GREMLIN Database
LIPC - Spore germination lipase LipC
UniProt: P42969 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (194)
Sequences: 2453 (1875)
Seq/√Len: 134.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_N168_I4.8811.00
5_Y76_T3.4731.00
130_A167_K3.3031.00
132_R169_A2.8631.00
117_K120_E2.6801.00
134_F202_V2.6131.00
56_I79_G2.5001.00
93_T96_D2.2651.00
7_A26_V2.2361.00
15_G18_S2.2261.00
131_I166_V2.1961.00
151_T172_Y2.1901.00
154_N172_Y2.1721.00
117_K121_I2.1501.00
46_F67_K2.1361.00
158_E162_S2.1201.00
13_T47_A2.0981.00
14_T49_S2.0971.00
16_R49_S1.9591.00
92_Q96_D1.9521.00
56_I114_M1.8841.00
112_E160_L1.8731.00
13_T78_T1.8671.00
28_R196_Q1.8671.00
101_S152_S1.8291.00
75_I129_Y1.7991.00
195_Y198_M1.7741.00
57_L117_K1.7571.00
25_F29_F1.7531.00
53_T114_M1.7191.00
135_N170_D1.7161.00
69_I72_A1.7091.00
29_F203_H1.6951.00
115_I133_V1.6921.00
74_M132_R1.6921.00
69_I122_K1.6741.00
133_V157_L1.6621.00
61_S117_K1.6471.00
181_E184_S1.6381.00
170_D173_S1.6141.00
122_K129_Y1.5741.00
150_I154_N1.5601.00
12_L137_Y1.5581.00
6_T72_A1.5571.00
115_I166_V1.5541.00
51_L55_E1.5161.00
93_T100_F1.4921.00
16_R195_Y1.4841.00
155_S158_E1.4621.00
24_G45_I1.4471.00
29_F202_V1.4251.00
112_E116_A1.4241.00
32_M203_H1.4211.00
25_F28_R1.4161.00
88_V91_Y1.4051.00
154_N157_L1.3931.00
79_G114_M1.3591.00
83_D110_N1.3351.00
196_Q200_E1.3281.00
160_L163_A1.3241.00
133_V161_A1.3231.00
96_D100_F1.3191.00
7_A76_T1.3081.00
23_P31_D1.3031.00
65_V68_C1.3011.00
111_F157_L1.2751.00
56_I65_V1.2691.00
8_L46_F1.2681.00
52_N55_E1.2611.00
7_A13_T1.2451.00
147_G151_T1.2381.00
48_R51_L1.2151.00
85_I91_Y1.1910.99
18_S195_Y1.1820.99
24_G195_Y1.1810.99
28_R32_M1.1730.99
136_L153_F1.1730.99
108_H159_T1.1570.99
108_H112_E1.1380.99
78_T81_G1.1230.99
155_S159_T1.1110.99
46_F68_C1.1090.99
17_G188_V1.1070.99
85_I88_V1.1030.99
123_G129_Y1.1010.99
26_V43_I1.0950.99
115_I131_I1.0840.99
27_Q31_D1.0700.99
192_S196_Q1.0660.99
148_K152_S1.0590.99
92_Q97_E1.0520.99
132_R167_K1.0500.99
171_A198_M1.0350.99
12_L139_P1.0310.99
87_S91_Y1.0260.98
53_T110_N1.0170.98
174_I201_A1.0170.98
23_P26_V1.0020.98
57_L65_V0.9960.98
29_F32_M0.9900.98
12_L190_P0.9870.98
55_E59_L0.9740.98
99_I102_R0.9670.98
121_I124_E0.9600.98
134_F198_M0.9550.98
161_A165_H0.9500.97
15_G195_Y0.9480.97
116_A164_P0.9430.97
180_Q184_S0.9350.97
66_Q121_I0.9310.97
113_K116_A0.9280.97
175_F194_G0.9250.97
47_A59_L0.9250.97
143_I147_G0.9210.97
53_T60_L0.9210.97
139_P150_I0.9080.97
99_I103_V0.9000.97
152_S156_H0.8960.96
79_G82_N0.8940.96
199_A203_H0.8910.96
28_R31_D0.8860.96
169_A202_V0.8800.96
32_M200_E0.8750.96
8_L60_L0.8750.96
24_G27_Q0.8710.96
190_P198_M0.8690.96
193_K196_Q0.8650.96
142_E145_I0.8590.95
57_L113_K0.8460.95
64_Y68_C0.8440.95
5_Y74_M0.8430.95
196_Q204_K0.8390.95
24_G47_A0.8370.95
105_A108_H0.8350.95
51_L59_L0.8320.95
107_C115_I0.8260.94
112_E163_A0.8240.94
133_V166_V0.8220.94
101_S106_H0.8210.94
12_L195_Y0.8200.94
6_T65_V0.8160.94
60_L65_V0.8160.94
106_H110_N0.8140.94
157_L168_I0.8100.94
30_G34_E0.8090.94
13_T134_F0.8070.94
107_C111_F0.8030.94
78_T134_F0.8010.93
135_N154_N0.7990.93
25_F30_G0.7900.93
57_L114_M0.7890.93
138_N175_F0.7860.93
173_S201_A0.7810.93
