GREMLIN Database
YCSG - Uncharacterized membrane protein YcsG
UniProt: P42964 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 404 (384)
Sequences: 4029 (2566)
Seq/√Len: 130.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_K84_M9.5671.00
173_P176_Q5.5481.00
310_I313_N4.7891.00
362_Y377_T4.5531.00
374_L378_S3.7951.00
361_A372_H3.5251.00
374_L377_T3.4341.00
266_S269_K3.4321.00
364_K371_K3.3071.00
358_L380_G3.2781.00
355_G388_A3.2111.00
315_R318_I3.0831.00
62_F383_V2.9071.00
372_H377_T2.8731.00
269_K274_N2.8001.00
355_G384_V2.7131.00
91_Y95_I2.6851.00
73_V370_Y2.6271.00
373_P376_L2.5831.00
65_T69_R2.5671.00
50_G242_I2.5411.00
242_I246_L2.5141.00
355_G359_V2.4701.00
177_A246_L2.4421.00
70_I361_A2.4411.00
309_K313_N2.4281.00
40_T44_T2.4271.00
210_H301_S2.4231.00
181_T242_I2.4181.00
392_I396_C2.4051.00
115_G285_W2.3791.00
314_S317_I2.3681.00
88_G92_F2.2711.00
314_S318_I2.2671.00
263_P266_S2.2321.00
179_A185_E2.2241.00
59_L383_V2.2041.00
269_K277_Y2.1691.00
174_V177_A2.1561.00
37_Q194_T2.0691.00
85_V359_V2.0051.00
66_N372_H1.9751.00
327_L330_V1.9741.00
359_V363_K1.9631.00
62_F376_L1.9281.00
116_L120_F1.9101.00
157_F161_I1.9051.00
77_R80_E1.9031.00
61_I231_V1.8821.00
393_Y397_T1.8731.00
123_T126_T1.8731.00
131_S285_W1.8491.00
385_I389_V1.8221.00
378_S381_A1.7981.00
354_L384_V1.7971.00
146_K150_R1.7961.00
70_I81_I1.7931.00
190_F341_L1.7711.00
65_T227_T1.7631.00
363_K366_I1.7581.00
334_Q337_K1.7561.00
362_Y372_H1.7261.00
166_V247_A1.7061.00
112_A131_S1.6811.00
220_K369_D1.6621.00
87_P91_Y1.6161.00
95_I99_L1.6101.00
190_F344_S1.6071.00
76_K81_I1.6011.00
381_A385_I1.5981.00
224_P228_K1.5941.00
69_R372_H1.5831.00
86_L89_L1.5731.00
176_Q180_N1.5601.00
73_V223_I1.5461.00
358_L384_V1.5431.00
362_Y381_A1.5181.00
66_N380_G1.5171.00
113_G124_P1.5141.00
23_F233_G1.4931.00
63_A354_L1.4931.00
175_G178_V1.4751.00
228_K232_V1.4261.00
47_A250_G1.4191.00
173_P177_A1.4061.00
134_I289_I1.4021.00
158_V282_L1.4001.00
54_L238_S1.3931.00
68_W226_V1.3831.00
116_L127_G1.3771.00
360_A366_I1.3741.00
172_P177_A1.3721.00
174_V178_V1.3621.00
122_I126_T1.3601.00
375_W378_S1.3591.00
278_K282_L1.3561.00
134_I137_L1.3391.00
38_T241_R1.3301.00
359_V381_A1.3211.00
275_V279_I1.3181.00
122_I127_G1.3171.00
15_W228_K1.3001.00
235_L239_V1.2951.00
41_F195_L1.2951.00
100_G349_I1.2891.00
48_S187_I1.2851.00
309_K312_K1.2831.00
371_K374_L1.2751.00
358_L362_Y1.2731.00
101_G302_F1.2591.00
322_I326_T1.2591.00
