IOLI - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

IOLI - Inosose isomerase

UniProt:	P42419	Sequences: MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLKDHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVVAVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEIVNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRVWPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYFSM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	278 (237)
Sequences:	16878 (11937)
Seq/√Len:	775.4

ECOLI - ULAE FRLC SGBU YCJR HYI YGBM YIHM
BACSU - IOLI IOLH YFIH IOLE END4
SULSO - Q97UI8 Q97UG9 Q97UI3 Q7LX49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
170_G	197_F	3.149	1.00
87_K	131_I	3.114	1.00
21_E	58_H	2.836	1.00
122_V	163_T	2.777	1.00
52_A	56_Q	2.774	1.00
226_D	229_A	2.746	1.00
203_D	221_G	2.458	1.00
91_E	135_Y	2.446	1.00
190_Q	233_A	2.429	1.00
30_Y	242_V	2.390	1.00
53_E	57_T	2.386	1.00
138_K	197_F	2.373	1.00
91_E	131_I	2.256	1.00
17_K	54_Y	2.172	1.00
15_N	18_L	2.147	1.00
94_K	135_Y	2.132	1.00
138_K	170_G	2.129	1.00
140_A	197_F	2.099	1.00
159_E	163_T	2.019	1.00
118_K	159_E	1.983	1.00
83_I	127_E	1.970	1.00
130_D	166_R	1.932	1.00
158_Y	191_A	1.889	1.00
100_Y	140_A	1.859	1.00
54_Y	58_H	1.810	1.00
80_N	84_T	1.771	1.00
158_Y	162_N	1.768	1.00
54_Y	57_T	1.748	1.00
233_A	236_E	1.714	1.00
21_E	25_K	1.712	1.00
47_S	50_D	1.690	1.00
90_M	135_Y	1.686	1.00
55_F	62_P	1.674	1.00
118_K	163_T	1.650	1.00
49_D	95_T	1.644	1.00
184_N	187_S	1.615	1.00
119_K	163_T	1.598	1.00
131_I	134_P	1.598	1.00
24_E	58_H	1.593	1.00
228_D	232_S	1.584	1.00
129_S	169_V	1.579	1.00
140_A	172_V	1.563	1.00
93_C	98_V	1.558	1.00
78_G	81_E	1.545	1.00
190_Q	236_E	1.543	1.00
113_V	116_E	1.532	1.00
116_E	119_K	1.525	1.00
122_V	126_T	1.522	1.00
79_H	124_V	1.506	1.00
199_Y	234_L	1.492	1.00
84_T	88_G	1.481	1.00
203_D	223_G	1.474	1.00
88_G	91_E	1.461	1.00
22_L	25_K	1.460	1.00
48_L	95_T	1.457	1.00
45_D	95_T	1.457	1.00
21_E	54_Y	1.455	1.00
187_S	191_A	1.445	1.00
131_I	135_Y	1.434	1.00
123_D	126_T	1.429	1.00
90_M	132_A	1.424	1.00
133_E	168_N	1.416	1.00
50_D	53_E	1.400	1.00
18_L	21_E	1.380	1.00
120_S	123_D	1.380	1.00
119_K	123_D	1.378	1.00
130_D	134_P	1.364	1.00
17_K	57_T	1.357	1.00
20_L	58_H	1.348	1.00
100_Y	138_K	1.346	1.00
170_G	195_K	1.344	1.00
232_S	236_E	1.335	1.00
