GREMLIN Database
LON2 - Lon protease 2
UniProt: P42425 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 552 (480)
Sequences: 3926 (2047)
Seq/√Len: 93.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
504_Y523_K5.5491.00
482_I485_V5.5351.00
504_Y507_Q4.5081.00
56_S60_S3.9981.00
61_E112_E3.7991.00
46_Q167_I3.6431.00
277_K289_E3.6191.00
499_K520_I3.5881.00
158_G183_L3.2271.00
373_V453_G3.2121.00
274_T278_T3.1691.00
522_V527_E3.0371.00
499_K518_E3.0271.00
520_I531_E2.9111.00
489_I519_I2.8191.00
448_I528_V2.7251.00
375_V457_A2.6801.00
81_L313_A2.6651.00
325_T328_D2.6651.00
288_S291_G2.6641.00
502_I521_A2.6611.00
45_E168_P2.6601.00
493_K516_G2.6491.00
156_Y234_L2.6001.00
468_A497_A2.5951.00
10_I37_D2.5901.00
466_T498_K2.5101.00
45_E238_F2.5071.00
281_D287_I2.4951.00
397_S400_K2.4201.00
7_A11_Q2.3771.00
168_P234_L2.3711.00
499_K531_E2.3541.00
522_V528_V2.3391.00
501_I531_E2.2861.00
452_A528_V2.2721.00
191_L199_M2.2661.00
507_Q521_A2.1851.00
527_E530_D2.1771.00
386_I403_R2.1681.00
510_I521_A2.1461.00
293_D297_S2.0961.00
501_I522_V2.0711.00
485_V502_I2.0681.00
315_M331_W2.0411.00
424_M428_D2.0241.00
523_K527_E2.0191.00
256_R261_E1.9961.00
56_S318_T1.9921.00
37_D222_I1.9831.00
451_A525_F1.9731.00
40_S234_L1.9691.00
451_A473_I1.9371.00
452_A532_I1.8891.00
448_I479_V1.8851.00
415_V418_V1.8791.00
54_S57_E1.8661.00
352_V460_K1.8601.00
49_K54_S1.8581.00
269_K296_T1.8541.00
46_Q125_Q1.8461.00
415_V526_Q1.8181.00
382_G430_D1.7801.00
461_I533_L1.7731.00
140_E202_V1.7701.00
162_M234_L1.7561.00
455_F529_L1.7561.00
489_I500_V1.7551.00
467_V499_K1.7431.00
274_T277_K1.6921.00
371_I449_A1.6921.00
502_I510_I1.6831.00
482_I502_I1.6791.00
297_S336_S1.6721.00
54_S58_P1.6671.00
308_M324_I1.6651.00
464_D499_K1.6621.00
312_A316_A1.6621.00
400_K406_S1.6611.00
314_G318_T1.6521.00
501_I528_V1.6521.00
253_P256_R1.6501.00
290_E326_I1.6411.00
127_V183_L1.6221.00
281_D305_A1.6171.00
350_P534_V1.6091.00
288_S325_T1.6051.00
489_I502_I1.6031.00
306_V310_Q1.5961.00
452_A463_I1.5941.00
20_L28_N1.5881.00
168_P238_F1.5751.00
293_D326_I1.5751.00
368_L495_S1.5711.00
126_A130_E1.5611.00
381_K427_S1.5611.00
359_A369_L1.5591.00
328_D332_V1.5531.00
107_A184_F1.5501.00
53_I318_T1.5301.00
284_E306_V1.5281.00
126_A132_D1.5261.00
350_P465_N1.5251.00
10_I14_F1.5191.00
127_V165_A1.5161.00
57_E61_E1.5141.00
16_I32_Q1.5061.00
248_P261_E1.4971.00
125_Q167_I1.4921.00
373_V457_A1.4831.00
8_L166_G1.4751.00
448_I522_V1.4741.00
85_L88_P1.4621.00
339_T505_E1.4481.00
