q237_K0.9250.99
337_L340_D0.9240.99
421_M424_H0.9240.99
302_E305_E0.9240.99
459_F515_A0.9240.99
555_L607_V0.9220.99
612_A625_T0.9200.99
256_A259_S0.9190.99
604_P607_V0.9190.99
644_E648_N0.9190.99
131_E178_R0.9190.99
569_A658_V0.9180.99
548_K579_D0.9140.99
336_E510_T0.9140.99
482_L485_M0.9140.99
390_K396_T0.9120.99
303_S307_K0.9110.99
391_N395_F0.9080.99
256_A277_A0.9080.99
611_L661_V0.9070.99
641_A646_I0.9070.99
480_A619_F0.9070.99
445_I515_A0.9060.99
505_L538_E0.9040.99
70_A88_L0.8990.99
130_A421_M0.8990.99
538_E543_V0.8970.99
358_A361_G0.8960.99
636_R650_Y0.8960.99
282_Y285_D0.8930.99
533_A537_V0.8920.99
588_M620_G0.8900.99
317_K320_E0.8870.99
57_N314_Q0.8860.99
613_I657_V0.8860.99
231_K235_N0.8860.99
231_K234_Q0.8840.99
325_L328_Q0.8800.99
600_N603_L0.8800.99
412_F444_A0.8790.99
407_F418_L0.8780.99
114_T120_G0.8770.99
142_S145_V0.8760.99
319_K326_A0.8760.99
313_A316_A0.8750.99
180_I232_A0.8740.99
143_F321_V0.8730.99
597_E601_E0.8690.99
543_V581_S0.8690.99
481_S485_M0.8680.99
265_P271_S0.8680.99
555_L598_Y0.8680.99
535_A540_G0.8670.99
636_R640_S0.8670.99
110_V113_T0.8660.99
551_T579_D0.8660.99
648_N653_S0.8650.99
439_D478_Q0.8650.99
534_L541_A0.8650.99
658_V662_K0.8630.99
526_I567_I0.8620.99
598_Y602_V0.8620.99
558_A582_V0.8560.99
489_S593_K0.8560.99
548_K551_T0.8550.99
294_E297_A0.8550.99
183_Y241_L0.8540.99
70_A74_S0.8540.99
603_L610_R0.8530.99
342_D345_V0.8530.99
632_L657_V0.8520.99
112_A116_P0.8480.99
212_E237_K0.8480.99
383_G406_W0.8470.99
390_K394_D0.8460.99
480_A484_A0.8450.99
83_L107_T0.8450.99
552_P581_S0.8450.99
445_I457_Y0.8430.99
342_D508_Q0.8430.99
545_S567_I0.8430.99
112_A118_G0.8400.99
536_G541_A0.8390.99
272_K283_E0.8380.99
438_S459_F0.8380.99
539_K544_V0.8340.99
534_L540_G0.8340.99
556_L580_V0.8320.99
62_V124_A0.8320.99
154_C159_L0.8290.98
131_E424_H0.8280.98
555_L603_L0.8280.98
66_G184_D0.8270.98
163_I416_A0.8270.98
336_E339_K0.8260.98
502_A537_V0.8250.98
592_E599_K0.8250.98
545_S574_A0.8250.98
534_L539_K0.8250.98
212_E236_E0.8210.98
337_L341_W0.8210.98
553_D580_V0.8210.98
301_K305_E0.8180.98
268_K272_K0.8170.98
135_A143_F0.8170.98
315_F326_A0.8170.98
557_I603_L0.8170.98
439_D442_R0.8160.98
491_I587_S0.8160.98
612_A615_M0.8160.98
587_S590_R0.8150.98
603_L607_V0.8140.98
297_A301_K0.8130.98
310_E314_Q0.8090.98
415_G459_F0.8070.98
229_I233_R0.8060.98
110_V115_G0.8060.98
653_S656_N0.8030.98
317_K321_V0.8030.98
281_T285_D0.8010.98
485_M490_L0.8000.98
568_E655_P0.7990.98
539_K542_Y0.7990.98
533_A541_A0.7990.98
611_L615_M0.7980.98
351_G525_T0.7970.98
121_I164_S0.7970.98
375_V427_L0.7960.98
