GREMLIN Database
LEPU - Signal peptidase I U
UniProt: P42959 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 187 (165)
Sequences: 6774 (4752)
Seq/√Len: 369.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_Q111_K3.6611.00
144_Y166_E3.1021.00
97_S136_E3.0831.00
96_D108_N2.9561.00
144_Y169_I2.7321.00
45_S48_A2.7311.00
99_K136_E2.6881.00
143_K165_S2.6551.00
71_R93_L2.5001.00
143_K163_M2.4971.00
69_F90_L2.3961.00
60_D63_V2.2491.00
97_S138_E2.2441.00
75_I146_V2.2371.00
48_A52_K2.0151.00
64_K69_F1.9901.00
71_R96_D1.9391.00
46_S88_K1.8611.00
44_G53_D1.8231.00
38_K61_K1.8091.00
33_R38_K1.8001.00
90_L146_V1.7711.00
71_R107_I1.7651.00
139_V163_M1.7501.00
79_D86_F1.7471.00
60_D174_S1.7341.00
87_V173_E1.7321.00
105_L112_V1.7121.00
59_V171_G1.7011.00
25_I29_I1.6801.00
85_S170_I1.6511.00
165_S168_D1.6421.00
75_I169_I1.6311.00
106_Y111_K1.6231.00
88_K154_S1.6011.00
148_G154_S1.5661.00
140_P163_M1.5631.00
59_V76_V1.5191.00
16_T20_L1.5041.00
94_P144_Y1.4941.00
51_L87_V1.4701.00
139_V143_K1.4601.00
21_S25_I1.4471.00
41_L56_R1.4381.00
93_L96_D1.4211.00
100_M105_L1.3981.00
142_G166_E1.3881.00
101_K106_Y1.3811.00
39_P177_F1.3531.00
77_I86_F1.3081.00
73_D172_T1.3041.00
161_M164_P1.2951.00
140_P143_K1.2901.00
155_L159_N1.2561.00
45_S53_D1.2531.00
77_I146_V1.2431.00
99_K106_Y1.2381.00
97_S109_D1.2271.00
42_I51_L1.2171.00
48_A53_D1.1981.00
64_K172_T1.1891.00
55_E182_E1.1821.00
98_I107_I1.1641.00
14_I18_V1.1581.00
55_E176_V1.1571.00
94_P166_E1.1511.00
37_Y174_S1.1211.00
137_V163_M1.1121.00
78_H85_S1.1071.00
108_N112_V1.1011.00
78_H170_I1.1011.00
42_I57_I1.0931.00
108_N111_K1.0921.00
12_R16_T1.0771.00
32_I36_F1.0761.00
68_G166_E1.0661.00
46_S154_S1.0651.00
88_K148_G1.0591.00
96_D107_I1.0501.00
47_M74_I1.0431.00
67_G73_D1.0391.00
43_E53_D1.0301.00
57_I173_E1.0221.00
56_R178_Y1.0131.00
14_I17_I1.0081.00
166_E169_I0.9791.00
15_K19_V0.9751.00
105_L147_M0.9711.00
101_K104_Q0.9691.00
18_V21_S0.9581.00
32_I37_Y0.9561.00
134_D137_V0.9451.00
13_K16_T0.9451.00
75_I90_L0.9301.00
173_E176_V0.9221.00
128_G133_G0.9211.00
37_Y58_L0.9191.00
92_G98_I0.9111.00
46_S148_G0.9091.00
127_S130_T0.9091.00
33_R39_P0.8931.00
56_R177_F0.8911.00
80_K168_D0.8891.00
57_I176_V0.8811.00
145_F157_S0.8811.00
86_F161_M0.8711.00
49_P52_K0.8681.00
49_P118_K0.8621.00
45_S153_N0.8551.00
90_L93_L0.8551.00
114_E151_R0.8511.00
79_D161_M0.8491.00
40_F85_S0.8491.00
76_V85_S0.8491.00
176_V182_E0.8421.00
79_D82_S0.8411.00
44_G51_L0.8411.00
18_V22_I0.8191.00
36_F62_A0.8141.00
132_T158_R0.8111.00
103_D152_L0.8111.00
91_I105_L0.8071.00
62_A65_W0.7991.00
17_I21_S0.7981.00
40_F59_V0.7971.00
99_K109_D0.7951.00
94_P141_S0.7931.00
16_T19_V0.7921.00
72_G116_Y0.7831.00
19_V23_I0.7811.00
51_L74_I0.7801.00
30_F34_L0.7741.00
