GREMLIN Database
TTUC - Probable tartrate dehydrogenase/decarboxylase
UniProt: P42958 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (335)
Sequences: 6861 (3099)
Seq/√Len: 169.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_K212_G4.1651.00
170_R209_D3.9001.00
169_M203_F3.0991.00
23_A344_T3.0421.00
170_R174_E2.8711.00
7_E41_S2.7551.00
26_K345_D2.7251.00
222_A226_F2.6701.00
306_D318_L2.6521.00
327_D350_R2.6321.00
29_H42_F2.4241.00
323_Q350_R2.3801.00
61_E65_H2.3581.00
346_E349_S2.3421.00
162_R166_E2.3221.00
21_V297_Q2.2721.00
23_A26_K2.2451.00
10_A25_E2.1991.00
306_D315_A2.1371.00
184_T216_S2.1171.00
45_F66_T2.1131.00
203_F215_T2.0841.00
182_H216_S2.0681.00
324_V350_R2.0231.00
298_I347_I2.0041.00
57_K61_E2.0031.00
25_E44_A1.9951.00
9_A66_T1.9901.00
46_P54_E1.9841.00
166_E205_Q1.9791.00
299_W321_M1.9751.00
310_E313_L1.9641.00
129_V175_L1.9631.00
169_M238_V1.9561.00
68_T101_L1.9501.00
290_G339_T1.9221.00
295_I347_I1.9181.00
166_E202_V1.9151.00
182_H214_E1.9061.00
230_R233_T1.8261.00
16_V292_A1.8261.00
315_A319_D1.8211.00
290_G341_A1.8151.00
174_E210_Y1.8071.00
51_Y60_P1.7991.00
18_K22_A1.7881.00
329_I346_E1.7741.00
65_H69_Q1.7641.00
204_Q217_S1.7461.00
162_R205_Q1.7351.00
344_T348_C1.7271.00
302_K318_L1.7251.00
205_Q208_A1.7241.00
170_R210_Y1.7111.00
152_E162_R1.7021.00
186_A223_L1.6891.00
111_K322_E1.6531.00
166_E170_R1.6471.00
68_T100_E1.6251.00
345_D349_S1.6071.00
202_V205_Q1.6031.00
311_E315_A1.5931.00
158_A240_S1.5631.00
31_A317_I1.5621.00
107_M129_V1.5431.00
9_A70_F1.5371.00
145_R201_E1.5171.00
65_H68_T1.5151.00
114_A326_A1.5021.00
43_T69_Q1.4951.00
50_D54_E1.4901.00
64_I100_E1.4891.00
339_T342_E1.4881.00
206_T209_D1.4821.00
11_I47_W1.4801.00
38_L310_E1.4791.00
24_A301_A1.4711.00
151_D163_K1.4681.00
131_I171_F1.4461.00
96_K100_E1.4431.00
170_R206_T1.4401.00
6_F310_E1.4381.00
306_D314_G1.4381.00
9_A45_F1.4331.00
228_V250_I1.4321.00
38_L313_L1.4241.00
42_F301_A1.4151.00
26_K348_C1.4101.00
174_E178_K1.4021.00
185_S203_F1.3951.00
290_G340_T1.3951.00
30_T348_C1.3861.00
28_L40_F1.3841.00
158_A195_A1.3711.00
25_E29_H1.3631.00
12_P44_A1.3631.00
180_R235_D1.3531.00
43_T70_F1.3501.00
348_C351_L1.3291.00
130_V248_T1.3181.00
115_G326_A1.3161.00
24_A74_F1.3051.00
46_P55_H1.3021.00
295_I343_V1.2881.00
291_L332_R1.2831.00
80_N83_L1.2681.00
304_M308_F1.2671.00
185_S217_S1.2621.00
324_V346_E1.2571.00
224_A247_L1.2541.00
218_Q226_F1.2531.00
46_P51_Y1.2531.00
59_M64_I1.2471.00
131_I175_L1.2461.00
306_D311_E1.2461.00
25_E42_F1.2231.00
43_T66_T1.2151.00
198_F202_V1.2121.00
7_E43_T1.2111.00
24_A297_Q1.2111.00
174_E177_K1.2071.00
343_V347_I1.1881.00
181_S235_D1.1861.00
305_L313_L1.1821.00