87_K	127_E	1.318	1.00
175_S	230_H	1.314	1.00
233_A	237_I	1.313	1.00
193_G	237_I	1.311	1.00
186_E	229_A	1.309	1.00
153_T	156_Q	1.287	1.00
53_E	56_Q	1.263	1.00
84_T	87_K	1.255	1.00
152_N	156_Q	1.255	1.00
87_K	91_E	1.247	1.00
129_S	164_V	1.228	1.00
50_D	54_Y	1.220	1.00
49_D	53_E	1.219	1.00
90_M	137_V	1.215	1.00
90_M	131_I	1.215	1.00
205_E	218_V	1.214	1.00
126_T	165_N	1.212	1.00
143_F	178_F	1.208	1.00
157_A	171_L	1.205	1.00
136_G	168_N	1.195	1.00
17_K	50_D	1.191	1.00
133_E	166_R	1.185	1.00
83_I	87_K	1.179	1.00
155_E	191_A	1.172	1.00
80_N	127_E	1.167	1.00
159_E	162_N	1.163	1.00
52_A	95_T	1.157	1.00
127_E	130_D	1.135	1.00
162_N	195_K	1.130	1.00
22_L	26_H	1.129	1.00
173_L	178_F	1.128	1.00
118_K	122_V	1.116	1.00
158_Y	195_K	1.115	1.00
122_V	164_V	1.113	1.00
86_F	128_L	1.112	1.00
219_W	222_Q	1.110	1.00
20_L	54_Y	1.108	1.00
229_A	233_A	1.104	1.00
75_D	78_G	1.104	1.00
133_E	167_D	1.103	1.00
126_T	164_V	1.101	1.00
24_E	59_H	1.091	1.00
87_K	134_P	1.086	1.00
132_A	139_I	1.085	1.00
76_E	80_N	1.081	1.00
114_K	156_Q	1.076	1.00
91_E	95_T	1.069	1.00
30_Y	61_K	1.067	1.00
20_L	55_F	1.059	1.00
130_D	133_E	1.059	1.00
234_L	237_I	1.050	1.00
22_L	258_E	1.036	1.00
23_C	28_Y	1.036	1.00
17_K	21_E	1.032	1.00
258_E	262_Q	1.016	1.00
123_D	127_E	1.000	1.00
55_F	60_I	0.999	1.00
65_L	93_C	0.995	1.00
30_Y	63_L	0.993	1.00
28_Y	245_V	0.992	1.00
100_Y	197_F	0.985	1.00
25_K	258_E	0.980	1.00
48_L	92_T	0.973	1.00
259_E	262_Q	0.960	1.00
87_K	135_Y	0.959	1.00
190_Q	237_I	0.955	1.00
187_S	190_Q	0.953	1.00
257_A	260_A	0.952	1.00
32_E	64_A	0.951	1.00
99_K	138_K	0.950	1.00
33_I	62_P	0.949	1.00
24_E	29_D	0.949	1.00
126_T	166_R	0.946	1.00
126_T	130_D	0.942	1.00
48_L	52_A	0.942	1.00
115_E	159_E	0.941	1.00
174_D	246_E	0.941	1.00
129_S	166_R	0.939	1.00
161_V	195_K	0.939	1.00
129_S	168_N	0.935	1.00
91_E	94_K	0.935	1.00
55_F	58_H	0.934	1.00
46_H	50_D	0.932	1.00
79_H	123_D	0.926	1.00
217_R	220_P	0.925	1.00
171_L	192_D	0.924	1.00
125_L	169_V	0.921	1.00
142_E	246_E	0.921	1.00
81_E	84_T	0.920	1.00
115_E	119_K	0.917	1.00
186_E	190_Q	0.917	1.00
225_I	230_H	0.912	1.00
164_V	169_V	0.911	1.00
158_Y	192_D	0.907	1.00
32_E	198_I	0.897	1.00
186_E	233_A	0.889	1.00
102_V	172_V	0.889	1.00
14_S	22_L	0.886	1.00
218_V	222_Q	0.885	1.00
179_H	224_A	0.881	1.00
93_C	101_V	0.876	1.00