385_N406_S1.4411.00
128_F131_L1.4360.99
435_F450_M1.4320.99
131_L185_I1.4290.99
310_Q314_G1.4260.99
291_G329_I1.4250.99
355_V463_I1.4230.99
482_I489_I1.4210.99
248_P256_R1.4200.99
44_M47_L1.4200.99
95_V110_V1.4130.99
10_I34_V1.4050.99
529_L533_L1.4030.99
489_I517_I1.4020.99
411_S525_F1.3850.99
43_E168_P1.3770.99
130_E133_A1.3710.99
11_Q14_F1.3620.99
187_E190_E1.3610.99
73_G314_G1.3600.99
376_T410_G1.3440.99
287_I329_I1.3400.99
461_I535_N1.3380.99
431_I458_I1.3370.99
287_I308_M1.3270.99
294_L308_M1.3100.99
485_V489_I1.3070.99
358_L500_V1.2970.99
355_V449_A1.2940.99
389_I397_S1.2940.99
247_M250_E1.2920.99
281_D292_L1.2760.99
449_A528_V1.2670.99
315_M332_V1.2590.99
128_F132_D1.2550.99
362_G365_S1.2550.99
452_A469_M1.2540.99
20_L30_R1.2520.99
212_S233_G1.2460.99
135_T218_E1.2400.99
485_V521_A1.2380.98
125_Q131_L1.2380.98
361_Y364_N1.2380.98
127_V131_L1.2350.98
127_V130_E1.2330.98
304_E307_N1.2270.98
126_A184_F1.2230.98
145_D221_Q1.2170.98
426_P458_I1.2070.98
128_F133_A1.2030.98
125_Q130_E1.2020.98
361_Y365_S1.1980.98
293_D336_S1.1950.98
343_E367_S1.1880.98
375_V429_Y1.1830.98
14_F38_K1.1760.98
55_L58_P1.1750.98
416_L421_T1.1720.98
162_M168_P1.1690.98
36_I157_Q1.1670.98
20_L27_K1.1670.98
315_M320_N1.1600.98
467_V531_E1.1600.98
56_S314_G1.1570.98
528_V532_I1.1550.98
502_I519_I1.1500.98
125_Q166_G1.1460.97
411_S415_V1.1440.97
126_A131_L1.1440.97
135_T138_F1.1380.97
273_K289_E1.1360.97
431_I454_I1.1350.97
386_I400_K1.1310.97
13_F23_W1.1310.97
409_K431_I1.1290.97
124_E131_L1.1250.97
321_R328_D1.1210.97
467_V520_I1.1110.97
356_N368_L1.1110.97
294_L333_I1.1070.97
355_V453_G1.0970.97
275_V280_A1.0970.97
124_E130_E1.0960.97
412_V455_F1.0910.97
351_Q478_L1.0870.97
106_A264_F1.0860.97
293_D329_I1.0850.97
291_G326_I1.0740.96
258_R262_V1.0650.96
58_P112_E1.0620.96
35_T39_E1.0600.96
67_S307_N1.0580.96
108_R112_E1.0570.96
68_F95_V1.0570.96
467_V532_I1.0520.96
390_A435_F1.0520.96
9_F13_F1.0500.96
127_V133_A1.0480.96
70_D311_I1.0460.96
277_K292_L1.0430.96
9_F23_W1.0390.96
127_V158_G1.0390.96
124_E133_A1.0370.95
126_A133_A1.0350.95
129_V158_G1.0350.95
56_S73_G1.0340.95
110_V242_G1.0330.95
188_I199_M1.0280.95
448_I469_M1.0260.95
129_V132_D1.0180.95
376_T413_E1.0090.95
12_L39_E1.0080.95
305_A310_Q1.0050.95
252_P262_V1.0040.95
481_P505_E1.0020.95
212_S221_Q1.0020.95
51_R54_S0.9970.94
330_E511_L0.9920.94
448_I452_A0.9900.94
522_V531_E0.9900.94
27_K30_R0.9880.94
415_V419_L0.9830.94
358_L468_A0.9810.94
296_T344_Q0.9780.94
258_R264_F0.9710.94
125_Q128_F0.9710.94
