GREMLIN Database
BGLA - Aryl-phospho-beta-D-glucosidase BglA
UniProt: P42973 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 479 (436)
Sequences: 6744 (4176)
Seq/√Len: 200.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_G105_A4.2561.00
393_H463_D4.1021.00
115_D167_K3.6571.00
408_L419_L3.2301.00
111_D167_K3.2221.00
77_A120_H3.1021.00
70_K116_E3.0651.00
111_D163_R2.9421.00
128_L160_C2.9361.00
116_E119_K2.9161.00
461_K465_F2.9161.00
64_D67_H2.8651.00
104_E108_Q2.8511.00
108_Q112_D2.7941.00
104_E163_R2.7921.00
94_F159_A2.7651.00
312_Y404_H2.7591.00
407_A410_K2.7271.00
247_S252_D2.6221.00
25_Q67_H2.6031.00
158_E162_T2.5801.00
12_G81_L2.5001.00
401_L424_P2.3751.00
359_R415_D2.3291.00
74_A120_H2.3101.00
363_N415_D2.2871.00
38_A60_H2.2781.00
147_R296_D2.2741.00
399_Q403_S2.2721.00
225_G234_I2.2641.00
151_D220_L2.2421.00
114_F164_Y2.1861.00
65_F109_F2.1791.00
223_A227_D2.1701.00
446_Y460_Y2.1701.00
70_K112_D2.1511.00
395_P463_D2.1451.00
83_C423_T2.0941.00
123_E169_K2.0681.00
73_I113_V2.0331.00
88_I126_I2.0321.00
469_K473_Q2.0261.00
65_F84_L2.0091.00
35_V135_L1.9661.00
154_V224_K1.9501.00
105_A108_Q1.9421.00
387_E391_K1.9361.00
118_L167_K1.9211.00
277_S281_K1.8931.00
158_E224_K1.8671.00
86_T114_F1.8661.00
212_H275_Y1.8541.00
295_G298_E1.8491.00
23_W30_P1.8461.00
31_S91_S1.8391.00
73_I120_H1.8381.00
111_D115_D1.8181.00
158_E228_I1.8061.00
229_N232_F1.7921.00
225_G232_F1.7781.00
359_R410_K1.7771.00
244_Y360_Y1.7681.00
30_P35_V1.7661.00
220_L299_I1.7581.00
10_W475_N1.7241.00
14_L19_F1.7091.00
115_D118_L1.6901.00
116_E120_H1.6891.00
86_T113_V1.6841.00
123_E170_Y1.6561.00
22_G25_Q1.6541.00
117_L122_I1.6461.00
114_F118_L1.6411.00
136_H140_E1.6311.00
356_T407_A1.6271.00
141_Y152_F1.6231.00
292_F297_D1.6211.00
470_N473_Q1.6171.00
362_L417_V1.6021.00
154_V220_L1.6011.00
111_D164_Y1.5931.00
73_I116_E1.5821.00
74_A116_E1.5811.00
312_Y357_G1.5791.00
43_V46_K1.5711.00
69_Y112_D1.5711.00
364_R368_R1.5701.00
359_R363_N1.5681.00
272_R370_Q1.5461.00
261_R278_Y1.5451.00
172_M237_M1.5341.00
9_L83_C1.5321.00
374_F420_I1.5321.00
83_C125_V1.5301.00
17_H59_N1.5231.00
149_V152_F1.5201.00
68_R71_E1.5021.00
145_R206_V1.4991.00
211_A266_F1.4981.00
29_G97_G1.4951.00
14_L84_L1.4761.00
267_P308_L1.4741.00
265_F279_A1.4661.00
161_F225_G1.4591.00
298_E302_N1.4551.00
166_D229_N1.4451.00
107_L159_A1.4391.00
76_F81_L1.4251.00
378_N422_Y1.4161.00
73_I117_L1.4151.00
358_L408_L1.4141.00
94_F102_P1.4071.00
172_M307_Y1.4021.00
409_K413_T1.3941.00
86_T126_I1.3901.00
78_E465_F1.3861.00
142_G146_N1.3851.00
424_P444_M1.3741.00
224_K227_D1.3591.00
35_V140_E1.3551.00
125_V423_T1.3541.00
170_Y233_Q1.3521.00
169_K231_E1.3401.00
274_Y280_L1.3301.00
22_G67_H1.3201.00
88_I160_C1.3171.00
470_N474_T1.3151.00