180_Q183_L0.7790.92
28_R199_A0.7780.92
26_V32_M0.7750.92
68_C72_A0.7680.92
137_Y198_M0.7620.92
12_L136_L0.7560.91
115_I168_I0.7540.91
160_L164_P0.7530.91
46_F65_V0.7500.91
21_F49_S0.7500.91
98_T102_R0.7490.91
138_N147_G0.7490.91
51_L56_I0.7480.91
112_E164_P0.7480.91
97_E146_A0.7460.91
54_E110_N0.7420.91
10_D154_N0.7420.91
55_E86_D0.7360.90
65_V117_K0.7330.90
10_D13_T0.7290.90
81_G136_L0.7210.89
108_H156_H0.7150.89
189_H194_G0.7090.88
82_N189_H0.7070.88
153_F157_L0.7030.88
88_V188_V0.7030.88
69_I121_I0.7010.88
156_H160_L0.7010.88
31_D71_D0.6970.88
118_V187_G0.6960.88
109_E113_K0.6920.87
118_V131_I0.6920.87
77_I118_V0.6890.87
198_M201_A0.6840.87
197_A201_A0.6830.87
29_F199_A0.6780.86
10_D168_I0.6760.86
19_G192_S0.6750.86
22_S26_V0.6720.86
76_T202_V0.6720.86
119_A131_I0.6680.85
48_R72_A0.6670.85
105_A152_S0.6610.85
191_N194_G0.6550.84
64_Y67_K0.6530.84
46_F69_I0.6520.84
14_T45_I0.6490.84
100_F103_V0.6480.84
24_G140_F0.6460.83
96_D99_I0.6430.83
94_S98_T0.6410.83
45_I48_R0.6410.83
137_Y168_I0.6380.83
98_T101_S0.6340.82
48_R91_Y0.6310.82
183_L187_G0.6300.82
169_A201_A0.6300.82
14_T21_F0.6290.82
12_L138_N0.6250.81
48_R55_E0.6210.81
11_S189_H0.6170.81
193_K197_A0.6170.81
130_A159_T0.6150.80
95_K182_Y0.6110.80
16_R19_G0.6100.80
66_Q98_T0.6080.80
25_F32_M0.6060.79
5_Y30_G0.6050.79
13_T26_V0.6040.79
143_I150_I0.6000.79
56_I59_L0.5990.79
84_L103_V0.5990.79
25_F47_A0.5920.78
106_H155_S0.5910.78
17_G81_G0.5910.78
102_R144_D0.5900.78
120_E148_K0.5870.77
156_H159_T0.5860.77
144_D156_H0.5850.77
50_G53_T0.5850.77
123_G130_A0.5850.77
91_Y135_N0.5820.77
97_E101_S0.5810.76
23_P29_F0.5800.76
33_M36_D0.5800.76
114_M117_K0.5780.76
151_T155_S0.5740.76
53_T111_F0.5740.76
197_A200_E0.5730.75
15_G191_N0.5720.75
109_E112_E0.5710.75
111_F160_L0.5670.75
118_V129_Y0.5650.74
85_I89_L0.5650.74
81_G190_P0.5590.74
117_K148_K0.5570.73
112_E166_V0.5570.73
49_S136_L0.5550.73
93_T97_E0.5540.73
175_F178_K0.5540.73
134_F157_L0.5540.73
105_A109_E0.5520.73
18_S192_S0.5510.73
34_E124_E0.5500.72
6_T75_I0.5490.72
12_L175_F0.5470.72
130_A134_F0.5460.72
190_P194_G0.5460.72
94_S99_I0.5430.72
78_T140_F0.5430.72
107_C153_F0.5410.71
111_F115_I0.5400.71
14_T81_G0.5400.71
10_D135_N0.5370.71
16_R47_A0.5340.70
35_A73_D0.5330.70
63_P66_Q0.5320.70
104_S141_P0.5320.70
25_F33_M0.5280.69
73_D124_E0.5270.69
73_D77_I0.5270.69
26_V30_G0.5250.69
138_N195_Y0.5230.69
24_G28_R0.5210.68
173_S176_K0.5190.68
78_T190_P0.5190.68
50_G82_N0.5170.68
99_I105_A0.5110.67
124_E173_S0.5100.67
113_K124_E0.5080.66
147_G172_Y0.5060.66
12_L198_M0.5060.66
141_P144_D0.5040.66
57_L61_S0.5030.66
19_G23_P0.5020.66
78_T150_I0.5010.65
174_I197_A0.5010.65
192_S200_E0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1escA 1 0.9671 100 0.389 Contact Map
4hyqA 1 0.9108 100 0.39 Contact Map
3bzwA 4 0.9484 100 0.487 Contact Map
4q9aA 2 0.9108 100 0.499 Contact Map
4jhlA 5 0.939 99.9 0.504 Contact Map
3dc7A 3 0.9155 99.9 0.505 Contact Map
1vjgA 2 0.8967 99.9 0.512 Contact Map
3hp4A 1 0.8545 99.9 0.512 Contact Map
4devA 5 0.9108 99.9 0.513 Contact Map
4m8kA 2 0.8638 99.9 0.519 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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