GREMLIN Database
YCSI - UPF0317 protein YcsI
UniProt: P42966 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (252)
Sequences: 799 (562)
Seq/√Len: 35.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_E208_S4.4671.00
126_A131_D4.2831.00
105_F235_M4.1631.00
143_I193_I3.1091.00
155_M185_I2.8311.00
29_A109_L2.7911.00
102_E105_F2.7601.00
228_A236_V2.6971.00
86_R92_E2.5751.00
34_L42_F2.4721.00
73_A245_L2.3651.00
64_P76_R2.3460.99
84_I94_V2.3430.99
33_V97_I2.3010.99
144_D154_Q2.2810.99
83_R93_E2.2300.99
154_Q226_A2.2180.99
46_C55_V2.2160.99
41_D150_A2.1780.99
3_P23_S2.0780.99
163_P167_A2.0670.99
163_P212_G2.0540.99
127_V137_S2.0230.98
162_V167_A1.9970.98
140_K203_F1.9930.98
38_L150_A1.9640.98
11_R78_D1.9620.98
66_P73_A1.8990.98
44_L48_R1.8790.97
125_I162_V1.8410.97
45_F145_C1.8390.97
163_P166_L1.8310.97
114_F135_N1.8190.97
77_T98_T1.7790.96
81_K93_E1.7290.96
84_I100_Y1.7210.96
87_H234_E1.7160.96
35_K102_E1.7140.96
210_R213_E1.7040.95
6_V10_I1.6920.95
134_T207_V1.6730.95
128_R213_E1.6630.95
147_P152_H1.6490.95
65_V72_D1.6440.94
9_L14_K1.6350.94
31_L107_G1.6340.94
70_A245_L1.6190.94
38_L234_E1.6050.94
132_E213_E1.5930.93
166_L169_R1.5750.93
169_R172_Q1.5410.92
169_R173_V1.5320.92
249_I253_S1.5140.92
209_I213_E1.5120.91
81_K95_S1.4910.91
171_A187_I1.4890.91
155_M193_I1.4840.91
70_A73_A1.4610.90
6_V22_M1.4570.90
59_T75_I1.4510.90
59_T107_G1.4430.89
132_E207_V1.4420.89
164_E167_A1.4380.89
81_K243_H1.4320.89
7_R248_D1.4290.89
57_D66_P1.4280.89
32_V238_T1.4250.89
43_L58_V1.4230.89
32_V228_A1.4180.89
203_F229_M1.3990.88
10_I246_I1.3960.88
75_I107_G1.3870.87
145_C154_Q1.3730.87
94_V100_Y1.3600.86
118_Q251_D1.3510.86
44_L47_Q1.3490.86
128_R210_R1.3480.86
92_E99_P1.3380.85
127_V130_I1.3250.85
6_V15_I1.3240.85
172_Q175_S1.3180.85
140_K154_Q1.3030.84
27_A251_D1.2990.84
38_L151_F1.2980.84
91_T94_V1.2860.83
27_A56_L1.2810.83
59_T66_P1.2800.83
57_D245_L1.2680.82
97_I237_I1.2630.82
109_L245_L1.2610.82
161_P213_E1.2590.82
102_E235_M1.2520.81
51_K219_A1.2460.81
3_P26_Y1.2430.81
60_E63_S1.2310.80
220_C239_H1.2290.80
168_V171_A1.2290.80
207_V213_E1.2260.80
250_R253_S1.2130.79
10_I15_I1.2120.79
42_F151_F1.2060.79
79_F107_G1.1870.78
221_G239_H1.1770.77
135_N138_M1.1760.77
198_L209_I1.1660.76
187_I214_V1.1600.76
40_F44_L1.1520.76
43_L47_Q1.1510.76
86_R91_T1.1230.74
6_V23_S1.1220.74
227_V231_V1.1220.74
121_I130_I1.1220.74
239_H244_M1.1210.74
38_L233_P1.1190.73
27_A180_V1.1170.73
92_E100_Y1.0830.71
4_K8_A1.0670.70
85_Y235_M1.0630.69
40_F60_E1.0600.69
64_P107_G1.0590.69
37_D150_A1.0560.69
8_A12_E1.0520.69
142_N193_I1.0450.68
169_R175_S1.0440.68
161_P207_V1.0180.66
75_I79_F1.0120.66
168_V172_Q1.0110.66
89_I232_K1.0100.65
