GREMLIN Database
KIPR - HTH-type transcriptional regulator KipR
UniProt: P42968 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 250 (242)
Sequences: 12710 (9364)
Seq/√Len: 602.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_V11_S3.1571.00
94_E235_K3.1461.00
9_V50_M2.8241.00
102_I138_C2.8091.00
87_V239_A2.7951.00
180_A184_N2.6261.00
16_N66_V2.5731.00
85_K113_E2.4581.00
140_R177_E2.4011.00
12_M52_F2.3511.00
152_E175_L2.3211.00
108_E130_R2.2281.00
140_R192_E2.1891.00
87_V242_Q2.1251.00
18_F53_L2.0991.00
146_L150_E2.0681.00
97_E223_R2.0501.00
89_E115_I2.0431.00
13_A50_M2.0091.00
145_F205_F1.9221.00
104_R133_L1.8861.00
202_A236_V1.8571.00
87_V246_K1.8461.00
202_A240_A1.8401.00
189_S199_A1.8341.00
190_Y198_A1.8221.00
90_E242_Q1.7991.00
198_A221_E1.7971.00
54_S62_S1.7831.00
233_T237_K1.7731.00
14_L29_L1.7551.00
90_E94_E1.7171.00
17_L24_L1.7031.00
92_C99_V1.7021.00
17_L32_L1.6951.00
84_A243_I1.6871.00
16_N50_M1.6841.00
17_L33_T1.6841.00
170_D173_K1.6811.00
44_V53_L1.6631.00
171_P175_L1.6581.00
17_L29_L1.6581.00
202_A237_K1.6541.00
191_S221_E1.6351.00
219_G224_F1.6011.00
24_L32_L1.5991.00
25_T28_E1.5881.00
44_V61_Y1.5571.00
228_R231_Y1.5461.00
186_Y233_T1.5391.00
217_I232_L1.5281.00
177_E180_A1.5241.00
95_V235_K1.5191.00
164_G167_T1.5171.00
29_L40_V1.5161.00
23_S62_S1.5071.00
87_V90_E1.5061.00
191_S196_Y1.5011.00
151_I175_L1.4861.00
35_M40_V1.4811.00
147_P150_E1.4801.00
181_S187_T1.4801.00
23_S60_A1.4731.00
235_K238_D1.4711.00
109_A142_I1.4221.00
66_V69_E1.4121.00
48_E53_L1.4051.00
116_E122_R1.4031.00
18_F23_S1.4031.00
205_F244_S1.3931.00
152_E171_P1.3801.00
48_E55_R1.3761.00
109_A133_L1.3501.00
84_A101_L1.3491.00
12_M50_M1.3421.00
56_D62_S1.3401.00
92_C115_I1.3291.00
16_N52_F1.3221.00
81_R113_E1.3201.00
107_N157_Q1.3051.00
240_A244_S1.2961.00
18_F24_L1.2951.00
91_L235_K1.2901.00
156_K171_P1.2671.00
88_M101_L1.2551.00
178_I181_S1.2471.00
168_I177_E1.2451.00
30_V40_V1.2451.00
85_K89_E1.2451.00
41_H45_S1.2421.00
91_L239_A1.2291.00
148_R175_L1.2231.00
238_D242_Q1.2211.00
36_P39_S1.2121.00
29_L44_V1.2091.00
205_F211_V1.1671.00
144_S181_S1.1651.00
148_R152_E1.1491.00
26_L41_H1.1301.00
104_R146_L1.1131.00
145_F203_P1.1111.00
202_A233_T1.1091.00
166_G191_S1.1091.00
27_S31_S1.1061.00
145_F211_V1.1021.00
9_V46_S1.0971.00
95_V232_L1.0941.00
237_K241_L1.0931.00
151_I182_V1.0901.00
135_A167_T1.0851.00
104_R107_N1.0841.00
102_I109_A1.0821.00
135_A163_I1.0771.00
21_K32_L1.0761.00
138_C214_G1.0711.00
25_T60_A1.0631.00
148_R151_I1.0591.00
101_L213_A1.0581.00
67_F74_V1.0581.00
9_V49_E1.0541.00
105_D130_R1.0531.00
