GREMLIN Database
YPJC - UPF0750 membrane protein YpjC
UniProt: P42978 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (272)
Sequences: 3718 (2690)
Seq/√Len: 163.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_L82_V5.7661.00
208_K211_L5.1001.00
228_K237_D3.9371.00
229_G240_V3.8161.00
214_K218_E3.4981.00
207_S238_I3.3661.00
206_S212_I3.1611.00
18_A90_F2.9851.00
113_F176_M2.7361.00
202_A253_L2.7101.00
230_Q235_K2.5461.00
38_F60_L2.5391.00
230_Q239_D2.4071.00
215_K256_V2.3661.00
206_S209_N2.3581.00
227_L240_V2.3421.00
210_D214_K2.2851.00
215_K219_E2.2141.00
200_K270_D2.1421.00
228_K239_D2.1101.00
224_V232_S2.0741.00
45_L49_F2.0401.00
10_I82_V2.0191.00
9_N79_Y1.9941.00
85_V89_L1.9681.00
25_V94_F1.9661.00
14_L86_A1.9411.00
166_L175_A1.9161.00
16_G121_G1.9131.00
222_R249_E1.9071.00
23_G118_I1.8841.00
20_F87_L1.8741.00
21_S90_F1.8661.00
187_R191_F1.8551.00
22_F26_H1.8491.00
12_F128_F1.8461.00
54_S92_S1.7991.00
125_I132_T1.7471.00
213_Q232_S1.7331.00
151_G190_D1.7101.00
166_L172_Y1.7021.00
257_I264_A1.6841.00
106_D177_Y1.6831.00
45_L56_S1.6731.00
216_I253_L1.6691.00
226_I241_L1.6571.00
207_S236_E1.6561.00
224_V241_L1.6281.00
31_N110_A1.6141.00
257_I266_V1.5811.00
171_S174_E1.5681.00
209_N239_D1.5681.00
9_N128_F1.5581.00
66_F70_R1.5321.00
220_M253_L1.5241.00
123_G192_I1.5011.00
213_Q235_K1.4981.00
207_S263_H1.4871.00
230_Q237_D1.4861.00
215_K260_I1.4811.00
210_D235_K1.4791.00
108_A180_V1.4651.00
242_Y267_A1.4441.00
201_G269_S1.4261.00
76_M131_T1.4171.00
213_Q226_I1.4101.00
18_A94_F1.4101.00
22_F94_F1.3881.00
203_T242_Y1.3771.00
25_V95_Q1.3761.00
160_C164_L1.3651.00
13_I83_G1.3641.00
16_G125_I1.3621.00
156_A160_C1.3611.00
38_F64_I1.3241.00
41_I45_L1.3181.00
229_G238_I1.3151.00
245_V253_L1.3061.00
62_I66_F1.2991.00
57_N91_L1.2741.00
52_S92_S1.2731.00
54_S88_S1.2711.00
162_I182_V1.2691.00
263_H277_E1.2651.00
211_L260_I1.2641.00
28_N114_A1.2571.00
119_G123_G1.2431.00
216_I243_C1.2371.00
155_F186_A1.2221.00
72_L76_M1.2201.00
78_V82_V1.1981.00
68_G77_F1.1941.00
13_I130_G1.1851.00
139_A154_M1.1821.00
204_I257_I1.1771.00
17_A86_A1.1771.00
201_G267_A1.1671.00
32_N174_E1.1661.00
23_G121_G1.1621.00
183_F187_R1.1611.00
69_W74_R1.1531.00
226_I239_D1.1531.00
23_G117_F1.1421.00
203_T269_S1.1421.00
65_F84_T1.1411.00
254_K273_D1.1391.00
201_G271_V1.1321.00
7_L11_F1.1231.00
217_L232_S1.1231.00
159_A163_I1.1231.00
116_V188_L1.1191.00
10_I79_Y1.1171.00
58_L88_S1.1151.00
215_K259_S1.1121.00
142_V146_F1.1121.00
250_L268_V1.1081.00
29_M53_P1.1051.00
54_S58_L1.0991.00
107_L174_E1.0901.00
261_D264_A1.0851.00
225_T229_G1.0810.99
202_A250_L1.0750.99
111_A115_G1.0710.99
86_A90_F1.0670.99
231_G234_T1.0590.99
8_K12_F1.0590.99
10_I14_L1.0490.99
69_W77_F1.0490.99
11_F15_I1.0440.99
82_V86_A1.0420.99
106_D173_K1.0330.99
213_Q224_V1.0330.99
109_L113_F1.0320.99
256_V259_S1.0320.99
226_I232_S1.0270.99
71_L145_Y1.0260.99
41_I164_L1.0240.99
