GREMLIN Database
CCA - CCA-adding enzyme
UniProt: P42977 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (369)
Sequences: 5468 (4011)
Seq/√Len: 208.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_E182_K3.8811.00
134_K138_Q3.8141.00
135_D142_R3.2351.00
348_T351_D3.2291.00
121_T125_K3.1001.00
131_G134_K2.9101.00
32_S120_M2.8921.00
113_L161_A2.7911.00
276_P279_V2.7571.00
34_M136_I2.7331.00
158_M220_L2.6591.00
22_A43_I2.6181.00
303_G307_L2.5481.00
226_G272_A2.4741.00
62_V70_I2.4691.00
115_I136_I2.4061.00
177_E218_T2.3661.00
177_E217_Q2.3661.00
56_F71_V2.3471.00
103_S106_E2.3151.00
108_L119_A2.3051.00
133_K137_D2.2771.00
51_Q54_R2.2751.00
118_M133_K2.2471.00
166_S205_G2.2251.00
24_F28_A2.2101.00
146_K149_D2.2061.00
115_I141_I2.1531.00
352_L364_V2.1511.00
21_Q46_D2.1271.00
118_M129_Y1.9771.00
188_S223_E1.9651.00
200_E248_R1.9421.00
363_W366_E1.9401.00
374_A379_K1.9041.00
53_E61_D1.9001.00
295_D298_T1.8871.00
169_G210_Q1.8731.00
173_S176_T1.8511.00
300_Y303_G1.8361.00
142_R173_S1.8181.00
362_K366_E1.7971.00
20_H47_A1.7751.00
317_R320_E1.7721.00
118_M126_V1.7621.00
134_K137_D1.7441.00
105_E129_Y1.7331.00
225_P228_Y1.7281.00
197_I201_K1.7261.00
23_Y83_F1.7211.00
165_M172_L1.6951.00
43_I46_D1.6851.00
267_P284_I1.6781.00
358_R363_W1.6781.00
148_E183_E1.6741.00
213_Q217_Q1.6711.00
374_A380_L1.6651.00
13_R17_E1.6591.00
161_A180_I1.6561.00
332_Y336_N1.6501.00
48_A51_Q1.6361.00
141_I161_A1.6311.00
196_T200_E1.6191.00
165_M214_T1.6121.00
270_L280_I1.6031.00
68_T81_T1.5751.00
16_I122_A1.5721.00
109_K130_F1.5631.00
158_M180_I1.5601.00
204_Q248_R1.5471.00
53_E64_K1.5461.00
353_L364_V1.5351.00
178_E182_K1.5331.00
202_L211_A1.5261.00
345_L375_V1.5181.00
271_K280_I1.5021.00
85_T106_E1.4951.00
141_I170_F1.4721.00
33_Y136_I1.4591.00
196_T275_L1.4591.00
155_A186_L1.4521.00
161_A172_L1.4501.00
360_A364_V1.4471.00
151_F176_T1.4461.00
162_V215_L1.4301.00
24_F41_V1.4171.00
365_S369_Q1.4121.00
346_D375_V1.4061.00
72_L77_T1.4061.00
266_A287_A1.3981.00
252_W270_L1.3971.00
277_G280_I1.3921.00
304_K307_L1.3901.00
143_T151_F1.3711.00
85_T101_I1.3711.00
120_M124_G1.3671.00
59_T69_I1.3651.00
21_Q121_T1.3641.00
172_L214_T1.3461.00
104_L119_A1.3391.00
352_L368_L1.3241.00
200_E275_L1.3221.00
152_Q183_E1.3181.00
172_L176_T1.3111.00
333_A337_L1.3071.00
200_E252_W1.3041.00
118_M136_I1.3031.00
367_E370_W1.2991.00
18_A55_L1.2961.00
270_L283_A1.2911.00
15_L52_V1.2851.00
172_L177_E1.2811.00
14_I55_L1.2791.00
43_I78_Y1.2701.00
216_I231_R1.2681.00
20_H46_D1.2641.00
89_Y97_E1.2631.00
252_W256_L1.2611.00
323_D327_L1.2551.00
236_S239_E1.2521.00
358_R367_E1.2411.00
300_Y304_K1.2411.00
350_K353_L1.2351.00
358_R364_V1.2301.00
334_Y337_L1.2281.00
128_D132_G1.1931.00
106_E109_K1.1921.00
200_E279_V1.1921.00
199_F211_A1.1891.00
16_I123_D1.1881.00
370_W374_A1.1881.00
58_R72_L1.1861.00
156_L191_S1.1861.00
351_D354_A1.1821.00
158_M187_L1.1811.00
94_R98_V1.1781.00
44_A83_F1.1721.00