542_Y545_S0.7950.98
280_W289_P0.7930.98
443_P447_L0.7930.98
261_V264_A0.7920.98
153_I182_L0.7910.98
328_Q332_A0.7910.98
98_T102_P0.7890.98
89_K286_F0.7890.98
340_D343_Q0.7880.98
282_Y287_Y0.7880.98
637_F640_S0.7870.98
131_E148_H0.7860.98
154_C158_D0.7860.98
585_M617_S0.7850.98
331_L336_E0.7840.98
96_S100_G0.7820.98
65_A68_G0.7810.98
418_L429_V0.7810.98
566_A657_V0.7790.98
407_F413_A0.7790.98
619_F622_G0.7780.98
129_I417_A0.7770.98
134_L424_H0.7770.98
191_D383_G0.7760.98
187_D193_D0.7730.98
268_K271_S0.7730.98
193_D259_S0.7730.98
165_S168_A0.7720.98
129_I395_F0.7700.98
534_L537_V0.7700.98
63_L72_L0.7680.97
146_V237_K0.7670.97
569_A661_V0.7670.97
377_G414_M0.7670.97
268_K285_D0.7640.97
345_V500_A0.7610.97
635_D642_P0.7610.97
659_N662_K0.7610.97
218_D224_E0.7590.97
570_Q580_V0.7570.97
363_V500_A0.7560.97
549_N552_P0.7560.97
316_A319_K0.7550.97
636_R645_T0.7550.97
113_T121_I0.7550.97
541_A588_M0.7530.97
611_L630_D0.7530.97
322_Y326_A0.7520.97
143_F322_Y0.7520.97
570_Q574_A0.7520.97
496_G525_T0.7510.97
535_A541_A0.7500.97
129_I405_F0.7480.97
344_E370_K0.7480.97
550_E579_D0.7480.97
177_G235_N0.7480.97
557_I588_M0.7470.97
99_P102_P0.7450.97
95_G106_H0.7450.97
104_F451_M0.7410.97
369_K391_N0.7410.97
308_E311_W0.7400.97
218_D221_N0.7390.97
523_L561_S0.7390.97
418_L457_Y0.7370.97
382_A388_T0.7370.97
441_L444_A0.7330.97
111_D114_T0.7320.97
481_S484_A0.7310.97
255_R261_V0.7280.97
618_S631_V0.7280.97
551_T607_V0.7280.97
625_T629_G0.7280.97
110_V118_G0.7260.96
616_G619_F0.7260.96
269_E272_K0.7240.96
129_I421_M0.7230.96
132_R177_G0.7230.96
634_I652_F0.7230.96
546_K549_N0.7230.96
635_D643_G0.7210.96
599_K604_P0.7210.96
183_Y243_E0.7200.96
637_F641_A0.7190.96
212_E238_K0.7190.96
151_Y233_R0.7180.96
562_E604_P0.7170.96
104_F423_L0.7170.96
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113_T117_L0.7150.96
657_V660_R0.7140.96
130_A424_H0.7130.96
559_S588_M0.7120.96
110_V114_T0.7090.96
444_A448_A0.7090.96
107_T118_G0.7090.96
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274_T277_A0.7080.96
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279_A283_E0.7060.96
106_H113_T0.7040.96
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448_A455_V0.7000.96
395_F400_Y0.6990.96
232_A240_T0.6980.96
283_E289_P0.6970.96
344_E347_V0.6950.96
551_T606_D0.6940.95
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290_S293_Y0.6900.95
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119_Q416_A0.6750.95
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304_G308_E0.6720.95
107_T116_P0.6720.95
494_A523_L0.6720.95
