GREMLIN Database
IOLH - Protein IolH
UniProt: P42418 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (241)
Sequences: 16580 (11616)
Seq/√Len: 748.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_K134_V3.1971.00
171_N201_T3.0281.00
21_Y63_T2.8121.00
125_I164_A2.8101.00
242_D245_T2.7111.00
57_K61_R2.6581.00
194_D249_K2.5091.00
141_K201_T2.4261.00
30_Y258_I2.3511.00
96_E138_E2.3351.00
58_R62_D2.3331.00
207_D237_G2.2731.00
17_E59_L2.1941.00
141_K171_N2.1601.00
96_E134_V2.1311.00
88_V130_E2.1081.00
143_N201_T2.1071.00
15_T18_E2.1001.00
99_V138_E2.1001.00
121_E160_D2.0611.00
160_D164_A2.0051.00
133_P167_K1.9841.00
159_M195_E1.8841.00
59_L62_D1.8661.00
105_L143_N1.8501.00
59_L63_T1.8301.00
188_D191_T1.8251.00
159_M163_R1.8081.00
249_K252_E1.7761.00
85_Q89_R1.7311.00
121_E164_A1.6981.00
21_Y25_E1.6901.00
24_A63_T1.6701.00
122_E164_A1.6681.00
132_L170_I1.6621.00
52_K55_Q1.6531.00
50_S100_E1.6421.00
134_V137_K1.6371.00
60_L67_L1.6311.00
54_K100_E1.6291.00
95_I138_E1.6231.00
270_R273_E1.6131.00
244_D248_R1.5941.00
98_A103_V1.5711.00
83_R86_A1.5411.00
194_D252_E1.5281.00
136_E169_W1.5271.00
22_K25_E1.5201.00
89_R93_R1.5171.00
143_N173_V1.5081.00
84_R127_S1.4951.00
53_I100_E1.4841.00
203_V250_L1.4681.00
116_D119_T1.4621.00
125_I129_D1.4371.00
55_Q58_R1.4351.00
126_K129_D1.4311.00
123_K126_K1.4281.00
105_L141_K1.4151.00
95_I135_F1.4141.00
119_T122_E1.4101.00
190_E245_T1.4061.00
21_Y59_L1.3951.00
133_P137_K1.3921.00
93_R96_E1.3841.00
154_T157_G1.3841.00
18_E21_Y1.3831.00
134_V138_E1.3741.00
17_E62_D1.3601.00
197_G253_M1.3291.00
20_V63_T1.3221.00
153_E157_G1.3221.00
248_R252_E1.3211.00
92_K130_E1.3201.00
176_T246_I1.3191.00
122_E126_K1.3181.00
207_D239_G1.3121.00
209_Y234_L1.3101.00
249_K253_M1.2971.00
171_N199_R1.2941.00
238_Q277_F1.2721.00
89_R92_K1.2661.00
55_Q59_L1.2651.00
22_K272_D1.2611.00
92_K96_E1.2361.00
132_L165_L1.2211.00
160_D163_R1.2171.00
146_A179_T1.2161.00
158_A172_L1.2091.00
191_T195_E1.2051.00
85_Q130_E1.1931.00
136_E167_K1.1931.00
58_R61_R1.1851.00
88_V92_K1.1711.00
159_M199_R1.1691.00
22_K26_L1.1691.00
129_D166_D1.1671.00
245_T249_K1.1611.00
95_I134_V1.1611.00
57_K100_E1.1591.00
95_I140_I1.1571.00
139_G169_W1.1551.00
174_Y179_T1.1531.00
54_K58_R1.1471.00
129_D165_L1.1321.00
91_W131_L1.1291.00
235_D238_Q1.1231.00
24_A64_G1.1221.00
163_R199_R1.1221.00
17_E55_Q1.1191.00
125_I165_L1.1121.00
136_E168_D1.1061.00
130_E133_P1.1041.00
273_E277_F1.1011.00
23_T28_Y1.1001.00
20_V59_L1.0971.00
81_E85_Q1.0951.00
50_S54_K1.0941.00
20_V60_L1.0891.00
80_D83_R1.0811.00
117_P157_G1.0711.00
121_E125_I1.0691.00
92_K137_K1.0611.00
