GREMLIN Database
PTMCB - PTS system mannitol-specific EIICB component
UniProt: P42956 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 478 (458)
Sequences: 569 (349)
Seq/√Len: 16.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
285_S327_V5.9801.00
281_A335_V5.6751.00
233_I279_A5.2501.00
187_V223_V4.7731.00
290_F324_G4.6131.00
59_S63_T4.5571.00
187_V204_L4.0301.00
412_N416_K3.9601.00
71_A91_A3.9061.00
184_S284_A3.8241.00
119_Q122_K3.6121.00
222_L309_L3.5201.00
120_T124_F3.4960.99
445_T459_S3.3870.99
295_A321_V3.3700.99
184_S287_L3.3530.99
54_L150_I3.2940.99
192_V269_I3.2430.99
293_F320_G3.1900.99
391_K434_D3.1330.99
310_M322_L3.1190.99
278_A336_S3.1070.99
290_F295_A3.0410.99
116_L144_V2.9860.98
42_L49_F2.9800.98
86_V141_A2.9090.98
362_G365_S2.8170.98
172_E176_H2.7630.97
274_A339_I2.7580.97
456_T475_K2.6660.97
113_G117_I2.6360.96
254_I258_F2.6280.96
289_T327_V2.6270.96
204_L223_V2.6170.96
120_T144_V2.6090.96
313_T318_Y2.5300.95
72_Y76_K2.5050.95
225_A309_L2.4940.95
392_I414_V2.4310.94
44_I58_V2.3060.92
362_G366_Q2.3060.92
225_A301_A2.2500.91
57_L96_V2.1920.90
445_T457_H2.1850.90
334_I338_V2.1740.90
301_A309_L2.1590.90
330_A334_I2.1560.89
295_A320_G2.1250.89
272_K343_S2.0450.87
38_I146_A2.0430.87
468_K471_E2.0000.85
250_P253_A1.9780.85
205_S300_A1.9720.85
192_V279_A1.9670.84
76_K81_H1.9230.83
185_V280_I1.9140.83
24_G77_M1.9130.83
114_G117_I1.8960.82
72_Y81_H1.8890.82
357_M360_M1.8850.82
295_A317_G1.8460.80
276_I279_A1.8430.80
310_M318_Y1.8430.80
437_I472_L1.8140.79
338_V342_S1.8090.79
46_A302_S1.7740.78
277_L281_A1.7690.77
33_F66_L1.7580.77
310_M313_T1.7570.77
256_H329_A1.7360.76
354_T357_M1.7300.76
143_I147_A1.7230.75
414_V419_L1.7110.75
130_Q408_S1.6920.74
54_L154_Y1.6780.73
358_Q365_S1.6740.73
86_V117_I1.6720.73
389_V437_I1.6680.73
90_A109_M1.6620.73
173_V177_A1.6600.73
275_L336_S1.6370.72
225_A300_A1.6310.71
417_A473_I1.5990.70
432_P435_A1.5680.68
66_L103_F1.5560.68
109_M152_A1.5540.67
363_K366_Q1.5480.67
350_L353_A1.5440.67
293_F323_A1.5330.66
269_I279_A1.5300.66
317_G320_G1.5190.66
233_I275_L1.5050.65
466_S469_Y1.4770.63
205_S209_I1.4660.63
87_G113_G1.4530.62
425_N457_H1.4460.62
284_A287_L1.4390.61
39_I57_L1.4320.61
45_P52_E1.4310.61
410_L469_Y1.4250.60
209_I221_F1.4090.60
80_D84_G1.4090.60
86_V113_G1.4070.59
168_A203_I1.3890.58
350_L361_K1.3770.58
120_T140_T1.3630.57
409_I464_L1.3600.57
318_Y322_L1.3530.56
