GREMLIN Database
MTLD - Mannitol-1-phosphate 5-dehydrogenase
UniProt: P42957 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (336)
Sequences: 2876 (1872)
Seq/√Len: 102.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_L238_H3.6571.00
30_A75_L3.4901.00
21_H58_E3.2851.00
127_S153_N3.1211.00
246_H272_K3.1011.00
71_Q74_E2.9331.00
242_R279_E2.8671.00
22_H58_E2.8551.00
130_K134_Y2.7761.00
20_L193_I2.7691.00
64_S78_L2.7131.00
73_E107_R2.6181.00
28_V78_L2.6041.00
80_N107_R2.5831.00
242_R246_H2.5221.00
219_V320_G2.3571.00
235_A241_I2.3291.00
45_E59_I2.3171.00
3_A20_L2.3031.00
233_K237_D2.2501.00
181_I196_A2.2431.00
137_L145_V2.2051.00
285_D289_R2.1531.00
114_L149_V2.1131.00
96_L99_P2.1051.00
107_R111_A2.0941.00
103_E107_R2.0721.00
109_N140_A2.0701.00
28_V64_S2.0501.00
4_L82_A2.0361.00
38_S42_E2.0281.00
49_E57_S2.0101.00
250_L271_I2.0051.00
134_Y146_S1.9541.00
222_Y294_P1.9341.00
64_S74_E1.9101.00
133_I151_F1.8871.00
124_G127_S1.8751.00
143_K147_E1.8751.00
150_G187_K1.8681.00
74_E77_R1.8651.00
103_E106_R1.8571.00
247_S251_E1.8431.00
66_I75_L1.8421.00
219_V248_A1.8421.00
223_V323_A1.8001.00
247_S316_A1.7961.00
193_I196_A1.7721.00
12_G16_I1.7691.00
106_R141_E1.7461.00
102_A136_H1.7391.00
19_L177_F1.7371.00
73_E77_R1.7281.00
79_M104_G1.7261.00
230_K234_E1.7241.00
252_T255_Y1.6931.00
37_V65_A1.6731.00
106_R110_T1.6721.00
138_T146_S1.6671.00
132_E135_S1.6521.00
83_A190_T1.6451.00
77_R111_A1.6431.00
232_V290_V1.6311.00
150_G184_S1.6261.00
216_G245_V1.6191.00
85_I114_L1.6121.00
138_T142_Q1.6051.00
116_I129_L1.5871.00
34_E38_S1.5791.00
47_T57_S1.5761.00
41_N64_S1.5581.00
224_G235_A1.5541.00
4_L30_A1.5521.00
29_F63_V1.5471.00
76_Y107_R1.5161.00
330_T335_A1.4891.00
115_N187_K1.4791.00
117_I181_I1.4771.00
47_T59_I1.4771.00
225_Y338_L1.4751.00
223_V319_E1.4691.00
221_A291_A1.4581.00
230_K286_D1.4461.00
79_M114_L1.4351.00
18_A48_V1.4341.00
308_A321_I1.4281.00
50_L173_V1.4251.00
45_E61_G1.4221.00
264_Q268_E1.4211.00
145_V151_F1.4201.00
4_L104_G1.3961.00
243_R247_S1.3911.00
20_L27_V1.3851.00
227_R240_E1.3791.00
48_V60_I1.3771.00
144_S148_T1.3751.00
77_R80_N1.3660.99
335_A342_I1.3530.99
41_N44_K1.3480.99
77_R107_R1.3480.99
212_T271_I1.3370.99
330_T342_I1.3340.99
275_I279_E1.3310.99
216_G249_L1.3280.99
199_V204_P1.3120.99
43_K167_D1.3060.99
28_V82_A1.3000.99
266_E269_Q1.2990.99
310_K313_E1.2910.99
16_I86_T1.2860.99
131_K135_S1.2820.99
101_I133_I1.2800.99
183_E200_D1.2800.99
105_L149_V1.2780.99
113_T149_V1.2720.99
236_I242_R1.2660.99
107_R110_T1.2660.99
101_I116_I1.2610.99
212_T249_L1.2580.99
220_T245_V1.2580.99
89_V97_I1.2580.99
102_A133_I1.2550.99
102_A137_L1.2290.99
233_K284_S1.2280.99
117_I154_S1.2270.99