177_E181_A1.1691.00
235_I239_E1.1691.00
145_G150_R1.1681.00
139_K169_G1.1671.00
47_A51_Q1.1611.00
240_F258_N1.1591.00
108_L130_F1.1591.00
91_D94_R1.1571.00
12_L15_L1.1531.00
367_E371_I1.1501.00
329_D333_A1.1481.00
186_L189_H1.1481.00
187_L223_E1.1461.00
162_V220_L1.1431.00
280_I284_I1.1391.00
136_I139_K1.1371.00
357_N361_G1.1341.00
314_S320_E1.1311.00
330_I333_A1.1291.00
117_A144_V1.1241.00
366_E370_W1.1171.00
148_E152_Q1.1171.00
71_V80_V1.1131.00
193_E274_K1.1091.00
169_G207_A1.0931.00
50_D54_R1.0931.00
350_K354_A1.0901.00
284_I288_D1.0891.00
114_T142_R1.0851.00
353_L360_A1.0841.00
38_I41_V1.0831.00
162_V218_T1.0811.00
192_V272_A1.0811.00
329_D332_Y1.0801.00
21_Q83_F1.0791.00
183_E186_L1.0731.00
333_A336_N1.0701.00
316_L319_N1.0691.00
180_I220_L1.0691.00
104_L108_L1.0681.00
323_D326_K1.0671.00
270_L275_L1.0641.00
257_I290_F1.0641.00
120_M126_V1.0621.00
118_M130_F1.0591.00
309_S312_K1.0521.00
225_P230_K1.0511.00
36_R167_Q1.0511.00
167_Q201_K1.0401.00
121_T127_L1.0351.00
185_S188_S1.0321.00
33_Y133_K1.0311.00
282_E312_K1.0311.00
85_T99_Q1.0301.00
248_R279_V1.0281.00
300_Y307_L1.0271.00
161_A176_T1.0261.00
48_A102_S1.0231.00
214_T217_Q1.0221.00
222_E228_Y1.0211.00
257_I260_G1.0201.00
33_Y118_M1.0161.00
53_E69_I1.0151.00
330_I337_L1.0111.00
296_A301_R1.0081.00
353_L357_N1.0071.00
361_G365_S0.9981.00
196_T279_V0.9951.00
332_Y335_Q0.9931.00
263_L288_D0.9911.00
152_Q186_L0.9861.00
207_A210_Q0.9841.00
139_K168_L0.9781.00
105_E109_K0.9731.00
258_N290_F0.9731.00
92_F186_L0.9721.00
177_E214_T0.9711.00
238_S241_P0.9661.00
197_I200_E0.9661.00
315_Q318_Q0.9631.00
263_L284_I0.9621.00
174_P178_E0.9571.00
259_L269_F0.9561.00
249_E279_V0.9520.99
285_H288_D0.9490.99
219_R222_E0.9490.99
20_H51_Q0.9480.99
314_S317_R0.9400.99
331_Q335_Q0.9370.99
46_D83_F0.9360.99
279_V283_A0.9320.99
108_L129_Y0.9310.99
214_T218_T0.9300.99
70_I77_T0.9260.99
294_L298_T0.9240.99
269_F272_A0.9240.99
180_I218_T0.9210.99
15_L22_A0.9190.99
330_I334_Y0.9180.99
158_M218_T0.9160.99
93_R156_L0.9160.99
346_D382_N0.9140.99
143_T176_T0.9120.99
257_I262_V0.9100.99
36_R168_L0.9070.99
28_A38_I0.9060.99
358_R365_S0.9060.99
328_K332_Y0.9040.99
14_I17_E0.9040.99
178_E181_A0.9000.99
64_K69_I0.8980.99
246_T250_E0.8970.99
237_T240_F0.8920.99
256_L266_A0.8850.99
261_I264_K0.8840.99
281_K284_I0.8790.99
362_K365_S0.8780.99
267_P280_I0.8740.99
167_Q205_G0.8730.99
140_V171_T0.8700.99
378_G381_S0.8650.99
256_L259_L0.8610.99
258_N262_V0.8540.99
248_R252_W0.8530.99
352_L357_N0.8490.99
253_A286_I0.8480.99
256_L269_F0.8470.99
63_G66_H0.8460.99
316_L320_E0.8450.99
23_Y104_L0.8430.99
86_E95_P0.8410.99
140_V173_S0.8400.99
199_F212_L0.8390.99
66_H81_T0.8360.99
150_R153_E0.8340.99
240_F290_F0.8290.99
311_A317_R0.8280.99
199_F224_L0.8260.99
31_D167_Q0.8260.99
92_F189_H0.8250.99
88_D95_P0.8250.99
31_D36_R0.8240.99
312_K317_R0.8230.99
149_D152_Q0.8210.98
277_G281_K0.8200.98
232_E235_I0.8190.98
209_R213_Q0.8160.98
