MTLD - BACSU - GREMLIN Contacts

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MTLD - Mannitol-1-phosphate 5-dehydrogenase

UniProt:	P42957	Sequences: MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKKEYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIAEGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIVPIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHAVTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIGRFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPEAVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	373 (336)
Sequences:	2876 (1872)
Seq/√Len:	102.1

ECOLI - MTLD YEIQ UXAB UXUB YDFI
BACSU - MTLD UXAB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
229_L	238_H	3.657	1.00
30_A	75_L	3.490	1.00
21_H	58_E	3.285	1.00
127_S	153_N	3.121	1.00
246_H	272_K	3.101	1.00
71_Q	74_E	2.933	1.00
242_R	279_E	2.867	1.00
22_H	58_E	2.855	1.00
130_K	134_Y	2.776	1.00
20_L	193_I	2.769	1.00
64_S	78_L	2.713	1.00
73_E	107_R	2.618	1.00
28_V	78_L	2.604	1.00
80_N	107_R	2.583	1.00
242_R	246_H	2.522	1.00
219_V	320_G	2.357	1.00
235_A	241_I	2.329	1.00
45_E	59_I	2.317	1.00
3_A	20_L	2.303	1.00
233_K	237_D	2.250	1.00
181_I	196_A	2.243	1.00
137_L	145_V	2.205	1.00
285_D	289_R	2.153	1.00
114_L	149_V	2.113	1.00
96_L	99_P	2.105	1.00
107_R	111_A	2.094	1.00
103_E	107_R	2.072	1.00
109_N	140_A	2.070	1.00
28_V	64_S	2.050	1.00
4_L	82_A	2.036	1.00
38_S	42_E	2.028	1.00
49_E	57_S	2.010	1.00
250_L	271_I	2.005	1.00
134_Y	146_S	1.954	1.00
222_Y	294_P	1.934	1.00
64_S	74_E	1.910	1.00
133_I	151_F	1.887	1.00
124_G	127_S	1.875	1.00
143_K	147_E	1.875	1.00
150_G	187_K	1.868	1.00
74_E	77_R	1.865	1.00
103_E	106_R	1.857	1.00
247_S	251_E	1.843	1.00
66_I	75_L	1.842	1.00
219_V	248_A	1.842	1.00
223_V	323_A	1.800	1.00
247_S	316_A	1.796	1.00
193_I	196_A	1.772	1.00
12_G	16_I	1.769	1.00
106_R	141_E	1.746	1.00
102_A	136_H	1.739	1.00
19_L	177_F	1.737	1.00
73_E	77_R	1.728	1.00
79_M	104_G	1.726	1.00
230_K	234_E	1.724	1.00
252_T	255_Y	1.693	1.00
37_V	65_A	1.673	1.00
106_R	110_T	1.672	1.00
138_T	146_S	1.667	1.00
132_E	135_S	1.652	1.00
83_A	190_T	1.645	1.00
77_R	111_A	1.643	1.00
232_V	290_V	1.631	1.00
150_G	184_S	1.626	1.00
216_G	245_V	1.619	1.00
85_I	114_L	1.612	1.00
138_T	142_Q	1.605	1.00
116_I	129_L	1.587	1.00
34_E	38_S	1.579	1.00
47_T	57_S	1.576	1.00
41_N	64_S	1.558	1.00
224_G	235_A	1.554	1.00
4_L	30_A	1.552	1.00
29_F	63_V	1.547	1.00
76_Y	107_R	1.516	1.00
330_T	335_A	1.489	1.00
115_N	187_K	1.479	1.00
117_I	181_I	1.477	1.00
47_T	59_I	1.477	1.00
225_Y	338_L	1.475	1.00
223_V	319_E	1.469	1.00
