YXDK - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

YXDK - Sensor histidine kinase YxdK

UniProt:	P42422	Sequences: MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQLLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKLHETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLLYSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWLKFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYTGENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (282)
Sequences:	76607 (61433)
Seq/√Len:	3658.3

ECOLI - TORS BARA RCSD GLRK RCSC BAES PHOQ CUSS CPXA CREC QSEC YEDV RSTB BASS ENVZ ARCB EVGS ZRAS KDPD ATOS PHOR DCUS DPIB NARQ NARX UHPB YPDA NTRB
BACSU - YXDK YCLK YVRG BCES YVCQ KINB CSSS YKOH YCBM YYCG RESE PHOR KINE KINA GLNK KIND YRKQ YESM KINC DCTS CITS MALK YBDK LYTS NATK LIAS YWPD COMP YFIJ YDFH DEGS YXJM DESK YVFT YHCY
HALSA - Q9HQ15 Q9HQG5 Q9HQ16 Q9HQE9 Q9HR10 O51970 Q9HRE4 Q9HRG1 BAT Q9HNM2 Q9HNA6 Q9HQB9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_V	213_T	3.285	1.00
256_K	316_S	3.283	1.00
250_R	320_S	3.176	1.00
257_D	261_G	3.003	1.00
306_D	318_R	2.988	1.00
295_K	299_D	2.820	1.00
254_E	316_S	2.790	1.00
134_I	145_I	2.674	1.00
254_E	318_R	2.570	1.00
243_N	254_E	2.558	1.00
202_K	241_E	2.518	1.00
247_D	252_V	2.490	1.00
213_T	301_L	2.421	1.00
176_A	212_Y	2.408	1.00
252_V	318_R	2.388	1.00
267_I	309_S	2.378	1.00
245_F	252_V	2.343	1.00
252_V	320_S	2.336	1.00
263_P	266_D	2.231	1.00
131_N	150_R	2.225	1.00
307_I	317_V	2.213	1.00
204_N	243_N	2.200	1.00
202_K	239_R	2.183	1.00
239_R	258_Y	2.168	1.00
176_A	210_Q	2.160	1.00
241_E	256_K	2.143	1.00
131_N	149_V	2.108	1.00
233_S	258_Y	2.102	1.00
245_F	254_E	2.088	1.00
294_V	305_V	2.034	1.00
310_S	313_E	2.010	1.00
308_S	318_R	1.982	1.00
271_F	305_V	1.945	1.00
243_N	256_K	1.926	1.00
221_A	298_T	1.918	1.00
178_S	181_E	1.913	1.00
308_S	316_S	1.903	1.00
267_I	307_I	1.899	1.00
185_S	219_K	1.854	1.00
304_T	320_S	1.836	1.00
262_I	270_V	1.805	1.00
269_R	275_Y	1.802	1.00
175_E	215_A	1.780	1.00
266_D	269_R	1.779	1.00
190_Y	223_G	1.777	1.00
269_R	272_D	1.774	1.00
200_Y	239_R	1.767	1.00
298_T	303_H	1.763	1.00
131_N	153_E	1.749	1.00
204_N	241_E	1.744	1.00
153_E	157_E	1.737	1.00
174_I	212_Y	1.732	1.00
264_S	267_I	1.722	1.00
238_D	258_Y	1.720	1.00
227_T	231_K	1.681	1.00
306_D	320_S	1.633	1.00
298_T	319_F	1.628	1.00
130_I	149_V	1.581	1.00
266_D	275_Y	1.576	1.00
213_T	218_L	1.570	1.00
309_S	315_T	1.569	1.00
262_I	266_D	1.544	1.00
221_A	294_V	1.537	1.00
266_D	277_G	1.500	1.00
110_D	114_T	1.479	1.00
194_F	230_V	1.459	1.00
133_I	141_V	1.456	1.00
221_A	297_I	1.446	1.00
87_L	92_M	1.434	1.00
271_F	307_I	1.431	1.00
135_Q	146_K	1.416	1.00
233_S	238_D	1.415	1.00
102_L	105_T	1.404	1.00
146_K	150_R	1.387	1.00
297_I	301_L	1.379	1.00
262_I	315_T	1.376	1.00
299_D	304_T	1.363	1.00