52_A	97_G	0.874	1.00
73_N	78_G	0.868	1.00
154_F	191_A	0.867	1.00
177_H	202_D	0.864	1.00
116_E	120_S	0.860	1.00
155_E	159_E	0.859	1.00
202_D	217_R	0.852	1.00
40_P	43_L	0.849	1.00
83_I	124_V	0.849	1.00
189_K	237_I	0.848	1.00
61_K	99_K	0.848	1.00
45_D	49_D	0.839	1.00
79_H	120_S	0.835	1.00
48_L	96_L	0.832	1.00
63_L	242_V	0.829	1.00
176_F	202_D	0.826	1.00
118_K	156_Q	0.826	1.00
201_I	227_L	0.824	1.00
231_L	235_K	0.820	1.00
71_F	124_V	0.812	1.00
138_K	168_N	0.811	1.00
44_K	47_S	0.809	1.00
94_K	137_V	0.807	1.00
94_K	136_G	0.807	1.00
23_C	31_I	0.803	1.00
49_D	52_A	0.798	1.00
154_F	183_S	0.796	1.00
205_E	224_A	0.794	1.00
92_T	96_L	0.788	1.00
114_K	117_I	0.784	1.00
62_P	98_V	0.782	1.00
205_E	216_D	0.778	1.00
229_A	232_S	0.772	1.00
206_D	224_A	0.751	1.00
199_Y	243_V	0.750	1.00
28_Y	261_I	0.748	1.00
8_A	11_L	0.746	1.00
21_E	57_T	0.745	1.00
238_G	241_D	0.745	1.00
175_S	227_L	0.744	1.00
189_K	233_A	0.743	1.00
176_F	204_T	0.743	1.00
202_D	248_F	0.739	1.00
124_V	127_E	0.738	1.00
161_V	171_L	0.737	1.00
198_I	244_S	0.733	1.00
142_E	200_H	0.730	1.00
126_T	163_T	0.729	1.00
151_V	157_A	0.727	1.00
88_G	92_T	0.725	1.00
120_S	124_V	0.724	1.00
61_K	242_V	0.724	1.00
66_N	69_V	0.722	1.00
85_E	88_G	0.719	1.00
128_L	139_I	0.716	1.00
70_F	73_N	0.709	1.00
172_V	198_I	0.709	1.00
189_K	193_G	0.706	1.00
20_L	24_E	0.701	1.00
201_I	243_V	0.701	1.00
156_Q	159_E	0.698	1.00
121_S	160_I	0.698	1.00
66_N	104_V	0.693	1.00
188_L	191_A	0.693	1.00
129_S	139_I	0.691	1.00
227_L	231_L	0.690	1.00
24_E	60_I	0.687	1.00
77_K	81_E	0.686	1.00
29_D	61_K	0.686	1.00
32_E	244_S	0.683	1.00
173_L	188_L	0.678	1.00
79_H	83_I	0.676	1.00
20_L	31_I	0.676	1.00
151_V	160_I	0.674	1.00
161_V	169_V	0.673	1.00
127_E	131_I	0.665	1.00
189_K	196_I	0.664	1.00
165_N	168_N	0.662	1.00
193_G	196_I	0.661	1.00
100_Y	198_I	0.659	1.00
89_M	101_V	0.658	1.00
77_K	80_N	0.656	1.00
154_F	158_Y	0.653	1.00
179_H	225_I	0.653	1.00
17_K	58_H	0.650	1.00
76_E	120_S	0.649	1.00
194_K	237_I	0.648	1.00
93_C	137_V	0.647	1.00
122_V	160_I	0.647	1.00
101_V	132_A	0.647	1.00
11_L	26_H	0.646	1.00
21_E	24_E	0.644	1.00
193_G	233_A	0.642	1.00
18_L	22_L	0.640	1.00
125_L	160_I	0.634	1.00
219_W	260_A	0.630	1.00
121_S	125_L	0.629	1.00
161_V	165_N	0.629	1.00
19_D	23_C	0.629	1.00
129_S	133_E	0.623	1.00
175_S	201_I	0.622	1.00
189_K	230_H	0.619	1.00
