GREMLIN Database
IOLJ - 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase
UniProt: P42420 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (277)
Sequences: 3972 (2022)
Seq/√Len: 121.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_R166_E4.0041.00
40_K272_R3.3621.00
40_K268_E3.2161.00
12_D16_E3.0201.00
113_I162_R2.8291.00
41_E276_R2.5821.00
161_E165_K2.5731.00
113_I117_I2.5691.00
36_Q268_E2.4981.00
195_E199_R2.4761.00
43_S280_S2.4411.00
39_Q77_T2.4171.00
97_I132_V2.4141.00
94_R126_Y2.3631.00
245_R249_E2.3361.00
190_G193_E2.3001.00
122_E125_D2.2991.00
106_I119_M2.2891.00
34_I45_V2.2741.00
112_P115_E2.2651.00
49_A101_F2.2101.00
215_Q277_E2.1941.00
176_L194_M2.1891.00
41_E272_R2.1541.00
12_D18_Y2.1321.00
118_A122_E2.0961.00
6_M81_V2.0641.00
41_E281_A2.0151.00
128_A170_D2.0061.00
242_E266_A1.9821.00
9_L81_V1.9381.00
195_E224_L1.9351.00
265_E269_E1.9301.00
121_K125_D1.9001.00
191_F220_K1.8891.00
268_E272_R1.8801.00
214_P217_Q1.8521.00
161_E200_M1.8271.00
11_E15_R1.8241.00
220_K223_T1.8161.00
7_K11_E1.8101.00
98_D126_Y1.8051.00
14_K227_A1.7591.00
115_E118_A1.7331.00
276_R281_A1.7151.00
6_M171_A1.7021.00
35_L76_I1.6971.00
242_E245_R1.6801.00
94_R98_D1.6521.00
124_T134_V1.6081.00
22_Q48_A1.6081.00
195_E220_K1.5891.00
158_T200_M1.5821.00
108_G111_Q1.5651.00
275_M281_A1.5321.00
191_F224_L1.5271.00
98_D130_H1.5241.00
45_V80_V1.5231.00
83_H103_S1.5171.00
159_E162_R1.5171.00
25_I47_A1.5011.00
205_L226_H1.4681.00
32_K264_I1.4581.00
111_Q115_E1.4481.00
114_D166_E1.4451.00
246_M250_N1.4421.00
220_K224_L1.4421.00
31_T70_L1.4311.00
269_E272_R1.4261.00
35_L80_V1.4251.00
223_T279_G1.4101.00
68_G72_E1.4021.00
14_K198_S1.4001.00
39_Q76_I1.3951.00
156_D159_E1.3841.00
126_Y130_H1.3831.00
266_A269_E1.3831.00
241_D245_R1.3761.00
196_A199_R1.3631.00
21_G271_V1.3461.00
65_A69_A1.3271.00
31_T67_V1.3241.00
90_A94_R1.2921.00
90_A122_E1.2871.00
270_T273_S1.2771.00
215_Q273_S1.2771.00
113_I159_E1.2701.00
65_A68_G1.2701.00
178_S213_I1.2591.00
244_R247_F1.2560.99
62_T70_L1.2470.99
143_G146_D1.2210.99
37_A271_V1.2150.99
37_A41_E1.2140.99
25_I31_T1.2100.99
64_A82_L1.2100.99
61_K72_E1.1980.99
42_Q77_T1.1930.99
17_Q223_T1.1900.99
193_E196_A1.1880.99
25_I34_I1.1850.99
121_K166_E1.1840.99
36_Q264_I1.1830.99
111_Q119_M1.1720.99
125_D129_K1.1700.99
120_T136_A1.1690.99
193_E197_I1.1690.99
90_A126_Y1.1670.99
215_Q219_K1.1640.99
262_P265_E1.1570.99
196_A200_M1.1560.99
113_I166_E1.1500.99
243_T263_G1.1490.99
68_G82_L1.1320.99
114_D118_A1.1280.99
38_A45_V1.1220.99
164_V203_I1.1210.99
51_D92_R1.1210.99
5_S133_S1.1160.99
222_I278_F1.1070.99
123_V134_V1.0990.99
104_V134_V1.0980.99
37_A268_E1.0920.99
104_V123_V1.0900.99
104_V127_A1.0850.99
265_E268_E1.0820.98
117_I166_E1.0780.98
69_A72_E1.0730.98
119_M122_E1.0680.98
192_K196_A1.0660.98
61_K95_Q1.0650.98
232_N236_M1.0620.98
114_D162_R1.0590.98
269_E273_S1.0430.98
21_G275_M1.0410.98
190_G196_A1.0400.98
37_A272_R1.0280.98
198_S227_A1.0280.98
91_E95_Q1.0280.98