90_G93_Q0.6710.95
75_M79_S0.6710.95
327_E331_L0.6710.95
143_F317_K0.6690.94
229_I242_I0.6690.94
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365_N369_K0.6460.93
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528_Q531_E0.6300.93
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417_A421_M0.6270.92
367_L371_I0.6260.92
129_I133_H0.6250.92
359_S499_T0.6240.92
441_L457_Y0.6230.92
499_T502_A0.6220.92
597_E603_L0.6210.92
604_P609_K0.6210.92
283_E290_S0.6200.92
412_F443_P0.6200.92
435_F479_L0.6190.92
454_P510_T0.6180.92
220_N244_V0.6170.92
636_R639_A0.6170.92
569_A613_I0.6170.92
368_A374_F0.6160.92
364_L368_A0.6150.92
505_L590_R0.6150.92
607_V610_R0.6150.92
574_A578_I0.6130.92
170_L413_A0.6130.92
272_K280_W0.6130.92
129_I375_V0.6120.91
288_V296_F0.6110.91
376_G381_L0.6110.91
428_R507_V0.6110.91
390_K395_F0.6110.91
461_H561_S0.6090.91
336_E340_D0.6080.91
288_V292_V0.6060.91
615_M647_I0.6060.91
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637_F644_E0.6040.91
185_S245_K0.6040.91
100_G104_F0.6040.91
599_K624_Y0.6020.91
503_W516_L0.6020.91
73_Y80_G0.6020.91
461_H519_T0.6020.91
106_H452_G0.6010.91
74_S80_G0.6000.91
133_H136_E0.5990.91
323_P329_L0.5970.90
211_W241_L0.5950.90
324_E327_E0.5930.90
505_L514_T0.5930.90
549_N553_D0.5930.90
493_P502_A0.5920.90
349_E352_S0.5910.90
108_A112_A0.5910.90
271_S277_A0.5910.90
99_P110_V0.5880.90
250_F256_A0.5870.90
651_G656_N0.5860.90
496_G529_T0.5840.89
181_V241_L0.5830.89
436_V466_V0.5830.89
142_S321_V0.5830.89
432_G458_V0.5830.89
292_V297_A0.5820.89
288_V291_E0.5820.89
442_R478_Q0.5800.89
84_S90_G0.5800.89
341_W345_V0.5800.89
514_T587_S0.5790.89
264_A267_G0.5780.89
251_G278_Y0.5760.89
65_A154_C0.5750.89
253_P270_E0.5740.89
491_I590_R0.5740.89
323_P328_Q0.5740.89
127_M150_T0.5740.89
165_S205_R0.5730.89
116_P119_Q0.5730.89
343_Q347_V0.5720.88
292_V296_F0.5720.88
548_K553_D0.5720.88
531_E536_G0.5710.88
431_G457_Y0.5710.88
94_W639_A0.5710.88
464_I650_Y0.5700.88
318_Y325_L0.5690.88
646_I651_G0.5690.88
537_V542_Y0.5680.88
537_V544_V0.5680.88
421_M429_V0.5680.88
252_S270_E0.5670.88
306_K309_Q0.5670.88
445_I485_M0.5670.88
122_A163_I0.5660.88
321_V324_E0.5650.88
326_A329_L0.5650.88
340_D347_V0.5640.88
478_Q559_S0.5640.88
589_D592_E0.5620.88
271_S274_T0.5610.88
479_L490_L0.5600.87
596_D603_L0.5590.87
495_D544_V0.5590.87
228_A232_A0.5590.87
124_A150_T0.5580.87
348_Y363_V0.5570.87
341_W508_Q0.5560.87
423_L451_M0.5560.87
335_G338_P0.5550.87
110_V116_P0.5550.87
169_S408_G0.5550.87
96_S103_E0.5530.87
207_E213_V0.5520.87
275_K279_A0.5520.87
594_Q598_Y0.5510.87
