GREMLIN Database
DAPB - 4-hydroxy-tetrahydrodipicolinate reductase
UniProt: P42976 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (240)
Sequences: 3788 (2305)
Seq/√Len: 148.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_P170_K3.8051.00
7_K32_D3.5731.00
138_K142_M3.2361.00
28_T250_E3.1841.00
88_K111_E2.6281.00
30_H250_E2.5751.00
61_D64_A2.3331.00
141_K177_E2.3091.00
139_F143_A2.2971.00
9_V71_P2.2931.00
84_K108_D2.2761.00
172_A206_L2.2611.00
105_S108_D2.1981.00
75_I249_V2.1941.00
219_E232_R2.1751.00
20_E23_K2.1231.00
124_I265_I2.0551.00
155_L214_L2.0511.00
136_M231_I2.0431.00
24_L246_K2.0271.00
34_V71_P2.0091.00
8_L31_F1.9971.00
114_S117_E1.9821.00
96_R122_G1.9781.00
219_E230_Q1.9661.00
110_K113_T1.9521.00
10_I21_A1.9341.00
142_M145_N1.8541.00
13_P36_A1.8261.00
150_V175_I1.7801.00
83_G104_F1.7361.00
228_T236_Y1.7311.00
153_I209_V1.7281.00
182_K185_G1.7161.00
91_L120_G1.7131.00
109_L125_I1.6801.00
25_A33_L1.6711.00
198_G203_G1.6611.00
79_T161_L1.6511.00
63_H92_E1.6401.00
21_A77_L1.6341.00
124_I252_V1.5991.00
113_T117_E1.5961.00
74_L90_A1.5961.00
89_I93_H1.5871.00
23_K27_R1.5761.00
71_P95_V1.5581.00
140_S171_T1.5511.00
16_R159_Q1.5481.00
19_Q23_K1.5441.00
31_F250_E1.5411.00
113_T259_V1.5401.00
141_K263_E1.5351.00
137_M174_M1.5121.00
124_I248_S1.4921.00
9_V35_G1.4501.00
170_K174_M1.4471.00
23_K239_A1.4391.00
84_K111_E1.4351.00
230_Q234_D1.4271.00
211_L223_G1.4141.00
11_A74_L1.4061.00
217_H234_D1.3981.00
257_Q260_Y1.3961.00
7_K72_D1.3881.00
132_G233_H1.3851.00
20_E239_A1.3761.00
25_A31_F1.3661.00
134_I262_L1.3291.00
85_V88_K1.3241.00
84_K104_F1.3161.00
188_D191_E1.3061.00
96_R253_M1.3061.00
10_I25_A1.3031.00
137_M171_T1.3011.00
170_K173_E1.3001.00
11_A86_H1.2991.00
136_M229_L1.2881.00
94_G120_G1.2841.00
109_L113_T1.2781.00
159_Q213_G1.2771.00
198_G202_N1.2631.00
153_I221_M1.2621.00
88_K92_E1.2551.00
141_K178_V1.2541.00
235_S240_S1.2451.00
106_E184_Q1.2331.00
79_T82_I1.2321.00
140_S175_I1.2061.00
14_R38_D1.2031.00
137_M170_K1.1971.00
106_E110_K1.1781.00
181_E202_N1.1721.00
60_T64_A1.1661.00
138_K263_E1.1641.00
107_A111_E1.1611.00
91_L121_I1.1551.00
138_K141_K1.1531.00
110_K114_S1.1521.00
13_P22_V1.1521.00
25_A246_K1.1341.00
98_V252_V1.1310.99
213_G226_G1.1280.99
17_M77_L1.1260.99
134_I137_M1.1230.99
235_S241_F1.1200.99
28_T31_F1.1100.99
63_H93_H1.1060.99
80_P108_D1.1020.99
87_T91_L1.1020.99
141_K145_N1.0960.99
73_V249_V1.0960.99
159_Q196_A1.0920.99
97_P123_A1.0870.99
187_P203_G1.0870.99
108_D111_E1.0790.99
189_E192_I1.0700.99
10_I22_V1.0680.99
91_L115_L1.0650.99
209_V221_M1.0620.99
84_K87_T1.0590.99