339_I342_S1.3460.56
53_Q154_Y1.3430.56
12_K364_K1.3360.55
238_M253_A1.3310.55
207_I269_I1.3310.55
464_L472_L1.3060.54
437_I458_I1.2960.53
413_K470_D1.2850.52
306_I325_V1.2840.52
364_K367_A1.2830.52
79_Y114_G1.2790.52
238_M250_P1.2700.52
221_F299_A1.2660.51
354_T368_A1.2560.51
186_F203_I1.2490.50
222_L321_V1.2490.50
222_L225_A1.2480.50
233_I269_I1.2480.50
79_Y123_L1.2460.50
14_K17_R1.2450.50
253_A258_F1.2390.50
209_I213_S1.2350.50
362_G367_A1.2310.49
200_N205_S1.2160.48
192_V276_I1.2140.48
20_S460_V1.2040.48
298_V315_R1.2030.48
81_H84_G1.2020.48
316_G322_L1.1880.47
357_M364_K1.1830.46
135_L200_N1.1810.46
469_Y473_I1.1770.46
18_F21_Y1.1720.46
425_N459_S1.1670.46
414_V425_N1.1670.46
100_I160_V1.1580.45
20_S220_L1.1580.45
208_G221_F1.1570.45
52_E56_T1.1500.45
233_I336_S1.1400.44
201_H205_S1.1400.44
414_V423_V1.1290.43
237_Y272_K1.1260.43
324_G394_F1.1210.43
316_G324_G1.1070.42
410_L413_K1.1050.42
13_V446_D1.1040.42
354_T365_S1.0990.42
147_A151_L1.0960.41
89_T145_G1.0920.41
366_Q369_A1.0910.41
86_V460_V1.0900.41
72_Y84_G1.0900.41
38_I143_I1.0790.40
113_G147_A1.0740.40
12_K419_L1.0680.40
175_V211_Q1.0660.40
43_F47_G1.0660.40
413_K466_S1.0650.40
286_G328_A1.0640.40
431_L435_A1.0630.40
31_G138_N1.0610.39
68_L92_I1.0600.39
358_Q362_G1.0600.39
414_V476_L1.0580.39
214_Q225_A1.0480.39
53_Q153_F1.0470.39
350_L354_T1.0460.39
152_A186_F1.0450.39
188_E230_G1.0430.38
349_D352_A1.0400.38
272_K340_L1.0370.38
174_I177_A1.0370.38
425_N445_T1.0300.38
412_N465_N1.0290.38
48_W310_M1.0280.38
358_Q367_A1.0250.37
299_A312_M1.0210.37
358_Q363_K1.0210.37
293_F317_G1.0150.37
460_V468_K1.0130.37
33_F101_P1.0110.37
17_R415_K1.0060.36
164_N210_E1.0020.36
188_E227_P0.9990.36
427_A430_N0.9960.36
225_A290_F0.9920.36
277_L284_A0.9900.36
269_I437_I0.9850.35
309_L313_T0.9840.35
77_M421_I0.9840.35
425_N428_I0.9820.35
409_I473_I0.9770.35
27_M201_H0.9740.35
40_T55_N0.9740.35
340_L344_K0.9710.35
150_I154_Y0.9670.34
230_G262_H0.9660.34
23_S406_G0.9650.34
207_I210_E0.9620.34
432_P454_N0.9600.34
40_T97_G0.9580.34
280_I284_A0.9580.34
32_A85_V0.9570.34
200_N463_F0.9570.34
178_N431_L0.9500.33
86_V114_G0.9490.33
358_Q366_Q0.9480.33
353_A361_K0.9470.33
257_F325_V0.9440.33
227_P230_G0.9430.33
12_K366_Q0.9420.33
187_V224_E0.9420.33
425_N463_F0.9400.33
413_K469_Y0.9390.33
171_V183_A0.9390.33
183_A284_A0.9380.33
317_G321_V0.9380.33
65_L88_A0.9330.33
30_I268_Y0.9310.32
417_A469_Y0.9300.32