134_I	146_K	1.347	1.00
101_K	105_T	1.345	1.00
247_D	320_S	1.343	1.00
91_Q	95_I	1.332	1.00
180_S	184_Q	1.313	1.00
214_D	217_W	1.306	1.00
222_I	253_L	1.293	1.00
191_K	195_I	1.293	1.00
88_Y	92_M	1.279	1.00
272_D	275_Y	1.278	1.00
189_S	219_K	1.267	1.00
131_N	146_K	1.255	1.00
114_T	118_Q	1.254	1.00
241_E	258_Y	1.251	1.00
178_S	210_Q	1.233	1.00
263_P	311_P	1.220	1.00
122_Q	220_F	1.216	1.00
77_Y	80_S	1.209	1.00
129_V	148_E	1.188	1.00
224_Q	294_V	1.179	1.00
133_I	144_Q	1.176	1.00
130_I	145_I	1.173	1.00
217_W	220_F	1.163	1.00
215_A	219_K	1.149	1.00
109_L	112_R	1.148	1.00
70_Q	74_D	1.146	1.00
95_I	99_H	1.143	1.00
89_E	92_M	1.143	1.00
87_L	91_Q	1.141	1.00
185_S	215_A	1.138	1.00
253_L	319_F	1.135	1.00
250_R	304_T	1.132	1.00
88_Y	91_Q	1.123	1.00
217_W	300_K	1.122	1.00
72_G	77_Y	1.118	1.00
187_I	203_M	1.114	1.00
92_M	95_I	1.111	1.00
112_R	116_M	1.111	1.00
102_L	106_E	1.109	1.00
218_L	301_L	1.105	1.00
184_Q	203_M	1.095	1.00
154_F	216_K	1.093	1.00
134_I	149_V	1.093	1.00
309_S	312_G	1.089	1.00
309_S	313_E	1.088	1.00
70_Q	73_T	1.083	1.00
114_T	273_P	1.082	1.00
180_S	244_V	1.081	1.00
205_V	244_V	1.079	1.00
178_S	208_D	1.063	1.00
270_V	307_I	1.060	1.00
59_D	62_V	1.059	1.00
233_S	240_L	1.057	1.00
94_L	98_Q	1.054	1.00
99_H	102_L	1.051	1.00
209_H	246_C	1.048	1.00
217_W	297_I	1.046	1.00
296_E	299_D	1.045	1.00
180_S	208_D	1.044	1.00
174_I	301_L	1.037	1.00
298_T	305_V	1.035	1.00
180_S	205_V	1.028	1.00
109_L	113_V	1.026	1.00
91_Q	94_L	1.024	1.00
221_A	319_F	1.022	1.00
193_F	196_Q	1.008	1.00
303_H	319_F	1.007	1.00
186_V	223_G	1.004	1.00
177_V	182_L	0.997	1.00
106_E	110_D	0.995	1.00
186_V	219_K	0.992	1.00
101_K	104_E	0.991	1.00
107_A	111_A	0.985	1.00
148_E	151_Q	0.982	1.00
129_V	133_I	0.982	1.00
172_F	214_D	0.980	1.00
77_Y	81_S	0.977	1.00
118_Q	273_P	0.973	1.00
189_S	223_G	0.970	1.00
138_D	141_V	0.964	1.00
95_I	98_Q	0.964	1.00
303_H	321_F	0.963	1.00
209_H	251_T	0.962	1.00
124_K	157_E	0.957	1.00
276_T	284_Q	0.950	1.00
182_L	213_T	0.950	1.00
52_L	56_W	0.945	1.00
257_D	314_G	0.945	1.00
144_Q	148_E	0.944	1.00
267_I	271_F	0.937	1.00
143_E	147_K	0.929	1.00
256_K	310_S	0.927	1.00
296_E	300_K	0.925	1.00
271_F	295_K	0.919	1.00
140_P	144_Q	0.919	1.00
187_I	191_K	0.918	1.00
134_I	142_F	0.916	1.00
247_D	250_R	0.911	1.00
182_L	186_V	0.910	1.00
183_L	244_V	0.900	1.00
190_Y	226_V	0.896	1.00
157_E	161_Y	0.889	1.00
186_V	190_Y	0.884	1.00
307_I	315_T	0.883	1.00
90_K	94_L	0.878	1.00
193_F	227_T	0.877	1.00
149_V	153_E	0.871	1.00
131_N	135_Q	0.871	1.00
257_D	315_T	0.866	1.00
178_S	209_H	0.864	1.00
108_K	112_R	0.859	1.00
219_K	223_G	0.855	1.00
150_R	153_E	0.846	1.00
261_G	315_T	0.844	1.00
158_T	217_W	0.843	1.00
224_Q	227_T	0.841	1.00
87_L	95_I	0.838	1.00
271_F	317_V	0.835	1.00
73_T	77_Y	0.835	1.00
177_V	215_A	0.834	1.00
104_E	107_A	0.833	1.00
