GREMLIN Database
IOLI - Inosose isomerase
UniProt: P42419 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (237)
Sequences: 16878 (11937)
Seq/√Len: 775.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_G197_F3.1491.00
87_K131_I3.1141.00
21_E58_H2.8361.00
122_V163_T2.7771.00
52_A56_Q2.7741.00
226_D229_A2.7461.00
203_D221_G2.4581.00
91_E135_Y2.4461.00
190_Q233_A2.4291.00
30_Y242_V2.3901.00
53_E57_T2.3861.00
138_K197_F2.3731.00
91_E131_I2.2561.00
17_K54_Y2.1721.00
15_N18_L2.1471.00
94_K135_Y2.1321.00
138_K170_G2.1291.00
140_A197_F2.0991.00
159_E163_T2.0191.00
118_K159_E1.9831.00
83_I127_E1.9701.00
130_D166_R1.9321.00
158_Y191_A1.8891.00
100_Y140_A1.8591.00
54_Y58_H1.8101.00
80_N84_T1.7711.00
158_Y162_N1.7681.00
54_Y57_T1.7481.00
233_A236_E1.7141.00
21_E25_K1.7121.00
47_S50_D1.6901.00
90_M135_Y1.6861.00
55_F62_P1.6741.00
118_K163_T1.6501.00
49_D95_T1.6441.00
184_N187_S1.6151.00
119_K163_T1.5981.00
131_I134_P1.5981.00
24_E58_H1.5931.00
228_D232_S1.5841.00
129_S169_V1.5791.00
140_A172_V1.5631.00
93_C98_V1.5581.00
78_G81_E1.5451.00
190_Q236_E1.5431.00
113_V116_E1.5321.00
116_E119_K1.5251.00
122_V126_T1.5221.00
79_H124_V1.5061.00
199_Y234_L1.4921.00
84_T88_G1.4811.00
203_D223_G1.4741.00
88_G91_E1.4611.00
22_L25_K1.4601.00
48_L95_T1.4571.00
45_D95_T1.4571.00
21_E54_Y1.4551.00
187_S191_A1.4451.00
131_I135_Y1.4341.00
123_D126_T1.4291.00
90_M132_A1.4241.00
133_E168_N1.4161.00
50_D53_E1.4001.00
18_L21_E1.3801.00
120_S123_D1.3801.00
119_K123_D1.3781.00
130_D134_P1.3641.00
17_K57_T1.3571.00
20_L58_H1.3481.00
100_Y138_K1.3461.00
170_G195_K1.3441.00
232_S236_E1.3351.00
87_K127_E1.3181.00
175_S230_H1.3141.00
233_A237_I1.3131.00
193_G237_I1.3111.00
186_E229_A1.3091.00
153_T156_Q1.2871.00
53_E56_Q1.2631.00
84_T87_K1.2551.00
152_N156_Q1.2551.00
87_K91_E1.2471.00
129_S164_V1.2281.00
50_D54_Y1.2201.00
49_D53_E1.2191.00
90_M137_V1.2151.00
90_M131_I1.2151.00
205_E218_V1.2141.00
126_T165_N1.2121.00
143_F178_F1.2081.00
157_A171_L1.2051.00
136_G168_N1.1951.00
17_K50_D1.1911.00
133_E166_R1.1851.00
83_I87_K1.1791.00
155_E191_A1.1721.00
80_N127_E1.1671.00
159_E162_N1.1631.00
52_A95_T1.1571.00
127_E130_D1.1351.00
162_N195_K1.1301.00
22_L26_H1.1291.00
173_L178_F1.1281.00
118_K122_V1.1161.00
158_Y195_K1.1151.00
122_V164_V1.1131.00
86_F128_L1.1121.00
219_W222_Q1.1101.00
20_L54_Y1.1081.00
229_A233_A1.1041.00
75_D78_G1.1041.00
133_E167_D1.1031.00
126_T164_V1.1011.00
24_E59_H1.0911.00
87_K134_P1.0861.00
132_A139_I1.0851.00
76_E80_N1.0811.00
114_K156_Q1.0761.00
91_E95_T1.0691.00
30_Y61_K1.0671.00
20_L55_F1.0591.00