307_I311_A0.9300.32
26_I89_T0.9280.32
285_S293_F0.9270.32
117_I141_A0.9240.32
27_M200_N0.9200.32
223_V287_L0.9170.32
127_K413_K0.9110.31
57_L153_F0.9100.31
314_P317_G0.9090.31
188_E262_H0.9050.31
128_V137_N0.9040.31
279_A283_G0.8940.31
73_T81_H0.8940.31
290_F321_V0.8920.31
185_V323_A0.8890.30
20_S23_S0.8860.30
354_T364_K0.8830.30
313_T337_A0.8830.30
124_F127_K0.8810.30
227_P262_H0.8790.30
365_S369_A0.8770.30
391_K422_S0.8750.30
24_G460_V0.8730.30
117_I120_T0.8720.30
132_F254_I0.8710.29
114_G148_L0.8690.29
393_I422_S0.8650.29
90_A113_G0.8620.29
100_I207_I0.8620.29
183_A187_V0.8590.29
74_G77_M0.8560.29
272_K468_K0.8530.29
445_T449_K0.8520.29
178_N307_I0.8500.28
241_G245_S0.8500.28
339_I415_K0.8480.28
191_K227_P0.8480.28
47_G50_P0.8480.28
439_I445_T0.8470.28
285_S331_V0.8460.28
313_T320_G0.8460.28
43_F50_P0.8460.28
409_I469_Y0.8450.28
283_G286_G0.8440.28
39_I101_P0.8430.28
439_I472_L0.8420.28
53_Q56_T0.8420.28
103_F132_F0.8420.28
68_L192_V0.8380.28
241_G340_L0.8370.28
288_L292_I0.8350.28
231_L253_A0.8350.28
439_I476_L0.8320.28
39_I55_N0.8310.28
293_F321_V0.8310.28
117_I144_V0.8300.28
30_I34_I0.8300.28
442_K461_D0.8250.27
313_T321_V0.8220.27
188_E191_K0.8210.27
71_A95_I0.8150.27
237_Y461_D0.8140.27
132_F258_F0.8120.27
327_V330_A0.8110.27
317_G324_G0.8110.27
272_K344_K0.8100.27
220_L272_K0.8090.27
278_A335_V0.8090.27
448_A453_P0.8080.27
464_L468_K0.8070.26
358_Q369_A0.8040.26
233_I329_A0.8020.26
163_L325_V0.8020.26
51_N55_N0.8010.26
159_V389_V0.8000.26
245_S300_A0.7970.26
339_I460_V0.7960.26
285_S330_A0.7950.26
163_L167_L0.7920.26
120_T365_S0.7910.26
9_G14_K0.7910.26
210_E220_L0.7890.26
275_L278_A0.7860.26
31_G256_H0.7850.25
410_L473_I0.7830.25
147_A390_N0.7820.25
433_S454_N0.7810.25
187_V287_L0.7790.25
235_L329_A0.7790.25
323_A327_V0.7790.25
210_E214_Q0.7790.25
79_Y117_I0.7730.25
122_K125_K0.7730.25
144_V149_T0.7720.25
80_D109_M0.7710.25
411_R446_D0.7710.25
191_K230_G0.7700.25
35_A89_T0.7690.25
9_G192_V0.7690.25
114_G174_I0.7680.25
151_L155_A0.7680.25
125_K432_P0.7670.25
208_G219_I0.7630.25
79_Y144_V0.7620.24
109_M112_L0.7610.24
169_A203_I0.7600.24
33_F63_T0.7600.24
313_T319_F0.7590.24
165_K307_I0.7580.24
301_A307_I0.7530.24
108_I335_V0.7520.24
413_K417_A0.7510.24
233_I332_S0.7500.24
258_F307_I0.7500.24
13_V20_S0.7490.24
12_K242_K0.7470.24
58_V278_A0.7470.24
292_I349_D0.7440.24
307_I312_M0.7430.24
299_A324_G0.7410.24
26_I460_V0.7400.24