51_I56_S1.0230.99
43_L46_Y0.9970.99
34_A165_S0.9830.99
72_L140_R0.9780.99
27_F113_F0.9760.99
83_G130_G0.9750.99
216_I222_R0.9700.99
203_T227_L0.9700.99
55_I92_S0.9630.99
200_K273_D0.9570.99
267_A271_V0.9520.99
111_A180_V0.9380.99
56_S60_L0.9280.98
34_A158_D0.9250.98
12_F124_I0.9240.98
201_G244_V0.9230.98
151_G186_A0.9140.98
190_D247_K0.9120.98
28_N181_A0.9110.98
107_L111_A0.9110.98
151_G189_I0.9090.98
253_L257_I0.9070.98
201_G242_Y0.9010.98
212_I256_V0.8980.98
116_V183_F0.8980.98
17_A83_G0.8960.98
203_T267_A0.8950.98
32_N47_A0.8940.98
251_V255_S0.8930.98
217_L224_V0.8920.98
39_T91_L0.8910.98
63_P66_F0.8850.98
75_T79_Y0.8790.98
6_R9_N0.8680.98
72_L131_T0.8680.98
71_L141_L0.8650.98
115_G119_G0.8630.98
92_S95_Q0.8450.97
246_P249_E0.8440.97
122_L126_F0.8400.97
67_I71_L0.8390.97
217_L223_G0.8370.97
34_A178_T0.8300.97
227_L242_Y0.8280.97
17_A125_I0.8240.97
44_L48_L0.8230.97
226_I230_Q0.8230.97
148_I153_T0.8230.97
120_A192_I0.8190.97
131_T140_R0.8190.97
65_F80_T0.8170.97
202_A245_V0.8130.96
185_A189_I0.8120.96
215_K218_E0.8060.96
20_F121_G0.8050.96
33_L111_A0.7980.96
46_Y53_P0.7980.96
202_A257_I0.7920.96
154_M158_D0.7900.96
107_L110_A0.7900.96
65_F81_L0.7900.96
199_A243_C0.7890.96
41_I44_L0.7870.96
256_V260_I0.7860.96
244_V267_A0.7850.96
8_K128_F0.7820.96
122_L189_I0.7780.95
123_G127_K0.7740.95
55_I59_V0.7730.95
141_L145_Y0.7720.95
19_I120_A0.7710.95
126_F140_R0.7700.95
214_K235_K0.7700.95
109_L176_M0.7690.95
23_G27_F0.7690.95
46_Y50_H0.7640.95
44_L169_Y0.7640.95
64_I138_I0.7630.95
142_V153_T0.7580.95
44_L164_L0.7580.95
156_A159_A0.7570.95
59_V63_P0.7570.95
18_A86_A0.7550.95
63_P67_I0.7550.95
213_Q217_L0.7500.94
255_S259_S0.7480.94
132_T136_D0.7350.94
149_P152_R0.7340.94
6_R79_Y0.7340.94
45_L51_I0.7340.94
208_K260_I0.7310.94
149_P190_D0.7310.94
17_A87_L0.7310.94
78_V81_L0.7300.94
24_L87_L0.7290.94
112_L184_V0.7260.93
135_V157_F0.7240.93
254_K275_L0.7220.93
200_K268_V0.7220.93
58_L62_I0.7180.93
58_L85_V0.7180.93
52_S55_I0.7180.93
187_R190_D0.7170.93
65_F68_G0.7120.93
138_I142_V0.7090.93
104_Q173_K0.7080.93
206_S261_D0.7070.93
224_V243_C0.7040.92
182_V186_A0.7030.92
41_I60_L0.7030.92
209_N212_I0.7020.92
135_V169_Y0.7010.92
110_A173_K0.6990.92
7_L10_I0.6990.92
219_E252_M0.6980.92
112_L180_V0.6980.92
164_L167_L0.6960.92
219_E256_V0.6960.92
26_H94_F0.6930.92
155_F183_F0.6920.92
160_C163_I0.6890.92
222_R246_P0.6850.91
45_L60_L0.6850.91
90_F93_I0.6810.91
208_K261_D0.6760.91
24_L42_T0.6750.91
42_T57_N0.6740.91
64_I80_T0.6730.91
198_A247_K0.6730.91
210_D239_D0.6730.91
20_F118_I0.6720.91
66_F69_W0.6710.90
258_N275_L0.6700.90
40_G177_Y0.6690.90
118_I185_A0.6690.90
252_M255_S0.6690.90
140_R150_M0.6680.90
15_I19_I0.6670.90
79_Y129_G0.6660.90
24_L29_M0.6650.90
12_F15_I0.6640.90
205_I242_Y0.6640.90
133_G136_D0.6630.90
152_R190_D0.6620.90
49_F56_S0.6620.90
222_R278_G0.6610.90
94_F97_Y0.6580.90
225_T231_G0.6550.89
125_I130_G0.6550.89