188_L	192_D	0.618	1.00
143_F	157_A	0.612	1.00
102_V	144_V	0.610	1.00
132_A	137_V	0.608	1.00
179_H	185_I	0.603	1.00
130_D	168_N	0.598	1.00
68_L	89_M	0.598	1.00
79_H	127_E	0.597	1.00
217_R	221_G	0.596	1.00
20_L	51_L	0.595	1.00
90_M	101_V	0.594	1.00
198_I	242_V	0.593	1.00
132_A	135_Y	0.591	1.00
14_S	18_L	0.590	1.00
83_I	128_L	0.586	1.00
173_L	189_K	0.585	1.00
231_L	243_V	0.584	1.00
81_E	85_E	0.583	1.00
26_H	262_Q	0.581	1.00
140_A	170_G	0.579	1.00
235_K	243_V	0.579	1.00
160_I	164_V	0.578	1.00
56_Q	95_T	0.577	1.00
119_K	122_V	0.575	1.00
154_F	187_S	0.573	1.00
178_F	188_L	0.572	1.00
51_L	54_Y	0.571	1.00
174_D	202_D	0.571	1.00
165_N	195_K	0.571	1.00
235_K	238_G	0.570	1.00
75_D	79_H	0.569	1.00
83_I	86_F	0.569	1.00
117_I	120_S	0.563	1.00
65_L	98_V	0.563	1.00
80_N	83_I	0.562	1.00
64_A	102_V	0.559	1.00
199_Y	239_F	0.556	1.00
142_E	177_H	0.554	1.00
234_L	239_F	0.554	1.00
99_K	136_G	0.554	1.00
64_A	244_S	0.553	1.00
125_L	129_S	0.553	1.00
215_E	220_P	0.551	1.00
52_A	96_L	0.547	1.00
157_A	161_V	0.546	1.00
192_D	196_I	0.545	1.00
166_R	169_V	0.545	1.00
56_Q	97_G	0.542	1.00
118_K	160_I	0.542	1.00
173_L	196_I	0.540	1.00
176_F	217_R	0.540	1.00
76_E	79_H	0.539	1.00
49_D	56_Q	0.538	1.00
82_I	85_E	0.536	1.00
257_A	261_I	0.536	1.00
67_A	89_M	0.535	1.00
97_G	137_V	0.533	1.00
158_Y	161_V	0.531	1.00
122_V	159_E	0.531	1.00
31_I	60_I	0.530	1.00
20_L	60_I	0.530	1.00
52_A	55_F	0.530	1.00
94_K	99_K	0.528	1.00
144_V	202_D	0.524	1.00
145_G	176_F	0.523	1.00
112_I	120_S	0.523	1.00
19_D	22_L	0.521	1.00
10_T	22_L	0.520	1.00
112_I	117_I	0.520	1.00
143_F	151_V	0.519	1.00
55_F	59_H	0.518	1.00
106_L	109_E	0.516	1.00
213_T	216_D	0.512	1.00
73_N	82_I	0.512	1.00
108_T	113_V	0.512	1.00
65_L	68_L	0.511	1.00
175_S	199_Y	0.510	1.00
83_I	131_I	0.508	1.00
102_V	198_I	0.507	1.00
144_V	248_F	0.501	1.00
200_H	246_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1i60A	1	0.9964	100	0.161	Contact Map
3u0hA	3	0.9784	100	0.226	Contact Map
2zdsA	5	0.9748	100	0.232	Contact Map
3cqjA	2	0.9568	100	0.24	Contact Map
3qc0A	2	0.946	100	0.241	Contact Map
2qulA	2	0.9353	100	0.249	Contact Map
3wqoA	2	0.9353	100	0.254	Contact Map
3kwsA	2	0.9137	100	0.254	Contact Map
2hk0A	3	0.9353	100	0.255	Contact Map
3dx5A	2	0.9353	100	0.256	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.