IOLH - BACSU - GREMLIN Contacts

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IOLH - Protein IolH

UniProt:	P42418	Sequences: MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYKYPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELEVDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMDMIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLRYIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSRFMLKKMKEELGLA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	289 (241)
Sequences:	16580 (11616)
Seq/√Len:	748.3

ECOLI - ULAE FRLC SGBU YCJR HYI YGBM YIHM
BACSU - IOLH IOLI YFIH IOLE
SULSO - Q97UI8 Q97UG9 Q97UI3 Q7LX49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
92_K	134_V	3.197	1.00
171_N	201_T	3.028	1.00
21_Y	63_T	2.812	1.00
125_I	164_A	2.810	1.00
242_D	245_T	2.711	1.00
57_K	61_R	2.658	1.00
194_D	249_K	2.509	1.00
141_K	201_T	2.426	1.00
30_Y	258_I	2.351	1.00
96_E	138_E	2.335	1.00
58_R	62_D	2.333	1.00
207_D	237_G	2.273	1.00
17_E	59_L	2.194	1.00
141_K	171_N	2.160	1.00
96_E	134_V	2.131	1.00
88_V	130_E	2.108	1.00
143_N	201_T	2.107	1.00
15_T	18_E	2.100	1.00
99_V	138_E	2.100	1.00
121_E	160_D	2.061	1.00
160_D	164_A	2.005	1.00
133_P	167_K	1.984	1.00
159_M	195_E	1.884	1.00
59_L	62_D	1.866	1.00
105_L	143_N	1.850	1.00
59_L	63_T	1.830	1.00
188_D	191_T	1.825	1.00
159_M	163_R	1.808	1.00
249_K	252_E	1.776	1.00
85_Q	89_R	1.731	1.00
121_E	164_A	1.698	1.00
21_Y	25_E	1.690	1.00
24_A	63_T	1.670	1.00
122_E	164_A	1.668	1.00
132_L	170_I	1.662	1.00
52_K	55_Q	1.653	1.00
50_S	100_E	1.642	1.00
134_V	137_K	1.637	1.00
60_L	67_L	1.631	1.00
54_K	100_E	1.629	1.00
95_I	138_E	1.623	1.00
270_R	273_E	1.613	1.00
244_D	248_R	1.594	1.00
98_A	103_V	1.571	1.00
83_R	86_A	1.541	1.00
194_D	252_E	1.528	1.00
136_E	169_W	1.527	1.00
22_K	25_E	1.520	1.00
89_R	93_R	1.517	1.00
143_N	173_V	1.508	1.00
84_R	127_S	1.495	1.00
53_I	100_E	1.484	1.00
203_V	250_L	1.468	1.00
116_D	119_T	1.462	1.00
125_I	129_D	1.437	1.00
55_Q	58_R	1.435	1.00
126_K	129_D	1.431	1.00
123_K	126_K	1.428	1.00
105_L	141_K	1.415	1.00
95_I	135_F	1.414	1.00
119_T	122_E	1.410	1.00
190_E	245_T	1.406	1.00
21_Y	59_L	1.395	1.00
133_P	137_K	1.392	1.00
93_R	96_E	1.384	1.00
154_T	157_G	1.384	1.00
18_E	21_Y	1.383	1.00
134_V	138_E	1.374	1.00
17_E	62_D	1.360	1.00
197_G	253_M	1.329	1.00
20_V	63_T	1.322	1.00
153_E	157_G	1.322	1.00
248_R	252_E	1.321	1.00