308_A318_A1.2120.99
227_R241_I1.2110.99
99_P136_H1.2060.99
305_V321_I1.2020.99
211_F310_K1.2020.99
332_D335_A1.1980.99
76_Y103_E1.1980.99
225_Y327_F1.1930.99
254_D271_I1.1910.99
66_I71_Q1.1890.99
153_N182_D1.1860.99
340_A344_E1.1830.98
87_T97_I1.1830.98
227_R238_H1.1810.98
8_A29_F1.1730.98
288_T327_F1.1620.98
330_T340_A1.1590.98
139_E143_K1.1500.98
124_G203_T1.1430.98
201_D204_P1.1410.98
231_T234_E1.1380.98
225_Y287_V1.1340.98
134_Y142_Q1.1280.98
79_M85_I1.1180.98
219_V244_V1.1150.98
18_A60_I1.1150.98
234_E237_D1.1000.98
134_Y145_V1.0930.97
244_V316_A1.0800.97
186_F191_P1.0800.97
332_D336_V1.0800.97
249_L275_I1.0790.97
105_L144_S1.0750.97
6_F97_I1.0750.97
231_T284_S1.0700.97
37_V70_S1.0660.97
4_L79_M1.0610.97
8_A63_V1.0560.97
267_H271_I1.0540.97
37_V41_N1.0430.97
340_A343_E1.0350.96
72_T100_S1.0320.96
232_V235_A1.0320.96
248_A317_L1.0290.96
140_A143_K1.0180.96
335_A340_A1.0160.96
268_E272_K1.0140.96
236_I275_I1.0060.96
80_N111_A1.0020.96
128_F131_K0.9990.96
35_T39_L0.9980.96
39_L168_P0.9880.95
273_K276_G0.9860.95
272_K275_I0.9860.95
143_K146_S0.9840.95
17_G27_V0.9770.95
67_N70_S0.9760.95
246_H250_L0.9760.95
116_I149_V0.9760.95
220_T241_I0.9670.95
269_Q273_K0.9670.95
85_I116_I0.9630.95
44_K64_S0.9620.95
109_N141_E0.9620.95
212_T274_I0.9600.95
307_P317_L0.9590.95
239_P243_R0.9540.94
286_D289_R0.9540.94
311_I314_P0.9480.94
232_V287_V0.9430.94
116_I151_F0.9410.94
333_P338_L0.9390.94
298_L304_L0.9370.94
85_I101_I0.9370.94
138_T143_K0.9330.94
115_N150_G0.9320.94
252_T256_L0.9310.94
139_E142_Q0.9250.93
252_T257_V0.9210.93
335_A338_L0.9140.93
226_Q323_A0.9140.93
127_S130_K0.9100.93
225_Y288_T0.9090.93
39_L42_E0.9090.93
212_T254_D0.8950.92
218_A297_K0.8950.92
295_L324_A0.8880.92
102_A145_V0.8810.92
163_Q170_K0.8800.92
194_N198_F0.8790.92
246_H275_I0.8750.91
249_L271_I0.8730.91
232_V245_V0.8730.91
72_T103_E0.8710.91
298_L320_G0.8670.91
314_P318_A0.8660.91
167_D170_K0.8640.91
104_G114_L0.8590.91
18_A22_H0.8580.91
80_N104_G0.8540.90
158_R173_V0.8490.90
30_A66_I0.8480.90
330_T333_P0.8440.90
41_N71_Q0.8440.90
250_L268_E0.8430.90
122_M125_G0.8400.90
3_A27_V0.8390.90
18_A58_E0.8380.90
250_L254_D0.8370.90
35_T38_S0.8300.89
339_Q342_I0.8260.89
142_Q145_V0.8220.89
123_I206_I0.8200.89
66_I78_L0.8160.88
207_E310_K0.8140.88
87_T118_A0.8140.88
83_A189_K0.8120.88
130_K146_S0.8110.88
141_E144_S0.8100.88
305_V308_A0.8090.88
216_G278_F0.8090.88
86_T179_W0.8080.88
4_L85_I0.8060.88
115_N186_F0.8010.87
33_N36_M0.7970.87
212_T253_G0.7950.87
5_H86_T0.7940.87
28_V66_I0.7890.87
31_D36_M0.7880.87
34_E70_S0.7860.86
68_S100_S0.7840.86
163_Q171_V0.7820.86
207_E258_K0.7800.86
212_T216_G0.7790.86
304_L320_G0.7790.86
