GREMLIN Database
YCSE - Putative phosphatase YcsE
UniProt: P42962 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (231)
Sequences: 11726 (9461)
Seq/√Len: 622.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_D242_K3.9341.00
24_D236_I3.2271.00
197_A211_A3.0401.00
234_T237_E2.7931.00
11_K194_N2.7271.00
208_I214_G2.5791.00
29_S238_D2.5021.00
185_T195_V2.4951.00
31_E238_D2.4471.00
15_I46_V2.3861.00
50_T57_C2.3801.00
222_D226_E2.2931.00
23_N27_L2.2451.00
31_E245_R2.1831.00
209_K227_T2.1791.00
182_A210_E2.1151.00
176_N206_A1.9501.00
192_M210_E1.9321.00
202_L223_I1.7821.00
205_I224_V1.7701.00
87_E183_K1.7591.00
10_I196_M1.7501.00
30_D34_K1.7351.00
202_L221_Q1.7351.00
205_I227_T1.7351.00
38_E41_D1.7161.00
191_T194_N1.6931.00
12_L47_V1.6921.00
14_A181_L1.6851.00
92_H95_H1.6541.00
38_E245_R1.6511.00
39_A44_V1.6441.00
215_V243_A1.6151.00
214_G229_D1.6121.00
233_D237_E1.6081.00
80_D84_N1.5931.00
183_K186_E1.5831.00
216_A228_A1.5751.00
222_D225_K1.5691.00
33_R63_S1.5681.00
183_K187_K1.5641.00
36_I46_V1.5581.00
104_N121_G1.5381.00
182_A186_E1.5361.00
197_A207_M1.5261.00
230_Y247_W1.5111.00
178_A210_E1.5001.00
213_L230_Y1.4991.00
213_L229_D1.4931.00
10_I44_V1.4921.00
17_M22_L1.4901.00
224_V227_T1.4901.00
181_L207_M1.4831.00
179_A182_A1.4701.00
38_E42_K1.4581.00
14_A49_S1.4521.00
230_Y243_A1.4331.00
89_K183_K1.4221.00
15_I198_M1.4101.00
34_K38_E1.4071.00
45_Y188_L1.3931.00
95_H157_E1.3881.00
10_I194_N1.3731.00
29_S32_N1.3691.00
198_M240_V1.3531.00
103_R137_F1.3471.00
149_L153_R1.3281.00
40_E67_S1.3211.00
10_I213_L1.3111.00
216_A220_A1.3091.00
98_M157_E1.3081.00
185_T192_M1.3021.00
31_E242_K1.2941.00
198_M243_A1.2841.00
93_T97_Q1.2631.00
32_N238_D1.2601.00
95_H98_M1.2531.00
230_Y246_H1.2431.00
205_I209_K1.2411.00
33_R37_R1.2281.00
193_E212_G1.2171.00
88_R131_E1.2101.00
106_H151_E1.1991.00
240_V244_I1.1941.00
159_E206_A1.1871.00
35_A241_A1.1841.00
192_M195_V1.1821.00
197_A208_I1.1541.00
218_G234_T1.1531.00
223_I226_E1.1521.00
232_T239_G1.1401.00
243_A247_W1.1381.00
31_E35_A1.1321.00
89_K172_A1.1311.00
208_I224_V1.1291.00
225_K231_I1.1291.00
85_L88_R1.1171.00
102_L106_H1.1161.00
47_V184_V1.1101.00
13_I244_I1.1051.00
77_E85_L1.0951.00
37_R41_D1.0911.00
13_I44_V1.0901.00
23_N236_I1.0801.00
144_I147_E1.0771.00
71_I180_A1.0741.00
176_N179_A1.0721.00
195_V211_A1.0671.00
95_H158_L1.0661.00
98_M155_N1.0641.00
40_E68_S1.0591.00
196_M247_W1.0581.00
35_A245_R1.0481.00
17_M60_L1.0451.00
12_L190_F1.0411.00
215_V232_T1.0291.00
157_E173_L1.0201.00