467_W471_V1.3151.00
362_L408_L1.3051.00
461_K466_E1.3041.00
236_A270_Q1.3001.00
64_D68_R1.2981.00
274_Y370_Q1.2801.00
348_D383_V1.2721.00
405_I408_L1.2591.00
174_F217_A1.2531.00
151_D154_V1.2481.00
147_R213_H1.2371.00
98_D152_F1.2341.00
174_F214_E1.2301.00
223_A302_N1.2281.00
148_K151_D1.2261.00
403_S406_E1.2231.00
402_K406_E1.2191.00
466_E469_K1.2071.00
107_L163_R1.2071.00
76_F445_I1.2061.00
297_D300_L1.2041.00
180_Q214_E1.2011.00
88_I93_I1.1961.00
74_A78_E1.1951.00
363_N417_V1.1901.00
111_D166_D1.1751.00
386_L460_Y1.1741.00
98_D141_Y1.1701.00
65_F113_V1.1691.00
5_P412_V1.1661.00
293_E296_D1.1661.00
96_K136_H1.1611.00
161_F221_A1.1611.00
366_Y371_I1.1601.00
391_K463_D1.1521.00
69_Y116_E1.1481.00
135_L140_E1.1461.00
133_M149_V1.1431.00
29_G136_H1.1391.00
63_I428_I1.1341.00
14_L86_T1.1321.00
162_T228_I1.1301.00
366_Y418_D1.1251.00
154_V221_A1.1231.00
268_D368_R1.1221.00
449_R457_M1.1201.00
144_F149_V1.1201.00
23_W28_K1.1191.00
250_P254_M1.1181.00
128_L153_F1.1171.00
245_P256_A1.1171.00
157_A221_A1.1161.00
191_T194_G1.1151.00
387_E393_H1.1141.00
107_L111_D1.0941.00
161_F234_I1.0941.00
225_G229_N1.0931.00
260_M364_R1.0921.00
114_F126_I1.0921.00
409_K412_V1.0881.00
268_D272_R1.0841.00
222_V226_K1.0831.00
245_P253_V1.0831.00
240_H361_T1.0771.00
114_F167_K1.0731.00
22_G26_G1.0711.00
148_K152_F1.0631.00
78_E461_K1.0591.00
138_A185_N1.0561.00
141_Y148_K1.0561.00
250_P253_V1.0551.00
356_T360_Y1.0541.00
224_K228_I1.0531.00
154_V158_E1.0531.00
243_I259_E1.0521.00
96_K101_E1.0421.00
102_P159_A1.0341.00
4_M412_V1.0331.00
468_Y472_I1.0281.00
251_E320_S1.0281.00
61_E449_R1.0271.00
246_F319_K1.0271.00
399_Q402_K1.0241.00
111_D118_L1.0241.00
249_N253_V1.0231.00
29_G95_P1.0221.00
213_H216_V1.0221.00
225_G230_P1.0211.00
254_M258_E1.0211.00
223_A303_G1.0161.00
358_L419_L1.0121.00
448_D458_K1.0111.00
390_G460_Y1.0111.00
251_E356_T1.0101.00
12_G76_F1.0081.00
4_M409_K1.0081.00
157_A224_K1.0061.00
194_G206_V1.0061.00
159_A163_R1.0021.00
61_E457_M1.0011.00
220_L224_K1.0001.00
257_E261_R0.9991.00
274_Y277_S0.9981.00
294_D297_D0.9961.00
68_R458_K0.9951.00
165_K232_F0.9901.00
451_N458_K0.9851.00
100_A155_N0.9841.00
133_M143_G0.9791.00
252_D320_S0.9791.00
261_R279_A0.9771.00
93_I159_A0.9730.99
281_K284_E0.9720.99
398_I467_W0.9720.99
358_L375_I0.9720.99
125_V170_Y0.9700.99
345_T403_S0.9640.99
150_V220_L0.9620.99
235_G309_G0.9610.99
152_F155_N0.9600.99
253_V256_A0.9570.99
28_K91_S0.9550.99
259_E318_V0.9550.99
204_K286_E0.9510.99
82_K475_N0.9510.99
9_L125_V0.9480.99
125_V374_F0.9410.99
7_D420_I0.9370.99
160_C164_Y0.9350.99
147_R293_E0.9330.99
19_F65_F0.9320.99
158_E229_N0.9320.99
428_I447_V0.9290.99
254_M257_E0.9210.99
222_V234_I0.9210.99
383_V439_K0.9190.99
161_F232_F0.9170.99
