GREMLIN Database
IOLE - Inosose dehydratase
UniProt: P42416 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (238)
Sequences: 13895 (9889)
Seq/√Len: 641.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_T144_I3.1831.00
181_H208_K2.9761.00
34_S63_R2.8841.00
248_D251_E2.8341.00
57_N61_K2.7351.00
43_G264_W2.6191.00
201_E255_L2.4961.00
135_C174_G2.4511.00
93_E148_H2.4171.00
30_Q59_E2.3411.00
58_K62_L2.2581.00
151_K181_H2.2361.00
93_E144_I2.2331.00
151_K208_K2.1731.00
96_Q148_H2.1551.00
28_T31_H2.1441.00
169_D202_K2.0861.00
153_V208_K2.0831.00
143_E177_P2.0241.00
214_D243_G2.0241.00
255_L258_K1.9691.00
283_L287_N1.9241.00
170_R174_G1.9161.00
131_W170_R1.9051.00
34_S38_V1.8991.00
85_A140_H1.8541.00
60_L67_I1.8161.00
59_E63_R1.8021.00
54_A97_Q1.7701.00
102_V153_V1.7671.00
195_D198_G1.7641.00
59_E62_L1.7541.00
277_N280_E1.7521.00
142_G180_V1.7451.00
92_C148_H1.7111.00
201_E258_K1.7081.00
250_R254_Q1.6921.00
144_I147_Q1.6791.00
164_T167_E1.6631.00
146_A179_H1.6371.00
131_W174_G1.6251.00
52_E55_I1.6201.00
53_P97_Q1.6061.00
169_D173_A1.6041.00
210_V256_L1.5831.00
197_M251_E1.5451.00
144_I148_H1.5441.00
80_G83_E1.5401.00
135_C139_N1.5371.00
153_V183_L1.5261.00
92_C145_A1.5241.00
37_V63_R1.5111.00
86_K90_L1.4891.00
30_Q62_L1.4701.00
95_L100_A1.4621.00
35_D38_V1.4541.00
129_D132_E1.4511.00
198_G202_K1.4461.00
143_E147_Q1.4421.00
254_Q258_K1.4341.00
82_G86_K1.4301.00
39_A286_R1.4251.00
244_D284_I1.4161.00
55_I58_K1.3891.00
126_F129_D1.3851.00
132_E174_G1.3611.00
132_E136_E1.3561.00
255_L259_H1.3551.00
136_E139_N1.3531.00
142_G175_T1.3511.00
33_L63_R1.3461.00
90_L93_E1.3461.00
204_I259_H1.3381.00
34_S59_E1.3371.00
35_D279_L1.3311.00
31_H34_S1.3281.00
89_T140_H1.3171.00
186_T252_V1.3151.00
181_H206_R1.3141.00
81_L137_G1.2951.00
102_V151_K1.2921.00
86_K89_T1.2891.00
92_C144_I1.2841.00
55_I59_E1.2631.00
280_E284_I1.2431.00
146_A177_P1.2211.00
168_V182_L1.2201.00
89_T93_E1.2191.00
85_A89_T1.2181.00
163_Q167_E1.2121.00
135_C175_T1.2051.00
57_N97_Q1.1911.00
146_A178_A1.1831.00
149_G179_H1.1821.00
251_E255_L1.1771.00
133_R136_E1.1731.00
214_D245_G1.1711.00
197_M201_E1.1651.00
82_G140_H1.1611.00
30_Q55_I1.1611.00
33_L60_L1.1571.00
37_V64_N1.1561.00
145_A152_L1.1531.00
169_D206_R1.1521.00
58_K61_K1.1501.00
169_D203_H1.1461.00
173_A206_R1.1441.00
89_T147_Q1.1371.00
201_E259_H1.1361.00
35_D39_A1.1221.00
54_A58_K1.1061.00
140_H143_E1.1011.00
46_V67_I1.0971.00
51_P97_Q1.0961.00
41_F267_I1.0891.00
43_G66_R1.0691.00
92_C150_L1.0671.00
184_Y189_A1.0611.00
93_E97_Q1.0521.00
241_V244_D1.0511.00
198_G201_E1.0491.00