92_K	130_E	1.320	1.00
176_T	246_I	1.319	1.00
122_E	126_K	1.318	1.00
207_D	239_G	1.312	1.00
209_Y	234_L	1.310	1.00
249_K	253_M	1.297	1.00
171_N	199_R	1.294	1.00
238_Q	277_F	1.272	1.00
89_R	92_K	1.266	1.00
55_Q	59_L	1.265	1.00
22_K	272_D	1.261	1.00
92_K	96_E	1.236	1.00
132_L	165_L	1.221	1.00
160_D	163_R	1.217	1.00
146_A	179_T	1.216	1.00
158_A	172_L	1.209	1.00
191_T	195_E	1.205	1.00
85_Q	130_E	1.193	1.00
136_E	167_K	1.193	1.00
58_R	61_R	1.185	1.00
88_V	92_K	1.171	1.00
159_M	199_R	1.169	1.00
22_K	26_L	1.169	1.00
129_D	166_D	1.167	1.00
245_T	249_K	1.161	1.00
95_I	134_V	1.161	1.00
57_K	100_E	1.159	1.00
95_I	140_I	1.157	1.00
139_G	169_W	1.155	1.00
174_Y	179_T	1.153	1.00
54_K	58_R	1.147	1.00
129_D	165_L	1.132	1.00
91_W	131_L	1.129	1.00
235_D	238_Q	1.123	1.00
24_A	64_G	1.122	1.00
163_R	199_R	1.122	1.00
17_E	55_Q	1.119	1.00
125_I	165_L	1.112	1.00
136_E	168_D	1.106	1.00
130_E	133_P	1.104	1.00
273_E	277_F	1.101	1.00
23_T	28_Y	1.100	1.00
20_V	59_L	1.097	1.00
81_E	85_Q	1.095	1.00
50_S	54_K	1.094	1.00
20_V	60_L	1.089	1.00
80_D	83_R	1.081	1.00
117_P	157_G	1.071	1.00
121_E	125_I	1.069	1.00
92_K	137_K	1.061	1.00
30_Y	66_K	1.059	1.00
135_F	142_L	1.058	1.00
194_D	253_M	1.054	1.00
17_E	21_Y	1.051	1.00
272_D	276_R	1.047	1.00
156_K	195_E	1.039	1.00
96_E	100_E	1.039	1.00
192_M	196_A	1.038	1.00
30_Y	68_S	1.021	1.00
28_Y	261_N	1.005	1.00
96_E	99_V	0.990	1.00
159_M	196_A	0.987	1.00
60_L	65_V	0.979	1.00
190_E	194_D	0.978	1.00
70_L	98_A	0.976	1.00
104_D	141_K	0.970	1.00
33_L	67_L	0.967	1.00
133_P	136_E	0.966	1.00
84_R	126_K	0.963	1.00
51_A	55_Q	0.962	1.00
60_L	63_T	0.961	1.00
191_T	194_D	0.959	1.00
193_F	197_G	0.955	1.00
129_D	133_P	0.952	1.00
86_A	89_R	0.951	1.00
132_L	167_K	0.951	1.00
105_L	201_T	0.949	1.00
92_K	138_E	0.946	1.00
250_L	253_M	0.942	1.00
129_D	167_K	0.938	1.00
118_L	160_D	0.932	1.00
126_K	130_E	0.931	1.00
247_F	251_R	0.916	1.00
32_E	69_S	0.914	1.00
190_E	249_K	0.909	1.00
241_V	246_I	0.909	1.00
23_T	31_I	0.904	1.00
53_I	97_I	0.902	1.00
162_I	199_R	0.901	1.00
193_F	253_M	0.897	1.00
132_L	169_W	0.892	1.00
14_L	22_K	0.888	1.00
53_I	57_K	0.887	1.00
24_A	29_E	0.886	1.00
99_V	139_G	0.886	1.00
180_F	240_E	0.886	1.00
145_Q	262_A	0.883	1.00
155_H	195_E	0.881	1.00
57_K	102_E	0.877	1.00
49_D	52_K	0.876	1.00
66_K	104_D	0.871	1.00
128_M	170_I	0.870	1.00
25_E	272_D	0.867	1.00
117_P	120_S	0.866	1.00
