IOLJ - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

IOLJ - 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase

UniProt:	P42420	Sequences: MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSPVIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFSSVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITECERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQIKKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMREFGSAGKAAKQQVG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	290 (277)
Sequences:	3972 (2022)
Seq/√Len:	121.5

ECOLI - GATY KBAY YDJI ALF
BACSU - IOLJ ALF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
162_R	166_E	4.004	1.00
40_K	272_R	3.362	1.00
40_K	268_E	3.216	1.00
12_D	16_E	3.020	1.00
113_I	162_R	2.829	1.00
41_E	276_R	2.582	1.00
161_E	165_K	2.573	1.00
113_I	117_I	2.569	1.00
36_Q	268_E	2.498	1.00
195_E	199_R	2.476	1.00
43_S	280_S	2.441	1.00
39_Q	77_T	2.417	1.00
97_I	132_V	2.414	1.00
94_R	126_Y	2.363	1.00
245_R	249_E	2.336	1.00
190_G	193_E	2.300	1.00
122_E	125_D	2.299	1.00
106_I	119_M	2.289	1.00
34_I	45_V	2.274	1.00
112_P	115_E	2.265	1.00
49_A	101_F	2.210	1.00
215_Q	277_E	2.194	1.00
176_L	194_M	2.189	1.00
41_E	272_R	2.154	1.00
12_D	18_Y	2.132	1.00
118_A	122_E	2.096	1.00
6_M	81_V	2.064	1.00
41_E	281_A	2.015	1.00
128_A	170_D	2.006	1.00
242_E	266_A	1.982	1.00
9_L	81_V	1.938	1.00
195_E	224_L	1.935	1.00
265_E	269_E	1.930	1.00
121_K	125_D	1.900	1.00
191_F	220_K	1.889	1.00
268_E	272_R	1.880	1.00
214_P	217_Q	1.852	1.00
161_E	200_M	1.827	1.00
11_E	15_R	1.824	1.00
220_K	223_T	1.816	1.00
7_K	11_E	1.810	1.00
98_D	126_Y	1.805	1.00
14_K	227_A	1.759	1.00
115_E	118_A	1.733	1.00
276_R	281_A	1.715	1.00
6_M	171_A	1.702	1.00
35_L	76_I	1.697	1.00
242_E	245_R	1.680	1.00
94_R	98_D	1.652	1.00
124_T	134_V	1.608	1.00
22_Q	48_A	1.608	1.00
195_E	220_K	1.589	1.00
158_T	200_M	1.582	1.00
108_G	111_Q	1.565	1.00
275_M	281_A	1.532	1.00
191_F	224_L	1.527	1.00
98_D	130_H	1.524	1.00
45_V	80_V	1.523	1.00
83_H	103_S	1.517	1.00
159_E	162_R	1.517	1.00
25_I	47_A	1.501	1.00
205_L	226_H	1.468	1.00
32_K	264_I	1.458	1.00
111_Q	115_E	1.448	1.00
114_D	166_E	1.445	1.00
246_M	250_N	1.442	1.00
220_K	224_L	1.442	1.00
31_T	70_L	1.431	1.00
269_E	272_R	1.426	1.00
35_L	80_V	1.425	1.00
223_T	279_G	1.410	1.00
68_G	72_E	1.402	1.00
14_K	198_S	1.400	1.00
39_Q	76_I	1.395	1.00
156_D	159_E	1.384	1.00
126_Y	130_H	1.383	1.00
266_A	269_E	1.383	1.00
241_D	245_R	1.376	1.00
196_A	199_R	1.363	1.00
21_G	271_V	1.346	1.00
65_A	69_A	1.327	1.00
31_T	67_V	1.324	1.00
90_A	94_R	1.292	1.00
90_A	122_E	1.287	1.00
270_T	273_S	1.277	1.00
215_Q	273_S	1.277	1.00
113_I	159_E	1.270	1.00