48_R148_A1.0080.65
20_A129_H1.0080.65
10_I22_M0.9980.65
189_N192_A0.9970.64
186_H190_P0.9890.64
162_V168_V0.9840.63
57_D109_L0.9840.63
35_K105_F0.9780.63
168_V187_I0.9730.63
15_I22_M0.9710.62
18_P135_N0.9690.62
6_V246_I0.9630.62
220_C244_M0.9580.61
145_C186_H0.9560.61
44_L148_A0.9470.60
76_R97_I0.9470.60
115_S251_D0.9440.60
18_P243_H0.9430.60
114_F138_M0.9390.60
48_R60_E0.9380.60
134_T205_D0.9380.60
57_D73_A0.9350.59
69_A75_I0.9330.59
164_E192_A0.9320.59
162_V166_L0.9310.59
40_F59_T0.9290.59
222_V242_G0.9200.58
31_L75_I0.9090.57
59_T73_A0.9080.57
85_Y238_T0.9070.57
231_V254_L0.9060.57
81_K240_A0.9030.57
37_D234_E0.8990.56
129_H137_S0.8930.56
53_C224_P0.8910.56
168_V175_S0.8910.56
27_A254_L0.8900.56
79_F109_L0.8870.55
249_I254_L0.8850.55
66_P245_L0.8770.55
34_L233_P0.8760.54
45_F227_V0.8760.54
203_F212_G0.8750.54
83_R90_L0.8690.54
208_S213_E0.8690.54
164_E214_V0.8680.54
203_F226_A0.8660.54
172_Q177_F0.8610.53
41_D149_G0.8530.52
138_M241_P0.8470.52
57_D67_S0.8450.52
25_G214_V0.8410.51
85_Y229_M0.8410.51
20_A130_I0.8400.51
33_V79_F0.8350.51
27_A94_V0.8310.51
10_I23_S0.8220.50
122_N252_E0.8200.50
26_Y250_R0.8190.50
110_I219_A0.8150.49
221_G244_M0.8130.49
56_L180_V0.8100.49
139_Y199_G0.8100.49
118_Q122_N0.8060.48
112_C220_C0.8010.48
186_H189_N0.7990.48
117_E160_R0.7990.48
16_N95_S0.7940.47
85_Y236_V0.7900.47
40_F43_L0.7880.47
121_I127_V0.7860.47
48_R236_V0.7840.47
138_M205_D0.7770.46
135_N205_D0.7740.46
170_A175_S0.7620.45
171_A175_S0.7610.45
134_T208_S0.7580.44
84_I97_I0.7580.44
136_V222_V0.7540.44
136_V205_D0.7490.44
112_C221_G0.7470.43
227_V236_V0.7460.43
41_D48_R0.7430.43
125_I166_L0.7420.43
85_Y94_V0.7420.43
86_R100_Y0.7410.43
173_V199_G0.7370.43
115_S254_L0.7350.42
143_I155_M0.7310.42
132_E210_R0.7210.41
179_A251_D0.7200.41
9_L23_S0.7200.41
10_I79_F0.7190.41
112_C239_H0.7170.41
167_A254_L0.7140.41
83_R240_A0.7130.41
13_G16_N0.7040.40
31_L97_I0.7030.40
75_I245_L0.7020.40
163_P168_V0.6990.39
80_P93_E0.6930.39
155_M219_A0.6920.39
128_R161_P0.6880.38
137_S207_V0.6850.38
180_V251_D0.6820.38
29_A174_T0.6790.38
39_A106_V0.6760.37
148_A229_M0.6750.37
33_V107_G0.6720.37
27_A177_F0.6680.37
75_I98_T0.6680.37
5_D9_L0.6680.37
81_K94_V0.6640.36
26_Y247_T0.6640.36
6_V14_K0.6590.36
121_I126_A0.6590.36
171_A183_G0.6550.36
25_G212_G0.6540.36
132_E161_P0.6510.35
209_I214_V0.6490.35
26_Y45_F0.6480.35
125_I170_A0.6470.35
60_E129_H0.6470.35
145_C236_V0.6430.35
124_G235_M0.6420.35
38_L85_Y0.6410.35
14_K228_A0.6370.34
135_N240_A0.6360.34
150_A231_V0.6350.34
69_A245_L0.6310.34
25_G250_R0.6300.34
32_V161_P0.6290.34
226_A230_N0.6290.34
25_G145_C0.6270.34
126_A166_L0.6250.33
3_P45_F0.6250.33
43_L48_R0.6250.33
226_A229_M0.6210.33