242_Q246_K1.0521.00
90_E239_A1.0411.00
89_E93_R1.0411.00
5_N46_S1.0401.00
101_L204_I1.0331.00
148_R179_D1.0311.00
103_M213_A1.0251.00
155_I171_P1.0181.00
95_V217_I1.0181.00
134_Y167_T1.0171.00
26_L30_V1.0141.00
136_G139_A1.0131.00
88_M99_V1.0121.00
234_E238_D1.0121.00
52_F70_F1.0091.00
206_N210_Q1.0071.00
215_I243_I1.0011.00
28_E31_S0.9891.00
150_E153_A0.9891.00
94_E238_D0.9851.00
241_L245_R0.9801.00
225_T228_R0.9751.00
162_S169_T0.9741.00
152_E156_K0.9701.00
85_K115_I0.9701.00
23_S56_D0.9581.00
27_S37_K0.9481.00
165_S195_N0.9451.00
181_S184_N0.9371.00
141_S145_F0.9351.00
102_I111_Y0.9331.00
83_I246_K0.9281.00
137_A199_A0.9281.00
179_D183_Q0.9131.00
150_E154_Y0.9121.00
6_K10_K0.9101.00
28_E32_L0.9091.00
203_P211_V0.9081.00
14_L33_T0.9051.00
110_I130_R0.9031.00
151_I178_I0.9021.00
176_Q180_A0.8991.00
200_I233_T0.8951.00
173_K177_E0.8851.00
153_A157_Q0.8851.00
175_L179_D0.8841.00
143_L174_L0.8821.00
230_P234_E0.8781.00
80_I213_A0.8751.00
176_Q179_D0.8731.00
163_I167_T0.8721.00
99_V217_I0.8721.00
163_I193_L0.8701.00
206_N212_A0.8651.00
88_M113_E0.8651.00
191_S195_N0.8601.00
15_L67_F0.8581.00
141_S211_V0.8481.00
88_M215_I0.8451.00
20_H32_L0.8411.00
239_A242_Q0.8351.00
190_Y221_E0.8341.00
38_T41_H0.8321.00
100_Q218_A0.8311.00
201_G216_S0.8261.00
141_S181_S0.8241.00
231_Y235_K0.8231.00
81_R85_K0.8141.00
10_K39_S0.8121.00
138_C216_S0.8111.00
137_A201_G0.8051.00
184_N233_T0.8021.00
105_D110_I0.8011.00
48_E61_Y0.8011.00
220_F223_R0.8001.00
97_E119_Q0.7941.00
33_T40_V0.7941.00
144_S178_I0.7931.00
173_K176_Q0.7921.00
168_I173_K0.7891.00
177_E181_S0.7851.00
180_A183_Q0.7831.00
104_R150_E0.7811.00
14_L43_M0.7751.00
236_V240_A0.7691.00
35_M39_S0.7611.00
7_T11_S0.7541.00
55_R59_G0.7531.00
177_E184_N0.7511.00
87_V243_I0.7461.00
142_I214_G0.7431.00
15_L52_F0.7411.00
205_F212_A0.7381.00
45_S49_E0.7381.00
45_S48_E0.7351.00
26_L40_V0.7331.00
67_F71_G0.7331.00
67_F70_F0.7311.00
151_I154_Y0.7311.00
26_L44_V0.7281.00
234_E237_K0.7281.00
119_Q223_R0.7281.00
24_L29_L0.7281.00
100_Q114_K0.7271.00
80_I84_A0.7261.00
88_M115_I0.7261.00
54_S64_G0.7191.00
30_V33_T0.7171.00
146_L151_I0.7161.00
55_R58_S0.7131.00
199_A216_S0.7111.00
200_I229_L0.7101.00
199_A218_A0.7061.00
135_A193_L0.7031.00
100_Q125_T0.7021.00
107_N154_Y0.7001.00
21_K24_L0.6961.00
140_R181_S0.6951.00
8_V43_M0.6921.00
238_D241_L0.6871.00
154_Y158_T0.6861.00
231_Y234_E0.6861.00
188_V229_L0.6851.00
190_Y226_E0.6781.00
229_L234_E0.6781.00
5_N43_M0.6781.00
63_L67_F0.6781.00
103_M112_V0.6781.00
14_L40_V0.6731.00
26_L37_K0.6731.00
168_I174_L0.6691.00
83_I86_P0.6641.00
71_G74_V0.6631.00
