GREMLIN Database
TAGG - Teichoic acid translocation permease protein TagG
UniProt: P42953 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (238)
Sequences: 15810 (11287)
Seq/√Len: 731.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_Y228_G4.0611.00
105_M108_K3.7671.00
23_A28_S2.9821.00
214_V218_K2.9291.00
211_P215_P2.7091.00
22_A122_A2.6351.00
22_A126_F2.6041.00
73_P76_I2.3911.00
112_P115_S2.3811.00
104_N108_K2.3531.00
160_M225_I2.3001.00
19_L23_A2.2691.00
212_E215_P2.2501.00
105_M109_M2.2391.00
211_P214_V2.2071.00
247_L251_L2.1731.00
170_F263_L2.1041.00
95_G168_S2.0951.00
21_L119_V2.0461.00
25_E120_A2.0291.00
162_A253_T2.0221.00
156_Y232_S2.0181.00
243_M247_L2.0021.00
18_I22_A1.9711.00
163_F253_T1.9471.00
170_F259_V1.9321.00
166_S260_G1.8861.00
215_P219_L1.8721.00
258_L262_I1.8651.00
104_N109_M1.8231.00
18_I115_S1.8141.00
215_P218_K1.7991.00
98_S102_R1.7931.00
166_S253_T1.7801.00
166_S169_L1.7611.00
133_V154_I1.7321.00
198_I226_I1.6901.00
163_F256_L1.6821.00
251_L255_L1.6301.00
176_V179_R1.6141.00
244_K247_L1.6121.00
151_L155_Y1.6111.00
231_N237_A1.6051.00
104_N107_A1.5911.00
224_Y245_Y1.5861.00
111_F116_L1.5781.00
28_S31_Q1.5571.00
210_H214_V1.5501.00
19_L22_A1.5361.00
227_E245_Y1.5321.00
224_Y248_Y1.5151.00
99_V103_I1.4891.00
212_E216_V1.4871.00
244_K248_Y1.4851.00
217_L223_F1.4831.00
197_P202_V1.4831.00
166_S256_L1.4721.00
227_E231_N1.4671.00
248_Y252_F1.4651.00
170_F256_L1.4631.00
248_Y251_L1.4441.00
218_K224_Y1.4371.00
149_H152_Q1.4221.00
79_L139_L1.3941.00
253_T257_L1.3791.00
151_L154_I1.3641.00
192_L222_L1.3571.00
88_I222_L1.3571.00
246_T250_W1.3571.00
18_I122_A1.3471.00
99_V102_R1.3441.00
157_F225_I1.3411.00
74_F78_M1.3391.00
80_A83_I1.3261.00
202_V217_L1.3251.00
231_N235_D1.3211.00
31_Q34_Y1.3161.00
202_V218_K1.2891.00
205_K217_L1.2711.00
177_L180_D1.2471.00
173_T263_L1.2441.00
77_W230_R1.2431.00
152_Q155_Y1.2421.00
159_C250_W1.2401.00
81_G230_R1.2191.00
192_L220_N1.2191.00
137_I141_V1.2171.00
98_S101_K1.2041.00
22_A119_V1.1921.00
255_L258_L1.1881.00
218_K223_F1.1791.00
160_M229_F1.1631.00
18_I119_V1.1611.00
101_K120_A1.1571.00
171_N175_S1.1551.00
18_I118_S1.1551.00
205_K213_L1.1291.00
166_S257_L1.1271.00
154_I158_I1.1271.00
197_P223_F1.1191.00
262_I266_K1.1101.00
152_Q232_S1.1081.00
100_F103_I1.1021.00
202_V214_V1.0971.00
252_F256_L1.0891.00
159_C253_T1.0691.00
114_S118_S1.0581.00
160_M164_M1.0581.00
30_Y40_Q1.0481.00
220_N223_F1.0361.00
223_F227_E1.0301.00
247_L250_W1.0281.00
202_V223_F1.0131.00
150_W154_I1.0101.00
85_W193_F1.0011.00
225_I249_F0.9981.00
153_Y229_F0.9931.00
95_G102_R0.9921.00