142_G145_R0.9150.99
221_A224_K0.9140.99
386_L391_K0.9130.99
441_R449_R0.9120.99
340_E346_S0.9100.99
382_A396_E0.9090.99
112_D115_D0.9090.99
181_M210_T0.9060.99
108_Q111_D0.9010.99
157_A161_F0.8980.99
27_G103_N0.8950.99
257_E278_Y0.8950.99
138_A194_G0.8940.99
271_V371_I0.8890.99
243_I256_A0.8870.99
268_D369_Y0.8810.99
156_F160_C0.8800.99
238_V267_P0.8780.99
166_D232_F0.8760.99
235_G307_Y0.8740.99
71_E74_A0.8720.99
203_A206_V0.8720.99
141_Y149_V0.8700.99
471_V475_N0.8680.99
260_M264_Y0.8670.99
358_L407_A0.8640.99
165_K229_N0.8610.99
129_S133_M0.8590.99
439_K451_N0.8590.99
135_L138_A0.8580.99
381_G440_K0.8540.99
163_R167_K0.8540.99
109_F113_V0.8540.99
32_V138_A0.8520.99
223_A299_I0.8510.99
107_L160_C0.8510.99
380_F396_E0.8500.99
111_D114_F0.8470.99
295_G299_I0.8460.99
346_S352_A0.8450.99
412_V419_L0.8450.99
406_E410_K0.8450.99
466_E470_N0.8430.99
218_S222_V0.8430.99
81_L427_I0.8420.99
97_G136_H0.8420.99
356_T410_K0.8400.99
392_V460_Y0.8390.98
248_S253_V0.8390.98
315_S352_A0.8380.98
74_A77_A0.8380.98
3_N6_K0.8360.98
118_L124_P0.8350.98
310_F373_L0.8330.98
150_V216_V0.8330.98
172_M309_G0.8280.98
363_N367_D0.8280.98
395_P399_Q0.8270.98
205_E290_I0.8260.98
386_L390_G0.8250.98
76_F122_I0.8210.98
366_Y370_Q0.8180.98
10_W405_I0.8140.98
240_H310_F0.8100.98
129_S132_E0.8090.98
319_K337_N0.8070.98
281_K285_R0.8050.98
179_N239_S0.8050.98
174_F180_Q0.8030.98
98_D140_E0.8010.98
282_E286_E0.8000.98
173_T236_A0.7960.98
359_R407_A0.7960.98
315_S354_D0.7950.98
315_S357_G0.7930.98
78_E469_K0.7920.98
349_W440_K0.7920.98
51_I439_K0.7900.98
451_N457_M0.7880.98
354_D357_G0.7860.98
246_F252_D0.7840.98
314_M352_A0.7830.98
16_A89_G0.7820.98
5_P418_D0.7820.98
173_T218_S0.7790.98
81_L468_Y0.7790.98
249_N252_D0.7790.98
146_N152_F0.7780.98
19_F63_I0.7780.98
220_L223_A0.7770.98
159_A162_T0.7760.97
363_N366_Y0.7710.97
153_F157_A0.7700.97
9_L123_E0.7680.97
61_E64_D0.7680.97
93_I160_C0.7670.97
69_Y73_I0.7670.97
362_L419_L0.7660.97
102_P107_L0.7650.97
205_E209_Q0.7650.97
387_E390_G0.7640.97
32_V133_M0.7640.97
104_E111_D0.7610.97
347_S380_F0.7600.97
463_D466_E0.7570.97
209_Q291_T0.7530.97
165_K228_I0.7490.97
28_K31_S0.7470.97
366_Y417_V0.7430.97
124_P169_K0.7420.97
77_A121_G0.7410.97
271_V308_L0.7390.97
277_S280_L0.7390.97
243_I318_V0.7360.97
353_I382_A0.7340.97
89_G132_E0.7340.97
79_M461_K0.7330.96
271_V305_V0.7310.96
106_G109_F0.7290.96
257_E364_R0.7250.96
373_L417_V0.7230.96
385_T388_E0.7210.96
430_I442_Y0.7180.96
211_A265_F0.7180.96
126_I168_V0.7180.96
173_T234_I0.7170.96
445_I461_K0.7170.96
192_N195_V0.7160.96
411_A417_V0.7160.96
371_I418_D0.7140.96
98_D136_H0.7140.96
59_N62_A0.7060.96
3_N409_K0.7040.96
349_W381_G0.7030.96
215_L270_Q0.7030.96
341_N344_I0.7010.95
138_A145_R0.6990.95