173_F210_Y1.1811.00
218_Q234_F1.1791.00
169_M206_T1.1781.00
6_F308_F1.1771.00
218_Q222_A1.1741.00
227_F237_I1.1621.00
166_E206_T1.1601.00
319_D323_Q1.1561.00
67_L73_V1.1501.00
10_A44_A1.1381.00
128_F227_F1.1381.00
162_R202_V1.1381.00
201_E205_Q1.1321.00
130_V251_S1.1301.00
156_Q195_A1.1281.00
51_Y55_H1.1261.00
224_A250_I1.1251.00
218_Q223_L1.1181.00
27_V317_I1.1181.00
316_K351_L1.1141.00
342_E345_D1.1091.00
204_Q207_A1.1051.00
107_M131_I1.1001.00
346_E350_R1.0991.00
104_S271_K1.0981.00
179_R235_D1.0971.00
335_G338_S1.0821.00
111_K127_D1.0811.00
267_N272_Y1.0771.00
267_N271_K1.0741.00
9_A67_L1.0741.00
173_F213_I1.0711.00
183_V215_T1.0711.00
28_L301_A1.0691.00
74_F301_A1.0570.99
165_T169_M1.0560.99
26_K341_A1.0550.99
189_S200_D1.0540.99
220_I246_I1.0500.99
290_G342_E1.0480.99
31_A313_L1.0470.99
55_H62_D1.0460.99
286_I292_A1.0460.99
323_Q327_D1.0430.99
102_E167_R1.0410.99
329_I338_S1.0320.99
153_I159_V1.0310.99
186_A220_I1.0290.99
143_G157_N1.0260.99
26_K344_T1.0190.99
22_A26_K1.0140.99
226_F233_T1.0080.99
138_E240_S1.0060.99
75_L94_L1.0030.99
125_D232_E1.0010.99
138_E158_A0.9990.99
154_A198_F0.9970.99
175_L179_R0.9970.99
160_F240_S0.9960.99
313_L316_K0.9920.99
134_N265_N0.9890.99
177_K181_S0.9840.99
229_T253_S0.9820.99
295_I325_T0.9790.99
24_A298_I0.9770.99
27_V348_C0.9730.99
216_S233_T0.9710.99
60_P63_G0.9690.99
23_A341_A0.9690.99
62_D65_H0.9630.99
203_F238_V0.9620.99
111_K318_L0.9610.99
51_Y63_G0.9600.99
299_W318_L0.9560.99
172_A183_V0.9510.99
27_V351_L0.9510.99
183_V206_T0.9480.99
123_P232_E0.9470.99
105_I168_V0.9460.99
114_A124_N0.9460.99
163_K166_E0.9430.99
57_K96_K0.9380.99
10_A21_V0.9370.99
128_F251_S0.9370.99
160_F165_T0.9370.99
7_E69_Q0.9350.99
173_F207_A0.9330.99
19_E288_G0.9260.99
187_T200_D0.9260.99
20_V297_Q0.9210.99
137_G158_A0.9180.99
177_K210_Y0.9180.99
295_I321_M0.9120.98
338_S342_E0.9060.98
173_F183_V0.9050.98
286_I291_L0.9040.98
177_K213_I0.9040.98
62_D66_T0.9040.98
183_V236_V0.9010.98
315_A318_L0.9000.98
325_T330_K0.8990.98
183_V238_V0.8990.98
113_M322_E0.8980.98
31_A301_A0.8980.98
23_A290_G0.8930.98
12_P22_A0.8880.98
137_G240_S0.8870.98
226_F230_R0.8860.98
27_V298_I0.8860.98
267_N273_P0.8820.98
286_I332_R0.8750.98
45_F63_G0.8710.98
45_F70_F0.8710.98
107_M171_F0.8700.98
158_A196_M0.8680.98
323_Q326_A0.8660.98
20_V76_G0.8650.98
196_M243_F0.8630.98
278_P297_Q0.8620.98
115_G322_E0.8610.98
23_A345_D0.8570.98
298_I321_M0.8540.98
185_S215_T0.8480.98
324_V329_I0.8450.97
47_W93_L0.8420.97
66_T70_F0.8400.97
53_L80_N0.8390.97
302_K306_D0.8380.97
10_A42_F0.8370.97
285_D332_R0.8360.97
110_A251_S0.8280.97
53_L82_K0.8260.97
6_F38_L0.8240.97
21_V76_G0.8160.97
