GREMLIN Database
YXDK - Sensor histidine kinase YxdK
UniProt: P42422 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (282)
Sequences: 76607 (61433)
Seq/√Len: 3658.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_V213_T3.2851.00
256_K316_S3.2831.00
250_R320_S3.1761.00
257_D261_G3.0031.00
306_D318_R2.9881.00
295_K299_D2.8201.00
254_E316_S2.7901.00
134_I145_I2.6741.00
254_E318_R2.5701.00
243_N254_E2.5581.00
202_K241_E2.5181.00
247_D252_V2.4901.00
213_T301_L2.4211.00
176_A212_Y2.4081.00
252_V318_R2.3881.00
267_I309_S2.3781.00
245_F252_V2.3431.00
252_V320_S2.3361.00
263_P266_D2.2311.00
131_N150_R2.2251.00
307_I317_V2.2131.00
204_N243_N2.2001.00
202_K239_R2.1831.00
239_R258_Y2.1681.00
176_A210_Q2.1601.00
241_E256_K2.1431.00
131_N149_V2.1081.00
233_S258_Y2.1021.00
245_F254_E2.0881.00
294_V305_V2.0341.00
310_S313_E2.0101.00
308_S318_R1.9821.00
271_F305_V1.9451.00
243_N256_K1.9261.00
221_A298_T1.9181.00
178_S181_E1.9131.00
308_S316_S1.9031.00
267_I307_I1.8991.00
185_S219_K1.8541.00
304_T320_S1.8361.00
262_I270_V1.8051.00
269_R275_Y1.8021.00
175_E215_A1.7801.00
266_D269_R1.7791.00
190_Y223_G1.7771.00
269_R272_D1.7741.00
200_Y239_R1.7671.00
298_T303_H1.7631.00
131_N153_E1.7491.00
204_N241_E1.7441.00
153_E157_E1.7371.00
174_I212_Y1.7321.00
264_S267_I1.7221.00
238_D258_Y1.7201.00
227_T231_K1.6811.00
306_D320_S1.6331.00
298_T319_F1.6281.00
130_I149_V1.5811.00
266_D275_Y1.5761.00
213_T218_L1.5701.00
309_S315_T1.5691.00
262_I266_D1.5441.00
221_A294_V1.5371.00
266_D277_G1.5001.00
110_D114_T1.4791.00
194_F230_V1.4591.00
133_I141_V1.4561.00
221_A297_I1.4461.00
87_L92_M1.4341.00
271_F307_I1.4311.00
135_Q146_K1.4161.00
233_S238_D1.4151.00
102_L105_T1.4041.00
146_K150_R1.3871.00
297_I301_L1.3791.00
262_I315_T1.3761.00
299_D304_T1.3631.00
134_I146_K1.3471.00
101_K105_T1.3451.00
247_D320_S1.3431.00
91_Q95_I1.3321.00
180_S184_Q1.3131.00
214_D217_W1.3061.00
222_I253_L1.2931.00
191_K195_I1.2931.00
88_Y92_M1.2791.00
272_D275_Y1.2781.00
189_S219_K1.2671.00
131_N146_K1.2551.00
114_T118_Q1.2541.00
241_E258_Y1.2511.00
178_S210_Q1.2331.00
263_P311_P1.2201.00
122_Q220_F1.2161.00
77_Y80_S1.2091.00
129_V148_E1.1881.00
224_Q294_V1.1791.00
133_I144_Q1.1761.00
130_I145_I1.1731.00
217_W220_F1.1631.00
215_A219_K1.1491.00
109_L112_R1.1481.00
70_Q74_D1.1461.00
95_I99_H1.1431.00
89_E92_M1.1431.00
87_L91_Q1.1411.00
185_S215_A1.1381.00
253_L319_F1.1351.00
250_R304_T1.1321.00
88_Y91_Q1.1231.00
217_W300_K1.1221.00
72_G77_Y1.1181.00
187_I203_M1.1141.00
92_M95_I1.1111.00
112_R116_M1.1111.00
102_L106_E1.1091.00
218_L301_L1.1051.00
184_Q203_M1.0951.00
154_F216_K1.0931.00
134_I149_V1.0931.00
309_S312_G1.0891.00
309_S313_E1.0881.00
70_Q73_T1.0831.00
114_T273_P1.0821.00
180_S244_V1.0811.00
205_V244_V1.0791.00
178_S208_D1.0631.00
270_V307_I1.0601.00
59_D62_V1.0591.00
233_S240_L1.0571.00
94_L98_Q1.0541.00
99_H102_L1.0511.00
209_H246_C1.0481.00
217_W297_I1.0461.00
296_E299_D1.0451.00
180_S208_D1.0441.00
174_I301_L1.0371.00
298_T305_V1.0351.00
180_S205_V1.0281.00
109_L113_V1.0261.00