221_A	291_A	1.458	1.00
230_K	286_D	1.446	1.00
79_M	114_L	1.435	1.00
18_A	48_V	1.434	1.00
308_A	321_I	1.428	1.00
50_L	173_V	1.425	1.00
45_E	61_G	1.422	1.00
264_Q	268_E	1.421	1.00
145_V	151_F	1.420	1.00
4_L	104_G	1.396	1.00
243_R	247_S	1.391	1.00
20_L	27_V	1.385	1.00
227_R	240_E	1.379	1.00
48_V	60_I	1.377	1.00
144_S	148_T	1.375	1.00
77_R	80_N	1.366	0.99
335_A	342_I	1.353	0.99
41_N	44_K	1.348	0.99
77_R	107_R	1.348	0.99
212_T	271_I	1.337	0.99
330_T	342_I	1.334	0.99
275_I	279_E	1.331	0.99
216_G	249_L	1.328	0.99
199_V	204_P	1.312	0.99
43_K	167_D	1.306	0.99
28_V	82_A	1.300	0.99
266_E	269_Q	1.299	0.99
310_K	313_E	1.291	0.99
16_I	86_T	1.286	0.99
131_K	135_S	1.282	0.99
101_I	133_I	1.280	0.99
183_E	200_D	1.280	0.99
105_L	149_V	1.278	0.99
113_T	149_V	1.272	0.99
236_I	242_R	1.266	0.99
107_R	110_T	1.266	0.99
101_I	116_I	1.261	0.99
212_T	249_L	1.258	0.99
220_T	245_V	1.258	0.99
89_V	97_I	1.258	0.99
102_A	133_I	1.255	0.99
102_A	137_L	1.229	0.99
233_K	284_S	1.228	0.99
117_I	154_S	1.227	0.99
308_A	318_A	1.212	0.99
227_R	241_I	1.211	0.99
99_P	136_H	1.206	0.99
305_V	321_I	1.202	0.99
211_F	310_K	1.202	0.99
332_D	335_A	1.198	0.99
76_Y	103_E	1.198	0.99
225_Y	327_F	1.193	0.99
254_D	271_I	1.191	0.99
66_I	71_Q	1.189	0.99
153_N	182_D	1.186	0.99
340_A	344_E	1.183	0.98
87_T	97_I	1.183	0.98
227_R	238_H	1.181	0.98
8_A	29_F	1.173	0.98
288_T	327_F	1.162	0.98
330_T	340_A	1.159	0.98
139_E	143_K	1.150	0.98
124_G	203_T	1.143	0.98
201_D	204_P	1.141	0.98
231_T	234_E	1.138	0.98
225_Y	287_V	1.134	0.98
134_Y	142_Q	1.128	0.98
79_M	85_I	1.118	0.98
219_V	244_V	1.115	0.98
18_A	60_I	1.115	0.98
234_E	237_D	1.100	0.98
134_Y	145_V	1.093	0.97
244_V	316_A	1.080	0.97
186_F	191_P	1.080	0.97
332_D	336_V	1.080	0.97
249_L	275_I	1.079	0.97
105_L	144_S	1.075	0.97
6_F	97_I	1.075	0.97
231_T	284_S	1.070	0.97
37_V	70_S	1.066	0.97
4_L	79_M	1.061	0.97
8_A	63_V	1.056	0.97
267_H	271_I	1.054	0.97
37_V	41_N	1.043	0.97
340_A	343_E	1.035	0.96
72_T	100_S	1.032	0.96
232_V	235_A	1.032	0.96
248_A	317_L	1.029	0.96
140_A	143_K	1.018	0.96
335_A	340_A	1.016	0.96
268_E	272_K	1.014	0.96
236_I	275_I	1.006	0.96
80_N	111_A	1.002	0.96
128_F	131_K	0.999	0.96
35_T	39_L	0.998	0.96
39_L	168_P	0.988	0.95
273_K	276_G	0.986	0.95
272_K	275_I	0.986	0.95
143_K	146_S	0.984	0.95
17_G	27_V	0.977	0.95
67_N	70_S	0.976	0.95
246_H	250_L	0.976	0.95
116_I	149_V	0.976	0.95
220_T	241_I	0.967	0.95
269_Q	273_K	0.967	0.95
85_I	116_I	0.963	0.95
44_K	64_S	0.962	0.95
109_N	141_E	0.962	0.95
212_T	274_I	0.960	0.95
307_P	317_L	0.959	0.95
239_P	243_R	0.954	0.94