137_L141_E0.7780.86
220_T287_V0.7780.86
291_A327_F0.7760.86
137_L142_Q0.7760.86
250_L272_K0.7760.86
76_Y100_S0.7750.86
326_R330_T0.7750.86
40_L169_L0.7740.86
6_F104_G0.7700.85
6_F75_L0.7700.85
109_N144_S0.7700.85
335_A339_Q0.7700.85
223_V244_V0.7690.85
341_L344_E0.7680.85
31_D37_V0.7680.85
249_L274_I0.7650.85
229_L234_E0.7600.85
22_H177_F0.7540.84
161_P270_Y0.7520.84
176_F179_W0.7460.83
11_I16_I0.7460.83
157_D277_R0.7410.83
21_H62_P0.7380.83
8_A31_D0.7380.83
244_V247_S0.7360.83
244_V319_E0.7330.82
31_D65_A0.7320.82
86_T154_S0.7310.82
287_V291_A0.7310.82
39_L169_L0.7290.82
208_R265_T0.7250.82
16_I119_C0.7240.82
225_Y328_D0.7240.82
337_E340_A0.7230.81
157_D213_V0.7220.81
20_L196_A0.7200.81
92_N296_R0.7200.81
193_I198_F0.7190.81
174_E280_N0.7180.81
222_Y327_F0.7140.81
77_R81_E0.7140.81
21_H61_G0.7120.80
48_V283_I0.7110.80
186_F190_T0.7110.80
159_I213_V0.7100.80
328_D339_Q0.7100.80
105_L145_V0.7090.80
228_G238_H0.7080.80
126_S152_P0.7080.80
246_H271_I0.7040.80
288_T341_L0.7030.80
114_L187_K0.7030.80
40_L167_D0.7020.80
191_P198_F0.7010.79
297_K303_R0.7010.79
91_P122_M0.7000.79
41_N65_A0.6990.79
269_Q272_K0.6980.79
190_T194_N0.6970.79
98_A132_E0.6960.79
178_E208_R0.6920.79
224_G229_L0.6900.78
92_N303_R0.6880.78
11_I119_C0.6880.78
86_T117_I0.6850.78
5_H157_D0.6840.78
109_N112_N0.6820.78
308_A317_L0.6810.77
159_I174_E0.6810.77
141_E145_V0.6790.77
331_G336_V0.6790.77
285_D290_V0.6790.77
212_T267_H0.6780.77
150_G188_G0.6780.77
119_C270_Y0.6710.76
254_D264_Q0.6710.76
128_F132_E0.6680.76
86_T119_C0.6680.76
248_A316_A0.6650.76
163_Q169_L0.6640.76
218_A222_Y0.6630.76
32_V36_M0.6620.75
253_G307_P0.6600.75
332_D341_L0.6580.75
232_V297_K0.6570.75
223_V241_I0.6560.75
15_F119_C0.6550.75
333_P337_E0.6540.75
319_E323_A0.6520.74
255_Y310_K0.6500.74
23_S194_N0.6500.74
265_T269_Q0.6480.74
105_L114_L0.6480.74
229_L241_I0.6460.74
11_I15_F0.6450.74
308_A314_P0.6440.73
74_E78_L0.6440.73
306_G309_K0.6430.73
318_A322_A0.6430.73
272_K276_G0.6420.73
208_R267_H0.6410.73
288_T338_L0.6410.73
331_G335_A0.6400.73
51_A172_S0.6390.73
296_R303_R0.6370.73
105_L116_I0.6370.73
285_D303_R0.6340.72
332_D340_A0.6330.72
18_A308_A0.6310.72
234_E287_V0.6300.72
27_V62_P0.6300.72
64_S77_R0.6300.72
152_P181_I0.6290.72
154_S179_W0.6280.72
220_T235_A0.6270.71
211_F307_P0.6250.71
183_E190_T0.6240.71
178_E270_Y0.6240.71
6_F30_A0.6230.71
215_T252_T0.6220.71
66_I74_E0.6220.71
240_E243_R0.6220.71
225_Y230_K0.6200.71
304_L321_I0.6160.70
12_G17_G0.6140.70
124_G153_N0.6120.70
253_G267_H0.6080.69
215_T307_P0.6070.69
76_Y80_N0.6060.69
338_L342_I0.6040.69
253_G317_L0.6000.68
101_I129_L0.5970.68
127_S133_I0.5970.68
88_A120_E0.5960.68
22_H239_P0.5940.67