349_E352_V0.9660.93
416_L420_R0.9660.93
255_I258_R0.9660.93
81_L316_A0.9620.93
9_F12_L0.9620.93
125_Q133_A0.9600.93
70_D314_G0.9580.93
34_V38_K0.9570.93
375_V458_I0.9560.93
500_V517_I0.9550.93
46_Q50_M0.9530.93
425_K458_I0.9520.93
354_I370_E0.9510.93
380_D430_D0.9510.93
36_I163_G0.9500.93
23_W27_K0.9500.93
276_A280_A0.9480.93
127_V132_D0.9470.93
418_V526_Q0.9470.93
479_V528_V0.9430.93
125_Q132_D0.9420.93
498_K516_G0.9420.93
55_L76_D0.9410.92
149_G158_G0.9350.92
313_A317_V0.9350.92
335_S511_L0.9330.92
474_S478_L0.9330.92
21_Y27_K0.9320.92
275_V284_E0.9310.92
510_I513_Q0.9300.92
68_F264_F0.9290.92
124_E128_F0.9290.92
356_N370_E0.9270.92
25_L148_I0.9260.92
268_E486_I0.9250.92
525_F529_L0.9230.92
256_R263_F0.9230.92
124_E127_V0.9200.92
311_I332_V0.9190.92
20_L25_L0.9150.91
507_Q511_L0.9120.91
6_I10_I0.9060.91
352_V462_P0.9060.91
324_I329_I0.9030.91
124_E132_D0.9020.91
524_T527_E0.9020.91
50_M80_A0.8970.91
273_K276_A0.8970.91
40_S156_Y0.8960.91
147_L151_V0.8950.90
252_P255_I0.8940.90
309_I313_A0.8920.90
52_A77_G0.8900.90
473_I525_F0.8900.90
304_E337_Q0.8890.90
474_S480_K0.8860.90
419_L455_F0.8860.90
461_I534_V0.8840.90
303_R310_Q0.8830.90
464_D532_I0.8820.90
146_P149_G0.8810.90
13_F21_Y0.8810.90
510_I519_I0.8800.90
312_A332_V0.8790.90
449_A491_A0.8760.90
276_A284_E0.8720.89
316_A319_E0.8720.89
252_P258_R0.8700.89
383_S430_D0.8670.89
489_I493_K0.8660.89
284_E305_A0.8650.89
328_D331_W0.8640.89
150_S153_D0.8640.89
389_I396_G0.8640.89
282_K286_N0.8610.89
261_E264_F0.8600.89
280_A284_E0.8580.89
448_I525_F0.8560.88
359_A362_G0.8550.88
478_L523_K0.8530.88
448_I451_A0.8510.88
31_T35_T0.8500.88
346_I495_S0.8500.88
260_L264_F0.8490.88
9_F221_Q0.8490.88
55_L73_G0.8450.88
469_M528_V0.8430.88
306_V309_I0.8300.87
98_P103_K0.8290.87
58_P61_E0.8260.87
407_M442_D0.8260.87
258_R267_L0.8220.86
162_M239_R0.8210.86
202_V236_A0.8190.86
96_Y256_R0.8170.86
158_G164_Q0.8140.86
506_N509_A0.8140.86
403_R433_I0.8130.86
288_S327_E0.8110.86
53_I57_E0.8080.85
250_E256_R0.8050.85
10_I38_K0.8040.85
287_I312_A0.8020.85
274_T286_N0.8020.85
352_V459_H0.7970.85
196_M252_P0.7960.85
162_M165_A0.7960.85
263_F266_E0.7950.84
15_G18_I0.7950.84
489_I521_A0.7950.84
525_F528_V0.7940.84
35_T38_K0.7910.84
128_F259_C0.7910.84
312_A317_V0.7890.84
126_A182_V0.7890.84
188_I191_L0.7870.84
252_P260_L0.7860.84
167_I170_P0.7850.84
290_E515_D0.7840.84
9_F21_Y0.7820.83
50_M54_S0.7810.83
275_V283_I0.7810.83
43_E234_L0.7800.83
307_N310_Q0.7780.83
17_I27_K0.7780.83
293_D330_E0.7710.83