149_D215_A1.2551.00
96_L349_I1.2371.00
116_L285_W1.2321.00
156_G290_T1.2221.00
321_F325_S1.2191.00
296_A300_V1.2191.00
330_V333_G1.2181.00
372_H376_L1.2171.00
358_L377_T1.2161.00
29_A237_T1.2151.00
175_G179_A1.2131.00
378_S385_I1.2121.00
72_A226_V1.2080.99
36_T264_A1.2070.99
53_I245_F1.2020.99
168_A172_P1.1990.99
253_S256_L1.1950.99
150_R153_Q1.1950.99
369_D373_P1.1920.99
358_L381_A1.1840.99
56_S199_T1.1840.99
85_V360_A1.1770.99
26_A30_I1.1720.99
164_V243_A1.1700.99
103_A342_V1.1660.99
82_A93_I1.1650.99
341_L345_L1.1500.99
79_Q302_F1.1480.99
384_V388_A1.1410.99
41_F191_A1.1380.99
28_S294_G1.1310.99
170_T272_A1.1190.99
108_N111_G1.1190.99
155_A286_S1.1160.99
231_V235_L1.1160.99
354_L383_V1.1130.99
170_T250_G1.1110.99
323_V326_T1.1090.99
179_A183_V1.1080.99
259_D263_P1.1080.99
176_Q179_A1.1060.99
58_I62_F1.1050.99
107_G342_V1.0950.99
79_Q206_F1.0910.99
158_V286_S1.0860.99
14_S17_L1.0850.99
32_P288_A1.0800.99
266_S270_L1.0740.99
122_I130_I1.0690.99
319_I323_V1.0630.99
167_A246_L1.0610.99
202_G346_N1.0530.99
66_N361_A1.0500.99
117_Q262_N1.0420.98
163_T240_M1.0400.98
351_P388_A1.0390.98
85_V89_L1.0370.98
83_N90_G1.0360.98
180_N185_E1.0340.98
320_G323_V1.0280.98
125_E129_L1.0270.98
348_L391_G1.0220.98
147_A150_R1.0160.98
329_F332_I1.0130.98
137_L141_I1.0130.98
172_P246_L1.0080.98
77_R213_L1.0080.98
372_H375_W1.0060.98
59_L196_V0.9970.98
222_S225_Q0.9930.98
22_A26_A0.9920.98
166_V169_T0.9910.98
382_L385_I0.9880.98
67_V71_I0.9870.98
24_L294_G0.9820.98
198_G201_G0.9810.98
248_V251_V0.9810.98
178_V181_T0.9770.98
62_F379_T0.9750.98
254_K259_D0.9710.98
368_G371_K0.9700.98
338_I342_V0.9690.98
162_L279_I0.9650.98
57_I238_S0.9600.97
64_Q206_F0.9600.97
204_I294_G0.9600.97
258_I261_S0.9590.97
48_S185_E0.9580.97
386_V389_V0.9570.97
278_K281_G0.9560.97
265_A277_Y0.9490.97
260_E263_P0.9470.97
308_P311_E0.9460.97
389_V393_Y0.9430.97
76_K80_E0.9350.97
251_V255_G0.9340.97
45_L188_S0.9300.97
274_N277_Y0.9280.97
62_F380_G0.9240.97
74_S366_I0.9210.97
216_G219_G0.9200.97
78_G206_F0.9120.96
371_K377_T0.9110.96
64_Q200_V0.9100.96
297_Y301_S0.9100.96
128_A132_A0.9050.96
64_Q79_Q0.9040.96
108_N198_G0.8980.96
378_S382_L0.8970.96
101_G299_S0.8960.96
74_S81_I0.8960.96
34_F38_T0.8900.96
180_N183_V0.8890.96
258_I263_P0.8880.96
66_N70_I0.8870.96
104_F108_N0.8870.96
204_I208_G0.8770.96
165_Y168_A0.8760.96
373_P377_T0.8740.96
39_A264_A0.8740.96
191_A340_V0.8700.95
88_G91_Y0.8620.95
