GREMLIN Database
SP5S - Stage V sporulation protein S
UniProt: P45693 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 86 (83)
Sequences: 235 (113)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_V81_L3.9190.99
51_G55_P3.6630.99
39_L81_L3.5850.99
10_S15_V3.5480.99
40_N44_K2.1610.81
53_V60_L2.0640.78
13_N46_V1.9750.75
4_L12_P1.8530.70
61_I84_E1.7440.65
39_L46_V1.7360.65
24_R52_F1.7320.64
19_L29_A1.6720.62
31_I52_F1.4910.53
44_K48_I1.4230.49
41_Q44_K1.3910.47
23_L69_I1.3890.47
34_I68_D1.3820.47
2_E75_E1.3590.46
40_N48_I1.3470.45
46_V81_L1.3430.45
45_A52_F1.3390.45
6_V10_S1.3110.43
46_V62_C1.3060.43
3_I9_K1.2750.42
37_G41_Q1.2310.39
34_I67_T1.2110.39
51_G54_A1.1940.38
17_G20_A1.1570.36
5_K44_K1.1560.36
45_A79_I1.1470.35
65_A80_K1.1380.35
60_L65_A1.1310.35
23_L75_E1.1300.35
11_S56_S1.1240.34
67_T80_K1.1150.34
40_N47_A1.0920.33
10_S18_A1.0830.33
65_A82_I1.0410.31
37_G79_I1.0380.31
35_G64_P1.0260.30
2_E84_E1.0230.30
21_G38_A1.0170.30
5_K40_N0.9990.29
19_L26_R0.9960.29
11_S52_F0.9960.29
68_D78_A0.9730.28
36_A57_G0.9690.28
39_L60_L0.9630.27
12_P18_A0.9440.27
19_L68_D0.9420.27
32_Q41_Q0.9310.26
13_N21_G0.9310.26
4_L43_V0.9150.26
58_V78_A0.8830.24
22_V34_I0.8800.24
28_A84_E0.8780.24
62_C68_D0.8770.24
30_E33_A0.8570.23
3_I82_I0.8540.23
39_L67_T0.8540.23
14_S58_V0.8500.23
44_K47_A0.8170.22
17_G52_F0.8000.21
54_A60_L0.7750.20
19_L53_V0.7670.20
13_N81_L0.7630.20
5_K9_K0.7620.20
73_G84_E0.7610.20
46_V55_P0.7550.20
2_E53_V0.7350.19
49_A81_L0.7330.19
4_L18_A0.7300.19
49_A53_V0.7300.19
32_Q59_D0.7290.19
14_S52_F0.7280.19
25_E52_F0.7250.19
6_V31_I0.7140.19
51_G78_A0.7110.18
20_A56_S0.7060.18
26_R74_E0.7060.18
33_A43_V0.6940.18
24_R78_A0.6870.18
2_E63_I0.6860.18
23_L53_V0.6860.18
41_Q48_I0.6850.18
19_L31_I0.6830.18
8_A28_A0.6770.17
36_A63_I0.6770.17
8_A14_S0.6670.17
62_C81_L0.6670.17
9_K43_V0.6600.17
2_E81_L0.6550.17
4_L39_L0.6530.17
39_L53_V0.6430.16
12_P17_G0.6250.16
33_A39_L0.6210.16
71_I79_I0.6190.16
31_I84_E0.6160.16
73_G83_V0.6070.15
16_A66_F0.6030.15
59_D64_P0.5970.15
33_A81_L0.5970.15
56_S62_C0.5950.15
13_N47_A0.5920.15
2_E50_R0.5900.15
32_Q44_K0.5900.15
28_A82_I0.5860.15
9_K52_F0.5790.15
32_Q40_N0.5660.14
62_C72_D0.5560.14
52_F79_I0.5530.14
34_I42_A0.5480.14
5_K41_Q0.5470.14
33_A76_R0.5450.14
54_A62_C0.5450.14
34_I71_I0.5320.14
22_V80_K0.5280.13
46_V49_A0.5130.13
13_N23_L0.5120.13
27_G56_S0.5080.13
50_R59_D0.5060.13
33_A67_T0.5010.13
72_D80_K0.5010.13
23_L58_V0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ek0A 3 1 100 0.046 Contact Map
1jq5A 5 0.9186 34.2 0.91 Contact Map
4mcaA 7 0.9186 33.4 0.91 Contact Map
3uhjA 5 0.9186 32.2 0.911 Contact Map
1ta9A 5 0.907 24 0.917 Contact Map
1kq3A 5 0.907 23.6 0.917 Contact Map
4fr2A 2 0.9651 21.7 0.918 Contact Map
3ce9A 3 0.8837 20.6 0.919 Contact Map
3w5sA 2 0.8837 20.3 0.919 Contact Map
3iv7A 2 0.8721 16.8 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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