286_D	289_R	0.954	0.94
311_I	314_P	0.948	0.94
232_V	287_V	0.943	0.94
116_I	151_F	0.941	0.94
333_P	338_L	0.939	0.94
298_L	304_L	0.937	0.94
85_I	101_I	0.937	0.94
138_T	143_K	0.933	0.94
115_N	150_G	0.932	0.94
252_T	256_L	0.931	0.94
139_E	142_Q	0.925	0.93
252_T	257_V	0.921	0.93
335_A	338_L	0.914	0.93
226_Q	323_A	0.914	0.93
127_S	130_K	0.910	0.93
225_Y	288_T	0.909	0.93
39_L	42_E	0.909	0.93
212_T	254_D	0.895	0.92
218_A	297_K	0.895	0.92
295_L	324_A	0.888	0.92
102_A	145_V	0.881	0.92
163_Q	170_K	0.880	0.92
194_N	198_F	0.879	0.92
246_H	275_I	0.875	0.91
249_L	271_I	0.873	0.91
232_V	245_V	0.873	0.91
72_T	103_E	0.871	0.91
298_L	320_G	0.867	0.91
314_P	318_A	0.866	0.91
167_D	170_K	0.864	0.91
104_G	114_L	0.859	0.91
18_A	22_H	0.858	0.91
80_N	104_G	0.854	0.90
158_R	173_V	0.849	0.90
30_A	66_I	0.848	0.90
330_T	333_P	0.844	0.90
41_N	71_Q	0.844	0.90
250_L	268_E	0.843	0.90
122_M	125_G	0.840	0.90
3_A	27_V	0.839	0.90
18_A	58_E	0.838	0.90
250_L	254_D	0.837	0.90
35_T	38_S	0.830	0.89
339_Q	342_I	0.826	0.89
142_Q	145_V	0.822	0.89
123_I	206_I	0.820	0.89
66_I	78_L	0.816	0.88
207_E	310_K	0.814	0.88
87_T	118_A	0.814	0.88
83_A	189_K	0.812	0.88
130_K	146_S	0.811	0.88
141_E	144_S	0.810	0.88
305_V	308_A	0.809	0.88
216_G	278_F	0.809	0.88
86_T	179_W	0.808	0.88
4_L	85_I	0.806	0.88
115_N	186_F	0.801	0.87
33_N	36_M	0.797	0.87
212_T	253_G	0.795	0.87
5_H	86_T	0.794	0.87
28_V	66_I	0.789	0.87
31_D	36_M	0.788	0.87
34_E	70_S	0.786	0.86
68_S	100_S	0.784	0.86
163_Q	171_V	0.782	0.86
207_E	258_K	0.780	0.86
212_T	216_G	0.779	0.86
304_L	320_G	0.779	0.86
137_L	141_E	0.778	0.86
220_T	287_V	0.778	0.86
291_A	327_F	0.776	0.86
137_L	142_Q	0.776	0.86
250_L	272_K	0.776	0.86
76_Y	100_S	0.775	0.86
326_R	330_T	0.775	0.86
40_L	169_L	0.774	0.86
6_F	104_G	0.770	0.85
6_F	75_L	0.770	0.85
109_N	144_S	0.770	0.85
335_A	339_Q	0.770	0.85
223_V	244_V	0.769	0.85
341_L	344_E	0.768	0.85
31_D	37_V	0.768	0.85
249_L	274_I	0.765	0.85
229_L	234_E	0.760	0.85
22_H	177_F	0.754	0.84
161_P	270_Y	0.752	0.84
176_F	179_W	0.746	0.83
11_I	16_I	0.746	0.83
157_D	277_R	0.741	0.83
21_H	62_P	0.738	0.83
8_A	31_D	0.738	0.83
244_V	247_S	0.736	0.83
244_V	319_E	0.733	0.82
31_D	65_A	0.732	0.82
86_T	154_S	0.731	0.82
287_V	291_A	0.731	0.82
39_L	169_L	0.729	0.82
208_R	265_T	0.725	0.82
16_I	119_C	0.724	0.82
225_Y	328_D	0.724	0.82
337_E	340_A	0.723	0.81
157_D	213_V	0.722	0.81
20_L	196_A	0.720	0.81
92_N	296_R	0.720	0.81
193_I	198_F	0.719	0.81
174_E	280_N	0.718	0.81
222_Y	327_F	0.714	0.81
77_R	81_E	0.714	0.81
21_H	61_G	0.712	0.80
48_V	283_I	0.711	0.80
186_F	190_T	0.711	0.80