140_S231_I1.0520.99
31_F246_K1.0510.99
145_N178_V1.0450.99
59_Y69_T1.0370.99
16_R238_R1.0320.99
140_S220_V1.0290.99
136_M171_T1.0260.99
225_D239_A1.0260.99
153_I207_H0.9980.99
214_L217_H0.9910.99
141_K174_M0.9900.99
116_T259_V0.9870.99
41_Y60_T0.9840.99
251_Q254_K0.9830.99
62_I89_I0.9800.99
251_Q265_I0.9740.98
213_G236_Y0.9730.98
155_L209_V0.9720.98
251_Q255_I0.9580.98
189_E207_H0.9560.98
11_A37_I0.9460.98
22_V36_A0.9450.98
189_E208_S0.9450.98
27_R239_A0.9420.98
246_K250_E0.9400.98
8_L25_A0.9400.98
17_M242_M0.9390.98
74_L95_V0.9370.98
211_L224_M0.9360.98
214_L223_G0.9340.98
24_L242_M0.9320.98
84_K88_K0.9280.98
135_L139_F0.9260.98
135_L146_Y0.9160.98
87_T99_V0.9140.98
80_P101_T0.9090.98
122_G260_Y0.9090.98
83_G99_V0.9080.98
196_A199_A0.9050.98
99_V112_L0.9010.97
131_L247_L0.8860.97
195_G198_G0.8810.97
22_V33_L0.8810.97
115_L121_I0.8800.97
10_I33_L0.8790.97
155_L217_H0.8760.97
149_D182_K0.8760.97
107_A110_K0.8750.97
7_K70_Q0.8680.97
9_V34_V0.8610.97
81_E108_D0.8610.97
152_I172_A0.8600.97
11_A76_D0.8590.97
77_L245_V0.8580.97
139_F231_I0.8570.97
87_T112_L0.8530.96
89_I92_E0.8520.96
217_H232_R0.8420.96
13_P58_I0.8400.96
6_I73_V0.8400.96
159_Q225_D0.8380.96
12_G15_G0.8320.96
63_H89_I0.8280.96
104_F112_L0.8220.96
211_L214_L0.8190.96
174_M178_V0.8190.96
73_V252_V0.8170.95
152_I206_L0.8110.95
89_I95_V0.8050.95
96_R252_V0.8020.95
221_M228_T0.8000.95
86_H97_P0.7990.95
228_T234_D0.7910.95
130_A227_Q0.7870.94
140_S174_M0.7850.94
144_A222_F0.7840.94
116_T123_A0.7820.94
148_E179_R0.7820.94
9_V37_I0.7800.94
134_I266_I0.7770.94
140_S143_A0.7740.94
24_L239_A0.7730.94
83_G86_H0.7690.94
88_K115_L0.7690.94
73_V98_V0.7680.94
161_L196_A0.7660.94
113_T116_T0.7660.94
155_L232_R0.7650.94
111_E114_S0.7630.94
92_E115_L0.7560.93
175_I220_V0.7530.93
6_I31_F0.7520.93
248_S265_I0.7480.93
83_G87_T0.7460.93
218_Q233_H0.7440.93
179_R182_K0.7430.93
21_A25_A0.7420.93
136_M218_Q0.7390.92
133_A137_M0.7390.92
11_A78_T0.7360.92
189_E194_P0.7360.92
17_M238_R0.7340.92
172_A176_S0.7260.92
176_S183_Q0.7260.92
20_E24_L0.7240.92
28_T246_K0.7220.92
92_E120_G0.7210.91
124_I129_F0.7200.91
7_K34_V0.7170.91
104_F108_D0.7170.91
215_I237_N0.7160.91
24_L28_T0.7140.91
78_T100_G0.7100.91
122_G257_Q0.7090.91
8_L75_I0.7090.91
6_I253_M0.7050.91
78_T86_H0.7030.90
21_A75_I0.7030.90
30_H246_K0.6980.90
186_H191_E0.6920.90
175_I178_V0.6920.90
90_A97_P0.6830.89
11_A104_F0.6790.89
24_L243_S0.6740.89
117_E120_G0.6690.88
91_L111_E0.6650.88
155_L219_E0.6650.88
226_G240_S0.6640.88
157_H238_R0.6640.88
113_T177_E0.6570.87
242_M245_V0.6540.87
251_Q262_L0.6500.87
90_A121_I0.6460.86