165_Y279_I0.8580.95
388_A392_I0.8540.95
31_G34_F0.8450.95
38_T244_L0.8450.95
326_T330_V0.8450.95
81_I360_A0.8420.95
369_D374_L0.8400.94
86_L363_K0.8360.94
35_L283_I0.8300.94
26_A72_A0.8260.94
44_T161_I0.8260.94
37_Q343_G0.8250.94
323_V327_L0.8250.94
129_L326_T0.8220.94
230_S234_I0.8210.94
30_I240_M0.8190.94
129_L133_V0.8170.94
84_M364_K0.8160.94
104_F107_G0.8140.94
116_L131_S0.8120.93
196_V351_P0.8080.93
36_T339_L0.8040.93
92_F96_L0.8030.93
347_G391_G0.8020.93
47_A180_N0.8020.93
326_T332_I0.8010.93
29_A203_Y0.7990.93
41_F53_I0.7970.93
320_G324_V0.7970.93
107_G339_L0.7950.93
273_G276_G0.7930.93
68_W208_G0.7920.93
178_V220_K0.7900.92
327_L331_T0.7900.92
220_K370_Y0.7900.92
376_L380_G0.7870.92
120_F278_K0.7850.92
157_F171_A0.7810.92
337_K341_L0.7800.92
378_S389_V0.7800.92
325_S330_V0.7770.92
270_L276_G0.7760.92
164_V168_A0.7750.92
375_W379_T0.7740.92
109_I132_A0.7730.92
51_F184_P0.7670.91
168_A171_A0.7670.91
64_Q202_G0.7660.91
165_Y169_T0.7660.91
346_N350_L0.7630.91
27_T156_G0.7630.91
105_N108_N0.7630.91
108_N291_S0.7600.91
119_L278_K0.7570.91
156_G160_I0.7570.91
300_V304_K0.7570.91
361_A367_V0.7550.91
51_F186_H0.7520.91
319_I322_I0.7520.91
274_N369_D0.7500.90
177_A249_L0.7500.90
274_N278_K0.7480.90
99_L146_K0.7470.90
328_A332_I0.7410.90
283_I287_A0.7390.90
70_I360_A0.7380.90
199_T343_G0.7380.90
81_I366_I0.7370.90
144_A147_A0.7370.90
392_I398_Q0.7340.89
53_I195_L0.7340.89
364_K369_D0.7320.89
229_S233_G0.7300.89
315_R326_T0.7300.89
242_I245_F0.7290.89
253_S258_I0.7290.89
224_P364_K0.7290.89
24_L27_T0.7260.89
203_Y209_G0.7230.89
27_T31_G0.7190.88
201_G346_N0.7140.88
33_G343_G0.7130.88
253_S257_H0.7110.88
126_T129_L0.7100.88
201_G208_G0.7100.88
280_F340_V0.7090.88
109_I127_G0.7080.88
83_N308_P0.7060.88
73_V213_L0.7050.87
80_E213_L0.7030.87
68_W72_A0.7020.87
118_V281_G0.7020.87
244_L283_I0.7010.87
89_L356_T0.7000.87
272_A279_I0.6990.87
386_V390_M0.6980.87
381_A384_V0.6970.87
29_A60_D0.6960.87
47_A173_P0.6940.87
38_T104_F0.6920.86
104_F346_N0.6900.86
96_L100_G0.6880.86
164_V239_V0.6870.86
166_V170_T0.6860.86
223_I227_T0.6820.86
32_P111_G0.6800.86
134_I327_L0.6770.85
133_V136_I0.6760.85
204_I207_A0.6730.85
30_I290_T0.6730.85
117_Q124_P0.6730.85
53_I247_A0.6710.85
288_A291_S0.6680.85
320_G332_I0.6670.84
54_L181_T0.6660.84
167_A243_A0.6650.84
28_S202_G0.6640.84
136_I140_V0.6620.84
81_I84_M0.6610.84
132_A326_T0.6610.84
21_A229_S0.6600.84
67_V212_L0.6600.84
220_K224_P0.6590.84