159_I	213_V	0.710	0.80
328_D	339_Q	0.710	0.80
105_L	145_V	0.709	0.80
228_G	238_H	0.708	0.80
126_S	152_P	0.708	0.80
246_H	271_I	0.704	0.80
288_T	341_L	0.703	0.80
114_L	187_K	0.703	0.80
40_L	167_D	0.702	0.80
191_P	198_F	0.701	0.79
297_K	303_R	0.701	0.79
91_P	122_M	0.700	0.79
41_N	65_A	0.699	0.79
269_Q	272_K	0.698	0.79
190_T	194_N	0.697	0.79
98_A	132_E	0.696	0.79
178_E	208_R	0.692	0.79
224_G	229_L	0.690	0.78
92_N	303_R	0.688	0.78
11_I	119_C	0.688	0.78
86_T	117_I	0.685	0.78
5_H	157_D	0.684	0.78
109_N	112_N	0.682	0.78
308_A	317_L	0.681	0.77
159_I	174_E	0.681	0.77
141_E	145_V	0.679	0.77
331_G	336_V	0.679	0.77
285_D	290_V	0.679	0.77
212_T	267_H	0.678	0.77
150_G	188_G	0.678	0.77
119_C	270_Y	0.671	0.76
254_D	264_Q	0.671	0.76
128_F	132_E	0.668	0.76
86_T	119_C	0.668	0.76
248_A	316_A	0.665	0.76
163_Q	169_L	0.664	0.76
218_A	222_Y	0.663	0.76
32_V	36_M	0.662	0.75
253_G	307_P	0.660	0.75
332_D	341_L	0.658	0.75
232_V	297_K	0.657	0.75
223_V	241_I	0.656	0.75
15_F	119_C	0.655	0.75
333_P	337_E	0.654	0.75
319_E	323_A	0.652	0.74
255_Y	310_K	0.650	0.74
23_S	194_N	0.650	0.74
265_T	269_Q	0.648	0.74
105_L	114_L	0.648	0.74
229_L	241_I	0.646	0.74
11_I	15_F	0.645	0.74
308_A	314_P	0.644	0.73
74_E	78_L	0.644	0.73
306_G	309_K	0.643	0.73
318_A	322_A	0.643	0.73
272_K	276_G	0.642	0.73
208_R	267_H	0.641	0.73
288_T	338_L	0.641	0.73
331_G	335_A	0.640	0.73
51_A	172_S	0.639	0.73
296_R	303_R	0.637	0.73
105_L	116_I	0.637	0.73
285_D	303_R	0.634	0.72
332_D	340_A	0.633	0.72
18_A	308_A	0.631	0.72
234_E	287_V	0.630	0.72
27_V	62_P	0.630	0.72
64_S	77_R	0.630	0.72
152_P	181_I	0.629	0.72
154_S	179_W	0.628	0.72
220_T	235_A	0.627	0.71
211_F	307_P	0.625	0.71
183_E	190_T	0.624	0.71
178_E	270_Y	0.624	0.71
6_F	30_A	0.623	0.71
215_T	252_T	0.622	0.71
66_I	74_E	0.622	0.71
240_E	243_R	0.622	0.71
225_Y	230_K	0.620	0.71
304_L	321_I	0.616	0.70
12_G	17_G	0.614	0.70
124_G	153_N	0.612	0.70
253_G	267_H	0.608	0.69
215_T	307_P	0.607	0.69
76_Y	80_N	0.606	0.69
338_L	342_I	0.604	0.69
253_G	317_L	0.600	0.68
101_I	129_L	0.597	0.68
127_S	133_I	0.597	0.68
88_A	120_E	0.596	0.68
22_H	239_P	0.594	0.67
138_T	141_E	0.594	0.67
42_E	168_P	0.594	0.67
254_D	267_H	0.591	0.67
124_G	128_F	0.591	0.67
44_K	65_A	0.590	0.67
160_V	283_I	0.583	0.66
215_T	304_L	0.582	0.66
236_I	245_V	0.581	0.66
161_P	171_V	0.579	0.65
65_A	303_R	0.579	0.65
238_H	241_I	0.578	0.65
335_A	341_L	0.577	0.65
222_Y	235_A	0.575	0.65
210_L	222_Y	0.575	0.65
308_A	312_K	0.575	0.65
161_P	179_W	0.574	0.65
51_A	283_I	0.571	0.64
326_R	333_P	0.569	0.64
121_N	289_R	0.569	0.64
17_G	29_F	0.568	0.64