168_S172_S0.9901.00
250_W253_T0.9861.00
238_W241_H0.9851.00
52_W78_M0.9851.00
138_V141_V0.9791.00
84_P160_M0.9751.00
92_I185_L0.9711.00
163_F252_F0.9651.00
250_W254_F0.9601.00
158_I162_A0.9591.00
20_R23_A0.9591.00
262_I265_M0.9531.00
193_F196_L0.9531.00
162_A257_L0.9501.00
205_K214_V0.9491.00
176_V180_D0.9481.00
106_V116_L0.9441.00
255_L259_V0.9421.00
98_S103_I0.9361.00
155_Y159_C0.9331.00
81_G84_P0.9311.00
157_F229_F0.9231.00
25_E29_K0.9221.00
183_F186_Q0.9221.00
245_Y249_F0.9191.00
119_V123_S0.9191.00
201_D204_A0.9161.00
97_N101_K0.9111.00
52_W75_I0.9101.00
156_Y246_T0.9091.00
153_Y232_S0.9071.00
26_T31_Q0.9061.00
125_L129_M0.9031.00
57_M204_A0.9011.00
224_Y228_G0.9001.00
175_S184_L0.8931.00
170_F260_G0.8901.00
33_N36_G0.8901.00
59_I62_G0.8841.00
163_F249_F0.8831.00
93_L189_T0.8771.00
48_M79_L0.8751.00
47_Q51_Y0.8711.00
239_F242_D0.8701.00
114_S261_S0.8681.00
228_G246_T0.8661.00
227_E230_R0.8641.00
259_V262_I0.8641.00
30_Y36_G0.8631.00
175_S181_Y0.8631.00
172_S175_S0.8611.00
254_F258_L0.8561.00
173_T267_F0.8541.00
88_I164_M0.8541.00
85_W189_T0.8531.00
84_P222_L0.8521.00
47_Q191_L0.8511.00
155_Y158_I0.8471.00
129_M133_V0.8461.00
26_T126_F0.8431.00
84_P226_I0.8361.00
120_A124_N0.8331.00
188_V191_L0.8331.00
45_L138_V0.8281.00
164_M168_S0.8101.00
171_N181_Y0.8091.00
137_I140_L0.8031.00
155_Y246_T0.8011.00
159_C246_T0.8001.00
96_S102_R0.7991.00
193_F199_F0.7941.00
95_G99_V0.7921.00
49_L53_F0.7921.00
197_P200_W0.7911.00
245_Y248_Y0.7881.00
125_L162_A0.7851.00
43_N47_Q0.7841.00
236_G239_F0.7831.00
259_V263_L0.7811.00
90_P94_D0.7791.00
169_L172_S0.7771.00
50_A54_V0.7761.00
83_I132_M0.7681.00
182_Q186_Q0.7641.00
252_F255_L0.7631.00
81_G200_W0.7601.00
193_F198_I0.7561.00
80_A84_P0.7561.00
165_F169_L0.7541.00
85_W89_S0.7491.00
258_L261_S0.7441.00
249_F253_T0.7441.00
197_P220_N0.7381.00
161_I164_M0.7371.00
257_L261_S0.7301.00
153_Y233_F0.7301.00
203_N214_V0.7261.00
263_L267_F0.7251.00
91_T164_M0.7201.00
202_V205_K0.7201.00
205_K210_H0.7151.00
230_R234_L0.7151.00
87_F128_Y0.7151.00
253_T256_L0.7141.00
83_I135_Y0.7111.00
251_L258_L0.7111.00
81_G198_I0.7091.00
121_I165_F0.7081.00
189_T193_F0.7061.00
166_S173_T0.7061.00
186_Q190_R0.7061.00
256_L260_G0.6971.00
235_D239_F0.6961.00
231_N236_G0.6961.00
91_T121_I0.6941.00
92_I189_T0.6921.00
87_F160_M0.6911.00
161_I165_F0.6871.00
26_T123_S0.6801.00
237_A241_H0.6791.00
80_A229_F0.6781.00
191_L195_L0.6781.00
190_R193_F0.6751.00
224_Y227_E0.6751.00
175_S180_D0.6731.00
228_G232_S0.6721.00
42_L49_L0.6721.00
150_W153_Y0.6711.00
251_L254_F0.6711.00
87_F91_T0.6711.00
210_H213_L0.6691.00
96_S99_V0.6691.00