215_L221_Y0.8110.98
143_T173_S0.8100.98
267_P281_K0.8100.98
322_L326_K0.8090.98
95_P98_V0.8020.98
349_G364_V0.8020.98
328_K331_Q0.8020.98
234_L237_T0.8020.98
52_V69_I0.8000.98
237_T241_P0.7990.98
348_T354_A0.7970.98
137_D140_V0.7970.98
208_S251_L0.7960.98
329_D335_Q0.7960.98
172_L180_I0.7940.98
311_A315_Q0.7940.98
264_K268_L0.7940.98
66_H70_I0.7930.98
262_V265_D0.7920.98
60_V75_D0.7900.98
199_F273_W0.7880.98
62_V66_H0.7830.98
267_P271_K0.7830.98
166_S211_A0.7820.98
16_I121_T0.7820.98
119_A130_F0.7810.98
51_Q102_S0.7800.98
247_S282_E0.7770.98
331_Q334_Y0.7770.98
14_I18_A0.7760.98
262_V266_A0.7750.98
351_D368_L0.7750.98
162_V211_A0.7730.98
313_I317_R0.7710.98
369_Q373_Q0.7710.98
51_Q55_L0.7680.98
298_T301_R0.7640.98
165_M210_Q0.7620.98
12_L16_I0.7610.98
299_M303_G0.7590.97
233_N236_S0.7590.97
247_S312_K0.7590.97
120_M125_K0.7580.97
378_G382_N0.7550.97
156_L193_E0.7550.97
322_L327_L0.7520.97
27_G40_D0.7510.97
69_I81_T0.7510.97
89_Y95_P0.7470.97
329_D336_N0.7470.97
227_F255_L0.7460.97
227_F231_R0.7440.97
239_E242_F0.7410.97
370_W373_Q0.7400.97
11_V78_Y0.7390.97
23_Y127_L0.7370.97
119_A129_Y0.7360.97
311_A316_L0.7360.97
307_L314_S0.7340.97
49_P82_T0.7340.97
262_V290_F0.7330.97
20_H55_L0.7300.97
254_A316_L0.7300.97
363_W367_E0.7280.97
171_T210_Q0.7260.97
45_T52_V0.7230.97
27_G30_R0.7200.97
12_L43_I0.7180.97
213_Q216_I0.7170.96
139_K171_T0.7160.96
318_Q328_K0.7160.96
259_L262_V0.7150.96
126_V133_K0.7150.96
296_A300_Y0.7140.96
311_A319_N0.7130.96
162_V214_T0.7130.96
60_V72_L0.7130.96
375_V382_N0.7090.96
175_E178_E0.7080.96
310_A314_S0.7070.96
342_L372_E0.7050.96
162_V180_I0.7050.96
308_L320_E0.7050.96
313_I316_L0.7030.96
233_N241_P0.7030.96
351_D355_L0.7010.96
174_P177_E0.7010.96
353_L358_R0.6990.96
287_A290_F0.6970.96
352_L367_E0.6970.96
122_A125_K0.6940.96
86_E93_R0.6930.96
239_E258_N0.6930.96
86_E92_F0.6920.96
275_L283_A0.6920.96
168_L205_G0.6920.96
366_E369_Q0.6910.96
374_A378_G0.6890.96
92_F155_A0.6880.96
349_G352_L0.6850.95
53_E59_T0.6800.95
253_A287_A0.6800.95
130_F144_V0.6780.95
331_Q336_N0.6780.95
291_G294_L0.6770.95
372_E376_V0.6760.95
25_V119_A0.6740.95
228_Y231_R0.6740.95
312_K315_Q0.6710.95
181_A217_Q0.6690.95
235_I238_S0.6690.95
275_L279_V0.6680.95
171_T174_P0.6660.95
15_L55_L0.6630.95
233_N237_T0.6600.94
235_I240_F0.6580.94
278_K282_E0.6580.94
282_E286_I0.6530.94
107_D163_R0.6520.94
91_D156_L0.6510.94
49_P53_E0.6490.94
216_I221_Y0.6490.94
305_K310_A0.6490.94
286_I313_I0.6490.94
143_T179_A0.6460.94
313_I320_E0.6450.94
373_Q377_T0.6450.94
246_T251_L0.6390.93
311_A320_E0.6390.93
226_G230_K0.6370.93
187_L190_V0.6360.93
92_F95_P0.6350.93
263_L287_A0.6330.93
147_P175_E0.6330.93
205_G208_S0.6330.93
212_L227_F0.6310.93
330_I336_N0.6310.93
260_G265_D0.6290.93
347_I371_I0.6200.92
269_F273_W0.6190.92
314_S318_Q0.6180.92
304_K310_A0.6180.92
307_L310_A0.6130.92
201_K205_G0.6130.92
343_K376_V0.6110.92
305_K308_L0.6100.92
20_H45_T0.6090.92
216_I229_H0.6080.92