88_F141_L1.0301.00
170_R173_A1.0261.00
43_G68_A1.0231.00
279_L283_L1.0171.00
30_Q34_S1.0091.00
89_T148_H1.0081.00
33_L59_E1.0031.00
284_I287_N0.9951.00
38_V279_L0.9881.00
199_M203_H0.9851.00
166_E202_K0.9791.00
53_P94_Y0.9781.00
284_I288_Y0.9721.00
157_H160_T0.9651.00
60_L65_L0.9621.00
139_N143_E0.9591.00
139_N175_T0.9591.00
41_F286_R0.9591.00
247_I252_V0.9581.00
156_H189_A0.9551.00
36_I44_T0.9551.00
280_E283_L0.9551.00
256_L259_H0.9551.00
142_G179_H0.9471.00
93_E96_Q0.9471.00
143_E146_A0.9441.00
200_L255_L0.9411.00
78_R82_G0.9391.00
101_D151_K0.9341.00
200_L259_H0.9341.00
131_W135_C0.9311.00
45_E69_G0.9311.00
53_P57_N0.9301.00
197_M255_L0.9241.00
129_D133_R0.9111.00
155_H268_E0.9031.00
83_E86_K0.9031.00
34_S62_L0.8991.00
139_N176_D0.8991.00
128_D132_E0.8921.00
242_P285_A0.8901.00
281_Y284_I0.8881.00
142_G177_P0.8821.00
175_T180_V0.8801.00
96_Q150_L0.8771.00
131_W167_E0.8731.00
60_L63_R0.8721.00
102_V208_K0.8671.00
151_K179_H0.8651.00
54_A57_N0.8561.00
139_N177_P0.8561.00
276_A280_E0.8521.00
127_T130_E0.8511.00
27_N35_D0.8501.00
138_L180_V0.8491.00
37_V42_Q0.8401.00
85_A137_G0.8331.00
81_L136_E0.8331.00
53_P98_V0.8321.00
87_T90_L0.8311.00
165_A202_K0.8311.00
253_Y257_L0.8301.00
68_A264_W0.8251.00
172_M206_R0.8221.00
165_A194_G0.8181.00
260_S263_G0.8151.00
216_R240_T0.8091.00
185_D268_E0.8091.00
95_L103_A0.8081.00
67_I100_A0.8041.00
182_L203_H0.8041.00
166_E170_R0.7951.00
212_F265_I0.7951.00
212_F249_F0.7951.00
251_E254_Q0.7931.00
33_L44_T0.7881.00
57_N99_N0.7751.00
103_A145_A0.7661.00
190_Y246_C0.7641.00
136_E140_H0.7631.00
45_E209_H0.7621.00
141_L152_L0.7611.00
186_T249_F0.7571.00
42_Q66_R0.7571.00
128_D170_R0.7561.00
188_H213_K0.7531.00
217_L246_C0.7521.00
213_K270_E0.7521.00
176_D179_H0.7501.00
66_R264_W0.7491.00
249_F253_Y0.7481.00
66_R101_D0.7481.00
278_P281_Y0.7461.00
216_R246_C0.7391.00
190_Y196_Y0.7391.00
41_F282_A0.7371.00
27_N31_H0.7361.00
277_N281_Y0.7351.00
36_I41_F0.7351.00
200_L203_H0.7291.00
216_R238_M0.7211.00
139_N174_G0.7201.00
32_L36_I0.7191.00
127_T167_E0.7171.00
155_H211_H0.7151.00
187_G213_K0.7151.00
253_Y265_I0.7141.00
104_V183_L0.7131.00
70_K95_L0.7131.00
105_V152_L0.7111.00
133_R137_G0.7091.00
78_R81_L0.7071.00
48_G51_P0.7011.00
45_E266_V0.7001.00
142_G146_A0.6991.00
187_G215_A0.6961.00
31_H35_D0.6921.00
156_H168_V0.6891.00
200_L207_I0.6851.00
184_Y200_L0.6831.00
184_Y199_M0.6801.00
137_G140_H0.6791.00
145_A150_L0.6781.00
167_E170_R0.6771.00
212_F289_I0.6771.00
90_L94_Y0.6771.00
172_M182_L0.6761.00
189_A199_M0.6751.00
94_Y98_V0.6731.00
30_Q63_R0.6721.00
138_L171_L0.6681.00