92_M	96_R	0.833	1.00
173_K	214_D	0.831	1.00
62_V	66_L	0.826	1.00
262_I	268_K	0.825	1.00
162_S	292_H	0.822	1.00
222_I	226_V	0.819	1.00
98_Q	102_L	0.815	1.00
145_I	149_V	0.815	1.00
56_W	59_D	0.810	1.00
110_D	113_V	0.809	1.00
74_D	77_Y	0.807	1.00
136_E	139_E	0.806	1.00
94_L	97_L	0.806	1.00
174_I	302_N	0.805	1.00
276_T	286_S	0.803	1.00
129_V	132_L	0.802	1.00
151_Q	219_K	0.800	1.00
133_I	148_E	0.800	1.00
206_C	245_F	0.800	1.00
97_L	100_Q	0.800	1.00
229_A	240_L	0.799	1.00
232_Y	260_V	0.796	1.00
216_K	219_K	0.796	1.00
98_Q	101_K	0.795	1.00
232_Y	276_T	0.792	1.00
63_Y	66_L	0.790	1.00
124_K	153_E	0.785	1.00
144_Q	147_K	0.785	1.00
187_I	201_P	0.784	1.00
278_E	283_F	0.784	1.00
262_I	267_I	0.781	1.00
161_Y	220_F	0.779	1.00
223_G	227_T	0.775	1.00
67_S	71_E	0.766	1.00
49_A	53_A	0.765	1.00
181_E	185_S	0.764	1.00
264_S	309_S	0.764	1.00
174_I	213_T	0.758	1.00
123_V	152_I	0.756	1.00
222_I	255_V	0.754	1.00
179_L	253_L	0.754	1.00
262_I	307_I	0.747	1.00
195_I	198_R	0.745	1.00
225_V	317_V	0.742	1.00
139_E	143_E	0.742	1.00
158_T	220_F	0.742	1.00
147_K	185_S	0.735	1.00
53_A	57_Y	0.731	1.00
199_V	203_M	0.729	1.00
198_R	237_S	0.727	1.00
113_V	166_D	0.723	1.00
107_A	110_D	0.721	1.00
154_F	158_T	0.721	1.00
100_Q	104_E	0.718	1.00
72_G	76_P	0.718	1.00
111_A	114_T	0.718	1.00
56_W	60_R	0.718	1.00
172_F	217_W	0.717	1.00
190_Y	227_T	0.717	1.00
96_R	100_Q	0.717	1.00
64_H	67_S	0.713	1.00
254_E	308_S	0.712	1.00
88_Y	95_I	0.712	1.00
183_L	222_I	0.708	1.00
115_Y	119_W	0.708	1.00
80_S	84_C	0.707	1.00
140_P	143_E	0.707	1.00
172_F	300_K	0.707	1.00
226_V	242_L	0.703	1.00
295_K	304_T	0.699	1.00
199_V	233_S	0.693	1.00
192_R	195_I	0.692	1.00
141_V	144_Q	0.690	1.00
217_W	301_L	0.689	1.00
194_F	201_P	0.687	1.00
289_I	293_L	0.685	1.00
273_P	296_E	0.684	1.00
294_V	298_T	0.683	1.00
220_F	297_I	0.683	1.00
103_H	107_A	0.682	1.00
70_Q	76_P	0.675	1.00
199_V	230_V	0.675	1.00
266_D	279_N	0.673	1.00
298_T	321_F	0.671	1.00
188_Q	191_K	0.666	1.00
81_S	84_C	0.665	1.00
87_L	94_L	0.665	1.00
225_V	294_V	0.665	1.00
225_V	319_F	0.663	1.00
99_H	103_H	0.662	1.00
186_V	226_V	0.661	1.00
63_Y	67_S	0.660	1.00
54_Y	58_K	0.656	1.00
125_T	129_V	0.653	1.00
50_G	54_Y	0.652	1.00
270_V	317_V	0.652	1.00
180_S	209_H	0.652	1.00
84_C	87_L	0.649	1.00
143_E	146_K	0.648	1.00
252_V	306_D	0.647	1.00
67_S	70_Q	0.645	1.00
89_E	93_E	0.642	1.00
88_Y	94_L	0.641	1.00
225_V	305_V	0.640	1.00
150_R	154_F	0.640	1.00
184_Q	188_Q	0.639	1.00
192_R	196_Q	0.639	1.00
233_S	237_S	0.638	1.00
177_V	212_Y	0.636	1.00
83_F	86_E	0.635	1.00
137_E	141_V	0.634	1.00
229_A	255_V	0.630	1.00
96_R	99_H	0.630	1.00
242_L	255_V	0.628	1.00
106_E	109_L	0.627	1.00
122_Q	224_Q	0.624	1.00
190_Y	230_V	0.623	1.00
65_W	69_G	0.623	1.00
93_E	97_L	0.621	1.00
87_L	90_K	0.621	1.00
206_C	244_V	0.620	1.00
184_Q	205_V	0.616	1.00