91_Q94_L1.0241.00
221_A319_F1.0221.00
193_F196_Q1.0081.00
303_H319_F1.0071.00
186_V223_G1.0041.00
177_V182_L0.9971.00
106_E110_D0.9951.00
186_V219_K0.9921.00
101_K104_E0.9911.00
107_A111_A0.9851.00
148_E151_Q0.9821.00
129_V133_I0.9821.00
172_F214_D0.9801.00
77_Y81_S0.9771.00
118_Q273_P0.9731.00
189_S223_G0.9701.00
138_D141_V0.9641.00
95_I98_Q0.9641.00
303_H321_F0.9631.00
209_H251_T0.9621.00
124_K157_E0.9571.00
276_T284_Q0.9501.00
182_L213_T0.9501.00
52_L56_W0.9451.00
257_D314_G0.9451.00
144_Q148_E0.9441.00
267_I271_F0.9371.00
143_E147_K0.9291.00
256_K310_S0.9271.00
296_E300_K0.9251.00
271_F295_K0.9191.00
140_P144_Q0.9191.00
187_I191_K0.9181.00
134_I142_F0.9161.00
247_D250_R0.9111.00
182_L186_V0.9101.00
183_L244_V0.9001.00
190_Y226_V0.8961.00
157_E161_Y0.8891.00
186_V190_Y0.8841.00
307_I315_T0.8831.00
90_K94_L0.8781.00
193_F227_T0.8771.00
149_V153_E0.8711.00
131_N135_Q0.8711.00
257_D315_T0.8661.00
178_S209_H0.8641.00
108_K112_R0.8591.00
219_K223_G0.8551.00
150_R153_E0.8461.00
261_G315_T0.8441.00
158_T217_W0.8431.00
224_Q227_T0.8411.00
87_L95_I0.8381.00
271_F317_V0.8351.00
73_T77_Y0.8351.00
177_V215_A0.8341.00
104_E107_A0.8331.00
92_M96_R0.8331.00
173_K214_D0.8311.00
62_V66_L0.8261.00
262_I268_K0.8251.00
162_S292_H0.8221.00
222_I226_V0.8191.00
98_Q102_L0.8151.00
145_I149_V0.8151.00
56_W59_D0.8101.00
110_D113_V0.8091.00
74_D77_Y0.8071.00
136_E139_E0.8061.00
94_L97_L0.8061.00
174_I302_N0.8051.00
276_T286_S0.8031.00
129_V132_L0.8021.00
151_Q219_K0.8001.00
133_I148_E0.8001.00
206_C245_F0.8001.00
97_L100_Q0.8001.00
229_A240_L0.7991.00
232_Y260_V0.7961.00
216_K219_K0.7961.00
98_Q101_K0.7951.00
232_Y276_T0.7921.00
63_Y66_L0.7901.00
124_K153_E0.7851.00
144_Q147_K0.7851.00
187_I201_P0.7841.00
278_E283_F0.7841.00
262_I267_I0.7811.00
161_Y220_F0.7791.00
223_G227_T0.7751.00
67_S71_E0.7661.00
49_A53_A0.7651.00
181_E185_S0.7641.00
264_S309_S0.7641.00
174_I213_T0.7581.00
123_V152_I0.7561.00
222_I255_V0.7541.00
179_L253_L0.7541.00
262_I307_I0.7471.00
195_I198_R0.7451.00
225_V317_V0.7421.00
139_E143_E0.7421.00
158_T220_F0.7421.00
147_K185_S0.7351.00
53_A57_Y0.7311.00
199_V203_M0.7291.00
198_R237_S0.7271.00
113_V166_D0.7231.00
107_A110_D0.7211.00
154_F158_T0.7211.00
100_Q104_E0.7181.00
72_G76_P0.7181.00
111_A114_T0.7181.00
56_W60_R0.7181.00
172_F217_W0.7171.00
190_Y227_T0.7171.00
96_R100_Q0.7171.00
64_H67_S0.7131.00
254_E308_S0.7121.00
88_Y95_I0.7121.00
183_L222_I0.7081.00
115_Y119_W0.7081.00
80_S84_C0.7071.00
140_P143_E0.7071.00
172_F300_K0.7071.00
226_V242_L0.7031.00
295_K304_T0.6991.00
199_V233_S0.6931.00
192_R195_I0.6921.00
141_V144_Q0.6901.00
217_W301_L0.6891.00
194_F201_P0.6871.00
289_I293_L0.6851.00
273_P296_E0.6841.00
294_V298_T0.6831.00
220_F297_I0.6831.00
103_H107_A0.6821.00
70_Q76_P0.6751.00
199_V230_V0.6751.00
266_D279_N0.6731.00
298_T321_F0.6711.00
188_Q191_K0.6661.00
81_S84_C0.6651.00
87_L94_L0.6651.00
225_V294_V0.6651.00
225_V319_F0.6631.00
99_H103_H0.6621.00
186_V226_V0.6611.00
63_Y67_S0.6601.00
54_Y58_K0.6561.00
125_T129_V0.6531.00