348_E411_R0.7360.23
431_L460_V0.7360.23
100_I280_I0.7340.23
290_F323_A0.7330.23
337_A359_S0.7320.23
340_L343_S0.7300.23
57_L289_T0.7290.23
222_L409_I0.7270.23
15_V78_I0.7260.23
209_I299_A0.7260.23
437_I456_T0.7260.23
156_I327_V0.7260.23
186_F390_N0.7250.23
84_G362_G0.7240.23
253_A269_I0.7240.23
191_K262_H0.7230.23
21_Y77_M0.7220.23
200_N225_A0.7210.23
46_A308_A0.7200.23
321_V471_E0.7200.23
34_I268_Y0.7170.23
71_A88_A0.7160.23
48_W315_R0.7140.22
290_F309_L0.7130.22
56_T154_Y0.7130.22
11_M18_F0.7130.22
432_P472_L0.7130.22
115_Y292_I0.7120.22
127_K392_I0.7120.22
40_T101_P0.7120.22
27_M463_F0.7120.22
293_F319_F0.7120.22
224_E264_I0.7110.22
421_I437_I0.7110.22
285_S289_T0.7100.22
183_A288_L0.7070.22
200_N224_E0.7040.22
39_I146_A0.7020.22
79_Y124_F0.7020.22
80_D112_L0.7010.22
427_A451_K0.7010.22
51_N315_R0.7000.22
436_D471_E0.7000.22
314_P322_L0.7000.22
143_I270_L0.7000.22
33_F54_L0.6990.22
309_L329_A0.6990.22
124_F144_V0.6980.22
130_Q258_F0.6980.22
225_A316_G0.6950.22
466_S473_I0.6950.22
59_S308_A0.6930.22
309_L324_G0.6930.22
38_I439_I0.6920.22
25_M28_P0.6900.21
458_I475_K0.6900.21
339_I343_S0.6880.21
48_W258_F0.6880.21
440_T459_S0.6870.21
389_V455_A0.6870.21
122_K246_K0.6860.21
12_K365_S0.6840.21
159_V352_A0.6840.21
320_G443_D0.6830.21
279_A332_S0.6830.21
242_K354_T0.6820.21
321_V458_I0.6810.21
209_I310_M0.6790.21
167_L186_F0.6790.21
182_V284_A0.6790.21
159_V163_L0.6790.21
358_Q364_K0.6780.21
410_L466_S0.6780.21
309_L314_P0.6770.21
231_L256_H0.6770.21
328_A332_S0.6770.21
167_L199_I0.6760.21
31_G120_T0.6710.21
461_D466_S0.6710.21
429_N466_S0.6700.21
219_I324_G0.6690.21
70_I198_A0.6690.21
242_K392_I0.6670.21
112_L115_Y0.6660.21
292_I390_N0.6650.21
302_S464_L0.6640.20
160_V286_G0.6640.20
154_Y192_V0.6640.20
84_G126_D0.6640.20
448_A463_F0.6620.20
425_N439_I0.6610.20
246_K391_K0.6600.20
48_W298_V0.6590.20
186_F249_A0.6590.20
102_M447_R0.6580.20
339_I462_N0.6570.20
363_K369_A0.6570.20
288_L291_T0.6560.20
9_G207_I0.6560.20
108_I127_K0.6550.20
126_D129_K0.6550.20
222_L465_N0.6530.20
309_L325_V0.6530.20
58_V308_A0.6520.20
201_H300_A0.6520.20
413_K473_I0.6510.20
212_A215_T0.6500.20
217_K317_G0.6500.20
43_F48_W0.6490.20
159_V437_I0.6490.20
222_L431_L0.6470.20
410_L429_N0.6440.20
284_A331_V0.6440.20
354_T358_Q0.6440.20
13_V409_I0.6430.20
71_A152_A0.6420.20
31_G157_G0.6420.20
435_A452_L0.6420.20
223_V394_F0.6410.20
246_K421_I0.6410.20