23_K26_E0.6450.86
216_A238_R0.6440.86
94_G121_I0.6410.86
130_A235_S0.6380.86
35_G65_C0.6380.86
40_T60_T0.6360.85
183_Q206_L0.6340.85
151_E207_H0.6280.85
112_L125_I0.6250.85
88_K91_L0.6240.84
147_F224_M0.6230.84
181_E198_G0.6210.84
132_G218_Q0.6190.84
185_G202_N0.6190.84
109_L173_E0.6170.84
100_G129_F0.6150.84
84_K112_L0.6140.83
10_I13_P0.6120.83
7_K71_P0.6110.83
155_L221_M0.6110.83
104_F125_I0.6100.83
193_L196_A0.6100.83
6_I250_E0.6090.83
127_P137_M0.6090.83
11_A82_I0.6070.83
9_V65_C0.6040.82
195_G199_A0.6020.82
122_G252_V0.6010.82
33_L36_A0.6010.82
126_A170_K0.5950.82
151_E197_R0.5900.81
39_H81_E0.5890.81
143_A222_F0.5850.80
223_G228_T0.5840.80
84_K115_L0.5840.80
158_D212_P0.5820.80
159_Q238_R0.5820.80
149_D158_D0.5790.80
82_I86_H0.5750.79
157_H216_A0.5730.79
79_T101_T0.5720.79
214_L221_M0.5710.79
17_M21_A0.5710.79
65_C69_T0.5700.79
96_R260_Y0.5690.79
25_A34_V0.5650.78
223_G236_Y0.5640.78
233_H241_F0.5620.78
158_D199_A0.5620.78
247_L251_Q0.5610.78
123_A259_V0.5610.78
99_V123_A0.5610.78
148_E212_P0.5600.77
24_L27_R0.5590.77
171_T175_I0.5560.77
191_E194_P0.5560.77
39_H42_D0.5520.76
186_H189_E0.5500.76
221_M232_R0.5490.76
155_L211_L0.5490.76
117_E257_Q0.5470.76
189_E195_G0.5450.76
37_I62_I0.5430.75
21_A39_H0.5420.75
192_I195_G0.5420.75
122_G125_I0.5420.75
176_S181_E0.5390.75
132_G235_S0.5380.75
173_E184_Q0.5370.75
72_D95_V0.5360.74
213_G228_T0.5350.74
256_D260_Y0.5340.74
224_M243_S0.5340.74
169_L172_A0.5310.74
183_Q186_H0.5310.74
252_V260_Y0.5300.74
213_G219_E0.5290.73
136_M220_V0.5280.73
8_L249_V0.5270.73
151_E223_G0.5270.73
136_M140_S0.5250.73
153_I208_S0.5250.73
25_A28_T0.5240.73
59_Y64_A0.5240.73
99_V104_F0.5230.73
129_F251_Q0.5230.73
196_A225_D0.5190.72
161_L193_L0.5190.72
38_D42_D0.5160.72
63_H85_V0.5160.72
226_G236_Y0.5150.71
262_L265_I0.5120.71
247_L250_E0.5120.71
134_I263_E0.5110.71
217_H236_Y0.5110.71
82_I85_V0.5110.71
63_H94_G0.5100.71
111_E115_L0.5080.70
189_E203_G0.5070.70
142_M146_Y0.5060.70
8_L73_V0.5040.70
9_V95_V0.5040.70
173_E186_H0.5030.70
171_T218_Q0.5030.70
6_I249_V0.5010.69
156_H218_Q0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ywjA 3 0.9588 100 0.17 Contact Map
1vm6A 4 0.8052 100 0.184 Contact Map
1p9lA 4 0.9064 100 0.206 Contact Map
1dihA 4 0.9738 100 0.229 Contact Map
3ijpA 4 0.9625 100 0.258 Contact Map
3qy9A 3 0.8951 100 0.409 Contact Map
4f3yA 4 0.9663 100 0.45 Contact Map
3wb9A 5 0.9139 100 0.515 Contact Map
1j5pA 2 0.8352 100 0.604 Contact Map
3wycA 2 0.9326 100 0.614 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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