232_T243_A1.0201.00
12_L185_T1.0181.00
14_A195_V1.0171.00
88_R133_L1.0171.00
184_V188_L1.0161.00
220_A225_K1.0131.00
146_N150_E1.0111.00
196_M215_V1.0101.00
241_A245_R1.0071.00
13_I39_A1.0061.00
24_D235_N1.0061.00
150_E153_R1.0041.00
185_T210_E0.9931.00
192_M212_G0.9911.00
159_E174_G0.9901.00
161_T171_N0.9811.00
37_R40_E0.9811.00
219_N235_N0.9791.00
201_S221_Q0.9731.00
30_D33_R0.9651.00
12_L195_V0.9641.00
146_N162_N0.9641.00
221_Q224_V0.9621.00
76_S175_I0.9571.00
78_I183_K0.9531.00
14_A47_V0.9521.00
242_K246_H0.9511.00
21_L32_N0.9501.00
217_M239_G0.9501.00
134_K169_E0.9461.00
178_A206_A0.9461.00
211_A214_G0.9401.00
243_A246_H0.9361.00
37_R65_K0.9331.00
196_M243_A0.9281.00
146_N149_L0.9271.00
215_V230_Y0.9261.00
182_A192_M0.9241.00
102_L105_K0.9221.00
89_K174_G0.9161.00
69_F188_L0.9131.00
233_D239_G0.9061.00
54_L72_T0.9041.00
72_T77_E0.8991.00
185_T212_G0.8901.00
181_L211_A0.8871.00
94_D98_M0.8871.00
217_M232_T0.8831.00
202_L205_I0.8761.00
50_T72_T0.8741.00
196_M213_L0.8711.00
101_D105_K0.8711.00
15_I240_V0.8691.00
79_W85_L0.8671.00
58_R83_F0.8671.00
78_I87_E0.8651.00
172_A175_I0.8621.00
216_A224_V0.8611.00
34_K37_R0.8611.00
218_G225_K0.8551.00
185_T190_F0.8541.00
21_L36_I0.8541.00
171_N176_N0.8531.00
147_E150_E0.8511.00
32_N241_A0.8361.00
39_A46_V0.8331.00
88_R115_V0.8331.00
90_L131_E0.8301.00
98_M102_L0.8291.00
47_V69_F0.8261.00
71_I184_V0.8261.00
97_Q101_D0.8251.00
49_S71_I0.8221.00
100_W104_N0.8131.00
78_I180_A0.8121.00
218_G233_D0.8071.00
151_E155_N0.8021.00
218_G237_E0.7951.00
147_E151_E0.7911.00
44_V196_M0.7871.00
72_T79_W0.7861.00
159_E176_N0.7851.00
208_I227_T0.7821.00
242_K245_R0.7801.00
160_I170_V0.7791.00
17_M48_I0.7781.00
54_L79_W0.7771.00
53_T73_A0.7761.00
233_D246_H0.7731.00
98_M101_D0.7731.00
223_I227_T0.7721.00
13_I196_M0.7721.00
195_V212_G0.7711.00
212_G229_D0.7671.00
149_L162_N0.7661.00
32_N35_A0.7651.00
86_V187_K0.7591.00
58_R62_E0.7581.00
195_V210_E0.7521.00
15_I21_L0.7471.00
39_A244_I0.7451.00
23_N29_S0.7411.00
181_L197_A0.7381.00
217_M220_A0.7331.00
84_N187_K0.7331.00
200_D220_A0.7331.00
151_E154_K0.7321.00
69_F184_V0.7321.00
102_L151_E0.7261.00
156_K173_L0.7131.00
140_E144_I0.7111.00
48_I57_C0.7101.00
105_K151_E0.7021.00
90_L133_L0.6951.00
175_I179_A0.6891.00
179_A183_K0.6881.00
77_E133_L0.6871.00
106_H147_E0.6851.00
31_E241_A0.6841.00
159_E173_L0.6811.00
214_G224_V0.6791.00
79_W83_F0.6771.00
93_T131_E0.6741.00
91_L172_A0.6721.00
182_A185_T0.6721.00
69_F80_D0.6721.00
49_S207_M0.6721.00