151_I179_D0.6601.00
54_S65_L0.6601.00
104_R142_I0.6601.00
91_L217_I0.6591.00
90_E93_R0.6581.00
79_D82_K0.6571.00
237_K240_A0.6541.00
148_R182_V0.6541.00
241_L244_S0.6541.00
91_L95_V0.6511.00
26_L61_Y0.6501.00
142_I146_L0.6491.00
92_C117_G0.6471.00
239_A243_I0.6451.00
151_I155_I0.6441.00
229_L233_T0.6441.00
215_I240_A0.6431.00
169_T173_K0.6411.00
100_Q199_A0.6401.00
179_D182_V0.6381.00
185_G205_F0.6371.00
202_A244_S0.6281.00
143_L178_I0.6271.00
134_Y160_L0.6261.00
13_A16_N0.6231.00
155_I159_E0.6201.00
16_N69_E0.6181.00
91_L99_V0.6141.00
132_P135_A0.6141.00
228_R232_L0.6121.00
215_I239_A0.6091.00
164_G168_I0.6071.00
10_K35_M0.6041.00
96_D118_T0.6031.00
191_S198_A0.6021.00
126_A129_R0.5981.00
97_E219_G0.5971.00
52_F66_V0.5971.00
8_V12_M0.5961.00
19_L70_F0.5951.00
45_S55_R0.5941.00
7_T43_M0.5931.00
89_E113_E0.5911.00
23_S58_S0.5901.00
30_V37_K0.5891.00
19_L63_L0.5881.00
13_A17_L0.5871.00
56_D60_A0.5871.00
143_L151_I0.5861.00
166_G195_N0.5861.00
11_S43_M0.5821.00
116_E126_A0.5801.00
242_Q245_R0.5781.00
114_K127_I0.5761.00
93_R118_T0.5751.00
86_P246_K0.5731.00
55_R61_Y0.5681.00
232_L235_K0.5671.00
172_E175_L0.5641.00
28_E60_A0.5641.00
142_I213_A0.5641.00
99_V115_I0.5631.00
186_Y237_K0.5611.00
97_E217_I0.5601.00
111_Y138_C0.5601.00
141_S201_G0.5591.00
235_K239_A0.5581.00
8_V46_S0.5571.00
51_G66_V0.5561.00
136_G199_A0.5540.99
15_L70_F0.5530.99
202_A215_I0.5480.99
83_I243_I0.5450.99
114_K125_T0.5430.99
111_Y125_T0.5410.99
109_A131_S0.5400.99
141_S203_P0.5390.99
204_I213_A0.5380.99
174_L178_I0.5370.99
17_L20_H0.5350.99
113_E127_I0.5340.99
84_A88_M0.5340.99
109_A138_C0.5300.99
121_V222_A0.5300.99
111_Y136_G0.5260.99
196_Y221_E0.5250.99
16_N70_F0.5250.99
140_R189_S0.5240.99
141_S214_G0.5180.99
107_N158_T0.5180.99
41_H55_R0.5170.99
72_Q75_A0.5170.99
141_S187_T0.5130.99
215_I236_V0.5100.99
98_A114_K0.5100.99
68_L75_A0.5090.99
86_P90_E0.5090.99
172_E176_Q0.5080.99
111_Y114_K0.5060.99
145_F182_V0.5060.99
11_S47_L0.5050.99
201_G214_G0.5040.99
109_A136_G0.5040.99
207_H244_S0.5030.99
125_T129_R0.5020.99
25_T37_K0.5020.99
100_Q216_S0.5020.99
10_K43_M0.5020.99
138_C199_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mq0A 2 0.988 100 0.084 Contact Map
1mkmA 4 0.984 100 0.088 Contact Map
2g7uA 6 0.996 100 0.088 Contact Map
2ia2A 4 0.984 100 0.089 Contact Map
3r4kA 2 0.984 100 0.097 Contact Map
2xrnA 3 0.956 100 0.122 Contact Map
2o0yA 4 0.968 100 0.136 Contact Map
1ysqA 1 0.696 100 0.395 Contact Map
1tf1A 1 0.732 100 0.395 Contact Map
1yspA 1 0.656 100 0.402 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.