GREMLIN Database
YCSN - Uncharacterized oxidoreductase YcsN
UniProt: P42972 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (262)
Sequences: 32360 (20473)
Seq/√Len: 1264.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_W272_S3.1921.00
111_E151_K3.0121.00
29_D64_N2.9121.00
67_A118_R2.8371.00
239_I286_Q2.7341.00
110_V146_L2.5201.00
5_Q11_Q2.5171.00
283_D286_Q2.5031.00
107_L145_A2.4291.00
107_L149_S2.3701.00
38_W42_H2.3271.00
238_E289_R2.1611.00
144_Q148_C2.0651.00
233_E237_G2.0091.00
238_E286_Q2.0021.00
121_Y153_R1.9921.00
33_L64_N1.9781.00
254_T287_W1.9771.00
4_I14_R1.9681.00
112_Q116_N1.9671.00
145_A149_S1.9471.00
198_L202_K1.9371.00
268_R272_S1.9021.00
199_C206_P1.9011.00
284_Q288_F1.8871.00
72_L75_N1.8851.00
234_S289_R1.8521.00
103_K145_A1.8351.00
57_T60_K1.8311.00
38_W268_R1.8251.00
16_I46_T1.8211.00
126_L178_T1.7971.00
42_H272_S1.7611.00
241_A280_Y1.7521.00
78_L119_T1.7501.00
145_A148_C1.7031.00
166_R170_S1.7031.00
80_T122_I1.6771.00
39_C44_I1.6771.00
33_L65_A1.6671.00
250_A280_Y1.6481.00
103_K107_L1.6421.00
60_K116_N1.6331.00
42_H275_I1.6321.00
28_S31_E1.6241.00
231_A234_S1.6191.00
80_T113_S1.6161.00
243_S273_A1.6131.00
166_R198_L1.6021.00
82_C125_L1.5981.00
110_V125_L1.5871.00
276_N279_S1.5751.00
107_L111_E1.5731.00
79_V126_L1.5661.00
33_L37_E1.5661.00
38_W41_D1.5641.00
288_F292_T1.5611.00
82_C106_I1.5571.00
205_P260_M1.5501.00
142_A145_A1.5411.00
19_L47_F1.5011.00
108_A112_Q1.4491.00
29_D33_L1.4461.00
126_L207_M1.4461.00
51_D109_S1.4381.00
10_L154_Y1.4281.00
40_I76_I1.4251.00
197_N201_E1.4041.00
122_I152_V1.4031.00
161_K164_Q1.3961.00
111_E115_M1.3961.00
241_A246_E1.3821.00
194_G197_N1.3761.00
31_E34_S1.3761.00
36_I65_A1.3491.00
181_I206_P1.3481.00
169_E202_K1.3441.00
250_A254_T1.3351.00
272_S276_N1.3211.00
37_E41_D1.3111.00
10_L77_E1.3071.00
103_K141_E1.2931.00
154_Y177_V1.2921.00
107_L142_A1.2901.00
265_S270_R1.2821.00
112_Q115_M1.2811.00
152_V155_F1.2801.00
169_E198_L1.2751.00
289_R292_T1.2711.00
146_L152_V1.2651.00
34_S38_W1.2591.00
77_E124_M1.2531.00
241_A247_V1.2491.00
103_K142_A1.2401.00
231_A289_R1.2311.00
117_L122_I1.2261.00
265_S271_I1.2251.00
162_D198_L1.2221.00
7_A177_V1.2171.00
243_S246_E1.2101.00
59_E113_S1.2091.00
257_A291_F1.2051.00
73_R121_Y1.1891.00
148_C173_P1.1871.00
64_N118_R1.1861.00
137_E171_Y1.1791.00
47_F62_F1.1761.00
63_G118_R1.1761.00
30_A34_S1.1721.00
196_L200_Q1.1711.00
124_M178_T1.1591.00
73_R119_T1.1571.00
234_S238_E1.1571.00
233_E244_L1.1511.00
200_Q256_P1.1441.00
60_K64_N1.1371.00
269_E272_S1.1361.00
105_H108_A1.1301.00
130_P164_Q1.1291.00
110_V122_I1.1251.00
46_T207_M1.1241.00
104_S108_A1.1241.00
186_Y229_R1.1151.00
166_R201_E1.1141.00
235_V247_V1.1061.00
147_K177_V1.1051.00
102_S105_H1.1041.00
185_A290_I1.1011.00
46_T79_V1.0941.00
8_E154_Y1.0921.00
166_R202_K1.0891.00
111_E149_S1.0891.00