232_T242_K0.6711.00
35_A38_E0.6711.00
57_C72_T0.6701.00
23_N235_N0.6701.00
194_N212_G0.6691.00
200_D217_M0.6651.00
220_A224_V0.6651.00
136_G169_E0.6651.00
73_A169_E0.6641.00
142_D146_N0.6591.00
230_Y242_K0.6581.00
145_R149_L0.6571.00
51_G203_N0.6571.00
94_D97_Q0.6551.00
197_A214_G0.6461.00
12_L184_V0.6451.00
74_N169_E0.6431.00
19_G217_M0.6421.00
25_E236_I0.6421.00
104_N110_F0.6411.00
31_E34_K0.6401.00
32_N36_I0.6381.00
54_L58_R0.6371.00
21_L28_I0.6361.00
198_M215_V0.6351.00
230_Y233_D0.6331.00
96_I100_W0.6271.00
17_M21_L0.6271.00
10_I45_Y0.6271.00
45_Y69_F0.6261.00
160_I168_I0.6241.00
76_S172_A0.6191.00
150_E154_K0.6181.00
178_A182_A0.6121.00
208_I228_A0.6111.00
57_C70_L0.6071.00
214_G228_A0.6071.00
13_I198_M0.6061.00
202_L224_V0.6041.00
21_L48_I0.6031.00
206_A209_K0.6021.00
219_N225_K0.6021.00
233_D243_A0.6021.00
85_L115_V0.5941.00
159_E171_N0.5931.00
21_L235_N0.5921.00
96_I132_W0.5911.00
45_Y68_S0.5901.00
102_L155_N0.5891.00
100_W112_A0.5881.00
73_A76_S0.5831.00
48_I61_A0.5831.00
198_M232_T0.5801.00
44_V194_N0.5801.00
11_K44_V0.5781.00
174_G179_A0.5731.00
141_D144_I0.5731.00
107_N144_I0.5721.00
17_M57_C0.5651.00
213_L243_A0.5641.00
35_A39_A0.5631.00
216_A227_T0.5631.00
143_D147_E0.5591.00
28_I33_R0.5591.00
148_V152_L0.5561.00
217_M235_N0.5521.00
78_I184_V0.5521.00
22_L235_N0.5511.00
114_T132_W0.5430.99
49_S74_N0.5400.99
114_T119_W0.5400.99
111_W136_G0.5390.99
99_M103_R0.5370.99
100_W110_F0.5370.99
190_F195_V0.5360.99
53_T56_T0.5340.99
224_V228_A0.5330.99
73_A167_N0.5310.99
20_T203_N0.5310.99
80_D187_K0.5300.99
115_V130_H0.5300.99
73_A133_L0.5270.99
238_D241_A0.5260.99
115_V131_E0.5240.99
15_I39_A0.5240.99
77_E115_V0.5230.99
164_S201_S0.5230.99
61_A70_L0.5210.99
12_L45_Y0.5200.99
40_E65_K0.5190.99
219_N234_T0.5190.99
205_I208_I0.5190.99
78_I187_K0.5170.99
29_S241_A0.5160.99
34_K245_R0.5150.99
221_Q225_K0.5120.99
21_L240_V0.5080.99
56_T167_N0.5070.99
198_M244_I0.5040.99
47_V68_S0.5030.99
73_A136_G0.5010.99
92_H96_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nrwA 1 0.9598 100 0.195 Contact Map
3pgvA 3 0.9639 100 0.212 Contact Map
3l7yA 1 0.9558 100 0.237 Contact Map
4qjbA 1 0.996 100 0.243 Contact Map
1rkqA 1 0.9719 100 0.25 Contact Map
3dnpA 2 0.9598 100 0.251 Contact Map
2b30A 2 0.992 100 0.252 Contact Map
3fzqA 2 0.9558 100 0.255 Contact Map
1nf2A 4 0.9598 100 0.255 Contact Map
2pq0A 1 0.9478 100 0.26 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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