TAGG - BACSU - GREMLIN Contacts

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TAGG - Teichoic acid translocation permease protein TagG

UniProt:	P42953	Sequences: MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNPLIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKRINMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICMIAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLKLNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	275 (238)
Sequences:	15810 (11287)
Seq/√Len:	731.6

ECOLI - YADH
BACSU - TAGG
HALSA - Q9HRJ5
SULSO - Q97U55 Q97VH7 Q97WP5 Q97Z04

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
156_Y	228_G	4.061	1.00
105_M	108_K	3.767	1.00
23_A	28_S	2.982	1.00
214_V	218_K	2.929	1.00
211_P	215_P	2.709	1.00
22_A	122_A	2.635	1.00
22_A	126_F	2.604	1.00
73_P	76_I	2.391	1.00
112_P	115_S	2.381	1.00
104_N	108_K	2.353	1.00
160_M	225_I	2.300	1.00
19_L	23_A	2.269	1.00
212_E	215_P	2.250	1.00
105_M	109_M	2.239	1.00
211_P	214_V	2.207	1.00
247_L	251_L	2.173	1.00
170_F	263_L	2.104	1.00
95_G	168_S	2.095	1.00
21_L	119_V	2.046	1.00
25_E	120_A	2.029	1.00
162_A	253_T	2.022	1.00
156_Y	232_S	2.018	1.00
243_M	247_L	2.002	1.00
18_I	22_A	1.971	1.00
163_F	253_T	1.947	1.00
170_F	259_V	1.932	1.00
166_S	260_G	1.886	1.00
215_P	219_L	1.872	1.00
258_L	262_I	1.865	1.00
104_N	109_M	1.823	1.00
18_I	115_S	1.814	1.00
215_P	218_K	1.799	1.00
98_S	102_R	1.793	1.00
166_S	253_T	1.780	1.00
166_S	169_L	1.761	1.00
133_V	154_I	1.732	1.00
198_I	226_I	1.690	1.00
163_F	256_L	1.682	1.00
251_L	255_L	1.630	1.00
176_V	179_R	1.614	1.00
244_K	247_L	1.612	1.00
151_L	155_Y	1.611	1.00
231_N	237_A	1.605	1.00
104_N	107_A	1.591	1.00
224_Y	245_Y	1.586	1.00
111_F	116_L	1.578	1.00
28_S	31_Q	1.557	1.00
210_H	214_V	1.550	1.00
19_L	22_A	1.536	1.00
227_E	245_Y	1.532	1.00
224_Y	248_Y	1.515	1.00
99_V	103_I	1.489	1.00
212_E	216_V	1.487	1.00
244_K	248_Y	1.485	1.00
217_L	223_F	1.483	1.00
197_P	202_V	1.483	1.00
166_S	256_L	1.472	1.00
227_E	231_N	1.467	1.00
248_Y	252_F	1.465	1.00
170_F	256_L	1.463	1.00
248_Y	251_L	1.444	1.00
218_K	224_Y	1.437	1.00
149_H	152_Q	1.422	1.00
79_L	139_L	1.394	1.00
253_T	257_L	1.379	1.00
151_L	154_I	1.364	1.00
192_L	222_L	1.357	1.00
88_I	222_L	1.357	1.00
246_T	250_W	1.357	1.00
18_I	122_A	1.347	1.00
99_V	102_R	1.344	1.00
157_F	225_I	1.341	1.00
74_F	78_M	1.339	1.00