143_F155_F1.0821.00
252_L261_P1.0741.00
35_L271_I1.0731.00
144_Q147_K1.0711.00
182_E187_E1.0701.00
19_L62_F1.0591.00
138_G141_E1.0571.00
127_I143_F1.0531.00
37_E65_A1.0521.00
230_T234_S1.0431.00
234_S237_G1.0331.00
45_T77_E1.0221.00
246_E276_N1.0201.00
167_M171_Y1.0141.00
34_S268_R1.0131.00
101_T127_I1.0121.00
146_L151_K1.0081.00
232_L244_L1.0001.00
200_Q257_A0.9981.00
162_D166_R0.9841.00
230_T233_E0.9831.00
5_Q9_D0.9831.00
157_V176_L0.9781.00
253_Y277_A0.9741.00
13_S45_T0.9731.00
185_A248_M0.9621.00
137_E167_M0.9541.00
59_E116_N0.9501.00
178_T207_M0.9451.00
246_E273_A0.9431.00
14_R253_Y0.9411.00
271_I275_I0.9411.00
13_S44_I0.9391.00
141_E145_A0.9381.00
146_L149_S0.9361.00
8_E177_V0.9361.00
200_Q258_G0.9341.00
197_N200_Q0.9311.00
147_K174_E0.9301.00
66_L76_I0.9301.00
207_M260_M0.9271.00
103_K138_G0.9261.00
193_D197_N0.9261.00
123_D153_R0.9251.00
51_D105_H0.9191.00
142_A146_L0.9131.00
273_A276_N0.9081.00
60_K115_M0.9051.00
51_D86_L0.9041.00
107_L110_V0.8991.00
144_Q173_P0.8921.00
34_S37_E0.8911.00
269_E273_A0.8861.00
14_R278_L0.8811.00
79_V207_M0.8811.00
108_A111_E0.8761.00
36_I47_F0.8751.00
157_V165_Y0.8741.00
179_N199_C0.8721.00
288_F291_F0.8721.00
254_T281_K0.8671.00
235_V239_I0.8611.00
267_K270_R0.8591.00
79_V124_M0.8511.00
285_D289_R0.8461.00
144_Q172_L0.8441.00
155_F176_L0.8431.00
141_E144_Q0.8431.00
167_M170_S0.8401.00
107_L146_L0.8391.00
249_Y277_A0.8391.00
40_I72_L0.8381.00
285_D288_F0.8321.00
238_E283_D0.8321.00
8_E147_K0.8301.00
198_L201_E0.8271.00
29_D57_T0.8241.00
144_Q155_F0.8151.00
239_I283_D0.8151.00
165_Y204_I0.8151.00
29_D61_L0.8081.00
159_N209_W0.8061.00
188_L291_F0.7981.00
19_L58_C0.7971.00
196_L257_A0.7951.00
17_H39_C0.7941.00
196_L206_P0.7891.00
51_D116_N0.7801.00
114_L151_K0.7741.00
170_S174_E0.7721.00
248_M252_L0.7691.00
38_W271_I0.7681.00
80_T125_L0.7681.00
129_R159_N0.7671.00
49_H62_F0.7661.00
254_T284_Q0.7661.00
183_L196_L0.7631.00
192_L197_N0.7621.00
250_A277_A0.7581.00
211_P263_V0.7571.00
169_E175_K0.7401.00
208_A211_P0.7391.00
162_D195_T0.7371.00
51_D112_Q0.7271.00
30_A33_L0.7271.00
140_A168_L0.7261.00
266_G270_R0.7241.00
4_I205_P0.7221.00
114_L119_T0.7211.00
195_T199_C0.7211.00
16_I263_V0.7201.00
101_T139_V0.7171.00
42_H276_N0.7171.00
188_L192_L0.7171.00
40_I47_F0.7011.00
37_E70_P0.7011.00
44_I275_I0.7001.00
162_D194_G0.6971.00
208_A261_P0.6971.00
231_A293_A0.6951.00
32_L61_L0.6951.00
251_W291_F0.6941.00
140_A176_L0.6931.00
140_A155_F0.6901.00
17_H22_L0.6901.00
109_S112_Q0.6891.00
15_V253_Y0.6861.00
35_L268_R0.6841.00
74_E121_Y0.6821.00
110_V151_K0.6771.00
188_L193_D0.6771.00
113_S125_L0.6771.00
106_I146_L0.6761.00
157_V160_F0.6751.00
199_C204_I0.6741.00
235_V286_Q0.6711.00
37_E72_L0.6691.00
282_L287_W0.6681.00
157_V179_N0.6621.00
239_I247_V0.6611.00
12_F260_M0.6581.00
205_P259_I0.6571.00
45_T75_N0.6571.00
