GREMLIN Database
YPJG - Uncharacterized deacetylase YpjG
UniProt: P42981 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 236 (192)
Sequences: 4752 (3298)
Seq/√Len: 238.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_G163_I3.2141.00
29_K169_A3.0931.00
74_L88_S3.0621.00
5_D33_K3.0401.00
59_E62_R2.9301.00
39_L116_A2.8701.00
35_M96_C2.8631.00
26_K30_Q2.8161.00
29_K166_T2.7661.00
27_F32_K2.4831.00
63_I176_A2.4781.00
8_A24_I2.4171.00
115_N118_A2.3581.00
35_M70_I2.3391.00
9_F120_V2.2891.00
26_K166_T2.2191.00
6_V27_F2.1661.00
37_C92_V2.1591.00
103_M120_V2.0911.00
41_E54_K2.0331.00
70_I95_I2.0121.00
55_E59_E1.9841.00
25_A169_A1.9481.00
172_Q175_N1.8641.00
201_E205_K1.8491.00
59_E176_A1.7951.00
38_D57_A1.7881.00
17_E60_A1.7721.00
54_K58_A1.7571.00
27_F102_F1.7181.00
7_L93_I1.6911.00
7_L37_C1.6811.00
101_V124_I1.6771.00
33_K67_D1.6711.00
28_V34_V1.6561.00
70_I92_V1.6421.00
5_D99_K1.5661.00
85_A119_L1.5391.00
9_F37_C1.5351.00
35_M68_K1.5311.00
8_A102_F1.5121.00
90_V126_S1.5021.00
24_I28_V1.5011.00
8_A16_V1.4701.00
63_I169_A1.4581.00
20_M102_F1.4531.00
5_D35_M1.4471.00
88_S91_T1.4321.00
114_G118_A1.4291.00
41_E73_T1.4161.00
11_A104_P1.4041.00
92_V96_C1.3991.00
171_K175_N1.3951.00
86_I122_E1.3941.00
22_G170_K1.3791.00
25_A29_K1.3351.00
24_I64_L1.3181.00
169_A172_Q1.3111.00
63_I172_Q1.3051.00
70_I96_C1.3031.00
26_K165_D1.2971.00
54_K73_T1.2591.00
23_T27_F1.2511.00
64_L173_S1.2471.00
93_I101_V1.2041.00
59_E178_K1.1951.00
24_I34_V1.1941.00
84_Q88_S1.1891.00
168_E172_Q1.1681.00
101_V120_V1.1631.00
92_V95_I1.1591.00
55_E58_A1.1451.00
197_I201_E1.1451.00
10_G16_V1.1411.00
54_K71_Q1.1361.00
28_V67_D1.1301.00
72_L88_S1.1271.00
58_A62_R1.1251.00
36_I61_A1.1241.00
25_A173_S1.1231.00
10_G104_P1.1231.00
29_K165_D1.1201.00
90_V94_R1.1191.00
4_A99_K1.1131.00
60_A173_S1.1011.00
25_A64_L1.0981.00
201_E204_E1.0731.00
37_C89_I1.0691.00
91_T95_I1.0561.00
178_K182_I1.0401.00
56_E180_Q1.0381.00
74_L85_A1.0341.00
86_I126_S1.0241.00
26_K161_I1.0191.00
140_A143_V1.0131.00
57_A71_Q1.0101.00
75_P78_G1.0071.00
59_E63_I0.9991.00
40_T79_L0.9861.00
25_A166_T0.9861.00
115_N119_L0.9661.00
21_G64_L0.9651.00
42_A76_D0.9641.00
16_V36_I0.9581.00
48_G51_S0.9471.00
162_D166_T0.9421.00
58_A69_R0.9421.00
167_I171_K0.9381.00
94_R127_A0.9371.00
116_A120_V0.9281.00
7_L96_C0.9251.00
22_G162_D0.9241.00
86_I90_V0.9161.00
6_V32_K0.9111.00
198_E201_E0.9101.00
130_H133_K0.9011.00
89_I119_L0.8931.00
7_L98_P0.8910.99
6_V102_F0.8890.99
23_T161_I0.8880.99
56_E179_S0.8720.99
39_L72_L0.8660.99
7_L92_V0.8610.99
61_A69_R0.8600.99
43_E75_P0.8530.99
28_V65_G0.8450.99
44_L75_P0.8430.99
32_K99_K0.8410.99
76_D112_D0.8370.99
129_I133_K0.8360.99
105_Y108_D0.8350.99
9_F116_A0.8350.99
117_A121_E0.8340.99
35_M67_D0.8310.99
6_V100_A0.8300.99
9_F89_I0.8300.99
58_A71_Q0.8280.99
41_E50_V0.8200.99
88_S92_V0.8160.99
38_D69_R0.8140.99
74_L79_L0.8130.99
9_F39_L0.8080.99
128_G143_V0.8050.99
163_I166_T0.8030.99
13_S42_A0.8030.99
24_I36_I0.8000.99
87_R126_S0.7980.99
171_K201_E0.7970.99
202_A206_L0.7860.99
4_A35_M0.7820.99
44_L78_G0.7820.99
52_L179_S0.7760.99
103_M117_A0.7740.99