50_G54_Y0.6521.00
270_V317_V0.6521.00
180_S209_H0.6521.00
84_C87_L0.6491.00
143_E146_K0.6481.00
252_V306_D0.6471.00
67_S70_Q0.6451.00
89_E93_E0.6421.00
88_Y94_L0.6411.00
225_V305_V0.6401.00
150_R154_F0.6401.00
184_Q188_Q0.6391.00
192_R196_Q0.6391.00
233_S237_S0.6381.00
177_V212_Y0.6361.00
83_F86_E0.6351.00
137_E141_V0.6341.00
229_A255_V0.6301.00
96_R99_H0.6301.00
242_L255_V0.6281.00
106_E109_L0.6271.00
122_Q224_Q0.6241.00
190_Y230_V0.6231.00
65_W69_G0.6231.00
93_E97_L0.6211.00
87_L90_K0.6211.00
206_C244_V0.6201.00
184_Q205_V0.6161.00
267_I308_S0.6161.00
231_K286_S0.6131.00
66_L70_Q0.6121.00
194_F240_L0.6121.00
183_L242_L0.6111.00
200_Y203_M0.6091.00
267_I317_V0.6081.00
80_S83_F0.6051.00
231_K278_E0.6041.00
246_C251_T0.6041.00
161_Y217_W0.6031.00
138_D142_F0.6021.00
185_S189_S0.5991.00
127_L156_L0.5981.00
62_V67_S0.5971.00
257_D260_V0.5971.00
97_L101_K0.5971.00
262_I309_S0.5951.00
199_V240_L0.5951.00
194_F198_R0.5941.00
234_A260_V0.5941.00
71_E75_I0.5931.00
148_E189_S0.5931.00
197_Y230_V0.5921.00
133_I145_I0.5901.00
74_D78_L0.5901.00
184_Q187_I0.5901.00
76_P79_G0.5901.00
128_S132_L0.5891.00
182_L219_K0.5881.00
180_S207_D0.5871.00
260_V284_Q0.5851.00
94_L99_H0.5821.00
84_C88_Y0.5811.00
231_K284_Q0.5781.00
57_Y61_G0.5751.00
64_H68_S0.5731.00
226_V240_L0.5721.00
264_S310_S0.5711.00
220_F223_G0.5661.00
182_L218_L0.5641.00
108_K111_A0.5621.00
76_P80_S0.5611.00
179_L251_T0.5601.00
160_L164_R0.5601.00
119_W159_L0.5541.00
206_C209_H0.5541.00
234_A238_D0.5541.00
188_Q192_R0.5531.00
73_T76_P0.5531.00
181_E215_A0.5481.00
166_D296_E0.5481.00
225_V298_T0.5481.00
58_K61_G0.5471.00
263_P277_G0.5471.00
183_L186_V0.5461.00
179_L211_I0.5461.00
194_F197_Y0.5441.00
263_P267_I0.5431.00
146_K149_V0.5421.00
79_G82_V0.5421.00
81_S85_S0.5411.00
244_V251_T0.5371.00
209_H244_V0.5371.00
141_V145_I0.5371.00
104_E108_K0.5371.00
270_V292_H0.5361.00
194_F199_V0.5331.00
266_D278_E0.5311.00
198_R235_G0.5291.00
303_H322_L0.5281.00
170_R217_W0.5281.00
250_R322_L0.5271.00
66_L69_G0.5261.00
204_N245_F0.5241.00
256_K312_G0.5241.00
183_L187_I0.5211.00
129_V144_Q0.5201.00
186_V189_S0.5191.00
62_V70_Q0.5181.00
72_G80_S0.5181.00
306_D319_F0.5171.00
90_K93_E0.5151.00
187_I242_L0.5121.00
142_F146_K0.5121.00
58_K62_V0.5121.00
121_H125_T0.5121.00
200_Y237_S0.5121.00
158_T216_K0.5101.00
60_R64_H0.5101.00
305_V317_V0.5101.00
128_S131_N0.5091.00
65_W68_S0.5071.00
50_G53_A0.5061.00
292_H296_E0.5051.00
276_T285_E0.5051.00
181_E184_Q0.5041.00
59_D63_Y0.5041.00
209_H212_Y0.5041.00
71_E74_D0.5011.00
93_E96_R0.5011.00
280_G283_F0.5011.00
240_L255_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.8123 100 0.302 Contact Map
4bixA 2 0.6831 100 0.33 Contact Map
4ctiA 2 0.6954 100 0.356 Contact Map
4q20A 2 0.6862 100 0.383 Contact Map
3jz3A 2 0.4677 100 0.4 Contact Map
4e01A 3 0.8646 100 0.409 Contact Map
4mpcA 2 0.8769 100 0.41 Contact Map
2c2aA 2 0.6892 100 0.41 Contact Map
4gczA 2 0.9446 100 0.411 Contact Map
3d36A 2 0.6523 100 0.422 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0107 seconds.