GREMLIN Database
MGSA - Methylglyoxal synthase
UniProt: P42980 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (121)
Sequences: 1263 (622)
Seq/√Len: 56.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_H51_R4.0721.00
2_K30_D3.5431.00
23_R46_G2.4101.00
19_T26_L2.3251.00
18_F78_L2.2921.00
111_T115_L2.2721.00
78_L109_M2.2531.00
33_A38_G2.2241.00
2_K32_Y2.1881.00
21_A113_E2.0931.00
79_R99_D2.0281.00
39_L43_E1.9491.00
66_L71_A1.9231.00
53_Q68_A1.9141.00
61_Q64_G1.8741.00
29_H73_D1.8661.00
6_I63_I1.8480.99
4_A63_I1.8280.99
3_I74_L1.8140.99
64_G93_A1.7790.99
52_F66_L1.7660.99
53_Q101_Y1.7430.99
36_T54_S1.7410.99
32_Y66_L1.7110.99
61_Q93_A1.6940.99
62_Q69_A1.6880.99
13_Q40_K1.6520.99
18_F113_E1.5600.98
50_E66_L1.5420.98
16_V40_K1.5330.98
11_K14_D1.5170.98
38_G51_R1.5050.98
19_T41_I1.4450.97
67_I75_V1.4430.97
99_D107_T1.4200.97
10_K83_T1.3990.96
32_Y72_L1.3950.96
88_E92_S1.3910.96
39_L51_R1.3850.96
18_F116_V1.3580.96
21_A109_M1.3350.95
6_I75_V1.3250.95
15_M41_I1.2940.94
74_L115_L1.2730.94
23_R27_K1.2540.93
43_E51_R1.2170.92
56_P87_H1.2020.92
20_T44_A1.1970.92
40_K44_A1.1960.92
24_D27_K1.1920.92
35_G51_R1.1760.91
13_Q17_Q1.1650.91
2_K72_L1.1540.90
61_Q97_L1.1330.89
56_P60_D1.1260.89
41_I45_T1.1260.89
52_F72_L1.0810.87
114_I118_T1.0810.87
18_F22_Y1.0730.87
22_Y25_I1.0600.86
32_Y52_F1.0310.84
3_I29_H1.0270.84
72_L102_S1.0270.84
22_Y113_E0.9470.79
67_I91_V0.9230.77
21_A122_G0.9140.77
92_S99_D0.9020.76
66_L69_A0.8930.75
42_H48_Q0.8930.75
14_D109_M0.8800.74
87_H90_D0.8800.74
29_H74_L0.8680.73
2_K29_H0.8680.73
95_I105_L0.8650.72
29_H118_T0.8640.72
9_D12_K0.8610.72
104_P110_G0.8610.72
42_H46_G0.8570.72
32_Y50_E0.8490.71
56_P90_D0.8300.69
54_S60_D0.8260.69
21_A25_I0.8150.68
15_M26_L0.8150.68
60_D87_H0.8100.67
27_K30_D0.8090.67
70_N122_G0.8040.67
17_Q21_A0.8030.67
52_F63_I0.8000.66
19_T45_T0.7990.66
21_A70_N0.7910.66
33_A41_I0.7880.65
56_P91_V0.7850.65
79_R83_T0.7820.65
52_F118_T0.7780.64
106_A111_T0.7740.64
98_C101_Y0.7450.61
85_Q93_A0.7450.61
25_I117_R0.7390.60
22_Y118_T0.7390.60
20_T23_R0.7370.60
18_F107_T0.7320.60
17_Q20_T0.7310.59
54_S87_H0.7240.59
54_S86_P0.7240.59
114_I117_R0.7170.58
20_T122_G0.7160.58
86_P100_V0.7140.58
30_D50_E0.7130.58
86_P91_V0.7120.57
67_I97_L0.7110.57
13_Q44_A0.7090.57
64_G90_D0.6960.56
98_C105_L0.6940.56
79_R92_S0.6880.55
79_R88_E0.6790.54
26_L76_I0.6770.54
72_L103_I0.6740.53
28_N120_D0.6730.53
36_T87_H0.6700.53
87_H91_V0.6630.52
79_R89_P0.6580.52
115_L118_T0.6490.51
41_I44_A0.6490.51
75_V98_C0.6450.50
79_R105_L0.6450.50
119_L122_G0.6430.50
80_D94_L0.6400.50
61_Q68_A0.6380.49
56_P82_L0.6330.49
82_L87_H0.6320.49
79_R107_T0.6310.49
56_P94_L0.6300.49
57_L101_Y0.6290.48
5_L19_T0.6240.48
117_R121_E0.6150.47
23_R42_H0.6030.46
23_R45_T0.6010.45
60_D90_D0.5960.45
106_A115_L0.5910.44
10_K85_Q0.5830.43
32_Y38_G0.5830.43
53_Q69_A0.5780.43
77_F87_H0.5780.43
55_G60_D0.5780.43
79_R101_Y0.5780.43
60_D86_P0.5770.43
5_L41_I0.5670.42
20_T50_E0.5650.42
82_L86_P0.5630.41
6_I52_F0.5620.41
4_A66_L0.5620.41
60_D100_V0.5600.41
30_D48_Q0.5590.41
79_R95_I0.5560.41
90_D96_R0.5540.40
17_Q109_M0.5510.40
14_D17_Q0.5460.40
56_P86_P0.5450.39
99_D104_P0.5420.39
34_T77_F0.5420.39
18_F110_G0.5390.39
41_I101_Y0.5380.39
95_I107_T0.5370.39
23_R48_Q0.5340.38
3_I117_R0.5300.38
62_Q110_G0.5300.38
62_Q101_Y0.5280.38
56_P100_V0.5270.38
21_A110_G0.5270.38
64_G91_V0.5230.37
18_F79_R0.5210.37
92_S101_Y0.5180.37
52_F57_L0.5160.36
86_P89_P0.5150.36
12_K34_T0.5130.36
65_A68_A0.5100.36
30_D119_L0.5090.36
56_P96_R0.5080.36
2_K71_A0.5040.35
9_D80_D0.5040.35
16_V45_T0.5040.35
15_M53_Q0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xw6A 5 0.927 100 0.426 Contact Map
1vmdA 5 0.9927 100 0.45 Contact Map
1b93A 5 0.9927 100 0.455 Contact Map
2yvqA 2 0.8175 99.9 0.581 Contact Map
1a9xA 3 0.9416 99.9 0.597 Contact Map
3zzmA 2 0.9708 95.8 0.886 Contact Map
1g8mA 2 0.9708 95.4 0.89 Contact Map
1zczA 2 0.8978 93.5 0.9 Contact Map
2pfzA 1 0.7956 58.8 0.932 Contact Map
3fxbA 1 0.7518 48.9 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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