121_E	157_G	0.866	1.00
273_E	276_R	0.859	1.00
98_A	106_M	0.851	1.00
118_L	122_E	0.848	1.00
141_K	169_W	0.848	1.00
90_N	93_R	0.843	1.00
271_A	274_S	0.842	1.00
84_R	123_K	0.840	1.00
119_T	123_K	0.839	1.00
175_S	262_A	0.838	1.00
68_S	258_I	0.827	1.00
209_Y	232_Q	0.827	1.00
274_S	277_F	0.824	1.00
54_K	57_K	0.818	1.00
205_F	243_F	0.818	1.00
107_N	173_V	0.817	1.00
32_E	202_H	0.817	1.00
269_E	273_E	0.814	1.00
165_L	170_I	0.812	1.00
67_L	103_V	0.810	1.00
193_F	249_K	0.810	1.00
172_L	196_A	0.806	1.00
78_G	83_R	0.805	1.00
245_T	248_R	0.803	1.00
156_K	160_D	0.802	1.00
123_K	127_S	0.797	1.00
76_W	127_S	0.792	1.00
157_G	160_D	0.792	1.00
209_Y	240_E	0.791	1.00
268_D	271_A	0.790	1.00
88_V	127_S	0.787	1.00
178_H	206_A	0.785	1.00
99_V	140_I	0.783	1.00
203_V	259_A	0.769	1.00
93_R	97_I	0.766	1.00
155_H	184_D	0.762	1.00
177_A	206_A	0.761	1.00
8_S	11_R	0.758	1.00
21_Y	62_D	0.757	1.00
162_I	172_L	0.754	1.00
193_F	200_L	0.753	1.00
75_H	78_G	0.750	1.00
71_L	74_Y	0.750	1.00
84_R	88_V	0.740	1.00
97_I	101_L	0.739	1.00
130_E	134_V	0.738	1.00
53_I	101_L	0.736	1.00
270_R	274_S	0.730	1.00
210_N	240_E	0.727	1.00
66_K	258_I	0.726	1.00
131_L	142_L	0.725	1.00
195_E	198_D	0.716	1.00
106_M	135_F	0.714	1.00
127_S	130_E	0.707	1.00
211_H	240_E	0.707	1.00
120_S	123_K	0.706	1.00
152_I	161_M	0.705	1.00
243_F	247_F	0.703	1.00
146_A	158_A	0.701	1.00
20_V	24_A	0.700	1.00
129_D	164_A	0.699	1.00
70_L	73_L	0.696	1.00
205_F	259_A	0.695	1.00
14_L	18_E	0.694	1.00
28_Y	275_S	0.690	1.00
7_P	10_Y	0.684	1.00
29_E	66_K	0.684	1.00
193_F	196_A	0.681	1.00
202_H	260_T	0.678	1.00
197_G	249_K	0.678	1.00
166_D	169_W	0.677	1.00
176_T	243_F	0.676	1.00
20_V	31_I	0.675	1.00
132_L	142_L	0.674	1.00
82_D	86_A	0.674	1.00
21_Y	24_A	0.671	1.00
71_L	109_E	0.669	1.00
32_E	260_T	0.668	1.00
19_M	23_T	0.662	1.00
177_A	208_T	0.661	1.00
206_A	264_F	0.661	1.00
180_F	241_V	0.659	1.00
162_I	170_I	0.658	1.00
122_E	125_I	0.656	1.00
108_S	142_L	0.656	1.00
125_I	161_M	0.654	1.00
80_D	84_R	0.653	1.00
145_Q	204_L	0.652	1.00
173_V	202_H	0.651	1.00
124_F	161_M	0.650	1.00
194_D	197_G	0.648	1.00
94_A	106_M	0.646	1.00
155_H	159_M	0.645	1.00
81_E	123_K	0.645	1.00
18_E	22_K	0.643	1.00
24_A	65_V	0.642	1.00
234_L	238_Q	0.640	1.00
128_M	161_M	0.640	1.00
193_F	246_I	0.639	1.00
98_A	140_I	0.638	1.00
82_D	85_Q	0.634	1.00
152_I	158_A	0.633	1.00
174_Y	192_M	0.630	1.00
133_P	169_W	0.629	1.00