345_T396_E0.6970.95
179_N183_V0.6960.95
22_G66_Y0.6960.95
356_T359_R0.6940.95
7_D475_N0.6930.95
14_L428_I0.6930.95
338_G342_P0.6930.95
161_F228_I0.6930.95
117_L120_H0.6900.95
242_P360_Y0.6900.95
26_G66_Y0.6890.95
118_L123_E0.6880.95
98_D155_N0.6870.95
23_W60_H0.6860.95
215_L300_L0.6850.95
253_V257_E0.6850.95
94_F101_E0.6850.95
398_I463_D0.6840.95
10_W82_K0.6840.95
279_A283_F0.6830.95
30_P38_A0.6830.95
254_M356_T0.6830.95
274_Y297_D0.6820.95
19_F430_I0.6820.95
145_R210_T0.6810.95
72_D459_R0.6810.95
178_N239_S0.6790.95
405_I424_P0.6790.95
284_E289_N0.6780.95
96_K100_A0.6770.95
217_A221_A0.6770.95
24_N30_P0.6760.94
432_S442_Y0.6750.94
48_T51_I0.6750.94
310_F365_F0.6730.94
158_E227_D0.6680.94
51_I58_P0.6680.94
147_R295_G0.6670.94
237_M311_S0.6660.94
96_K140_E0.6650.94
444_M468_Y0.6630.94
471_V474_T0.6610.94
76_F427_I0.6600.94
240_H267_P0.6590.94
68_R457_M0.6590.94
114_F168_V0.6580.94
79_M444_M0.6570.94
118_L169_K0.6550.94
213_H293_E0.6550.94
345_T399_Q0.6540.93
244_Y315_S0.6540.93
431_V437_E0.6520.93
311_S376_V0.6520.93
59_N436_G0.6510.93
147_R216_V0.6460.93
38_A43_V0.6460.93
157_A160_C0.6460.93
240_H264_Y0.6440.93
190_W194_G0.6430.93
82_K123_E0.6420.93
86_T117_L0.6420.93
23_W89_G0.6410.93
362_L411_A0.6400.93
162_T224_K0.6400.93
308_L371_I0.6390.93
151_D155_N0.6380.93
195_V203_A0.6380.93
255_L259_E0.6370.93
219_A300_L0.6370.93
145_R209_Q0.6370.93
205_E289_N0.6360.93
238_V266_F0.6360.93
47_I51_I0.6350.92
168_V171_W0.6340.92
153_F174_F0.6330.92
160_C171_W0.6330.92
70_K74_A0.6320.92
73_I122_I0.6320.92
11_G423_T0.6300.92
9_L82_K0.6280.92
30_P135_L0.6270.92
118_L121_G0.6260.92
294_D298_E0.6260.92
457_M461_K0.6260.92
249_N320_S0.6260.92
212_H292_F0.6250.92
202_N205_E0.6240.92
117_L121_G0.6240.92
155_N159_A0.6240.92
312_Y358_L0.6240.92
405_I471_V0.6230.92
145_R194_G0.6230.92
410_K415_D0.6220.92
125_V172_M0.6210.92
246_F317_T0.6200.92
222_V305_V0.6200.92
431_V449_R0.6190.91
391_K460_Y0.6190.91
85_R175_N0.6190.91
4_M475_N0.6160.91
372_P418_D0.6150.91
233_Q420_I0.6150.91
129_S180_Q0.6140.91
408_L412_V0.6140.91
13_A423_T0.6140.91
223_A304_T0.6130.91
88_I114_F0.6130.91
281_K410_K0.6110.91
209_Q213_H0.6110.91
43_V47_I0.6100.91
386_L392_V0.6100.91
427_I445_I0.6080.91
208_Y283_F0.6060.91
93_I107_L0.6050.91
321_D324_N0.6050.91
446_Y462_K0.6040.90
94_F155_N0.6040.90
374_F421_G0.6040.90
107_L164_Y0.6040.90
97_G137_L0.6030.90
446_Y458_K0.6030.90
390_G458_K0.6020.90
273_G302_N0.6020.90
150_V217_A0.6000.90
128_L161_F0.6000.90
137_L152_F0.5990.90
247_S319_K0.5980.90
391_K466_E0.5960.90
82_K472_I0.5950.90
395_P398_I0.5940.90
348_D382_A0.5900.89
30_P91_S0.5890.89
75_L428_I0.5880.89
348_D440_K0.5870.89
219_A304_T0.5840.89
112_D116_E0.5840.89
262_Q279_A0.5830.89
228_I232_F0.5830.89
