GREMLIN Database
YSLB - Uncharacterized protein YslB
UniProt: P42955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (132)
Sequences: 248 (199)
Seq/√Len: 17.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_Y68_A4.6551.00
113_E116_Q4.4131.00
89_G92_I3.4991.00
64_F68_A3.1860.99
125_S138_L3.0100.99
62_P138_L2.7210.97
54_P114_Q2.3420.94
25_I33_M2.1690.91
29_V33_M2.0830.89
29_V45_A2.0400.88
32_D48_H2.0090.87
21_A25_I1.8870.84
81_Q123_A1.8650.83
29_V44_W1.8640.83
108_A138_L1.8110.81
66_E72_T1.7610.79
19_A92_I1.7600.79
104_F136_V1.7530.79
28_I53_F1.7330.78
24_L64_F1.6910.76
92_I104_F1.6580.75
61_F115_I1.6260.73
60_E67_E1.5900.72
18_N69_G1.5670.71
57_S136_V1.4620.65
55_L118_M1.4540.65
31_P95_R1.4510.64
92_I95_R1.4420.64
58_W75_N1.3960.61
105_Q127_E1.3610.59
57_S60_E1.3520.59
53_F67_E1.3510.59
97_K134_D1.3440.58
19_A23_E1.3350.58
28_I37_D1.3210.57
126_Y141_K1.2930.55
20_Y114_Q1.2600.53
56_E82_E1.2450.52
81_Q144_M1.2330.52
49_L110_F1.2220.51
22_Y25_I1.2180.51
31_P124_E1.1900.49
78_A119_N1.1730.48
44_W106_L1.1650.48
25_I140_V1.1530.47
29_V55_L1.1500.47
122_I143_D1.1430.46
35_G42_M1.1350.46
82_E141_K1.1290.45
74_T136_V1.1260.45
47_K89_G1.1240.45
27_E104_F1.1200.45
113_E126_Y1.1030.44
70_W142_W1.1030.44
77_S137_V1.0990.44
61_F111_I1.0980.44
81_Q141_K1.0840.43
73_L85_F1.0770.42
102_P116_Q1.0730.42
75_N78_A1.0720.42
32_D61_F1.0710.42
89_G95_R1.0650.42
128_Q139_T1.0550.41
31_P104_F1.0380.40
79_K106_L1.0320.40
116_Q120_D1.0190.39
113_E117_L1.0190.39
57_S72_T1.0100.38
96_L104_F1.0050.38
111_I125_S0.9930.38
79_K85_F0.9920.37
50_A110_F0.9710.36
35_G85_F0.9670.36
13_K98_H0.9630.36
20_Y24_L0.9510.35
68_A114_Q0.9460.35
80_K85_F0.9410.35
90_P122_I0.9280.34
120_D143_D0.9250.34
20_Y53_F0.9070.33
42_M102_P0.9070.33
18_N49_L0.9030.33
117_L121_Q0.8990.32
100_K140_V0.8940.32
75_N119_N0.8890.32
57_S138_L0.8880.32
63_A67_E0.8720.31
96_L102_P0.8590.30
95_R104_F0.8540.30
33_M63_A0.8500.30
28_I86_E0.8300.29
15_I27_E0.8280.29
89_G104_F0.8270.29
31_P38_Y0.8270.29
59_E78_A0.8180.28
25_I31_P0.8180.28
57_S75_N0.8130.28
31_P92_I0.8100.28
115_I140_V0.8070.28
56_E132_R0.8060.28
93_S138_L0.8040.28
50_A95_R0.8030.28
60_E63_A0.8000.27
22_Y85_F0.7920.27
27_E123_A0.7910.27
25_I56_E0.7790.26
72_T117_L0.7650.26
82_E127_E0.7630.26
52_K83_L0.7620.26
22_Y70_W0.7600.25
123_A143_D0.7590.25
45_A124_E0.7570.25
17_M142_W0.7560.25
127_E141_K0.7550.25
50_A124_E0.7450.25
38_Y92_I0.7390.25
14_E132_R0.7390.25
86_E135_K0.7370.24
41_M127_E0.7280.24
62_P73_L0.7260.24
64_F114_Q0.7250.24
59_E136_V0.7220.24
27_E89_G0.7210.24
53_F94_N0.7110.23
81_Q120_D0.7110.23
83_L115_I0.7070.23
88_E96_L0.7020.23
24_L77_S0.6990.23
86_E128_Q0.6980.23
27_E70_W0.6950.23
65_F68_A0.6950.23
33_M102_P0.6950.23
45_A68_A0.6860.22
108_A136_V0.6790.22
127_E139_T0.6710.22
27_E44_W0.6700.22
13_K123_A0.6700.22
27_E47_K0.6640.21
42_M111_I0.6630.21
83_L125_S0.6620.21
21_A70_W0.6590.21
81_Q121_Q0.6580.21
125_S142_W0.6560.21
105_Q125_S0.6440.21
101_E119_N0.6430.21
61_F138_L0.6420.20
19_A111_I0.6380.20
13_K133_A0.6360.20
46_G109_G0.6350.20
46_G107_E0.6350.20
24_L68_A0.6300.20
125_S140_V0.6270.20
25_I48_H0.6250.20
75_N83_L0.6170.20
36_Q39_S0.6130.19
18_N21_A0.6090.19
122_I132_R0.6060.19
70_W111_I0.6040.19
32_D55_L0.6040.19
39_S101_E0.6030.19
37_D68_A0.6000.19
41_M128_Q0.5910.19
59_E70_W0.5890.18
55_L114_Q0.5870.18
40_S69_G0.5870.18
93_S108_A0.5860.18
104_F124_E0.5800.18
84_E139_T0.5780.18
85_F113_E0.5730.18
48_H86_E0.5710.18
76_V86_E0.5710.18
20_Y45_A0.5700.18
83_L92_I0.5640.18
47_K63_A0.5610.17
83_L142_W0.5570.17
67_E119_N0.5500.17
95_R102_P0.5480.17
17_M44_W0.5470.17
49_L104_F0.5430.17
30_L66_E0.5430.17
21_A80_K0.5370.17
21_A111_I0.5360.17
130_K135_K0.5360.17
37_D94_N0.5340.17
57_S118_M0.5330.17
94_N98_H0.5300.16
27_E102_P0.5280.16
23_E80_K0.5280.16
29_V64_F0.5230.16
40_S105_Q0.5190.16
59_E120_D0.5110.16
24_L51_R0.5110.16
47_K87_L0.5100.16
18_N142_W0.5090.16
84_E133_A0.5090.16
23_E27_E0.5080.16
56_E79_K0.5060.16
26_R46_G0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3njcA 2 0.9797 100 0.295 Contact Map
2osoA 2 0.9122 99.7 0.691 Contact Map
2mnjA 1 0.1554 9.3 0.955 Contact Map
3aj1A 5 0.9054 9 0.955 Contact Map
2pa8L 1 0.4392 6 0.958 Contact Map
4qjvB 1 0.4392 5.8 0.959 Contact Map
1xppA 3 0.4527 3.8 0.962 Contact Map
1jnsA 1 0.2095 3.8 0.962 Contact Map
4kw3A 1 0.9122 3.4 0.963 Contact Map
3p9cA 2 0.5946 3.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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