20_L24_M0.7711.00
39_P56_R0.7701.00
142_G165_S0.7701.00
44_G161_M0.7661.00
109_D112_V0.7651.00
92_G96_D0.7581.00
74_I173_E0.7541.00
63_V67_G0.7521.00
90_L144_Y0.7451.00
157_S162_G0.7281.00
131_L134_D0.7251.00
79_D83_G0.7231.00
26_A30_F0.7131.00
48_A150_N0.7131.00
51_L173_E0.7090.99
146_V164_P0.7080.99
139_V142_G0.7070.99
31_T35_V0.7050.99
86_F155_L0.7050.99
86_F164_P0.7030.99
60_D172_T0.7030.99
147_M151_R0.6980.99
78_H168_D0.6960.99
42_I53_D0.6960.99
79_D85_S0.6920.99
179_P182_E0.6870.99
43_E51_L0.6810.99
57_I87_V0.6800.99
28_L32_I0.6780.99
131_L159_N0.6740.99
91_I147_M0.6700.99
52_K182_E0.6640.99
13_K17_I0.6640.99
25_I28_L0.6630.99
43_E55_E0.6620.99
114_E117_L0.6600.99
176_V179_P0.6590.99
29_I33_R0.6540.99
45_S150_N0.6480.99
69_F169_I0.6440.99
145_F163_M0.6420.99
60_D65_W0.6380.99
40_F76_V0.6360.99
52_K179_P0.6340.99
42_I87_V0.6330.99
40_F176_V0.6270.99
52_K55_E0.6270.99
150_N153_N0.6250.99
128_G131_L0.6250.99
15_K18_V0.6240.99
98_I139_V0.6220.99
118_K150_N0.6200.99
28_L31_T0.6160.99
45_S52_K0.6130.99
58_L174_S0.6120.98
76_V170_I0.6120.98
129_V132_T0.6090.98
22_I26_A0.6080.98
99_K135_F0.6070.98
13_K20_L0.6010.98
155_L161_M0.5970.98
107_I112_V0.5950.98
76_V173_E0.5920.98
100_M103_D0.5920.98
50_T74_I0.5890.98
40_F57_I0.5890.98
118_K121_K0.5880.98
24_M28_L0.5780.98
69_F93_L0.5780.98
71_R92_G0.5730.98
110_K141_S0.5720.98
32_I35_V0.5690.98
98_I145_F0.5660.97
33_R40_F0.5660.97
44_G55_E0.5650.97
44_G148_G0.5600.97
96_D139_V0.5600.97
117_L120_Y0.5590.97
107_I151_R0.5570.97
45_S54_S0.5550.97
63_V174_S0.5530.97
63_V172_T0.5500.97
66_T69_F0.5490.97
82_S168_D0.5480.97
70_H141_S0.5460.97
36_F39_P0.5440.97
27_A30_F0.5430.97
40_F170_I0.5420.97
130_T133_G0.5420.97
127_S131_L0.5380.97
77_I164_P0.5360.97
121_K152_L0.5340.96
115_P118_K0.5330.96
74_I88_K0.5290.96
92_G107_I0.5290.96
21_S24_M0.5290.96
77_I88_K0.5290.96
14_I19_V0.5270.96
80_K161_M0.5270.96
132_T135_F0.5250.96
128_G137_V0.5240.96
133_G136_E0.5230.96
12_R20_L0.5200.96
76_V171_G0.5180.96
99_K134_D0.5180.96
67_G70_H0.5160.96
105_L151_R0.5160.96
40_F87_V0.5140.96
79_D84_R0.5130.96
17_I20_L0.5120.96
70_H172_T0.5090.95
116_Y119_E0.5060.95
100_M158_R0.5050.95
88_K146_V0.5040.95
158_R164_P0.5010.95
44_G86_F0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b12A 1 0.8235 100 0.223 Contact Map
4nv4A 2 0.5882 100 0.227 Contact Map
4me8A 1 0.5829 100 0.279 Contact Map
4n31A 5 0.754 100 0.318 Contact Map
4k8wA 2 0.6257 100 0.37 Contact Map
1kcaA 6 0.508 98.9 0.785 Contact Map
1umuA 2 0.5615 98.5 0.815 Contact Map
3bdnA 2 0.6684 98.4 0.82 Contact Map
2hnfA 1 0.5775 97.7 0.848 Contact Map
1jhfA 2 0.6631 97.3 0.859 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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