184_K220_L0.6070.92
162_V177_E0.6060.92
296_A303_G0.6030.91
295_D303_G0.6030.91
371_I374_A0.6020.91
26_G30_R0.6000.91
187_L191_S0.5960.91
236_S240_F0.5940.91
300_Y305_K0.5940.91
355_L358_R0.5930.91
115_I168_L0.5930.91
232_E237_T0.5920.91
104_L129_Y0.5910.91
343_K375_V0.5910.91
22_A46_D0.5910.91
310_A317_R0.5910.91
27_G31_D0.5880.90
239_E290_F0.5870.90
210_Q213_Q0.5870.90
181_A184_K0.5870.90
52_V56_F0.5860.90
285_H306_A0.5850.90
151_F158_M0.5840.90
328_K335_Q0.5840.90
121_T124_G0.5830.90
47_A52_V0.5810.90
148_E179_A0.5810.90
190_V195_K0.5790.90
151_F179_A0.5790.90
142_R175_E0.5780.90
66_H94_R0.5770.89
297_M301_R0.5770.89
318_Q321_K0.5760.89
249_E253_A0.5750.89
200_E204_Q0.5750.89
211_A215_L0.5740.89
237_T242_F0.5730.89
87_S97_E0.5720.89
324_E328_K0.5710.89
265_D268_L0.5710.89
240_F257_I0.5670.89
63_G150_R0.5660.89
266_A284_I0.5650.88
303_G306_A0.5650.88
151_F180_I0.5650.88
256_L270_L0.5620.88
28_A41_V0.5620.88
216_I228_Y0.5620.88
177_E180_I0.5610.88
184_K223_E0.5600.88
349_G360_A0.5580.88
131_G138_Q0.5580.88
252_W275_L0.5560.88
266_A275_L0.5550.88
352_L358_R0.5550.88
84_R110_R0.5540.87
144_V150_R0.5530.87
162_V172_L0.5530.87
238_S242_F0.5530.87
330_I335_Q0.5500.87
236_S241_P0.5480.87
374_A381_S0.5480.87
349_G353_L0.5480.87
215_L220_L0.5480.87
74_E78_Y0.5470.87
314_S338_P0.5470.87
349_G355_L0.5460.87
86_E110_R0.5460.87
61_D64_K0.5440.87
63_G145_G0.5430.86
349_G368_L0.5430.86
187_L220_L0.5420.86
68_T95_P0.5400.86
239_E257_I0.5390.86
20_H82_T0.5380.86
302_A307_L0.5370.86
45_T80_V0.5370.86
15_L20_H0.5360.86
235_I257_I0.5350.86
56_F80_V0.5350.86
263_L266_A0.5350.86
36_R206_R0.5350.86
233_N238_S0.5340.86
135_D138_Q0.5340.86
303_G310_A0.5330.85
158_M183_E0.5310.85
371_I378_G0.5310.85
306_A309_S0.5300.85
135_D140_V0.5300.85
304_K317_R0.5290.85
314_S319_N0.5290.85
254_A257_I0.5280.85
215_L224_L0.5250.85
47_A82_T0.5220.84
161_A165_M0.5220.84
181_A219_R0.5220.84
94_R97_E0.5210.84
303_G309_S0.5180.84
260_G290_F0.5170.84
86_E98_V0.5170.84
165_M169_G0.5160.84
226_G265_D0.5160.84
297_M303_G0.5140.83
227_F230_K0.5140.83
52_V71_V0.5140.83
39_G201_K0.5140.83
369_Q372_E0.5130.83
50_D53_E0.5130.83
61_D70_I0.5120.83
376_V380_L0.5110.83
312_K320_E0.5100.83
307_L317_R0.5100.83
129_Y132_G0.5100.83
115_I118_M0.5070.83
285_H289_T0.5070.83
232_E236_S0.5060.82
82_T150_R0.5040.82
311_A314_S0.5030.82
61_D98_V0.5010.82
252_W279_V0.5000.82
224_L273_W0.5000.82
49_P52_V0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1miwA 2 0.9698 100 0.167 Contact Map
4x4wA 2 0.937 100 0.217 Contact Map
3h38A 1 0.9572 100 0.223 Contact Map
4wbyA 1 0.8514 100 0.251 Contact Map
3wfoA 1 0.7859 100 0.258 Contact Map
3wfrE 1 0.801 100 0.31 Contact Map
3wfpA 2 0.8035 100 0.342 Contact Map
3aqlA 2 0.8489 100 0.348 Contact Map
3wfsC 1 0.7935 100 0.384 Contact Map
4wh5A 2 0.3703 91.9 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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