42_H271_I0.6551.00
140_A172_L0.6541.00
21_R214_G0.6541.00
106_I139_V0.6541.00
232_L290_I0.6531.00
252_L259_I0.6511.00
211_P252_L0.6501.00
10_L153_R0.6501.00
36_I40_I0.6491.00
245_D273_A0.6471.00
20_W210_S0.6441.00
247_V282_L0.6421.00
270_R273_A0.6421.00
226_R230_T0.6411.00
122_I125_L0.6391.00
147_K154_Y0.6391.00
52_I83_G0.6361.00
229_R233_E0.6351.00
126_L156_G0.6291.00
31_E268_R0.6281.00
236_Q247_V0.6271.00
241_A279_S0.6241.00
226_R229_R0.6221.00
37_E71_G0.6201.00
135_D138_G0.6191.00
71_G76_I0.6191.00
227_R230_T0.6191.00
106_I142_A0.6171.00
143_F147_K0.6161.00
237_G240_G0.6161.00
147_K152_V0.6161.00
82_C101_T0.6161.00
110_V114_L0.6151.00
139_V142_A0.6141.00
183_L252_L0.6131.00
67_A71_G0.6081.00
35_L265_S0.6051.00
48_D180_Q0.6031.00
183_L206_P0.5971.00
232_L248_M0.5951.00
282_L286_Q0.5931.00
41_D268_R0.5921.00
241_A250_A0.5891.00
23_N58_C0.5871.00
136_P171_Y0.5861.00
16_I260_M0.5861.00
107_L151_K0.5861.00
22_L35_L0.5861.00
236_Q244_L0.5851.00
286_Q289_R0.5841.00
86_L105_H0.5831.00
166_R169_E0.5801.00
131_D134_M0.5791.00
125_L143_F0.5771.00
183_L188_L0.5771.00
169_E172_L0.5761.00
24_E61_L0.5761.00
247_V280_Y0.5751.00
208_A258_G0.5731.00
227_R231_A0.5731.00
102_S139_V0.5731.00
40_I45_T0.5721.00
57_T61_L0.5721.00
247_V290_I0.5701.00
40_I75_N0.5691.00
247_V286_Q0.5681.00
114_L122_I0.5681.00
164_Q167_M0.5671.00
236_Q239_I0.5661.00
22_L32_L0.5641.00
235_V289_R0.5621.00
125_L152_V0.5621.00
210_S214_G0.5611.00
135_D167_M0.5601.00
185_A251_W0.5591.00
114_L120_D0.5581.00
241_A276_N0.5581.00
82_C109_S0.5571.00
15_V278_L0.5551.00
216_K229_R0.5541.00
6_L205_P0.5531.00
186_Y216_K0.5491.00
36_I62_F0.5481.00
72_L76_I0.5471.00
114_L121_Y0.5461.00
16_I262_I0.5451.00
136_P139_V0.5431.00
12_F46_T0.5381.00
84_I129_R0.5371.00
157_V168_L0.5351.00
253_Y261_P0.5331.00
51_D83_G0.5321.00
144_Q174_E0.5321.00
172_L176_L0.5311.00
127_I139_V0.5301.00
17_H35_L0.5291.00
183_L259_I0.5291.00
59_E80_T0.5261.00
235_V238_E0.5261.00
47_F66_L0.5241.00
62_F65_A0.5231.00
39_C47_F0.5231.00
268_R271_I0.5201.00
250_A281_K0.5191.00
40_I65_A0.5171.00
84_I101_T0.5171.00
246_E280_Y0.5171.00
103_K106_I0.5161.00
136_P167_M0.5141.00
110_V142_A0.5141.00
46_T77_E0.5131.00
49_H58_C0.5121.00
40_I71_G0.5091.00
137_E141_E0.5091.00
265_S274_A0.5081.00
232_L236_Q0.5071.00
169_E204_I0.5011.00
130_P160_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r9oA 5 0.9733 100 0.075 Contact Map
1pyfA 1 0.9467 100 0.086 Contact Map
3eauA 3 0.97 100 0.089 Contact Map
1pz1A 1 0.9633 100 0.09 Contact Map
3lutA 3 0.9667 100 0.09 Contact Map
3v0sA 1 0.9 100 0.091 Contact Map
4xk2A 5 0.94 100 0.093 Contact Map
1lqaA 2 0.98 100 0.093 Contact Map
3n2tA 1 0.97 100 0.101 Contact Map
3n6qA 5 0.9667 100 0.107 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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