261_R364_R0.5820.89
75_L445_I0.5820.89
194_G203_A0.5810.89
37_T431_V0.5790.89
223_A226_K0.5770.88
342_P345_T0.5760.88
96_K152_F0.5730.88
365_F373_L0.5720.88
7_D412_V0.5720.88
84_L117_L0.5710.88
37_T43_V0.5710.88
336_P340_E0.5710.88
430_I433_F0.5690.88
14_L427_I0.5690.88
136_H152_F0.5690.88
150_V154_V0.5680.88
80_G469_K0.5660.87
240_H365_F0.5640.87
170_Y374_F0.5640.87
346_S350_G0.5640.87
235_G374_F0.5630.87
380_F384_D0.5620.87
299_I303_G0.5620.87
279_A282_E0.5610.87
62_A457_M0.5600.87
79_M465_F0.5600.87
29_G94_F0.5600.87
202_N206_V0.5590.87
4_M10_W0.5590.87
115_D166_D0.5580.87
242_P260_M0.5580.87
65_F76_F0.5560.87
265_F283_F0.5560.87
115_D119_K0.5560.87
219_A303_G0.5550.86
245_P252_D0.5550.86
128_L157_A0.5550.86
47_I431_V0.5540.86
190_W193_S0.5540.86
19_F84_L0.5540.86
258_E320_S0.5540.86
125_V420_I0.5530.86
241_V316_T0.5520.86
293_E297_D0.5520.86
349_W435_T0.5520.86
386_L389_D0.5510.86
373_L419_L0.5510.86
218_S270_Q0.5470.86
70_K73_I0.5460.86
78_E466_E0.5440.85
77_A119_K0.5430.85
374_F423_T0.5430.85
313_Y377_E0.5400.85
292_F295_G0.5400.85
347_S350_G0.5390.85
267_P365_F0.5390.85
244_Y354_D0.5390.85
141_Y146_N0.5360.84
37_T59_N0.5350.84
216_V299_I0.5350.84
426_G430_I0.5340.84
48_T435_T0.5340.84
191_T195_V0.5340.84
133_M138_A0.5320.84
32_V129_S0.5310.84
61_E67_H0.5310.84
360_Y363_N0.5310.84
387_E460_Y0.5300.84
23_W38_A0.5290.84
14_L65_F0.5280.84
376_V420_I0.5280.84
441_R446_Y0.5280.84
65_F73_I0.5260.83
347_S381_G0.5260.83
22_G28_K0.5250.83
401_L405_I0.5240.83
94_F98_D0.5240.83
7_D82_K0.5220.83
81_L122_I0.5220.83
392_V446_Y0.5210.83
309_G376_V0.5200.83
49_D439_K0.5200.83
291_T295_G0.5200.83
347_S382_A0.5180.82
410_K413_T0.5170.82
17_H37_T0.5160.82
76_F84_L0.5130.82
144_F174_F0.5120.82
137_L149_V0.5110.82
407_A415_D0.5110.82
280_L297_D0.5100.81
65_F69_Y0.5090.81
267_P271_V0.5090.81
437_E451_N0.5080.81
398_I402_K0.5080.81
14_L430_I0.5080.81
426_G449_R0.5080.81
425_W430_I0.5070.81
222_V303_G0.5070.81
213_H291_T0.5070.81
138_A143_G0.5060.81
247_S253_V0.5050.81
173_T221_A0.5030.81
33_V433_F0.5030.81
241_V263_R0.5030.81
268_D274_Y0.5030.81
445_I465_F0.5030.81
450_D458_K0.5020.80
33_V36_M0.5020.80
127_T237_M0.5020.80
9_L170_Y0.5020.80
185_N210_T0.5010.80
165_K230_P0.5010.80
338_G341_N0.5000.80
435_T440_K0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v02A 2 0.9499 100 0.125 Contact Map
2jf7A 5 0.9415 100 0.126 Contact Map
3ptmA 1 0.952 100 0.127 Contact Map
3wq5A 1 0.952 100 0.129 Contact Map
2dgaA 5 0.9562 100 0.13 Contact Map
1v08A 2 0.952 100 0.132 Contact Map
1cbgA 2 0.952 100 0.134 Contact Map
3f5lA 2 0.9457 100 0.136 Contact Map
4f66A 2 0.9791 100 0.136 Contact Map
3viiA 2 0.9395 100 0.139 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0135 seconds.