179_R182_Q0.6671.00
129_M158_I0.6631.00
226_I230_R0.6621.00
197_P227_E0.6621.00
74_F77_W0.6591.00
133_V137_I0.6581.00
84_P229_F0.6571.00
106_V109_M0.6561.00
167_F256_L0.6521.00
196_L222_L0.6521.00
187_A191_L0.6511.00
82_L86_F0.6511.00
95_G98_S0.6491.00
36_G39_W0.6481.00
152_Q238_W0.6441.00
132_M157_F0.6401.00
89_S93_L0.6391.00
234_L237_A0.6361.00
228_G249_F0.6351.00
166_S170_F0.6351.00
131_M135_Y0.6331.00
218_K227_E0.6321.00
80_A85_W0.6321.00
228_G242_D0.6321.00
124_N128_Y0.6301.00
30_Y33_N0.6291.00
24_Y28_S0.6291.00
41_F130_I0.6291.00
130_I133_V0.6281.00
173_T260_G0.6271.00
232_S235_D0.6271.00
242_D245_Y0.6261.00
192_L196_L0.6261.00
25_E123_S0.6261.00
58_G204_A0.6251.00
38_L42_L0.6191.00
241_H244_K0.6131.00
231_N242_D0.6111.00
22_A123_S0.6101.00
173_T264_H0.6101.00
175_S179_R0.6091.00
204_A211_P0.6041.00
35_L39_W0.6041.00
169_L173_T0.6031.00
219_L224_Y0.6001.00
154_I157_F0.5951.00
96_S185_L0.5951.00
70_G73_P0.5951.00
224_Y252_F0.5931.00
242_D246_T0.5901.00
156_Y160_M0.5901.00
92_I171_N0.5891.00
228_G231_N0.5891.00
158_I161_I0.5881.00
93_L96_S0.5861.00
204_A210_H0.5851.00
170_F173_T0.5801.00
174_I263_L0.5801.00
114_S117_P0.5731.00
172_S176_V0.5671.00
106_V113_I0.5661.00
84_P225_I0.5621.00
39_W43_N0.5571.00
90_P124_N0.5551.00
237_A242_D0.5531.00
95_G101_K0.5521.00
22_A26_T0.5511.00
39_W42_L0.5491.00
124_N165_F0.5481.00
172_S179_R0.5471.00
171_N174_I0.5471.00
163_F171_N0.5461.00
45_L49_L0.5451.00
97_N102_R0.5431.00
52_W142_N0.5431.00
46_I49_L0.5421.00
30_Y34_Y0.5421.00
159_C249_F0.5401.00
143_G147_S0.5391.00
263_L266_K0.5371.00
100_F179_R0.5351.00
127_S131_M0.5301.00
149_H153_Y0.5291.00
57_M60_R0.5291.00
172_S193_F0.5281.00
29_K32_M0.5271.00
76_I80_A0.5261.00
21_L111_F0.5241.00
121_I166_S0.5211.00
224_Y249_F0.5191.00
163_F225_I0.5151.00
98_S120_A0.5141.00
203_N211_P0.5121.00
239_F243_M0.5111.00
222_L226_I0.5111.00
217_L220_N0.5091.00
47_Q193_F0.5071.00
152_Q228_G0.5071.00
118_S122_A0.5061.00
52_W56_G0.5061.00
97_N100_F0.5061.00
51_Y82_L0.5051.00
156_Y161_I0.5030.99
261_S265_M0.5020.99
89_S189_T0.5000.99
254_F257_L0.5000.99
148_V239_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mp7B 1 0.1964 5.7 0.952 Contact Map
3bo0B 1 0.2291 4 0.956 Contact Map
4b19A 1 0.1091 3.9 0.956 Contact Map
2ks1B 1 0.16 3.4 0.957 Contact Map
1iflA 10 0.1927 2.6 0.96 Contact Map
2jwaA 2 0.1564 2.5 0.96 Contact Map
2m8rA 1 0.1891 2.4 0.961 Contact Map
4ev6A 3 0.3273 2.3 0.961 Contact Map
3dinD 1 0.2036 2.2 0.961 Contact Map
3zuxA 1 0.7673 2.2 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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