65_A	68_G	1.270	1.00
178_S	213_I	1.259	1.00
244_R	247_F	1.256	0.99
62_T	70_L	1.247	0.99
143_G	146_D	1.221	0.99
37_A	271_V	1.215	0.99
37_A	41_E	1.214	0.99
25_I	31_T	1.210	0.99
64_A	82_L	1.210	0.99
61_K	72_E	1.198	0.99
42_Q	77_T	1.193	0.99
17_Q	223_T	1.190	0.99
193_E	196_A	1.188	0.99
25_I	34_I	1.185	0.99
121_K	166_E	1.184	0.99
36_Q	264_I	1.183	0.99
111_Q	119_M	1.172	0.99
125_D	129_K	1.170	0.99
120_T	136_A	1.169	0.99
193_E	197_I	1.169	0.99
90_A	126_Y	1.167	0.99
215_Q	219_K	1.164	0.99
262_P	265_E	1.157	0.99
196_A	200_M	1.156	0.99
113_I	166_E	1.150	0.99
243_T	263_G	1.149	0.99
68_G	82_L	1.132	0.99
114_D	118_A	1.128	0.99
38_A	45_V	1.122	0.99
164_V	203_I	1.121	0.99
51_D	92_R	1.121	0.99
5_S	133_S	1.116	0.99
222_I	278_F	1.107	0.99
123_V	134_V	1.099	0.99
104_V	134_V	1.098	0.99
37_A	268_E	1.092	0.99
104_V	123_V	1.090	0.99
104_V	127_A	1.085	0.99
265_E	268_E	1.082	0.98
117_I	166_E	1.078	0.98
69_A	72_E	1.073	0.98
119_M	122_E	1.068	0.98
192_K	196_A	1.066	0.98
61_K	95_Q	1.065	0.98
232_N	236_M	1.062	0.98
114_D	162_R	1.059	0.98
269_E	273_S	1.043	0.98
21_G	275_M	1.041	0.98
190_G	196_A	1.040	0.98
37_A	272_R	1.028	0.98
198_S	227_A	1.028	0.98
91_E	95_Q	1.028	0.98
273_S	277_E	1.025	0.98
12_D	15_R	1.024	0.98
246_M	253_L	1.020	0.98
97_I	126_Y	1.014	0.98
16_E	283_K	1.012	0.98
272_R	276_R	1.012	0.98
97_I	130_H	1.009	0.98
94_R	130_H	1.006	0.98
192_K	195_E	1.004	0.98
8_E	12_D	1.003	0.98
33_A	267_V	0.991	0.97
61_K	73_D	0.990	0.97
157_I	200_M	0.990	0.97
49_A	63_I	0.984	0.97
144_M	149_V	0.982	0.97
231_I	278_F	0.979	0.97
108_G	119_M	0.973	0.97
243_T	259_Y	0.973	0.97
250_N	253_L	0.967	0.97
238_A	270_T	0.966	0.97
26_N	53_L	0.964	0.97
219_K	223_T	0.957	0.97
174_A	197_I	0.955	0.97
38_A	275_M	0.950	0.97
97_I	127_A	0.941	0.96
21_G	278_F	0.940	0.96
157_I	196_A	0.938	0.96
229_I	278_F	0.937	0.96
154_Y	193_E	0.935	0.96
10_L	171_A	0.933	0.96
191_F	217_Q	0.932	0.96
31_T	47_A	0.929	0.96
17_Q	227_A	0.927	0.96
136_A	169_I	0.924	0.96
26_N	30_W	0.921	0.96
71_I	76_I	0.919	0.96
143_G	148_L	0.917	0.96
76_I	80_V	0.903	0.95
88_S	110_H	0.897	0.95
34_I	271_V	0.896	0.95
136_A	163_I	0.884	0.95
201_T	205_L	0.881	0.95
102_S	133_S	0.880	0.95
9_L	20_I	0.879	0.95
115_E	119_M	0.876	0.95
67_V	82_L	0.874	0.95
253_L	258_G	0.869	0.94
42_Q	282_G	0.864	0.94
218_I	229_I	0.863	0.94
51_D	88_S	0.859	0.94
64_A	68_G	0.855	0.94
23_F	271_V	0.852	0.94
182_K	237_V	0.851	0.94
43_S	279_G	0.847	0.94
207_L	221_A	0.845	0.93
62_T	66_M	0.840	0.93
275_M	280_S	0.836	0.93
262_P	266_A	0.831	0.93
10_L	20_I	0.829	0.93
271_V	275_M	0.829	0.93
18_Y	43_S	0.829	0.93
138_V	164_V	0.827	0.93
218_I	278_F	0.825	0.93
38_A	78_V	0.824	0.93