273_S277_E1.0250.98
12_D15_R1.0240.98
246_M253_L1.0200.98
97_I126_Y1.0140.98
16_E283_K1.0120.98
272_R276_R1.0120.98
97_I130_H1.0090.98
94_R130_H1.0060.98
192_K195_E1.0040.98
8_E12_D1.0030.98
33_A267_V0.9910.97
61_K73_D0.9900.97
157_I200_M0.9900.97
49_A63_I0.9840.97
144_M149_V0.9820.97
231_I278_F0.9790.97
108_G119_M0.9730.97
243_T259_Y0.9730.97
250_N253_L0.9670.97
238_A270_T0.9660.97
26_N53_L0.9640.97
219_K223_T0.9570.97
174_A197_I0.9550.97
38_A275_M0.9500.97
97_I127_A0.9410.96
21_G278_F0.9400.96
157_I196_A0.9380.96
229_I278_F0.9370.96
154_Y193_E0.9350.96
10_L171_A0.9330.96
191_F217_Q0.9320.96
31_T47_A0.9290.96
17_Q227_A0.9270.96
136_A169_I0.9240.96
26_N30_W0.9210.96
71_I76_I0.9190.96
143_G148_L0.9170.96
76_I80_V0.9030.95
88_S110_H0.8970.95
34_I271_V0.8960.95
136_A163_I0.8840.95
201_T205_L0.8810.95
102_S133_S0.8800.95
9_L20_I0.8790.95
115_E119_M0.8760.95
67_V82_L0.8740.95
253_L258_G0.8690.94
42_Q282_G0.8640.94
218_I229_I0.8630.94
51_D88_S0.8590.94
64_A68_G0.8550.94
23_F271_V0.8520.94
182_K237_V0.8510.94
43_S279_G0.8470.94
207_L221_A0.8450.93
62_T66_M0.8400.93
275_M280_S0.8360.93
262_P266_A0.8310.93
10_L20_I0.8290.93
271_V275_M0.8290.93
18_Y43_S0.8290.93
138_V164_V0.8270.93
218_I278_F0.8250.93
38_A78_V0.8240.93
140_T152_V0.8200.92
146_D150_G0.8190.92
160_C197_I0.8180.92
160_C201_T0.8170.92
235_C267_V0.8130.92
155_A160_C0.8130.92
50_S53_L0.8130.92
104_V132_V0.8060.92
176_L207_L0.8030.92
50_S232_N0.8000.91
57_L63_I0.7990.91
51_D89_S0.7990.91
39_Q78_V0.7920.91
127_A132_V0.7920.91
61_K65_A0.7890.91
5_S8_E0.7830.91
219_K279_G0.7800.90
126_Y129_K0.7800.90
218_I222_I0.7780.90
158_T161_E0.7770.90
37_A275_M0.7750.90
44_P79_P0.7740.90
162_R165_K0.7740.90
120_T124_T0.7710.90
128_A131_G0.7690.90
197_I201_T0.7660.90
244_R248_Q0.7650.90
183_Y187_P0.7630.89
140_T150_G0.7620.89
245_R248_Q0.7620.89
48_A83_H0.7610.89
48_A232_N0.7590.89
49_A54_V0.7570.89
96_A101_F0.7500.89
178_S189_L0.7490.89
219_K277_E0.7450.88
280_S283_K0.7420.88
123_V126_Y0.7400.88
242_E263_G0.7400.88
23_F34_I0.7400.88
106_I123_V0.7370.88
28_L66_M0.7350.88
27_G30_W0.7350.88
5_S131_G0.7340.88
89_S92_R0.7310.87
216_D219_K0.7230.87
8_E11_E0.7210.87
124_T128_A0.7210.87
23_F45_V0.7190.86
39_Q42_Q0.7180.86
144_M147_G0.7140.86
157_I193_E0.7130.86
275_M282_G0.7100.86
53_L232_N0.7090.86
89_S93_C0.7080.86
234_E274_K0.7050.85
151_G156_D0.7000.85
247_F259_Y0.6990.85
9_L12_D0.6980.85
52_R257_R0.6970.85
194_M226_H0.6960.85
24_N50_S0.6940.84
194_M224_L0.6940.84
239_W260_L0.6930.84
155_A197_I0.6880.84
112_P118_A0.6880.84
164_V201_T0.6880.84
155_A174_A0.6860.84
11_E14_K0.6850.84
267_V271_V0.6850.84
154_Y190_G0.6840.84
29_Q239_W0.6810.83
5_S102_S0.6780.83
246_M249_E0.6770.83
6_M133_S0.6710.82
239_W263_G0.6690.82
25_I63_I0.6690.82
214_P218_I0.6660.82
255_E258_G0.6660.82
97_I104_V0.6650.82
171_A206_V0.6630.82
6_M9_L0.6630.82
32_K36_Q0.6620.82
64_A101_F0.6590.81
242_E246_M0.6570.81
69_A73_D0.6570.81
138_V163_I0.6560.81
