GREMLIN Database
NASE - Assimilatory nitrite reductase [NAD(P)H] small subunit
UniProt: P42436 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 106 (96)
Sequences: 2994 (2039)
Seq/√Len: 208.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_C101_H4.3541.00
8_K96_L2.6231.00
14_I42_I2.5041.00
45_I90_V2.3401.00
10_C103_Y2.1771.00
96_L103_Y2.1051.00
46_E91_K1.9391.00
76_S79_D1.9391.00
47_N57_A1.9341.00
98_E103_Y1.8771.00
13_K101_H1.7481.00
13_K16_E1.7331.00
56_L90_V1.6541.00
64_Q78_E1.6341.00
30_K46_E1.6301.00
54_G69_P1.5971.00
64_Q76_S1.5831.00
41_S78_E1.5631.00
61_V77_L1.5081.00
46_E93_Y1.4931.00
73_W86_D1.4861.00
10_C13_K1.4501.00
32_L44_A1.4351.00
65_Y74_K1.3971.00
22_G33_A1.3821.00
19_E36_K1.3741.00
31_E47_N1.3711.00
22_G35_F1.3551.00
42_I95_T1.3231.00
35_F45_I1.2781.00
14_I97_I1.2691.00
81_I89_C1.2411.00
12_G17_L1.2251.00
47_N55_V1.1661.00
65_Y83_Q1.1631.00
36_K40_G1.1541.00
82_V89_C1.1401.00
42_I97_I1.1301.00
48_R53_G1.1231.00
15_E100_E1.1101.00
16_E23_K1.1091.00
73_W82_V1.0961.00
13_K100_E1.0841.00
54_G70_M1.0821.00
37_L64_Q1.0621.00
14_I100_E1.0301.00
97_I102_V1.0231.00
22_G61_V1.0151.00
36_K42_I1.0141.00
49_C71_H1.0081.00
35_F66_V1.0051.00
24_T47_N1.0021.00
37_L43_R1.0011.00
18_P21_L0.9991.00
18_P36_K0.9961.00
49_C68_C0.9641.00
37_L41_S0.9480.99
82_V85_P0.9450.99
50_P75_I0.9430.99
50_P90_V0.9280.99
43_R92_T0.9240.99
52_K70_M0.9210.99
12_G34_V0.9100.99
22_G66_V0.9070.99
68_C71_H0.9050.99
17_L42_I0.9010.99
8_K103_Y0.8750.99
24_T57_A0.8720.99
42_I102_V0.8500.99
43_R78_E0.8410.99
50_P73_W0.8300.99
24_T31_E0.8290.99
9_V27_I0.8240.99
24_T55_V0.8220.98
34_V42_I0.8220.98
82_V86_D0.8190.98
76_S83_Q0.8170.98
19_E40_G0.8160.98
73_W89_C0.8140.98
60_I67_F0.8010.98
52_K73_W0.7890.98
20_Q36_K0.7880.98
30_K93_Y0.7880.98
33_A57_A0.7780.98
12_G102_V0.7690.98
60_I72_D0.7610.98
11_I104_L0.7590.97
27_I30_K0.7570.97
26_Y31_E0.7560.97
19_E39_D0.7550.97
17_L34_V0.7480.97
35_F77_L0.7450.97
51_H75_I0.7430.97
74_K84_E0.7410.97
50_P89_C0.7410.97
97_I100_E0.7400.97
47_N90_V0.7350.97
51_H68_C0.7200.97
33_A45_I0.7050.96
17_L21_L0.6910.96
55_V70_M0.6890.96
32_L104_L0.6830.95
73_W85_P0.6800.95
45_I92_T0.6800.95
67_F74_K0.6770.95
67_F72_D0.6760.95
48_R55_V0.6740.95
37_L77_L0.6700.95
53_G70_M0.6520.94
30_K91_K0.6500.94
26_Y29_D0.6470.94
39_D64_Q0.6430.94
11_I44_A0.6430.94
50_P86_D0.6430.94
85_P88_G0.6420.94
11_I25_V0.6410.93
41_S64_Q0.6320.93
51_H71_H0.6270.93
27_I104_L0.6200.92
18_P22_G0.6180.92
45_I77_L0.6030.91
76_S81_I0.5990.91
8_K98_E0.5950.91
17_L23_K0.5770.89
33_A90_V0.5680.89
17_L36_K0.5660.88
79_D92_T0.5650.88
46_E90_V0.5570.88
62_S67_F0.5540.87
72_D84_E0.5500.87
69_P72_D0.5490.87
17_L102_V0.5490.87
31_E46_E0.5460.87
37_L63_G0.5440.86
12_G23_K0.5300.85
25_V34_V0.5260.85
50_P84_E0.5210.84
53_G72_D0.5170.84
61_V67_F0.5120.83
12_G16_E0.5110.83
51_H85_P0.5040.82
86_D89_C0.5020.82
74_K83_Q0.5010.82
84_E87_H0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gceA 1 0.9434 100 0.267 Contact Map
1vm9A 1 0.9434 100 0.269 Contact Map
4aivA 1 0.9717 100 0.271 Contact Map
3c0dA 1 0.9528 100 0.271 Contact Map
2jzaA 1 0.9623 100 0.272 Contact Map
3dqyA 1 0.934 100 0.273 Contact Map
1fqtA 2 0.9434 100 0.273 Contact Map
2de6D 1 0.934 100 0.274 Contact Map
2i7fA 1 0.934 100 0.275 Contact Map
2qpzA 1 0.9528 100 0.276 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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