47_W97_I0.8130.97
105_I171_F0.8120.97
186_A247_L0.8100.97
153_I161_T0.8100.97
331_T343_V0.8080.97
187_T217_S0.8070.97
289_Q332_R0.8020.97
144_G155_I0.8000.97
24_A28_L0.7990.96
72_A308_F0.7980.96
189_S219_H0.7970.96
31_A38_L0.7950.96
301_A304_M0.7930.96
52_Y58_M0.7920.96
102_E135_S0.7920.96
114_A322_E0.7890.96
23_A348_C0.7890.96
184_T218_Q0.7880.96
324_V347_I0.7860.96
264_A276_F0.7840.96
186_A237_I0.7820.96
183_V213_I0.7780.96
202_V206_T0.7770.96
154_A195_A0.7750.96
220_I224_A0.7740.96
169_M215_T0.7730.96
138_E242_L0.7720.96
206_T210_Y0.7670.96
320_V324_V0.7660.96
172_A238_V0.7620.95
110_A255_M0.7620.95
145_R194_H0.7620.95
319_D322_E0.7590.95
46_P50_D0.7560.95
106_N279_V0.7560.95
158_A242_L0.7540.95
47_W75_L0.7540.95
11_I67_L0.7530.95
204_Q215_T0.7480.95
77_A280_H0.7460.95
262_P303_L0.7440.95
122_H125_D0.7420.95
49_C53_L0.7400.95
227_F251_S0.7400.95
220_I240_S0.7380.95
162_R198_F0.7380.95
130_V247_L0.7380.95
178_K309_G0.7370.95
22_A341_A0.7360.94
262_P299_W0.7340.94
103_L275_M0.7330.94
341_A345_D0.7330.94
66_T69_Q0.7310.94
64_I68_T0.7310.94
28_L305_L0.7290.94
301_A305_L0.7280.94
171_F175_L0.7250.94
74_F297_Q0.7250.94
332_R339_T0.7240.94
22_A44_A0.7210.94
110_A128_F0.7200.94
88_I92_G0.7190.94
147_H153_I0.7190.94
40_F301_A0.7180.94
131_I168_V0.7130.94
145_R154_A0.7090.93
223_L237_I0.7070.93
285_D292_A0.7060.93
49_C83_L0.7020.93
45_F62_D0.7010.93
200_D204_Q0.6980.93
283_A286_I0.6970.93
136_E164_A0.6910.92
127_D235_D0.6910.92
143_G155_I0.6860.92
23_A298_I0.6820.92
173_F215_T0.6820.92
158_A243_F0.6800.92
112_Q126_F0.6800.92
128_F254_L0.6800.92
345_D348_C0.6750.92
129_V236_V0.6720.91
341_A344_T0.6700.91
28_L42_F0.6680.91
31_A37_G0.6660.91
257_S296_G0.6660.91
21_V24_A0.6610.91
324_V343_V0.6570.90
223_L234_F0.6570.90
73_V275_M0.6550.90
222_A258_I0.6530.90
187_T219_H0.6530.90
165_T202_V0.6520.90
174_E209_D0.6520.90
68_T273_P0.6510.90
50_D53_L0.6500.90
226_F229_T0.6490.90
168_V238_V0.6490.90
61_E96_K0.6490.90
152_E201_E0.6480.90
49_C80_N0.6460.90
314_G318_L0.6460.90
166_E208_A0.6440.90
113_M299_W0.6420.89
308_F311_E0.6410.89
186_A239_A0.6410.89
276_F307_H0.6390.89
298_I317_I0.6390.89
264_A303_L0.6390.89
93_L96_K0.6360.89
322_E326_A0.6340.89
330_K334_I0.6340.89
207_A215_T0.6330.89
51_Y59_M0.6320.89
8_I40_F0.6320.89
279_V296_G0.6310.89
207_A211_S0.6290.88
273_P276_F0.6280.88
165_T240_S0.6280.88
117_T121_L0.6280.88
59_M97_I0.6260.88
171_F271_K0.6260.88
156_Q197_P0.6220.88
312_E315_A0.6220.88
185_S199_W0.6220.88
266_I307_H0.6210.88
26_K29_H0.6170.87
260_I334_I0.6170.87
331_T334_I0.6150.87
152_E163_K0.6150.87
262_P296_G0.6140.87
21_V25_E0.6140.87
28_L317_I0.6080.87
142_V159_V0.6060.87