216_G	271_I	0.568	0.64
253_G	257_V	0.568	0.64
38_S	41_N	0.567	0.64
113_T	187_K	0.566	0.64
179_W	213_V	0.565	0.64
309_K	313_E	0.561	0.63
91_P	125_G	0.560	0.63
187_K	191_P	0.560	0.63
225_Y	329_F	0.558	0.63
155_A	180_V	0.558	0.63
6_F	79_M	0.556	0.62
304_L	307_P	0.556	0.62
331_G	340_A	0.555	0.62
242_R	275_I	0.555	0.62
52_E	175_P	0.554	0.62
174_E	277_R	0.553	0.62
202_L	206_I	0.552	0.62
220_T	236_I	0.551	0.62
287_V	290_V	0.550	0.61
74_E	138_T	0.550	0.61
20_L	198_F	0.548	0.61
80_N	103_E	0.548	0.61
28_V	81_E	0.547	0.61
203_T	207_E	0.546	0.61
253_G	271_I	0.545	0.61
49_E	170_K	0.544	0.61
23_S	26_D	0.544	0.61
95_K	98_A	0.542	0.60
176_F	196_A	0.541	0.60
54_G	281_P	0.541	0.60
190_T	198_F	0.539	0.60
119_C	176_F	0.538	0.60
252_T	316_A	0.538	0.60
37_V	163_Q	0.537	0.60
263_K	266_E	0.537	0.60
256_L	307_P	0.536	0.60
92_N	293_S	0.536	0.60
175_P	276_G	0.535	0.59
251_E	317_L	0.534	0.59
42_E	70_S	0.533	0.59
276_G	279_E	0.533	0.59
3_A	84_L	0.532	0.59
326_R	331_G	0.531	0.59
305_V	309_K	0.530	0.59
291_A	296_R	0.529	0.59
9_G	13_R	0.529	0.59
160_V	290_V	0.529	0.59
296_R	300_E	0.529	0.59
155_A	202_L	0.528	0.58
231_T	286_D	0.527	0.58
159_I	277_R	0.525	0.58
135_S	146_S	0.524	0.58
18_A	177_F	0.523	0.58
77_R	250_L	0.523	0.58
31_D	67_N	0.522	0.58
330_T	343_E	0.521	0.57
336_V	340_A	0.521	0.57
223_V	320_G	0.518	0.57
51_A	173_V	0.518	0.57
91_P	218_A	0.518	0.57
72_T	75_L	0.517	0.57
94_L	206_I	0.517	0.57
142_Q	146_S	0.517	0.57
218_A	289_R	0.517	0.57
218_A	294_P	0.517	0.57
86_T	157_D	0.517	0.57
224_G	287_V	0.516	0.57
159_I	179_W	0.514	0.56
124_G	207_E	0.514	0.56
234_E	284_S	0.513	0.56
159_I	280_N	0.512	0.56
306_G	310_K	0.512	0.56
208_R	287_V	0.512	0.56
10_N	221_A	0.511	0.56
56_S	282_F	0.511	0.56
158_R	177_F	0.510	0.56
26_D	64_S	0.509	0.56
304_L	317_L	0.507	0.55
12_G	86_T	0.506	0.55
197_L	266_E	0.506	0.55
339_Q	343_E	0.505	0.55
11_I	173_V	0.505	0.55
212_T	215_T	0.504	0.55
231_T	283_I	0.504	0.55
221_A	224_G	0.503	0.55
52_E	282_F	0.503	0.55
46_Y	60_I	0.502	0.55
75_L	79_M	0.502	0.55
64_S	81_E	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3h2zA	2	0.9866	100	0.117	Contact Map
4im7A	1	0.9839	100	0.176	Contact Map
1lj8A	1	0.9866	100	0.182	Contact Map
2ew2A	2	0.8016	98.9	0.893	Contact Map
3wfiA	2	0.8016	98.8	0.896	Contact Map
3i83A	2	0.7989	98.6	0.904	Contact Map
2qytA	1	0.7131	98.5	0.904	Contact Map
3hn2A	2	0.7909	98.5	0.906	Contact Map
1bg6A	2	0.866	98.3	0.911	Contact Map
3egoA	2	0.7587	98.2	0.914	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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