80_A	83_I	1.326	1.00
202_V	217_L	1.325	1.00
231_N	235_D	1.321	1.00
31_Q	34_Y	1.316	1.00
202_V	218_K	1.289	1.00
205_K	217_L	1.271	1.00
177_L	180_D	1.247	1.00
173_T	263_L	1.244	1.00
77_W	230_R	1.243	1.00
152_Q	155_Y	1.242	1.00
159_C	250_W	1.240	1.00
81_G	230_R	1.219	1.00
192_L	220_N	1.219	1.00
137_I	141_V	1.217	1.00
98_S	101_K	1.204	1.00
22_A	119_V	1.192	1.00
255_L	258_L	1.188	1.00
218_K	223_F	1.179	1.00
160_M	229_F	1.163	1.00
18_I	119_V	1.161	1.00
101_K	120_A	1.157	1.00
171_N	175_S	1.155	1.00
18_I	118_S	1.155	1.00
205_K	213_L	1.129	1.00
166_S	257_L	1.127	1.00
154_I	158_I	1.127	1.00
197_P	223_F	1.119	1.00
262_I	266_K	1.110	1.00
152_Q	232_S	1.108	1.00
100_F	103_I	1.102	1.00
202_V	214_V	1.097	1.00
252_F	256_L	1.089	1.00
159_C	253_T	1.069	1.00
114_S	118_S	1.058	1.00
160_M	164_M	1.058	1.00
30_Y	40_Q	1.048	1.00
220_N	223_F	1.036	1.00
223_F	227_E	1.030	1.00
247_L	250_W	1.028	1.00
202_V	223_F	1.013	1.00
150_W	154_I	1.010	1.00
85_W	193_F	1.001	1.00
225_I	249_F	0.998	1.00
153_Y	229_F	0.993	1.00
95_G	102_R	0.992	1.00
168_S	172_S	0.990	1.00
250_W	253_T	0.986	1.00
238_W	241_H	0.985	1.00
52_W	78_M	0.985	1.00
138_V	141_V	0.979	1.00
84_P	160_M	0.975	1.00
92_I	185_L	0.971	1.00
163_F	252_F	0.965	1.00
250_W	254_F	0.960	1.00
158_I	162_A	0.959	1.00
20_R	23_A	0.959	1.00
262_I	265_M	0.953	1.00
193_F	196_L	0.953	1.00
162_A	257_L	0.950	1.00
205_K	214_V	0.949	1.00
176_V	180_D	0.948	1.00
106_V	116_L	0.944	1.00
255_L	259_V	0.942	1.00
98_S	103_I	0.936	1.00
155_Y	159_C	0.933	1.00
81_G	84_P	0.931	1.00
157_F	229_F	0.923	1.00
25_E	29_K	0.922	1.00
183_F	186_Q	0.922	1.00
245_Y	249_F	0.919	1.00
119_V	123_S	0.919	1.00
201_D	204_A	0.916	1.00
97_N	101_K	0.911	1.00
52_W	75_I	0.910	1.00
156_Y	246_T	0.909	1.00
153_Y	232_S	0.907	1.00
26_T	31_Q	0.906	1.00
125_L	129_M	0.903	1.00
57_M	204_A	0.901	1.00
224_Y	228_G	0.900	1.00
175_S	184_L	0.893	1.00
170_F	260_G	0.890	1.00
33_N	36_G	0.890	1.00
59_I	62_G	0.884	1.00
163_F	249_F	0.883	1.00
93_L	189_T	0.877	1.00
48_M	79_L	0.875	1.00
47_Q	51_Y	0.871	1.00
239_F	242_D	0.870	1.00
114_S	261_S	0.868	1.00
228_G	246_T	0.866	1.00
227_E	230_R	0.864	1.00
259_V	262_I	0.864	1.00
30_Y	36_G	0.863	1.00
175_S	181_Y	0.863	1.00
172_S	175_S	0.861	1.00
254_F	258_L	0.856	1.00
173_T	267_F	0.854	1.00
88_I	164_M	0.854	1.00
85_W	189_T	0.853	1.00
84_P	222_L	0.852	1.00
47_Q	191_L	0.851	1.00