174_I208_G0.6390.20
104_L306_I0.6390.20
12_K209_I0.6360.19
412_N452_L0.6360.19
25_M36_W0.6350.19
425_N431_L0.6350.19
433_S437_I0.6340.19
44_I308_A0.6320.19
55_N101_P0.6310.19
290_F298_V0.6310.19
161_L164_N0.6300.19
147_A150_I0.6300.19
421_I464_L0.6300.19
356_K360_M0.6270.19
223_V290_F0.6260.19
124_F136_I0.6250.19
52_E55_N0.6200.19
120_T211_Q0.6190.19
15_V394_F0.6190.19
223_V299_A0.6190.19
82_R139_F0.6180.19
222_L301_A0.6180.19
391_K439_I0.6170.19
61_M89_T0.6160.19
71_A87_G0.6150.19
108_I210_E0.6140.19
20_S461_D0.6140.19
72_Y223_V0.6140.19
364_K369_A0.6130.19
186_F269_I0.6130.19
276_I436_D0.6120.19
208_G269_I0.6120.19
44_I50_P0.6110.19
458_I472_L0.6110.19
384_L392_I0.6100.18
20_S412_N0.6090.18
78_I123_L0.6080.18
140_T251_G0.6070.18
424_T461_D0.6070.18
98_S161_L0.6060.18
28_P36_W0.6050.18
440_T445_T0.6050.18
357_M366_Q0.6020.18
242_K343_S0.6020.18
56_T61_M0.6010.18
29_N93_G0.6000.18
233_I277_L0.6000.18
185_V284_A0.5990.18
169_A185_V0.5990.18
54_L153_F0.5990.18
171_V224_E0.5980.18
443_D460_V0.5960.18
214_Q380_E0.5950.18
220_L408_S0.5940.18
207_I220_L0.5910.18
458_I467_P0.5910.18
167_L435_A0.5910.18
174_I183_A0.5890.18
295_A322_L0.5890.18
355_E416_K0.5870.18
420_D449_K0.5860.18
20_S339_I0.5850.18
174_I290_F0.5850.18
203_I462_N0.5850.18
357_M368_A0.5840.18
237_Y271_M0.5830.18
190_A233_I0.5830.18
411_R425_N0.5830.18
128_V239_F0.5830.18
103_F438_V0.5820.18
286_G459_S0.5810.17
253_A340_L0.5800.17
20_S240_F0.5800.17
13_V411_R0.5760.17
409_I466_S0.5760.17
411_R431_L0.5760.17
20_S427_A0.5760.17
428_I457_H0.5750.17
258_F380_E0.5740.17
147_A452_L0.5730.17
117_I414_V0.5720.17
120_T145_G0.5720.17
13_V429_N0.5700.17
175_V287_L0.5700.17
45_P437_I0.5700.17
314_P318_Y0.5700.17
167_L439_I0.5690.17
220_L410_L0.5690.17
270_L360_M0.5690.17
147_A383_E0.5680.17
94_V105_G0.5670.17
275_L463_F0.5640.17
124_F321_V0.5640.17
79_Y409_I0.5630.17
428_I451_K0.5620.17
77_M84_G0.5620.17
109_M151_L0.5600.17
278_A337_A0.5600.17
407_A425_N0.5590.17
38_I270_L0.5590.17
141_A149_T0.5580.17
17_R164_N0.5580.17
17_R418_E0.5570.17
446_D449_K0.5570.17
101_P193_L0.5570.17
98_S155_A0.5570.17
114_G347_E0.5560.17
148_L476_L0.5560.17
238_M256_H0.5560.17
123_L169_A0.5550.17
278_A321_V0.5550.17
12_K414_V0.5550.17
79_Y460_V0.5540.17
205_S220_L0.5540.17
13_V461_D0.5530.17
341_K404_A0.5520.17
162_T166_L0.5500.16
62_I101_P0.5490.16
408_S460_V0.5490.16
96_V101_P0.5490.16
295_A324_G0.5480.16