129_V133_A0.7710.83
25_L29_Q0.7700.83
374_S410_G0.7690.82
449_A452_A0.7690.82
251_I255_I0.7680.82
103_K243_A0.7670.82
383_S406_S0.7670.82
96_Y247_M0.7660.82
433_I450_M0.7640.82
273_K277_K0.7620.82
252_P256_R0.7620.82
143_I146_P0.7610.82
96_Y250_E0.7600.82
504_Y527_E0.7570.81
16_I36_I0.7560.81
48_R114_A0.7540.81
12_L163_G0.7540.81
186_D189_G0.7520.81
40_S220_T0.7520.81
63_V274_T0.7520.81
359_A491_A0.7490.81
464_D534_V0.7470.81
156_Y162_M0.7450.80
206_R237_D0.7450.80
284_E309_I0.7420.80
367_S371_I0.7410.80
256_R262_V0.7400.80
146_P152_H0.7390.80
147_L153_D0.7390.80
455_F533_L0.7390.80
258_R268_E0.7350.80
279_A284_E0.7330.79
114_A240_L0.7330.79
75_E79_K0.7310.79
6_I14_F0.7310.79
95_V107_A0.7300.79
147_L158_G0.7240.78
262_V266_E0.7230.78
158_G165_A0.7220.78
384_I403_R0.7220.78
36_I220_T0.7210.78
347_G476_N0.7200.78
149_G165_A0.7190.78
433_I454_I0.7180.78
37_D40_S0.7170.78
11_Q15_G0.7160.78
127_V134_T0.7140.78
7_A38_K0.7130.77
521_A527_E0.7120.77
74_Q314_G0.7120.77
38_K222_I0.7120.77
426_P429_Y0.7110.77
27_K31_T0.7110.77
131_L141_R0.7110.77
449_A469_M0.7110.77
25_L28_N0.7100.77
279_A283_I0.7090.77
6_I37_D0.7070.77
260_L267_L0.7070.77
20_L24_N0.7060.77
354_I478_L0.7010.76
53_I56_S0.6990.76
413_E426_P0.6960.76
149_G153_D0.6960.76
247_M256_R0.6930.75
146_P170_P0.6920.75
252_P266_E0.6920.75
258_R266_E0.6910.75
452_A533_L0.6910.75
452_A529_L0.6910.75
357_G371_I0.6900.75
24_N36_I0.6900.75
262_V268_E0.6880.75
104_T111_L0.6880.75
217_E220_T0.6870.75
313_A316_A0.6870.75
8_L18_I0.6850.75
153_D170_P0.6840.74
264_F267_L0.6820.74
507_Q510_I0.6810.74
510_I514_I0.6800.74
498_K518_E0.6800.74
256_R266_E0.6790.74
165_A170_P0.6780.74
502_I507_Q0.6760.74
191_L196_M0.6750.74
455_F525_F0.6740.73
258_R263_F0.6720.73
111_L114_A0.6700.73
48_R169_Q0.6700.73
489_I510_I0.6690.73
379_Q429_Y0.6690.73
9_F370_E0.6670.73
252_P264_F0.6650.72
129_V183_L0.6640.72
275_V286_N0.6630.72
361_Y491_A0.6600.72
6_I222_I0.6600.72
413_E425_K0.6600.72
348_V465_N0.6590.72
147_L152_H0.6590.72
21_Y25_L0.6580.72
351_Q476_N0.6580.72
358_L368_L0.6580.72
145_D153_D0.6570.71
66_K70_D0.6570.71
421_T459_H0.6550.71
48_R79_K0.6550.71
429_Y458_I0.6540.71
191_L252_P0.6540.71
500_V520_I0.6530.71
8_L11_Q0.6520.71
83_A87_G0.6520.71
303_R314_G0.6510.71
322_K327_E0.6490.71
273_K295_L0.6460.70
188_I243_A0.6450.70
47_L83_A0.6450.70
22_F25_L0.6450.70
33_K37_D0.6440.70
146_P150_S0.6440.70
384_I409_K0.6440.70
470_T483_G0.6430.70
296_T343_E0.6400.70
146_P158_G0.6400.70
371_I435_F0.6390.69