155_Y	158_I	0.847	1.00
129_M	133_V	0.846	1.00
26_T	126_F	0.843	1.00
84_P	226_I	0.836	1.00
120_A	124_N	0.833	1.00
188_V	191_L	0.833	1.00
45_L	138_V	0.828	1.00
164_M	168_S	0.810	1.00
171_N	181_Y	0.809	1.00
137_I	140_L	0.803	1.00
155_Y	246_T	0.801	1.00
159_C	246_T	0.800	1.00
96_S	102_R	0.799	1.00
193_F	199_F	0.794	1.00
95_G	99_V	0.792	1.00
49_L	53_F	0.792	1.00
197_P	200_W	0.791	1.00
245_Y	248_Y	0.788	1.00
125_L	162_A	0.785	1.00
43_N	47_Q	0.784	1.00
236_G	239_F	0.783	1.00
259_V	263_L	0.781	1.00
90_P	94_D	0.779	1.00
169_L	172_S	0.777	1.00
50_A	54_V	0.776	1.00
83_I	132_M	0.768	1.00
182_Q	186_Q	0.764	1.00
252_F	255_L	0.763	1.00
81_G	200_W	0.760	1.00
193_F	198_I	0.756	1.00
80_A	84_P	0.756	1.00
165_F	169_L	0.754	1.00
85_W	89_S	0.749	1.00
258_L	261_S	0.744	1.00
249_F	253_T	0.744	1.00
197_P	220_N	0.738	1.00
161_I	164_M	0.737	1.00
257_L	261_S	0.730	1.00
153_Y	233_F	0.730	1.00
203_N	214_V	0.726	1.00
263_L	267_F	0.725	1.00
91_T	164_M	0.720	1.00
202_V	205_K	0.720	1.00
205_K	210_H	0.715	1.00
230_R	234_L	0.715	1.00
87_F	128_Y	0.715	1.00
253_T	256_L	0.714	1.00
83_I	135_Y	0.711	1.00
251_L	258_L	0.711	1.00
81_G	198_I	0.709	1.00
121_I	165_F	0.708	1.00
189_T	193_F	0.706	1.00
166_S	173_T	0.706	1.00
186_Q	190_R	0.706	1.00
256_L	260_G	0.697	1.00
235_D	239_F	0.696	1.00
231_N	236_G	0.696	1.00
91_T	121_I	0.694	1.00
92_I	189_T	0.692	1.00
87_F	160_M	0.691	1.00
161_I	165_F	0.687	1.00
26_T	123_S	0.680	1.00
237_A	241_H	0.679	1.00
80_A	229_F	0.678	1.00
191_L	195_L	0.678	1.00
190_R	193_F	0.675	1.00
224_Y	227_E	0.675	1.00
175_S	180_D	0.673	1.00
228_G	232_S	0.672	1.00
42_L	49_L	0.672	1.00
150_W	153_Y	0.671	1.00
251_L	254_F	0.671	1.00
87_F	91_T	0.671	1.00
210_H	213_L	0.669	1.00
96_S	99_V	0.669	1.00
179_R	182_Q	0.667	1.00
129_M	158_I	0.663	1.00
226_I	230_R	0.662	1.00
197_P	227_E	0.662	1.00
74_F	77_W	0.659	1.00
133_V	137_I	0.658	1.00
84_P	229_F	0.657	1.00
106_V	109_M	0.656	1.00
167_F	256_L	0.652	1.00
196_L	222_L	0.652	1.00
187_A	191_L	0.651	1.00
82_L	86_F	0.651	1.00
95_G	98_S	0.649	1.00
36_G	39_W	0.648	1.00
152_Q	238_W	0.644	1.00
132_M	157_F	0.640	1.00
89_S	93_L	0.639	1.00
234_L	237_A	0.636	1.00
228_G	249_F	0.635	1.00
166_S	170_F	0.635	1.00
131_M	135_Y	0.633	1.00
218_K	227_E	0.632	1.00
80_A	85_W	0.632	1.00
228_G	242_D	0.632	1.00
124_N	128_Y	0.630	1.00
30_Y	33_N	0.629	1.00
24_Y	28_S	0.629	1.00