138_T141_E0.5940.67
42_E168_P0.5940.67
254_D267_H0.5910.67
124_G128_F0.5910.67
44_K65_A0.5900.67
160_V283_I0.5830.66
215_T304_L0.5820.66
236_I245_V0.5810.66
161_P171_V0.5790.65
65_A303_R0.5790.65
238_H241_I0.5780.65
335_A341_L0.5770.65
222_Y235_A0.5750.65
210_L222_Y0.5750.65
308_A312_K0.5750.65
161_P179_W0.5740.65
51_A283_I0.5710.64
326_R333_P0.5690.64
121_N289_R0.5690.64
17_G29_F0.5680.64
216_G271_I0.5680.64
253_G257_V0.5680.64
38_S41_N0.5670.64
113_T187_K0.5660.64
179_W213_V0.5650.64
309_K313_E0.5610.63
91_P125_G0.5600.63
187_K191_P0.5600.63
225_Y329_F0.5580.63
155_A180_V0.5580.63
6_F79_M0.5560.62
304_L307_P0.5560.62
331_G340_A0.5550.62
242_R275_I0.5550.62
52_E175_P0.5540.62
174_E277_R0.5530.62
202_L206_I0.5520.62
220_T236_I0.5510.62
287_V290_V0.5500.61
74_E138_T0.5500.61
20_L198_F0.5480.61
80_N103_E0.5480.61
28_V81_E0.5470.61
203_T207_E0.5460.61
253_G271_I0.5450.61
49_E170_K0.5440.61
23_S26_D0.5440.61
95_K98_A0.5420.60
176_F196_A0.5410.60
54_G281_P0.5410.60
190_T198_F0.5390.60
119_C176_F0.5380.60
252_T316_A0.5380.60
37_V163_Q0.5370.60
263_K266_E0.5370.60
256_L307_P0.5360.60
92_N293_S0.5360.60
175_P276_G0.5350.59
251_E317_L0.5340.59
42_E70_S0.5330.59
276_G279_E0.5330.59
3_A84_L0.5320.59
326_R331_G0.5310.59
305_V309_K0.5300.59
291_A296_R0.5290.59
9_G13_R0.5290.59
160_V290_V0.5290.59
296_R300_E0.5290.59
155_A202_L0.5280.58
231_T286_D0.5270.58
159_I277_R0.5250.58
135_S146_S0.5240.58
18_A177_F0.5230.58
77_R250_L0.5230.58
31_D67_N0.5220.58
330_T343_E0.5210.57
336_V340_A0.5210.57
223_V320_G0.5180.57
51_A173_V0.5180.57
91_P218_A0.5180.57
72_T75_L0.5170.57
94_L206_I0.5170.57
142_Q146_S0.5170.57
218_A289_R0.5170.57
218_A294_P0.5170.57
86_T157_D0.5170.57
224_G287_V0.5160.57
159_I179_W0.5140.56
124_G207_E0.5140.56
234_E284_S0.5130.56
159_I280_N0.5120.56
306_G310_K0.5120.56
208_R287_V0.5120.56
10_N221_A0.5110.56
56_S282_F0.5110.56
158_R177_F0.5100.56
26_D64_S0.5090.56
304_L317_L0.5070.55
12_G86_T0.5060.55
197_L266_E0.5060.55
339_Q343_E0.5050.55
11_I173_V0.5050.55
212_T215_T0.5040.55
231_T283_I0.5040.55
221_A224_G0.5030.55
52_E282_F0.5030.55
46_Y60_I0.5020.55
75_L79_M0.5020.55
64_S81_E0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h2zA 2 0.9866 100 0.117 Contact Map
4im7A 1 0.9839 100 0.176 Contact Map
1lj8A 1 0.9866 100 0.182 Contact Map
2ew2A 2 0.8016 98.9 0.893 Contact Map
3wfiA 2 0.8016 98.8 0.896 Contact Map
3i83A 2 0.7989 98.6 0.904 Contact Map
2qytA 1 0.7131 98.5 0.904 Contact Map
3hn2A 2 0.7909 98.5 0.906 Contact Map
1bg6A 2 0.866 98.3 0.911 Contact Map
3egoA 2 0.7587 98.2 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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