267_I	308_S	0.616	1.00
231_K	286_S	0.613	1.00
66_L	70_Q	0.612	1.00
194_F	240_L	0.612	1.00
183_L	242_L	0.611	1.00
200_Y	203_M	0.609	1.00
267_I	317_V	0.608	1.00
80_S	83_F	0.605	1.00
231_K	278_E	0.604	1.00
246_C	251_T	0.604	1.00
161_Y	217_W	0.603	1.00
138_D	142_F	0.602	1.00
185_S	189_S	0.599	1.00
127_L	156_L	0.598	1.00
62_V	67_S	0.597	1.00
257_D	260_V	0.597	1.00
97_L	101_K	0.597	1.00
262_I	309_S	0.595	1.00
199_V	240_L	0.595	1.00
194_F	198_R	0.594	1.00
234_A	260_V	0.594	1.00
71_E	75_I	0.593	1.00
148_E	189_S	0.593	1.00
197_Y	230_V	0.592	1.00
133_I	145_I	0.590	1.00
74_D	78_L	0.590	1.00
184_Q	187_I	0.590	1.00
76_P	79_G	0.590	1.00
128_S	132_L	0.589	1.00
182_L	219_K	0.588	1.00
180_S	207_D	0.587	1.00
260_V	284_Q	0.585	1.00
94_L	99_H	0.582	1.00
84_C	88_Y	0.581	1.00
231_K	284_Q	0.578	1.00
57_Y	61_G	0.575	1.00
64_H	68_S	0.573	1.00
226_V	240_L	0.572	1.00
264_S	310_S	0.571	1.00
220_F	223_G	0.566	1.00
182_L	218_L	0.564	1.00
108_K	111_A	0.562	1.00
76_P	80_S	0.561	1.00
179_L	251_T	0.560	1.00
160_L	164_R	0.560	1.00
119_W	159_L	0.554	1.00
206_C	209_H	0.554	1.00
234_A	238_D	0.554	1.00
188_Q	192_R	0.553	1.00
73_T	76_P	0.553	1.00
181_E	215_A	0.548	1.00
166_D	296_E	0.548	1.00
225_V	298_T	0.548	1.00
58_K	61_G	0.547	1.00
263_P	277_G	0.547	1.00
183_L	186_V	0.546	1.00
179_L	211_I	0.546	1.00
194_F	197_Y	0.544	1.00
263_P	267_I	0.543	1.00
146_K	149_V	0.542	1.00
79_G	82_V	0.542	1.00
81_S	85_S	0.541	1.00
244_V	251_T	0.537	1.00
209_H	244_V	0.537	1.00
141_V	145_I	0.537	1.00
104_E	108_K	0.537	1.00
270_V	292_H	0.536	1.00
194_F	199_V	0.533	1.00
266_D	278_E	0.531	1.00
198_R	235_G	0.529	1.00
303_H	322_L	0.528	1.00
170_R	217_W	0.528	1.00
250_R	322_L	0.527	1.00
66_L	69_G	0.526	1.00
204_N	245_F	0.524	1.00
256_K	312_G	0.524	1.00
183_L	187_I	0.521	1.00
129_V	144_Q	0.520	1.00
186_V	189_S	0.519	1.00
62_V	70_Q	0.518	1.00
72_G	80_S	0.518	1.00
306_D	319_F	0.517	1.00
90_K	93_E	0.515	1.00
187_I	242_L	0.512	1.00
142_F	146_K	0.512	1.00
58_K	62_V	0.512	1.00
121_H	125_T	0.512	1.00
200_Y	237_S	0.512	1.00
158_T	216_K	0.510	1.00
60_R	64_H	0.510	1.00
305_V	317_V	0.510	1.00
128_S	131_N	0.509	1.00
65_W	68_S	0.507	1.00
50_G	53_A	0.506	1.00
292_H	296_E	0.505	1.00
276_T	285_E	0.505	1.00
181_E	184_Q	0.504	1.00
59_D	63_Y	0.504	1.00
209_H	212_Y	0.504	1.00
71_E	74_D	0.501	1.00
93_E	96_R	0.501	1.00
280_G	283_F	0.501	1.00
240_L	255_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.8123	100	0.302	Contact Map
4bixA	2	0.6831	100	0.33	Contact Map
4ctiA	2	0.6954	100	0.356	Contact Map
4q20A	2	0.6862	100	0.383	Contact Map
3jz3A	2	0.4677	100	0.4	Contact Map
4e01A	3	0.8646	100	0.409	Contact Map
4mpcA	2	0.8769	100	0.41	Contact Map
2c2aA	2	0.6892	100	0.41	Contact Map
4gczA	2	0.9446	100	0.411	Contact Map
3d36A	2	0.6523	100	0.422	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.