30_Y66_K1.0591.00
135_F142_L1.0581.00
194_D253_M1.0541.00
17_E21_Y1.0511.00
272_D276_R1.0471.00
156_K195_E1.0391.00
96_E100_E1.0391.00
192_M196_A1.0381.00
30_Y68_S1.0211.00
28_Y261_N1.0051.00
96_E99_V0.9901.00
159_M196_A0.9871.00
60_L65_V0.9791.00
190_E194_D0.9781.00
70_L98_A0.9761.00
104_D141_K0.9701.00
33_L67_L0.9671.00
133_P136_E0.9661.00
84_R126_K0.9631.00
51_A55_Q0.9621.00
60_L63_T0.9611.00
191_T194_D0.9591.00
193_F197_G0.9551.00
129_D133_P0.9521.00
86_A89_R0.9511.00
132_L167_K0.9511.00
105_L201_T0.9491.00
92_K138_E0.9461.00
250_L253_M0.9421.00
129_D167_K0.9381.00
118_L160_D0.9321.00
126_K130_E0.9311.00
247_F251_R0.9161.00
32_E69_S0.9141.00
190_E249_K0.9091.00
241_V246_I0.9091.00
23_T31_I0.9041.00
53_I97_I0.9021.00
162_I199_R0.9011.00
193_F253_M0.8971.00
132_L169_W0.8921.00
14_L22_K0.8881.00
53_I57_K0.8871.00
24_A29_E0.8861.00
99_V139_G0.8861.00
180_F240_E0.8861.00
145_Q262_A0.8831.00
155_H195_E0.8811.00
57_K102_E0.8771.00
49_D52_K0.8761.00
66_K104_D0.8711.00
128_M170_I0.8701.00
25_E272_D0.8671.00
117_P120_S0.8661.00
121_E157_G0.8661.00
273_E276_R0.8591.00
98_A106_M0.8511.00
118_L122_E0.8481.00
141_K169_W0.8481.00
90_N93_R0.8431.00
271_A274_S0.8421.00
84_R123_K0.8401.00
119_T123_K0.8391.00
175_S262_A0.8381.00
68_S258_I0.8271.00
209_Y232_Q0.8271.00
274_S277_F0.8241.00
54_K57_K0.8181.00
205_F243_F0.8181.00
107_N173_V0.8171.00
32_E202_H0.8171.00
269_E273_E0.8141.00
165_L170_I0.8121.00
67_L103_V0.8101.00
193_F249_K0.8101.00
172_L196_A0.8061.00
78_G83_R0.8051.00
245_T248_R0.8031.00
156_K160_D0.8021.00
123_K127_S0.7971.00
76_W127_S0.7921.00
157_G160_D0.7921.00
209_Y240_E0.7911.00
268_D271_A0.7901.00
88_V127_S0.7871.00
178_H206_A0.7851.00
99_V140_I0.7831.00
203_V259_A0.7691.00
93_R97_I0.7661.00
155_H184_D0.7621.00
177_A206_A0.7611.00
8_S11_R0.7581.00
21_Y62_D0.7571.00
162_I172_L0.7541.00
193_F200_L0.7531.00
75_H78_G0.7501.00
71_L74_Y0.7501.00
84_R88_V0.7401.00
97_I101_L0.7391.00
130_E134_V0.7381.00
53_I101_L0.7361.00
270_R274_S0.7301.00
210_N240_E0.7271.00
66_K258_I0.7261.00
131_L142_L0.7251.00
195_E198_D0.7161.00
106_M135_F0.7141.00
127_S130_E0.7071.00
211_H240_E0.7071.00
120_S123_K0.7061.00
152_I161_M0.7051.00
243_F247_F0.7031.00
146_A158_A0.7011.00
20_V24_A0.7001.00
129_D164_A0.6991.00
70_L73_L0.6961.00
205_F259_A0.6951.00
14_L18_E0.6941.00
28_Y275_S0.6901.00
7_P10_Y0.6841.00
29_E66_K0.6841.00
193_F196_A0.6811.00
202_H260_T0.6781.00
197_G249_K0.6781.00
166_D169_W0.6771.00
176_T243_F0.6761.00
20_V31_I0.6751.00
132_L142_L0.6741.00
82_D86_A0.6741.00
21_Y24_A0.6711.00
71_L109_E0.6691.00
32_E260_T0.6681.00
19_M23_T0.6621.00