44_P283_K0.6550.81
113_I138_V0.6540.81
50_S257_R0.6510.81
63_I67_V0.6490.80
10_L133_S0.6490.80
90_A123_V0.6460.80
138_V160_C0.6450.80
81_V133_S0.6450.80
106_I111_Q0.6390.79
222_I225_G0.6390.79
23_F275_M0.6370.79
26_N232_N0.6360.79
43_S275_M0.6340.79
61_K69_A0.6320.79
216_D220_K0.6310.78
54_V92_R0.6310.78
35_L47_A0.6290.78
87_G93_C0.6260.78
26_N50_S0.6260.78
270_T274_K0.6250.78
174_A194_M0.6250.78
28_L62_T0.6220.77
237_V241_D0.6220.77
88_S92_R0.6170.77
6_M46_I0.6170.77
119_M123_V0.6130.76
46_I81_V0.6120.76
108_G136_A0.6100.76
68_G71_I0.6090.76
14_K202_D0.6080.76
143_G150_G0.6060.76
64_A99_A0.6030.75
226_H229_I0.6020.75
240_T247_F0.6010.75
183_Y225_G0.5990.75
6_M10_L0.5980.75
143_G147_G0.5960.74
249_E252_D0.5950.74
93_C123_V0.5940.74
261_T265_E0.5940.74
15_R196_A0.5930.74
71_I80_V0.5910.74
218_I277_E0.5890.74
13_A18_Y0.5880.73
142_G210_A0.5870.73
53_L255_E0.5840.73
136_A156_D0.5820.73
124_T168_N0.5800.72
81_V102_S0.5800.72
218_I231_I0.5790.72
64_A71_I0.5790.72
33_A264_I0.5760.72
117_I162_R0.5760.72
95_Q99_A0.5740.72
26_N256_P0.5720.71
35_L78_V0.5710.71
211_S234_E0.5710.71
242_E262_P0.5690.71
140_T193_E0.5670.71
121_K124_T0.5670.71
185_G233_T0.5660.71
197_I205_L0.5660.71
198_S202_D0.5640.70
45_V275_M0.5630.70
33_A37_A0.5630.70
176_L224_L0.5630.70
120_T167_T0.5610.70
82_L102_S0.5600.70
236_M255_E0.5590.70
90_A93_C0.5570.69
246_M262_P0.5560.69
265_E276_R0.5540.69
136_A167_T0.5530.69
258_G262_P0.5530.69
18_Y279_G0.5530.69
181_G187_P0.5520.69
66_M69_A0.5510.69
147_G150_G0.5500.68
12_D283_K0.5500.68
92_R95_Q0.5500.68
158_T162_R0.5490.68
176_L221_A0.5460.68
108_G120_T0.5440.68
116_N139_G0.5430.67
156_D196_A0.5410.67
156_D193_E0.5410.67
159_E166_E0.5400.67
15_R249_E0.5400.67
118_A166_E0.5400.67
114_D117_I0.5390.67
260_L263_G0.5370.67
210_A231_I0.5360.66
235_C271_V0.5340.66
179_V187_P0.5330.66
31_T66_M0.5300.66
28_L57_L0.5300.66
273_S276_R0.5300.66
231_I234_E0.5300.66
26_N49_A0.5290.65
169_I203_I0.5290.65
243_T260_L0.5290.65
231_I274_K0.5280.65
113_I172_L0.5280.65
133_S171_A0.5270.65
217_Q220_K0.5260.65
10_L14_K0.5260.65
256_P259_Y0.5240.65
65_A72_E0.5230.65
95_Q98_D0.5220.64
219_K222_I0.5190.64
138_V156_D0.5190.64
91_E94_R0.5190.64
43_S282_G0.5180.64
20_I133_S0.5170.64
30_W267_V0.5130.63
24_N56_Y0.5130.63
56_Y257_R0.5120.63
97_I128_A0.5120.63
158_T196_A0.5120.63
33_A268_E0.5110.63
135_E228_K0.5050.62
182_K234_E0.5020.61
175_A179_V0.5020.61
41_E275_M0.5000.61
144_M148_L0.5000.61
37_A45_V0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gvfA 3 0.9517 100 0.056 Contact Map
4to8A 2 0.9621 100 0.061 Contact Map
2iswA 2 0.9483 100 0.063 Contact Map
3n9rA 3 0.9448 100 0.068 Contact Map
1rvgA 3 0.9621 100 0.07 Contact Map
3elfA 4 0.9517 100 0.108 Contact Map
3pm6A 2 0.9517 100 0.121 Contact Map
1dosA 2 0.9207 100 0.126 Contact Map
3qm3A 4 0.9552 100 0.131 Contact Map
3txvA 2 0.8655 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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