169_T276_G0.6590.84
201_G343_G0.6590.84
240_M244_L0.6580.84
127_G130_I0.6580.84
167_A174_V0.6580.84
60_D199_T0.6580.84
167_A247_A0.6570.84
40_T336_A0.6550.83
314_S325_S0.6550.83
223_I370_Y0.6540.83
94_A306_F0.6520.83
251_V254_K0.6520.83
112_A115_G0.6520.83
126_T178_V0.6510.83
57_I61_I0.6510.83
100_G339_L0.6480.83
67_V78_G0.6470.83
29_A34_F0.6450.82
24_L28_S0.6440.82
65_T223_I0.6440.82
157_F242_I0.6440.82
22_A115_G0.6440.82
109_I131_S0.6440.82
145_G211_R0.6410.82
163_T268_F0.6400.82
135_A292_V0.6400.82
154_I165_Y0.6390.82
194_T199_T0.6380.82
349_I353_A0.6370.82
137_L210_H0.6360.82
255_G258_I0.6320.81
25_M230_S0.6320.81
152_T293_I0.6310.81
392_I395_L0.6300.81
111_G288_A0.6290.81
20_G229_S0.6270.81
82_A85_V0.6260.81
161_I165_Y0.6250.80
243_A247_A0.6230.80
310_I314_S0.6230.80
255_G382_L0.6230.80
124_P324_V0.6210.80
133_V137_L0.6190.80
120_F127_G0.6190.80
126_T153_Q0.6180.80
19_M23_F0.6180.80
170_T251_V0.6170.80
161_I266_S0.6160.79
363_K371_K0.6160.79
64_Q199_T0.6150.79
218_K370_Y0.6140.79
205_T354_L0.6140.79
322_I330_V0.6110.79
58_I185_E0.6110.79
377_T381_A0.6110.79
202_G210_H0.6100.79
189_I193_V0.6100.79
104_F343_G0.6090.79
45_L191_A0.6090.79
24_L204_I0.6070.78
30_I163_T0.6060.78
296_A303_F0.6060.78
186_H192_I0.6060.78
66_N69_R0.6050.78
129_L137_L0.6050.78
321_F324_V0.6040.78
71_I78_G0.6040.78
32_P339_L0.6030.78
125_E330_V0.6030.78
115_G292_V0.6020.78
155_A159_M0.6020.78
34_F201_G0.6020.78
30_I38_T0.6010.78
84_M393_Y0.6000.78
154_I385_I0.5970.77
151_F368_G0.5960.77
55_I386_V0.5960.77
198_G343_G0.5960.77
63_A383_V0.5950.77
86_L359_V0.5940.77
93_I356_T0.5930.77
200_V284_M0.5920.77
128_A151_F0.5920.77
201_G205_T0.5920.77
31_G104_F0.5910.77
162_L272_A0.5900.76
203_Y347_G0.5900.76
319_I325_S0.5880.76
47_A246_L0.5880.76
173_P385_I0.5880.76
51_F187_I0.5870.76
141_I334_Q0.5870.76
31_G108_N0.5860.76
31_G38_T0.5860.76
226_V229_S0.5860.76
77_R305_T0.5850.76
70_I357_L0.5840.76
66_N362_Y0.5840.76
34_F198_G0.5830.76
373_P378_S0.5830.76
90_G96_L0.5820.76
374_L396_C0.5820.76
40_T43_N0.5810.75
96_L352_I0.5800.75
163_T264_A0.5790.75
389_V392_I0.5780.75
69_R227_T0.5770.75
130_I133_V0.5770.75
152_T290_T0.5740.75
325_S332_I0.5710.74
64_Q71_I0.5710.74
251_V276_G0.5710.74
28_S35_L0.5700.74
58_I61_I0.5690.74
251_V270_L0.5660.74
101_G295_A0.5650.73
293_I297_Y0.5640.73
323_V329_F0.5640.73
94_A98_V0.5640.73
25_M205_T0.5610.73
178_V184_P0.5600.73
24_L385_I0.5600.73
194_T344_S0.5600.73