177_A208_T0.6611.00
206_A264_F0.6611.00
180_F241_V0.6591.00
162_I170_I0.6581.00
122_E125_I0.6561.00
108_S142_L0.6561.00
125_I161_M0.6541.00
80_D84_R0.6531.00
145_Q204_L0.6521.00
173_V202_H0.6511.00
124_F161_M0.6501.00
194_D197_G0.6481.00
94_A106_M0.6461.00
155_H159_M0.6451.00
81_E123_K0.6451.00
18_E22_K0.6431.00
24_A65_V0.6421.00
234_L238_Q0.6401.00
128_M161_M0.6401.00
193_F246_I0.6391.00
98_A140_I0.6381.00
82_D85_Q0.6341.00
152_I158_A0.6331.00
174_Y192_M0.6301.00
133_P169_W0.6291.00
70_L103_V0.6251.00
254_K257_G0.6241.00
81_E84_R0.6231.00
105_L202_H0.6221.00
247_F259_A0.6211.00
192_M197_G0.6181.00
147_H150_D0.6181.00
174_Y193_F0.6181.00
197_G200_L0.6131.00
17_E63_T0.6121.00
124_F128_M0.6111.00
61_R102_E0.6051.00
166_D199_R0.6041.00
192_M195_E0.6011.00
162_I166_D0.5991.00
143_N171_N0.5951.00
161_M165_L0.5941.00
180_F189_I0.5931.00
233_H236_I0.5881.00
176_T205_F0.5881.00
73_L94_A0.5851.00
88_V131_L0.5831.00
251_R259_A0.5821.00
268_D274_S0.5811.00
86_A90_N0.5801.00
20_V56_L0.5731.00
57_K101_L0.5711.00
20_V65_V0.5711.00
155_H191_T0.5711.00
132_L136_E0.5691.00
95_I106_M0.5641.00
251_R254_K0.5641.00
84_R130_E0.5621.00
159_M162_I0.5621.00
69_S107_N0.5591.00
172_L200_L0.5591.00
11_R26_L0.5581.00
235_D274_S0.5531.00
72_P94_A0.5491.00
56_L59_L0.5491.00
196_A200_L0.5471.00
88_V91_W0.5451.00
198_D253_M0.5451.00
87_A90_N0.5441.00
88_V134_V0.5441.00
174_Y200_L0.5401.00
167_K170_I0.5381.00
115_Y120_S0.5371.00
47_K93_R0.5341.00
135_F138_E0.5341.00
85_Q88_V0.5331.00
179_T192_M0.5321.00
202_H255_F0.5311.00
202_H258_I0.5301.00
115_Y119_T0.5291.00
250_L255_F0.5281.00
108_S128_M0.5271.00
107_N143_N0.5251.00
206_A233_H0.5231.00
113_S116_D0.5231.00
31_I65_V0.5231.00
104_D139_G0.5221.00
135_F140_I0.5191.00
10_Y22_K0.5141.00
132_L135_F0.5131.00
26_L276_R0.5131.00
96_E137_K0.5121.00
269_E274_S0.5111.00
68_S104_D0.5101.00
236_I239_G0.5081.00
107_N202_H0.5081.00
61_R100_E0.5071.00
124_F127_S0.5051.00
203_V255_F0.5051.00
165_L168_D0.5041.00
33_L56_L0.5021.00
243_F246_I0.5011.00
19_M22_K0.5011.00
179_T184_D0.5011.00
151_F156_K0.5001.00
117_P121_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i60A 1 0.9308 100 0.233 Contact Map
3cqjA 2 0.9239 100 0.235 Contact Map
2zdsA 5 0.9654 100 0.238 Contact Map
3qc0A 2 0.8893 100 0.25 Contact Map
3dx5A 2 0.9377 100 0.251 Contact Map
3u0hA 3 0.9135 100 0.251 Contact Map
4ovxA 1 0.8927 100 0.251 Contact Map
3cnyA 1 0.9308 100 0.255 Contact Map
2qulA 2 0.8789 100 0.256 Contact Map
3wqoA 2 0.8754 100 0.261 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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