212_I260_I0.6550.89
19_I117_F0.6530.89
223_G233_Y0.6510.89
202_A268_V0.6510.89
68_G76_M0.6490.89
135_V158_D0.6490.89
122_L132_T0.6490.89
124_I128_F0.6480.89
106_D111_A0.6400.88
255_S258_N0.6380.88
76_M140_R0.6370.88
126_F136_D0.6360.88
105_H173_K0.6350.88
84_T88_S0.6350.88
111_A184_V0.6320.88
222_R279_F0.6310.88
231_G238_I0.6290.87
154_M189_I0.6250.87
163_I167_L0.6240.87
162_I165_S0.6220.87
29_M46_Y0.6220.87
140_R144_K0.6220.87
21_S87_L0.6180.87
56_S59_V0.6170.86
29_M43_L0.6170.86
137_I151_G0.6160.86
122_L185_A0.6150.86
165_S175_A0.6140.86
111_A181_A0.6140.86
102_P108_A0.6120.86
244_V271_V0.6100.86
113_F179_L0.6080.86
39_T87_L0.6070.86
67_I141_L0.6070.86
204_I253_L0.6050.85
73_G199_A0.6010.85
152_R155_F0.6010.85
80_T137_I0.6000.85
35_E136_D0.5990.85
175_A181_A0.5990.85
209_N213_Q0.5960.85
194_E272_H0.5960.85
89_L93_I0.5950.84
34_A43_L0.5940.84
158_D178_T0.5910.84
219_E259_S0.5910.84
268_V273_D0.5870.84
200_K238_I0.5870.84
8_K127_K0.5870.84
46_Y56_S0.5820.83
203_T240_V0.5790.83
42_T242_Y0.5790.83
265_F274_V0.5780.83
115_G184_V0.5760.82
119_G189_I0.5760.82
104_Q110_A0.5730.82
178_T245_V0.5720.82
67_I70_R0.5720.82
245_V250_L0.5720.82
81_L84_T0.5710.82
206_S239_D0.5700.82
79_Y178_T0.5680.82
48_L63_P0.5670.81
158_D278_G0.5660.81
150_M190_D0.5660.81
120_A188_L0.5650.81
204_I243_C0.5630.81
70_R88_S0.5620.81
83_G132_T0.5620.81
26_H30_Q0.5560.80
137_I189_I0.5530.80
254_K258_N0.5530.80
20_F122_L0.5490.79
43_L242_Y0.5460.79
225_T265_F0.5450.79
107_L177_Y0.5420.79
18_A22_F0.5410.78
42_T60_L0.5410.78
43_L53_P0.5400.78
50_H56_S0.5400.78
53_P57_N0.5380.78
203_T271_V0.5350.78
126_F150_M0.5350.78
157_F161_V0.5320.77
221_E277_E0.5270.77
43_L47_A0.5270.77
148_I152_R0.5230.76
44_L161_V0.5230.76
212_I257_I0.5220.76
234_T263_H0.5210.76
52_S96_R0.5210.76
226_I235_K0.5210.76
103_L107_L0.5210.76
104_Q107_L0.5200.76
112_L238_I0.5190.76
143_N147_G0.5170.75
211_L214_K0.5160.75
115_G185_A0.5150.75
109_L183_F0.5150.75
65_F106_D0.5140.75
63_P187_R0.5140.75
30_Q127_K0.5120.75
65_F138_I0.5110.74
196_G199_A0.5100.74
64_I133_G0.5100.74
74_R77_F0.5090.74
54_S57_N0.5080.74
156_A164_L0.5080.74
207_S212_I0.5080.74
262_P270_D0.5070.74
98_E103_L0.5050.74
86_A93_I0.5040.73
218_E221_E0.5030.73
171_S175_A0.5030.73
47_A169_Y0.5030.73
9_N75_T0.5030.73
108_A118_I0.5020.73
241_L266_V0.5020.73
9_N12_F0.5010.73
166_L171_S0.5010.73
80_T84_T0.5000.73
28_N165_S0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hluA 2 0.2517 99.9 0.691 Contact Map
2gw8A 3 0.3103 81 0.943 Contact Map
3l7pA 4 0.2862 76.4 0.946 Contact Map
4rwwA 3 0.2897 76.2 0.946 Contact Map
2dclA 5 0.3 75.6 0.946 Contact Map
2eg2A 5 0.3 74.5 0.946 Contact Map
4co3A 3 0.2966 73.8 0.947 Contact Map
4affA 3 0.3207 71.5 0.948 Contact Map
3ncqA 4 0.3207 71.1 0.948 Contact Map
2j9cA 3 0.3276 70.8 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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