140_T	152_V	0.820	0.92
146_D	150_G	0.819	0.92
160_C	197_I	0.818	0.92
160_C	201_T	0.817	0.92
235_C	267_V	0.813	0.92
155_A	160_C	0.813	0.92
50_S	53_L	0.813	0.92
104_V	132_V	0.806	0.92
176_L	207_L	0.803	0.92
50_S	232_N	0.800	0.91
57_L	63_I	0.799	0.91
51_D	89_S	0.799	0.91
39_Q	78_V	0.792	0.91
127_A	132_V	0.792	0.91
61_K	65_A	0.789	0.91
5_S	8_E	0.783	0.91
219_K	279_G	0.780	0.90
126_Y	129_K	0.780	0.90
218_I	222_I	0.778	0.90
158_T	161_E	0.777	0.90
37_A	275_M	0.775	0.90
44_P	79_P	0.774	0.90
162_R	165_K	0.774	0.90
120_T	124_T	0.771	0.90
128_A	131_G	0.769	0.90
197_I	201_T	0.766	0.90
244_R	248_Q	0.765	0.90
183_Y	187_P	0.763	0.89
140_T	150_G	0.762	0.89
245_R	248_Q	0.762	0.89
48_A	83_H	0.761	0.89
48_A	232_N	0.759	0.89
49_A	54_V	0.757	0.89
96_A	101_F	0.750	0.89
178_S	189_L	0.749	0.89
219_K	277_E	0.745	0.88
280_S	283_K	0.742	0.88
123_V	126_Y	0.740	0.88
242_E	263_G	0.740	0.88
23_F	34_I	0.740	0.88
106_I	123_V	0.737	0.88
28_L	66_M	0.735	0.88
27_G	30_W	0.735	0.88
5_S	131_G	0.734	0.88
89_S	92_R	0.731	0.87
216_D	219_K	0.723	0.87
8_E	11_E	0.721	0.87
124_T	128_A	0.721	0.87
23_F	45_V	0.719	0.86
39_Q	42_Q	0.718	0.86
144_M	147_G	0.714	0.86
157_I	193_E	0.713	0.86
275_M	282_G	0.710	0.86
53_L	232_N	0.709	0.86
89_S	93_C	0.708	0.86
234_E	274_K	0.705	0.85
151_G	156_D	0.700	0.85
247_F	259_Y	0.699	0.85
9_L	12_D	0.698	0.85
52_R	257_R	0.697	0.85
194_M	226_H	0.696	0.85
24_N	50_S	0.694	0.84
194_M	224_L	0.694	0.84
239_W	260_L	0.693	0.84
155_A	197_I	0.688	0.84
112_P	118_A	0.688	0.84
164_V	201_T	0.688	0.84
155_A	174_A	0.686	0.84
11_E	14_K	0.685	0.84
267_V	271_V	0.685	0.84
154_Y	190_G	0.684	0.84
29_Q	239_W	0.681	0.83
5_S	102_S	0.678	0.83
246_M	249_E	0.677	0.83
6_M	133_S	0.671	0.82
239_W	263_G	0.669	0.82
25_I	63_I	0.669	0.82
214_P	218_I	0.666	0.82
255_E	258_G	0.666	0.82
97_I	104_V	0.665	0.82
171_A	206_V	0.663	0.82
6_M	9_L	0.663	0.82
32_K	36_Q	0.662	0.82
64_A	101_F	0.659	0.81
242_E	246_M	0.657	0.81
69_A	73_D	0.657	0.81
138_V	163_I	0.656	0.81
44_P	283_K	0.655	0.81
113_I	138_V	0.654	0.81
50_S	257_R	0.651	0.81
63_I	67_V	0.649	0.80
10_L	133_S	0.649	0.80
90_A	123_V	0.646	0.80
138_V	160_C	0.645	0.80
81_V	133_S	0.645	0.80
106_I	111_Q	0.639	0.79
222_I	225_G	0.639	0.79
23_F	275_M	0.637	0.79
26_N	232_N	0.636	0.79
43_S	275_M	0.634	0.79
61_K	69_A	0.632	0.79
216_D	220_K	0.631	0.78
54_V	92_R	0.631	0.78
35_L	47_A	0.629	0.78
87_G	93_C	0.626	0.78
26_N	50_S	0.626	0.78
270_T	274_K	0.625	0.78
174_A	194_M	0.625	0.78
28_L	62_T	0.622	0.77
237_V	241_D	0.622	0.77
88_S	92_R	0.617	0.77
6_M	46_I	0.617	0.77
119_M	123_V	0.613	0.76
46_I	81_V	0.612	0.76
108_G	136_A	0.610	0.76
68_G	71_I	0.609	0.76
14_K	202_D	0.608	0.76