70_L	103_V	0.625	1.00
254_K	257_G	0.624	1.00
81_E	84_R	0.623	1.00
105_L	202_H	0.622	1.00
247_F	259_A	0.621	1.00
192_M	197_G	0.618	1.00
147_H	150_D	0.618	1.00
174_Y	193_F	0.618	1.00
197_G	200_L	0.613	1.00
17_E	63_T	0.612	1.00
124_F	128_M	0.611	1.00
61_R	102_E	0.605	1.00
166_D	199_R	0.604	1.00
192_M	195_E	0.601	1.00
162_I	166_D	0.599	1.00
143_N	171_N	0.595	1.00
161_M	165_L	0.594	1.00
180_F	189_I	0.593	1.00
233_H	236_I	0.588	1.00
176_T	205_F	0.588	1.00
73_L	94_A	0.585	1.00
88_V	131_L	0.583	1.00
251_R	259_A	0.582	1.00
268_D	274_S	0.581	1.00
86_A	90_N	0.580	1.00
20_V	56_L	0.573	1.00
57_K	101_L	0.571	1.00
20_V	65_V	0.571	1.00
155_H	191_T	0.571	1.00
132_L	136_E	0.569	1.00
95_I	106_M	0.564	1.00
251_R	254_K	0.564	1.00
84_R	130_E	0.562	1.00
159_M	162_I	0.562	1.00
69_S	107_N	0.559	1.00
172_L	200_L	0.559	1.00
11_R	26_L	0.558	1.00
235_D	274_S	0.553	1.00
72_P	94_A	0.549	1.00
56_L	59_L	0.549	1.00
196_A	200_L	0.547	1.00
88_V	91_W	0.545	1.00
198_D	253_M	0.545	1.00
87_A	90_N	0.544	1.00
88_V	134_V	0.544	1.00
174_Y	200_L	0.540	1.00
167_K	170_I	0.538	1.00
115_Y	120_S	0.537	1.00
47_K	93_R	0.534	1.00
135_F	138_E	0.534	1.00
85_Q	88_V	0.533	1.00
179_T	192_M	0.532	1.00
202_H	255_F	0.531	1.00
202_H	258_I	0.530	1.00
115_Y	119_T	0.529	1.00
250_L	255_F	0.528	1.00
108_S	128_M	0.527	1.00
107_N	143_N	0.525	1.00
206_A	233_H	0.523	1.00
113_S	116_D	0.523	1.00
31_I	65_V	0.523	1.00
104_D	139_G	0.522	1.00
135_F	140_I	0.519	1.00
10_Y	22_K	0.514	1.00
132_L	135_F	0.513	1.00
26_L	276_R	0.513	1.00
96_E	137_K	0.512	1.00
269_E	274_S	0.511	1.00
68_S	104_D	0.510	1.00
236_I	239_G	0.508	1.00
107_N	202_H	0.508	1.00
61_R	100_E	0.507	1.00
124_F	127_S	0.505	1.00
203_V	255_F	0.505	1.00
165_L	168_D	0.504	1.00
33_L	56_L	0.502	1.00
243_F	246_I	0.501	1.00
19_M	22_K	0.501	1.00
179_T	184_D	0.501	1.00
151_F	156_K	0.500	1.00
117_P	121_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1i60A	1	0.9308	100	0.233	Contact Map
3cqjA	2	0.9239	100	0.235	Contact Map
2zdsA	5	0.9654	100	0.238	Contact Map
3qc0A	2	0.8893	100	0.25	Contact Map
3dx5A	2	0.9377	100	0.251	Contact Map
3u0hA	3	0.9135	100	0.251	Contact Map
4ovxA	1	0.8927	100	0.251	Contact Map
3cnyA	1	0.9308	100	0.255	Contact Map
2qulA	2	0.8789	100	0.256	Contact Map
3wqoA	2	0.8754	100	0.261	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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