5_D32_K0.7730.99
82_S85_A0.7690.99
167_I201_E0.7680.99
57_A61_A0.7670.98
36_I66_A0.7620.98
129_I132_Y0.7620.98
17_E177_Y0.7610.98
144_S147_Y0.7600.98
167_I204_E0.7590.98
122_E125_F0.7590.98
53_R76_D0.7550.98
198_E202_A0.7450.98
138_L142_K0.7440.98
80_I83_D0.7440.98
131_K134_D0.7360.98
168_E171_K0.7210.98
166_T169_A0.7210.98
68_K96_C0.7200.98
172_Q176_A0.7170.98
32_K102_F0.7090.97
79_L85_A0.7080.97
21_G170_K0.7020.97
25_A28_V0.7000.97
37_C96_C0.6980.97
21_G173_S0.6970.97
44_L77_R0.6930.97
43_E50_V0.6930.97
79_L112_D0.6900.97
198_E205_K0.6890.97
79_L115_N0.6860.97
203_R206_L0.6860.97
145_K148_Y0.6860.97
86_I123_A0.6770.97
53_R180_Q0.6770.97
199_I206_L0.6760.97
106_K117_A0.6750.97
14_D113_H0.6750.97
45_S76_D0.6740.97
38_D71_Q0.6730.97
89_I120_V0.6730.97
129_I134_D0.6730.97
61_A66_A0.6710.97
145_K149_Y0.6690.96
138_L141_H0.6690.96
104_P108_D0.6650.96
22_G166_T0.6590.96
83_D87_R0.6510.96
17_E57_A0.6500.96
87_R91_T0.6470.96
139_P143_V0.6450.96
33_K68_K0.6400.95
39_L79_L0.6390.95
14_D110_H0.6380.95
138_L147_Y0.6340.95
184_S187_S0.6330.95
39_L89_I0.6310.95
5_D96_C0.6310.95
37_C72_L0.6300.95
139_P142_K0.6270.95
60_A176_A0.6260.95
199_I202_A0.6260.95
14_D53_R0.6220.95
84_Q87_R0.6180.94
79_L116_A0.6120.94
51_S55_E0.6110.94
16_V57_A0.6100.94
15_D113_H0.6100.94
99_K144_S0.6060.94
51_S54_K0.6060.94
21_G25_A0.6030.94
118_A122_E0.6020.94
42_A77_R0.6020.94
181_F186_D0.6020.94
146_V149_Y0.6010.94
47_N51_S0.5980.93
90_V123_A0.5960.93
142_K145_K0.5950.93
17_E21_G0.5930.93
143_V147_Y0.5910.93
163_I170_K0.5880.93
57_A177_Y0.5850.93
108_D117_A0.5830.93
81_M118_A0.5810.92
11_A116_A0.5810.92
144_S150_M0.5800.92
154_F157_P0.5780.92
10_G20_M0.5740.92
124_I128_G0.5740.92
7_L101_V0.5710.92
147_Y150_M0.5700.92
41_E71_Q0.5690.92
163_I167_I0.5670.92
108_D114_G0.5620.91
93_I123_A0.5590.91
45_S180_Q0.5580.91
20_M23_T0.5570.91
124_I143_V0.5540.91
142_K146_V0.5510.90
85_A88_S0.5510.90
93_I124_I0.5480.90
174_L181_F0.5450.90
49_T180_Q0.5410.90
14_D177_Y0.5400.90
17_E61_A0.5400.90
45_S49_T0.5390.89
153_G157_P0.5380.89
23_T102_F0.5350.89
144_S148_Y0.5340.89
145_K150_M0.5330.89
162_D165_D0.5330.89
104_P114_G0.5320.89
42_A53_R0.5300.89
12_H15_D0.5280.88
31_E34_V0.5280.88
4_A32_K0.5230.88
63_I173_S0.5210.88
20_M104_P0.5200.88
175_N182_I0.5200.88
143_V146_V0.5200.88
38_D177_Y0.5200.88
77_R111_P0.5180.88
197_I204_E0.5180.88
94_R141_H0.5130.87
139_P145_K0.5100.87
53_R56_E0.5090.87
93_I98_P0.5070.86
199_I205_K0.5060.86
40_T53_R0.5050.86
140_A147_Y0.5040.86
116_A119_L0.5040.86
102_F149_Y0.5020.86
103_M116_A0.5020.86
18_I21_G0.5010.86
23_T26_K0.5000.86
143_V149_Y0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ixdA 5 0.9831 100 0.18 Contact Map
1uanA 5 0.9322 100 0.208 Contact Map
4xlzA 5 0.9534 100 0.235 Contact Map
5bmoA 3 0.9195 100 0.253 Contact Map
3dfiA 1 0.8856 100 0.301 Contact Map
3dffA 1 0.911 100 0.303 Contact Map
1q74A 1 0.9153 100 0.333 Contact Map
3ot5A 2 0.9153 94.1 0.904 Contact Map
2iuyA 1 0.7331 89.4 0.916 Contact Map
4fkzA 2 0.9153 83.9 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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