143_G	150_G	0.606	0.76
64_A	99_A	0.603	0.75
226_H	229_I	0.602	0.75
240_T	247_F	0.601	0.75
183_Y	225_G	0.599	0.75
6_M	10_L	0.598	0.75
143_G	147_G	0.596	0.74
249_E	252_D	0.595	0.74
93_C	123_V	0.594	0.74
261_T	265_E	0.594	0.74
15_R	196_A	0.593	0.74
71_I	80_V	0.591	0.74
218_I	277_E	0.589	0.74
13_A	18_Y	0.588	0.73
142_G	210_A	0.587	0.73
53_L	255_E	0.584	0.73
136_A	156_D	0.582	0.73
124_T	168_N	0.580	0.72
81_V	102_S	0.580	0.72
218_I	231_I	0.579	0.72
64_A	71_I	0.579	0.72
33_A	264_I	0.576	0.72
117_I	162_R	0.576	0.72
95_Q	99_A	0.574	0.72
26_N	256_P	0.572	0.71
35_L	78_V	0.571	0.71
211_S	234_E	0.571	0.71
242_E	262_P	0.569	0.71
140_T	193_E	0.567	0.71
121_K	124_T	0.567	0.71
185_G	233_T	0.566	0.71
197_I	205_L	0.566	0.71
198_S	202_D	0.564	0.70
45_V	275_M	0.563	0.70
33_A	37_A	0.563	0.70
176_L	224_L	0.563	0.70
120_T	167_T	0.561	0.70
82_L	102_S	0.560	0.70
236_M	255_E	0.559	0.70
90_A	93_C	0.557	0.69
246_M	262_P	0.556	0.69
265_E	276_R	0.554	0.69
136_A	167_T	0.553	0.69
258_G	262_P	0.553	0.69
18_Y	279_G	0.553	0.69
181_G	187_P	0.552	0.69
66_M	69_A	0.551	0.69
147_G	150_G	0.550	0.68
12_D	283_K	0.550	0.68
92_R	95_Q	0.550	0.68
158_T	162_R	0.549	0.68
176_L	221_A	0.546	0.68
108_G	120_T	0.544	0.68
116_N	139_G	0.543	0.67
156_D	196_A	0.541	0.67
156_D	193_E	0.541	0.67
159_E	166_E	0.540	0.67
15_R	249_E	0.540	0.67
118_A	166_E	0.540	0.67
114_D	117_I	0.539	0.67
260_L	263_G	0.537	0.67
210_A	231_I	0.536	0.66
235_C	271_V	0.534	0.66
179_V	187_P	0.533	0.66
31_T	66_M	0.530	0.66
28_L	57_L	0.530	0.66
273_S	276_R	0.530	0.66
231_I	234_E	0.530	0.66
26_N	49_A	0.529	0.65
169_I	203_I	0.529	0.65
243_T	260_L	0.529	0.65
231_I	274_K	0.528	0.65
113_I	172_L	0.528	0.65
133_S	171_A	0.527	0.65
217_Q	220_K	0.526	0.65
10_L	14_K	0.526	0.65
256_P	259_Y	0.524	0.65
65_A	72_E	0.523	0.65
95_Q	98_D	0.522	0.64
219_K	222_I	0.519	0.64
138_V	156_D	0.519	0.64
91_E	94_R	0.519	0.64
43_S	282_G	0.518	0.64
20_I	133_S	0.517	0.64
30_W	267_V	0.513	0.63
24_N	56_Y	0.513	0.63
56_Y	257_R	0.512	0.63
97_I	128_A	0.512	0.63
158_T	196_A	0.512	0.63
33_A	268_E	0.511	0.63
135_E	228_K	0.505	0.62
182_K	234_E	0.502	0.61
175_A	179_V	0.502	0.61
41_E	275_M	0.500	0.61
144_M	148_L	0.500	0.61
37_A	45_V	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1gvfA	3	0.9517	100	0.056	Contact Map
4to8A	2	0.9621	100	0.061	Contact Map
2iswA	2	0.9483	100	0.063	Contact Map
3n9rA	3	0.9448	100	0.068	Contact Map
1rvgA	3	0.9621	100	0.07	Contact Map
3elfA	4	0.9517	100	0.108	Contact Map
3pm6A	2	0.9517	100	0.121	Contact Map
1dosA	2	0.9207	100	0.126	Contact Map
3qm3A	4	0.9552	100	0.131	Contact Map
3txvA	2	0.8655	100	0.257	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.