130_D133_E1.0591.00
234_L237_I1.0501.00
22_L258_E1.0361.00
23_C28_Y1.0361.00
17_K21_E1.0321.00
258_E262_Q1.0161.00
123_D127_E1.0001.00
55_F60_I0.9991.00
65_L93_C0.9951.00
30_Y63_L0.9931.00
28_Y245_V0.9921.00
100_Y197_F0.9851.00
25_K258_E0.9801.00
48_L92_T0.9731.00
259_E262_Q0.9601.00
87_K135_Y0.9591.00
190_Q237_I0.9551.00
187_S190_Q0.9531.00
257_A260_A0.9521.00
32_E64_A0.9511.00
99_K138_K0.9501.00
33_I62_P0.9491.00
24_E29_D0.9491.00
126_T166_R0.9461.00
126_T130_D0.9421.00
48_L52_A0.9421.00
115_E159_E0.9411.00
174_D246_E0.9411.00
129_S166_R0.9391.00
161_V195_K0.9391.00
129_S168_N0.9351.00
91_E94_K0.9351.00
55_F58_H0.9341.00
46_H50_D0.9321.00
79_H123_D0.9261.00
217_R220_P0.9251.00
171_L192_D0.9241.00
125_L169_V0.9211.00
142_E246_E0.9211.00
81_E84_T0.9201.00
115_E119_K0.9171.00
186_E190_Q0.9171.00
225_I230_H0.9121.00
164_V169_V0.9111.00
158_Y192_D0.9071.00
32_E198_I0.8971.00
186_E233_A0.8891.00
102_V172_V0.8891.00
14_S22_L0.8861.00
218_V222_Q0.8851.00
179_H224_A0.8811.00
93_C101_V0.8761.00
52_A97_G0.8741.00
73_N78_G0.8681.00
154_F191_A0.8671.00
177_H202_D0.8641.00
116_E120_S0.8601.00
155_E159_E0.8591.00
202_D217_R0.8521.00
40_P43_L0.8491.00
83_I124_V0.8491.00
189_K237_I0.8481.00
61_K99_K0.8481.00
45_D49_D0.8391.00
79_H120_S0.8351.00
48_L96_L0.8321.00
63_L242_V0.8291.00
176_F202_D0.8261.00
118_K156_Q0.8261.00
201_I227_L0.8241.00
231_L235_K0.8201.00
71_F124_V0.8121.00
138_K168_N0.8111.00
44_K47_S0.8091.00
94_K137_V0.8071.00
94_K136_G0.8071.00
23_C31_I0.8031.00
49_D52_A0.7981.00
154_F183_S0.7961.00
205_E224_A0.7941.00
92_T96_L0.7881.00
114_K117_I0.7841.00
62_P98_V0.7821.00
205_E216_D0.7781.00
229_A232_S0.7721.00
206_D224_A0.7511.00
199_Y243_V0.7501.00
28_Y261_I0.7481.00
8_A11_L0.7461.00
21_E57_T0.7451.00
238_G241_D0.7451.00
175_S227_L0.7441.00
189_K233_A0.7431.00
176_F204_T0.7431.00
202_D248_F0.7391.00
124_V127_E0.7381.00
161_V171_L0.7371.00
198_I244_S0.7331.00
142_E200_H0.7301.00
126_T163_T0.7291.00
151_V157_A0.7271.00
88_G92_T0.7251.00
120_S124_V0.7241.00
61_K242_V0.7241.00
66_N69_V0.7221.00
85_E88_G0.7191.00
128_L139_I0.7161.00
70_F73_N0.7091.00
172_V198_I0.7091.00
189_K193_G0.7061.00
20_L24_E0.7011.00
201_I243_V0.7011.00
156_Q159_E0.6981.00
121_S160_I0.6981.00
66_N104_V0.6931.00
188_L191_A0.6931.00
129_S139_I0.6911.00
227_L231_L0.6901.00
24_E60_I0.6871.00
77_K81_E0.6861.00
29_D61_K0.6861.00
32_E244_S0.6831.00
173_L188_L0.6781.00
79_H83_I0.6761.00
20_L31_I0.6761.00
151_V160_I0.6741.00
161_V169_V0.6731.00
127_E131_I0.6651.00
189_K196_I0.6641.00
165_N168_N0.6621.00