41_F	130_I	0.629	1.00
130_I	133_V	0.628	1.00
173_T	260_G	0.627	1.00
232_S	235_D	0.627	1.00
242_D	245_Y	0.626	1.00
192_L	196_L	0.626	1.00
25_E	123_S	0.626	1.00
58_G	204_A	0.625	1.00
38_L	42_L	0.619	1.00
241_H	244_K	0.613	1.00
231_N	242_D	0.611	1.00
22_A	123_S	0.610	1.00
173_T	264_H	0.610	1.00
175_S	179_R	0.609	1.00
204_A	211_P	0.604	1.00
35_L	39_W	0.604	1.00
169_L	173_T	0.603	1.00
219_L	224_Y	0.600	1.00
154_I	157_F	0.595	1.00
96_S	185_L	0.595	1.00
70_G	73_P	0.595	1.00
224_Y	252_F	0.593	1.00
242_D	246_T	0.590	1.00
156_Y	160_M	0.590	1.00
92_I	171_N	0.589	1.00
228_G	231_N	0.589	1.00
158_I	161_I	0.588	1.00
93_L	96_S	0.586	1.00
204_A	210_H	0.585	1.00
170_F	173_T	0.580	1.00
174_I	263_L	0.580	1.00
114_S	117_P	0.573	1.00
172_S	176_V	0.567	1.00
106_V	113_I	0.566	1.00
84_P	225_I	0.562	1.00
39_W	43_N	0.557	1.00
90_P	124_N	0.555	1.00
237_A	242_D	0.553	1.00
95_G	101_K	0.552	1.00
22_A	26_T	0.551	1.00
39_W	42_L	0.549	1.00
124_N	165_F	0.548	1.00
172_S	179_R	0.547	1.00
171_N	174_I	0.547	1.00
163_F	171_N	0.546	1.00
45_L	49_L	0.545	1.00
97_N	102_R	0.543	1.00
52_W	142_N	0.543	1.00
46_I	49_L	0.542	1.00
30_Y	34_Y	0.542	1.00
159_C	249_F	0.540	1.00
143_G	147_S	0.539	1.00
263_L	266_K	0.537	1.00
100_F	179_R	0.535	1.00
127_S	131_M	0.530	1.00
149_H	153_Y	0.529	1.00
57_M	60_R	0.529	1.00
172_S	193_F	0.528	1.00
29_K	32_M	0.527	1.00
76_I	80_A	0.526	1.00
21_L	111_F	0.524	1.00
121_I	166_S	0.521	1.00
224_Y	249_F	0.519	1.00
163_F	225_I	0.515	1.00
98_S	120_A	0.514	1.00
203_N	211_P	0.512	1.00
239_F	243_M	0.511	1.00
222_L	226_I	0.511	1.00
217_L	220_N	0.509	1.00
47_Q	193_F	0.507	1.00
152_Q	228_G	0.507	1.00
118_S	122_A	0.506	1.00
52_W	56_G	0.506	1.00
97_N	100_F	0.506	1.00
51_Y	82_L	0.505	1.00
156_Y	161_I	0.503	0.99
261_S	265_M	0.502	0.99
89_S	189_T	0.500	0.99
254_F	257_L	0.500	0.99
148_V	239_F	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mp7B	1	0.1964	5.7	0.952	Contact Map
3bo0B	1	0.2291	4	0.956	Contact Map
4b19A	1	0.1091	3.9	0.956	Contact Map
2ks1B	1	0.16	3.4	0.957	Contact Map
1iflA	10	0.1927	2.6	0.96	Contact Map
2jwaA	2	0.1564	2.5	0.96	Contact Map
2m8rA	1	0.1891	2.4	0.961	Contact Map
4ev6A	3	0.3273	2.3	0.961	Contact Map
3dinD	1	0.2036	2.2	0.961	Contact Map
3zuxA	1	0.7673	2.2	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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