420_G424_H0.5510.87
552_P555_L0.5490.86
612_A617_S0.5470.86
371_I507_V0.5470.86
639_A646_I0.5460.86
150_T424_H0.5460.86
123_M451_M0.5460.86
396_T399_D0.5450.86
570_Q579_D0.5430.86
505_L512_H0.5430.86
571_A574_A0.5430.86
504_K534_L0.5420.86
636_R644_E0.5420.86
629_G633_G0.5420.86
436_V439_D0.5410.86
491_I516_L0.5410.86
107_T121_I0.5410.86
216_V244_V0.5400.85
355_A384_S0.5400.85
555_L581_S0.5390.85
123_M412_F0.5390.85
113_T120_G0.5390.85
636_R646_I0.5380.85
111_D118_G0.5380.85
490_L589_D0.5380.85
658_V661_V0.5370.85
563_V582_V0.5370.85
467_G521_Q0.5370.85
652_F660_R0.5350.85
485_M589_D0.5350.85
418_L421_M0.5340.85
276_E279_A0.5340.85
123_M419_N0.5340.85
565_L568_E0.5330.85
303_S308_E0.5330.85
165_S413_A0.5330.85
107_T112_A0.5330.85
216_V225_L0.5330.85
432_G459_F0.5320.85
55_W58_R0.5310.85
196_R406_W0.5310.85
637_F645_T0.5310.85
87_D91_F0.5310.85
349_E353_S0.5310.85
70_A75_M0.5300.84
423_L453_L0.5290.84
537_V543_V0.5290.84
111_D116_P0.5280.84
407_F417_A0.5280.84
93_Q642_P0.5270.84
476_V517_V0.5270.84
416_A441_L0.5270.84
648_N656_N0.5260.84
418_L422_A0.5260.84
277_A280_W0.5250.84
249_G255_R0.5220.84
136_E401_S0.5220.84
96_S101_H0.5220.84
76_L79_S0.5210.83
353_S644_E0.5200.83
501_A505_L0.5200.83
347_V351_G0.5200.83
73_Y76_L0.5200.83
68_G71_L0.5200.83
610_R629_G0.5190.83
501_A538_E0.5180.83
125_V171_A0.5180.83
350_K353_S0.5170.83
151_Y229_I0.5170.83
190_L385_N0.5170.83
135_A145_V0.5160.83
225_L244_V0.5160.83
416_A444_A0.5150.83
629_G634_I0.5150.83
165_S379_A0.5150.83
494_A526_I0.5130.82
256_A261_V0.5130.82
485_M617_S0.5130.82
159_L165_S0.5120.82
121_I154_C0.5110.82
439_D481_S0.5110.82
422_A428_R0.5110.82
72_L76_L0.5090.82
260_G387_T0.5090.82
198_F202_V0.5090.82
566_A604_P0.5080.82
336_E341_W0.5080.82
297_A302_E0.5070.82
392_A403_K0.5070.82
130_A427_L0.5070.82
588_M619_F0.5050.82
255_R258_T0.5040.81
501_A512_H0.5040.81
546_K574_A0.5030.81
459_F516_L0.5020.81
354_L496_G0.5020.81
476_V617_S0.5020.81
482_L490_L0.5020.81
614_E621_W0.5010.81
207_E212_E0.5000.81
88_L93_Q0.5000.81
446_R458_V0.5000.81
452_G487_N0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r9jA 2 0.979 100 0.215 Contact Map
2r8oA 2 0.9865 100 0.229 Contact Map
3m49A 2 0.997 100 0.23 Contact Map
1itzA 2 0.985 100 0.232 Contact Map
3rimA 2 0.994 100 0.236 Contact Map
3komA 2 0.961 100 0.238 Contact Map
4c7vA 2 0.9895 100 0.239 Contact Map
3uk1A 2 0.9715 100 0.243 Contact Map
1gpuA 2 0.9805 100 0.249 Contact Map
2e6kA 2 0.97 100 0.255 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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