282_A286_R0.6651.00
200_L252_V0.6601.00
81_L133_R0.6581.00
200_L204_I0.6581.00
83_E87_T0.6541.00
51_P54_A0.6501.00
71_W106_S0.6461.00
209_H266_V0.6411.00
275_V281_Y0.6411.00
79_D83_E0.6401.00
34_S37_V0.6371.00
143_E179_H0.6361.00
172_M176_D0.6361.00
183_L209_H0.6361.00
95_L150_L0.6341.00
275_V278_P0.6311.00
99_N150_L0.6241.00
33_L65_L0.6241.00
283_L286_R0.6221.00
241_V281_Y0.6191.00
140_H144_I0.6171.00
50_F53_P0.6141.00
85_A141_L0.6131.00
130_E133_R0.6111.00
24_G39_A0.6101.00
165_A169_D0.6091.00
204_I207_I0.6011.00
84_A87_T0.5981.00
210_V265_I0.5971.00
190_Y247_I0.5931.00
91_H103_A0.5931.00
102_V209_H0.5921.00
135_C171_L0.5921.00
61_K97_Q0.5911.00
37_V65_L0.5881.00
209_H261_Y0.5861.00
171_L175_T0.5861.00
239_F242_P0.5851.00
285_A289_I0.5851.00
162_V171_L0.5831.00
134_L138_L0.5821.00
205_G259_H0.5811.00
39_A283_L0.5761.00
33_L56_L0.5761.00
56_L59_E0.5751.00
257_L265_I0.5721.00
204_I255_L0.5721.00
267_I285_A0.5721.00
158_L161_G0.5691.00
162_V168_V0.5671.00
256_L261_Y0.5671.00
285_A288_Y0.5671.00
70_K73_S0.5671.00
78_R133_R0.5661.00
132_E135_C0.5641.00
61_K99_N0.5641.00
210_V252_V0.5621.00
276_A284_I0.5591.00
134_L171_L0.5551.00
242_P288_Y0.5541.00
85_A88_F0.5531.00
153_V181_H0.5521.00
209_H264_W0.5511.00
157_H161_G0.5511.00
125_H130_E0.5501.00
169_D172_M0.5501.00
33_L37_V0.5491.00
240_T244_D0.5491.00
85_A144_I0.5481.00
101_D149_G0.5471.00
96_Q149_G0.5441.00
189_A194_G0.5441.00
38_V283_L0.5441.00
176_D206_R0.5380.99
70_K100_A0.5380.99
105_V138_L0.5380.99
91_H95_L0.5370.99
104_V153_V0.5360.99
69_G104_V0.5340.99
29_L56_L0.5310.99
94_Y97_Q0.5300.99
186_T210_V0.5290.99
220_M238_M0.5280.99
74_S77_L0.5280.99
200_L256_L0.5260.99
24_G27_N0.5250.99
145_A148_H0.5240.99
156_H162_V0.5220.99
71_W104_V0.5220.99
212_F253_Y0.5200.99
79_D82_G0.5190.99
211_H268_E0.5160.99
185_D213_K0.5150.99
213_K239_F0.5140.99
82_G85_A0.5130.99
276_A281_Y0.5120.99
211_H266_V0.5120.99
57_N98_V0.5110.99
72_F75_F0.5100.99
68_A266_V0.5090.99
73_S91_H0.5080.99
93_E147_Q0.5050.99
190_Y194_G0.5050.99
165_A198_G0.5040.99
182_L207_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cnyA 1 0.9933 100 0.256 Contact Map
2zdsA 5 0.9461 100 0.282 Contact Map
3dx5A 2 0.8889 100 0.287 Contact Map
1i60A 1 0.8788 100 0.294 Contact Map
4ovxA 1 0.8485 100 0.297 Contact Map
3u0hA 3 0.8754 100 0.298 Contact Map
3cqjA 2 0.862 100 0.308 Contact Map
3tvaA 1 0.8721 100 0.318 Contact Map
3kwsA 2 0.8451 100 0.32 Contact Map
3wqoA 2 0.8418 100 0.32 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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