13_F33_K0.6380.69
248_P263_F0.6370.69
262_V265_R0.6370.69
84_A238_F0.6360.69
151_V170_P0.6360.69
26_L30_R0.6340.69
38_K43_E0.6330.69
386_I409_K0.6310.68
13_F32_Q0.6310.68
26_L35_T0.6310.68
36_I40_S0.6310.68
276_A292_L0.6300.68
294_L332_V0.6300.68
47_L51_R0.6290.68
252_P263_F0.6270.68
417_T422_M0.6270.68
21_Y39_E0.6260.68
73_G76_D0.6250.68
451_A455_F0.6250.68
107_A126_A0.6240.68
486_I490_K0.6240.68
403_R449_A0.6230.67
331_W515_D0.6230.67
255_I262_V0.6220.67
412_V454_I0.6220.67
108_R206_R0.6220.67
43_E47_L0.6210.67
466_T497_A0.6210.67
285_K309_I0.6210.67
28_N32_Q0.6190.67
258_R272_L0.6190.67
149_G170_P0.6180.67
134_T218_E0.6180.67
79_K85_L0.6170.67
482_I521_A0.6170.67
278_T282_K0.6170.67
291_G324_I0.6150.66
109_L112_E0.6150.66
30_R37_D0.6140.66
147_L170_P0.6140.66
463_I533_L0.6110.66
53_I320_N0.6110.66
147_L155_I0.6100.66
15_G22_F0.6090.66
362_G399_S0.6090.66
153_D163_G0.6090.66
56_S66_K0.6070.65
315_M321_R0.6070.65
36_I156_Y0.6060.65
478_L524_T0.6050.65
106_A157_Q0.6050.65
411_S414_N0.6040.65
280_A294_L0.6040.65
6_I12_L0.6030.65
482_I506_N0.6020.65
348_V462_P0.5990.64
146_P153_D0.5990.64
330_E334_H0.5990.64
274_T284_E0.5990.64
48_R125_Q0.5980.64
34_V79_K0.5980.64
147_L169_Q0.5980.64
24_N29_Q0.5970.64
32_Q36_I0.5970.64
11_Q18_I0.5970.64
276_A283_I0.5960.64
275_V279_A0.5950.64
267_L272_L0.5930.64
153_D169_Q0.5930.64
134_T140_E0.5920.64
352_V465_N0.5920.64
260_L263_F0.5910.63
15_G345_K0.5900.63
52_A60_S0.5900.63
416_L419_L0.5890.63
278_T286_N0.5890.63
12_L16_I0.5890.63
30_R35_T0.5870.63
275_V278_T0.5860.63
350_P466_T0.5860.63
294_L305_A0.5860.63
379_Q428_D0.5860.63
246_R434_N0.5850.63
316_A321_R0.5850.63
47_L50_M0.5840.62
10_I43_E0.5840.62
500_V519_I0.5830.62
463_I466_T0.5830.62
140_E198_K0.5820.62
134_T191_L0.5820.62
20_L23_W0.5820.62
150_S169_Q0.5810.62
287_I291_G0.5800.62
22_F30_R0.5800.62
134_T197_N0.5800.62
5_G18_I0.5790.62
354_I368_L0.5790.62
133_A136_A0.5790.62
157_Q164_Q0.5780.62
262_V272_L0.5770.62
495_S498_K0.5760.61
152_H165_A0.5750.61
457_A476_N0.5740.61
22_F27_K0.5740.61
18_I21_Y0.5730.61
262_V267_L0.5730.61
287_I324_I0.5720.61
25_L39_E0.5710.61
154_P212_S0.5710.61
95_V242_G0.5700.61
146_P165_A0.5680.60
165_A168_P0.5680.60
80_A317_V0.5680.60
288_S328_D0.5670.60
287_I305_A0.5660.60
21_Y24_N0.5660.60
8_L418_V0.5640.60
294_L335_S0.5640.60
330_E336_S0.5640.60
356_N465_N0.5630.60
112_E279_A0.5620.60
407_M410_G0.5610.59
293_D296_T0.5610.59
273_K292_L0.5600.59
145_D150_S0.5570.59
112_E115_K0.5570.59
152_H170_P0.5570.59