12_E211_D0.6140.33
34_L205_D0.6130.33
40_F47_Q0.6110.32
150_A233_P0.6080.32
135_N222_V0.6080.32
9_L12_E0.6070.32
135_N203_F0.6060.32
169_R254_L0.6050.32
167_A170_A0.6030.32
123_N252_E0.6030.32
164_E185_I0.5960.31
101_W225_Q0.5950.31
119_A173_V0.5930.31
66_P75_I0.5910.31
77_T96_D0.5910.31
180_V254_L0.5900.31
136_V220_C0.5900.31
51_K129_H0.5890.31
116_F220_C0.5860.31
139_Y162_V0.5850.30
5_D192_A0.5840.30
167_A187_I0.5820.30
57_D69_A0.5820.30
199_G206_A0.5820.30
48_R58_V0.5820.30
30_N221_G0.5810.30
100_Y107_G0.5800.30
10_I97_I0.5790.30
135_N161_P0.5780.30
6_V179_A0.5770.30
144_D230_N0.5740.30
81_K85_Y0.5740.30
15_I27_A0.5720.29
161_P208_S0.5720.29
55_V147_P0.5690.29
69_A76_R0.5680.29
170_A218_W0.5680.29
40_F58_V0.5650.29
95_S200_K0.5640.29
93_E240_A0.5620.29
66_P110_I0.5600.29
192_A212_G0.5590.29
178_P183_G0.5590.29
137_S199_G0.5580.29
206_A234_E0.5550.28
171_A186_H0.5550.28
139_Y207_V0.5540.28
43_L60_E0.5540.28
71_P99_P0.5540.28
30_N239_H0.5510.28
4_K248_D0.5470.28
35_K104_D0.5460.28
97_I235_M0.5460.28
50_Q225_Q0.5450.28
115_S118_Q0.5450.28
91_T155_M0.5440.28
71_P107_G0.5440.28
138_M220_C0.5430.27
139_Y165_R0.5410.27
3_P10_I0.5400.27
61_A197_D0.5390.27
73_A109_L0.5380.27
167_A171_A0.5380.27
165_R168_V0.5370.27
137_S153_G0.5360.27
16_N81_K0.5340.27
59_T63_S0.5340.27
22_M246_I0.5330.27
40_F48_R0.5330.27
144_D147_P0.5320.27
138_M222_V0.5310.27
124_G139_Y0.5310.27
158_S198_L0.5310.27
25_G163_P0.5300.27
114_F136_V0.5300.27
37_D67_S0.5290.27
52_P110_I0.5290.27
57_D146_V0.5270.26
243_H250_R0.5270.26
63_S67_S0.5260.26
8_A72_D0.5260.26
189_N211_D0.5250.26
145_C155_M0.5250.26
24_G52_P0.5240.26
9_L24_G0.5240.26
115_S177_F0.5230.26
118_Q137_S0.5230.26
102_E234_E0.5200.26
162_V187_I0.5190.26
140_K226_A0.5160.26
36_K44_L0.5160.26
5_D8_A0.5150.26
79_F245_L0.5130.25
38_L52_P0.5120.25
152_H230_N0.5110.25
251_D254_L0.5100.25
17_G165_R0.5100.25
36_K102_E0.5090.25
135_N207_V0.5090.25
144_D185_I0.5080.25
138_M244_M0.5080.25
10_I42_F0.5080.25
221_G224_P0.5050.25
26_Y253_S0.5050.25
16_N122_N0.5040.25
47_Q231_V0.5030.25
123_N253_S0.5030.25
163_P187_I0.5020.25
150_A155_M0.5020.25
20_A135_N0.5020.25
105_F237_I0.5010.25
139_Y198_L0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pifA 2 0.9533 100 0.013 Contact Map
3nekA 2 0.7549 89.7 0.958 Contact Map
2ltkA 1 0.4008 16.8 0.977 Contact Map
2yadA 3 0.249 14.3 0.977 Contact Map
3mtwA 5 0.2335 13 0.978 Contact Map
4cw9A 2 0.3774 10.6 0.979 Contact Map
3dupA 2 0.1946 10.6 0.979 Contact Map
1ns5A 2 0.5331 10.1 0.979 Contact Map
3iv4A 1 0.3813 9.2 0.979 Contact Map
1l0wA 2 0.2918 8.6 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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