193_G196_I0.6611.00
100_Y198_I0.6591.00
89_M101_V0.6581.00
77_K80_N0.6561.00
154_F158_Y0.6531.00
179_H225_I0.6531.00
17_K58_H0.6501.00
76_E120_S0.6491.00
194_K237_I0.6481.00
93_C137_V0.6471.00
122_V160_I0.6471.00
101_V132_A0.6471.00
11_L26_H0.6461.00
21_E24_E0.6441.00
193_G233_A0.6421.00
18_L22_L0.6401.00
125_L160_I0.6341.00
219_W260_A0.6301.00
121_S125_L0.6291.00
161_V165_N0.6291.00
19_D23_C0.6291.00
129_S133_E0.6231.00
175_S201_I0.6221.00
189_K230_H0.6191.00
188_L192_D0.6181.00
143_F157_A0.6121.00
102_V144_V0.6101.00
132_A137_V0.6081.00
179_H185_I0.6031.00
130_D168_N0.5981.00
68_L89_M0.5981.00
79_H127_E0.5971.00
217_R221_G0.5961.00
20_L51_L0.5951.00
90_M101_V0.5941.00
198_I242_V0.5931.00
132_A135_Y0.5911.00
14_S18_L0.5901.00
83_I128_L0.5861.00
173_L189_K0.5851.00
231_L243_V0.5841.00
81_E85_E0.5831.00
26_H262_Q0.5811.00
140_A170_G0.5791.00
235_K243_V0.5791.00
160_I164_V0.5781.00
56_Q95_T0.5771.00
119_K122_V0.5751.00
154_F187_S0.5731.00
178_F188_L0.5721.00
51_L54_Y0.5711.00
174_D202_D0.5711.00
165_N195_K0.5711.00
235_K238_G0.5701.00
75_D79_H0.5691.00
83_I86_F0.5691.00
117_I120_S0.5631.00
65_L98_V0.5631.00
80_N83_I0.5621.00
64_A102_V0.5591.00
199_Y239_F0.5561.00
142_E177_H0.5541.00
234_L239_F0.5541.00
99_K136_G0.5541.00
64_A244_S0.5531.00
125_L129_S0.5531.00
215_E220_P0.5511.00
52_A96_L0.5471.00
157_A161_V0.5461.00
192_D196_I0.5451.00
166_R169_V0.5451.00
56_Q97_G0.5421.00
118_K160_I0.5421.00
173_L196_I0.5401.00
176_F217_R0.5401.00
76_E79_H0.5391.00
49_D56_Q0.5381.00
82_I85_E0.5361.00
257_A261_I0.5361.00
67_A89_M0.5351.00
97_G137_V0.5331.00
158_Y161_V0.5311.00
122_V159_E0.5311.00
31_I60_I0.5301.00
20_L60_I0.5301.00
52_A55_F0.5301.00
94_K99_K0.5281.00
144_V202_D0.5241.00
145_G176_F0.5231.00
112_I120_S0.5231.00
19_D22_L0.5211.00
10_T22_L0.5201.00
112_I117_I0.5201.00
143_F151_V0.5191.00
55_F59_H0.5181.00
106_L109_E0.5161.00
213_T216_D0.5121.00
73_N82_I0.5121.00
108_T113_V0.5121.00
65_L68_L0.5111.00
175_S199_Y0.5101.00
83_I131_I0.5081.00
102_V198_I0.5071.00
144_V248_F0.5011.00
200_H246_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i60A 1 0.9964 100 0.161 Contact Map
3u0hA 3 0.9784 100 0.226 Contact Map
2zdsA 5 0.9748 100 0.232 Contact Map
3cqjA 2 0.9568 100 0.24 Contact Map
3qc0A 2 0.946 100 0.241 Contact Map
2qulA 2 0.9353 100 0.249 Contact Map
3wqoA 2 0.9353 100 0.254 Contact Map
3kwsA 2 0.9137 100 0.254 Contact Map
2hk0A 3 0.9353 100 0.255 Contact Map
3dx5A 2 0.9353 100 0.256 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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