307_N314_G0.5570.59
366_G484_G0.5570.59
527_E531_E0.5570.59
37_D43_E0.5560.59
252_P257_S0.5550.59
276_A286_N0.5550.59
287_I292_L0.5540.58
442_D449_A0.5540.58
260_L272_L0.5540.58
114_A182_V0.5540.58
13_F221_Q0.5530.58
313_A324_I0.5530.58
15_G19_G0.5530.58
19_G23_W0.5520.58
464_D497_A0.5520.58
166_G170_P0.5510.58
147_L150_S0.5510.58
131_L134_T0.5500.58
15_G39_E0.5500.58
151_V167_I0.5490.58
463_I532_I0.5490.58
35_T40_S0.5470.58
493_K514_I0.5470.58
297_S343_E0.5460.57
81_L317_V0.5460.57
9_F30_R0.5460.57
363_P442_D0.5460.57
13_F184_F0.5430.57
182_V240_L0.5430.57
290_E331_W0.5420.57
9_F27_K0.5420.57
515_D518_E0.5410.57
72_V106_A0.5410.57
73_G345_K0.5410.57
27_K164_Q0.5400.57
249_N439_I0.5390.56
149_G166_G0.5370.56
417_T423_G0.5370.56
49_K115_K0.5360.56
63_V278_T0.5360.56
27_K184_F0.5340.56
254_A257_S0.5330.56
7_A61_E0.5320.55
131_L136_A0.5320.55
40_S168_P0.5320.55
146_P151_V0.5320.55
335_S508_Q0.5320.55
285_K316_A0.5310.55
251_I258_R0.5300.55
396_G403_R0.5290.55
149_G152_H0.5290.55
319_E328_D0.5280.55
145_D514_I0.5270.55
36_I39_E0.5260.55
132_D136_A0.5250.54
96_Y263_F0.5220.54
274_T279_A0.5220.54
288_S326_I0.5210.54
370_E457_A0.5200.54
35_T72_V0.5190.54
145_D151_V0.5190.54
7_A43_E0.5190.54
53_I515_D0.5190.54
10_I510_I0.5190.54
101_V105_A0.5180.53
54_S61_E0.5180.53
335_S512_K0.5170.53
42_K45_E0.5170.53
16_I35_T0.5170.53
416_L455_F0.5160.53
49_K53_I0.5160.53
280_A286_N0.5160.53
57_E60_S0.5150.53
530_D536_P0.5130.53
273_K278_T0.5130.53
255_I264_F0.5120.53
9_F222_I0.5110.53
47_L57_E0.5110.53
403_R435_F0.5100.52
155_I162_M0.5100.52
479_V522_V0.5100.52
281_D285_K0.5090.52
81_L233_G0.5090.52
202_V243_A0.5090.52
312_A329_I0.5080.52
345_K505_E0.5080.52
25_L192_H0.5070.52
359_A367_S0.5070.52
151_V158_G0.5070.52
137_R141_R0.5060.52
19_G50_M0.5060.52
448_I473_I0.5060.52
200_L258_R0.5050.52
346_I465_N0.5050.52
25_L30_R0.5040.52
10_I36_I0.5030.51
429_Y460_K0.5020.51
144_A147_L0.5020.51
47_L53_I0.5010.51
133_A146_P0.5010.51
345_K370_E0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m6aA 3 0.8279 100 0.506 Contact Map
3k1jA 4 0.8659 100 0.588 Contact Map
4fwgA 3 0.837 100 0.593 Contact Map
3wu4A 3 0.3424 100 0.78 Contact Map
2x36A 3 0.3388 100 0.782 Contact Map
1xhkA 2 0.3261 100 0.79 Contact Map
1z0wA 3 0.3533 100 0.798 Contact Map
1r6bX 1 0.5543 100 0.852 Contact Map
4ciuA 1 0.5272 100 0.854 Contact Map
1g41A 3 0.4348 99.9 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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