89_L382_L0.5590.73
61_I235_L0.5580.72
102_L105_N0.5580.72
54_L242_I0.5580.72
108_N203_Y0.5560.72
171_A174_V0.5560.72
256_L259_D0.5540.72
49_F189_I0.5540.72
117_Q120_F0.5520.72
151_F157_F0.5520.72
82_A306_F0.5510.72
248_V252_V0.5510.72
295_A346_N0.5490.71
145_G214_D0.5490.71
319_I326_T0.5480.71
44_T345_L0.5470.71
15_W19_M0.5450.71
180_N299_S0.5450.71
194_T280_F0.5420.70
353_A356_T0.5420.70
140_V328_A0.5410.70
68_W75_G0.5410.70
117_Q359_V0.5410.70
175_G278_K0.5400.70
326_T329_F0.5390.70
203_Y241_R0.5380.70
319_I330_V0.5370.70
32_P208_G0.5360.69
110_G113_G0.5350.69
284_M338_I0.5340.69
171_A179_A0.5330.69
67_V209_G0.5330.69
267_V283_I0.5320.69
28_S204_I0.5320.69
203_Y206_F0.5320.69
154_I278_K0.5320.69
131_S139_F0.5310.69
130_I259_D0.5310.69
262_N265_A0.5310.69
63_A205_T0.5310.69
96_L101_G0.5310.69
43_N252_V0.5310.69
324_V330_V0.5300.69
16_S217_I0.5280.68
236_I240_M0.5280.68
154_I327_L0.5270.68
163_T244_L0.5270.68
71_I209_G0.5260.68
22_A50_G0.5250.68
60_D237_T0.5250.68
264_A280_F0.5250.68
28_S205_T0.5240.68
60_D234_I0.5220.67
166_V268_F0.5210.67
80_E84_M0.5210.67
264_A267_V0.5200.67
170_T388_A0.5190.67
51_F188_S0.5180.67
47_A249_L0.5180.67
247_A267_V0.5160.67
151_F228_K0.5150.66
22_A233_G0.5150.66
178_V183_V0.5140.66
55_I126_T0.5120.66
124_P128_A0.5120.66
30_I159_M0.5120.66
77_R209_G0.5120.66
73_V367_V0.5120.66
138_I142_K0.5110.66
97_V302_F0.5110.66
25_M28_S0.5110.66
108_N202_G0.5110.66
193_V388_A0.5110.66
14_S18_L0.5100.66
328_A331_T0.5100.66
371_K376_L0.5100.66
197_G298_T0.5100.66
106_I342_V0.5090.66
262_N266_S0.5090.66
363_K377_T0.5090.66
28_S353_A0.5080.65
35_L204_I0.5080.65
48_S186_H0.5080.65
28_S288_A0.5080.65
342_V346_N0.5080.65
109_I292_V0.5070.65
195_L199_T0.5050.65
131_S135_A0.5050.65
35_L198_G0.5040.65
25_M204_I0.5040.65
206_F357_L0.5020.64
44_T48_S0.5020.64
71_I77_R0.5020.64
321_F328_A0.5020.64
133_V138_I0.5020.64
89_L360_A0.5000.64
184_P187_I0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wgvA 2 0.9035 100 0.236 Contact Map
3dh4A 3 0.9208 99.2 0.853 Contact Map
2xq2A 2 0.9257 99 0.868 Contact Map
3l1lA 2 0.9109 98.9 0.87 Contact Map
3giaA 1 0.9307 98.8 0.876 Contact Map
2jlnA 1 0.9703 98.5 0.886 Contact Map
4djkA 2 0.901 98.4 0.89 Contact Map
2a65A 2 0.9604 98 0.902 Contact Map
4us3A 1 0.9183 97.9 0.903 Contact Map
4xp4A 1 0.9406 97.6 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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