357_M363_K0.5480.16
71_A154_Y0.5480.16
15_V336_S0.5460.16
61_M68_L0.5450.16
96_V100_I0.5450.16
17_R421_I0.5450.16
29_N73_T0.5440.16
410_L439_I0.5440.16
393_I435_A0.5440.16
33_F138_N0.5430.16
38_I212_A0.5430.16
78_I84_G0.5420.16
119_Q415_K0.5400.16
191_K286_G0.5400.16
311_A314_P0.5380.16
116_L151_L0.5380.16
103_F152_A0.5380.16
103_F418_E0.5370.16
20_S429_N0.5370.16
297_L301_A0.5370.16
173_V441_H0.5370.16
157_G425_N0.5360.16
396_C402_S0.5350.16
396_C399_G0.5350.16
399_G402_S0.5350.16
281_A338_V0.5340.16
438_V455_A0.5340.16
24_G146_A0.5340.16
280_I293_F0.5340.16
127_K148_L0.5320.16
155_A159_V0.5310.16
219_I244_S0.5310.16
61_M101_P0.5310.16
156_I193_L0.5300.16
62_I211_Q0.5300.16
209_I307_I0.5300.16
151_L156_I0.5300.16
124_F312_M0.5290.16
87_G411_R0.5280.16
46_A56_T0.5280.16
307_I441_H0.5270.16
393_I424_T0.5270.16
386_P456_T0.5270.16
56_T323_A0.5260.16
100_I164_N0.5260.16
77_M300_A0.5250.16
116_L274_A0.5250.16
76_K80_D0.5250.16
126_D247_S0.5240.16
88_A335_V0.5240.16
314_P323_A0.5240.16
207_I437_I0.5230.16
256_H309_L0.5230.16
220_L466_S0.5220.16
10_G474_E0.5220.16
22_L74_G0.5210.16
359_S420_D0.5210.16
81_H436_D0.5200.16
362_G412_N0.5200.16
99_D154_Y0.5200.16
20_S468_K0.5190.15
258_F280_I0.5180.15
356_K419_L0.5180.15
175_V183_A0.5170.15
55_N391_K0.5170.15
119_Q151_L0.5170.15
238_M245_S0.5170.15
295_A334_I0.5160.15
321_V324_G0.5160.15
214_Q446_D0.5160.15
98_S129_K0.5150.15
159_V162_T0.5150.15
117_I225_A0.5140.15
290_F300_A0.5130.15
312_M429_N0.5120.15
80_D340_L0.5120.15
222_L243_G0.5110.15
20_S272_K0.5110.15
460_V469_Y0.5100.15
84_G363_K0.5090.15
50_P55_N0.5090.15
411_R422_S0.5090.15
257_F289_T0.5080.15
134_M400_M0.5070.15
80_D94_V0.5070.15
204_L249_A0.5060.15
192_V465_N0.5060.15
171_V220_L0.5060.15
350_L360_M0.5060.15
151_L169_A0.5030.15
145_G343_S0.5030.15
23_S200_N0.5030.15
157_G428_I0.5020.15
116_L150_I0.5020.15
101_P138_N0.5020.15
49_F108_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.7406 99.9 0.88 Contact Map
1vkrA 1 0.1925 99.8 0.912 Contact Map
3czcA 1 0.1862 99.4 0.933 Contact Map
1tvmA 1 0.2218 99.3 0.935 Contact Map
1e2bA 1 0.1904 99.3 0.936 Contact Map
2l2qA 1 0.1925 99.2 0.94 Contact Map
4mgeA 3 0.1841 99.1 0.942 Contact Map
3nbmA 1 0.1862 98.7 0.951 Contact Map
4tn5A 2 0.1883 98.1 0.958 Contact Map
2m1zA 1 0.1904 98 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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