71_E272_Y0.6060.87
292_A332_R0.6040.86
91_W96_K0.6040.86
171_F174_E0.6000.86
188_K221_D0.5990.86
8_I42_F0.5990.86
305_L314_G0.5980.86
316_K320_V0.5980.86
8_I304_M0.5970.86
228_V254_L0.5930.85
102_E163_K0.5910.85
77_A297_Q0.5910.85
57_K62_D0.5900.85
147_H152_E0.5900.85
143_G146_I0.5890.85
84_V89_S0.5870.85
155_I159_V0.5860.85
63_G93_L0.5860.85
31_A316_K0.5860.85
76_G297_Q0.5850.85
129_V179_R0.5850.85
196_M240_S0.5840.84
305_L317_I0.5830.84
130_V237_I0.5820.84
102_E136_E0.5820.84
298_I344_T0.5800.84
181_S212_G0.5800.84
51_Y54_E0.5800.84
164_A167_R0.5800.84
46_P62_D0.5740.83
329_I343_V0.5720.83
142_V157_N0.5700.83
139_Y277_E0.5670.83
11_I45_F0.5660.83
53_L83_L0.5660.83
222_A233_T0.5660.83
334_I338_S0.5650.82
67_L70_F0.5640.82
44_A50_D0.5640.82
290_G345_D0.5620.82
28_L31_A0.5620.82
329_I350_R0.5600.82
156_Q192_I0.5590.82
169_M202_V0.5560.81
127_D180_R0.5560.81
52_Y88_I0.5550.81
126_F232_E0.5540.81
92_G96_K0.5530.81
40_F313_L0.5530.81
274_S307_H0.5520.81
22_A25_E0.5520.81
67_L101_L0.5510.81
146_I201_E0.5450.80
24_A27_V0.5450.80
240_S243_F0.5450.80
156_Q194_H0.5440.80
201_E208_A0.5420.80
101_L275_M0.5420.80
257_S260_I0.5420.80
75_L97_I0.5410.80
59_M63_G0.5410.80
9_A43_T0.5400.80
40_F310_E0.5390.79
102_E267_N0.5390.79
330_K343_V0.5380.79
58_M90_L0.5370.79
67_L97_I0.5360.79
153_I162_R0.5350.79
21_V74_F0.5330.79
245_D249_D0.5330.79
340_T344_T0.5300.78
223_L247_L0.5300.78
154_A240_S0.5290.78
57_K88_I0.5290.78
47_W59_M0.5280.78
45_F60_P0.5270.78
59_M96_K0.5260.78
302_K314_G0.5250.78
329_I349_S0.5230.77
84_V88_I0.5230.77
12_P18_K0.5220.77
104_S168_V0.5210.77
267_N274_S0.5200.77
131_I172_A0.5180.77
64_I96_K0.5180.77
332_R336_G0.5170.77
48_S51_Y0.5170.77
248_T258_I0.5160.76
89_S92_G0.5160.76
18_K50_D0.5150.76
87_H92_G0.5130.76
147_H151_D0.5120.76
129_V180_R0.5120.76
175_L178_K0.5120.76
177_K211_S0.5110.76
318_L322_E0.5110.76
281_G284_P0.5100.76
19_E290_G0.5100.76
174_E206_T0.5100.76
99_R141_E0.5100.76
176_A183_V0.5090.76
245_D280_H0.5090.76
8_I72_A0.5090.76
312_E316_K0.5080.75
222_A234_F0.5070.75
68_T73_V0.5030.75
85_P88_I0.5020.75
124_N232_E0.5010.74
266_I274_S0.5000.74
286_I289_Q0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3flkA 3 0.9859 100 0.025 Contact Map
2y3zA 2 0.9633 100 0.04 Contact Map
3u1hA 2 0.9576 100 0.041 Contact Map
3r8wA 2 0.9746 100 0.044 Contact Map
3uduA 3 0.9689 100 0.046 Contact Map
2e0cA 2 0.9576 100 0.048 Contact Map
1a05A 2 0.9746 100 0.048 Contact Map
1x0lA 4 0.9379 100 0.048 Contact Map
1cnzA 2 0.9859 100 0.049 Contact Map
2iv0A 2 0.9774 100 0.051 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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