IOLD - BACSU - GREMLIN Contacts

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IOLD - 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase

UniProt:	P42415	Sequences: MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNVLGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAAAGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRPEQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSERELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFANNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQAYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREAFDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRLWHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQYNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTYRANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAYEAKEKKLESAKQY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	637 (540)
Sequences:	14217 (9003)
Seq/√Len:	387.4

ECOLI - GCL POXB ILVB ILVI OXC ILVG MEND
BACSU - IOLD ILVX ILVB YDAP MEND
HALSA - MEND
SULSO - Q7LXT8 Q97UP3 Q97ZB3 Q97U16 Q97XR3 Q980V7 Q97V62

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
556_K	559_E	4.980	1.00
519_D	591_E	3.895	1.00
70_A	102_A	3.794	1.00
425_T	575_K	3.645	1.00
255_E	275_F	3.559	1.00
566_Y	580_D	3.453	1.00
249_E	352_G	3.189	1.00
33_E	82_R	3.089	1.00
570_T	573_E	3.004	1.00
567_R	593_K	2.972	1.00
221_Q	357_L	2.913	1.00
249_E	348_K	2.871	1.00
345_A	350_T	2.703	1.00
429_T	579_E	2.681	1.00
79_Q	482_H	2.640	1.00
237_V	250_L	2.585	1.00
223_A	326_L	2.545	1.00
566_Y	588_T	2.539	1.00
28_E	57_H	2.463	1.00
274_D	454_N	2.458	1.00
569_N	573_E	2.458	1.00
564_K	586_V	2.447	1.00
425_T	428_E	2.440	1.00
328_I	350_T	2.415	1.00
34_G	59_K	2.409	1.00
303_I	347_A	2.404	1.00
297_A	300_I	2.347	1.00
475_T	489_S	2.317	1.00
28_E	54_D	2.314	1.00
566_Y	577_A	2.289	1.00
90_T	99_L	2.259	1.00
497_L	561_Y	2.190	1.00
564_K	580_D	2.175	1.00
553_D	556_K	2.147	1.00
567_R	591_E	2.138	1.00
114_L	171_F	2.131	1.00
97_A	101_A	2.120	1.00
428_E	575_K	2.115	1.00
482_H	485_R	2.058	1.00
83_R	175_T	2.041	1.00
103_A	115_L	2.040	1.00
226_L	341_F	2.038	1.00
302_G	305_T	2.034	1.00
21_Y	50_A	2.023	1.00
557_V	560_G	2.021	1.00
63_G	69_M	1.982	1.00
117_P	184_T	1.962	1.00
226_L	299_L	1.948	1.00
235_I	254_S	1.932	1.00
226_L	324_K	1.928	1.00
568_A	577_A	1.905	1.00
166_S	185_I	1.905	1.00
555_A	565_T	1.877	1.00
74_M	78_K	1.868	1.00
479_K	512_K	1.861	1.00
431_P	434_S	1.851	1.00
145_D	148_K	1.850	1.00
25_D	29_E	1.850	1.00
507_I	563_A	1.845	1.00
254_S	261_L	1.838	1.00
496_F	500_H	1.827	1.00
227_I	301_I	1.821	1.00
256_A	355_H	1.810	1.00
222_G	225_E	1.769	1.00
225_E	229_S	1.760	1.00
21_Y	53_Q	1.759	1.00
435_V	478_L	1.759	1.00
83_R	114_L	1.753	1.00
581_A	590_I	1.734	1.00
235_I	301_I	1.724	1.00
235_I	259_I	1.720	1.00
439_S	491_V	1.717	1.00
575_K	579_E	1.715	1.00
427_N	452_H	1.713	1.00
256_A	359_E	1.710	1.00
517_L	589_L	1.709	1.00
216_S	219_E	1.703	1.00
217_E	353_K	1.703	1.00
252_A	256_A	1.697	1.00
579_E	583_K	1.686	1.00
573_E	576_A	1.669	1.00
54_D	57_H	1.664	1.00
159_R	162_Q	1.662	1.00
335_A	344_V	1.660	1.00
559_E	564_K	1.639	1.00
564_K	588_T	1.637	1.00
439_S	495_S	1.633	1.00
426_I	490_I	1.631	1.00
303_I	328_I	1.629	1.00
470_Y	474_G	1.621	1.00
48_G	60_V	1.618	1.00
17_L	25_D	1.604	1.00
251_V	255_E	1.595	1.00
155_D	185_I	1.594	1.00
37_T	60_V	1.590	1.00
80_M	481_A	1.571	1.00
424_L	428_E	1.571	1.00
460_H	478_L	1.567	1.00
258_N	277_N	1.538	1.00
248_D	252_A	1.538	1.00
569_N	593_K	1.537	1.00
506_A	563_A	1.525	1.00
230_S	233_P	1.525	1.00
296_Q	379_E	1.520	1.00
555_A	567_R	1.519	1.00
261_L	271_V	1.510	1.00
99_L	115_L	1.504	1.00
151_S	184_T	1.499	1.00
576_A	580_D	1.499	1.00
227_I	299_L	1.497	1.00
479_K	511_K	1.495	1.00
23_H	187_I	1.489	1.00
152_R	181_G	1.476	1.00
421_T	571_V	1.462	1.00
26_G	168_L	1.461	1.00
503_L	563_A	1.453	1.00
516_L	590_I	1.440	1.00
116_I	187_I	1.437	1.00
63_G	72_A	1.435	1.00
506_A	513_I	1.433	1.00
103_A	113_V	1.429	1.00
434_S	486_E	1.427	1.00
68_G	502_E	1.423	1.00
253_I	257_Y	1.423	1.00
299_L	326_L	1.421	1.00
23_H	167_L	1.421	1.00
224_A	354_L	1.412	1.00
160_P	194_E	1.411	1.00
500_H	557_V	1.410	1.00
379_E	383_L	1.406	1.00
516_L	578_L	1.405	1.00
576_A	579_E	1.403	1.00
458_T	485_R	1.402	1.00
421_T	425_T	1.388	1.00
431_P	486_E	1.386	1.00
429_T	575_K	1.380	1.00
219_E	222_G	1.373	1.00
425_T	429_T	1.370	1.00
25_D	28_E	1.366	1.00
96_A	117_P	1.365	1.00
422_A	592_M	1.355	1.00
430_I	488_Y	1.353	1.00
114_L	174_M	1.347	1.00
468_M	498_M	1.344	1.00
230_S	299_L	1.337	1.00
488_Y	582_K	1.333	1.00
224_A	357_L	1.329	1.00
30_P	171_F	1.329	1.00
59_K	509_Y	1.327	1.00
252_A	355_H	1.324	1.00
122_A	190_D	1.323	1.00
24_V	54_D	1.320	1.00
33_E	59_K	1.318	1.00
303_I	351_L	1.316	1.00
253_I	351_L	1.315	1.00
512_K	586_V	1.310	1.00
514_N	581_A	1.309	1.00
157_I	163_L	1.306	1.00
336_Y	339_D	1.301	1.00
476_L	506_A	1.299	1.00
516_L	592_M	1.293	1.00
215_P	350_T	1.292	1.00
74_M	105_T	1.283	1.00
480_L	511_K	1.278	1.00
432_E	454_N	1.276	1.00
18_N	21_Y	1.274	1.00
250_L	351_L	1.273	1.00
253_I	355_H	1.272	1.00
220_L	357_L	1.269	1.00
417_L	592_M	1.269	1.00
324_K	340_A	1.268	1.00
167_L	185_I	1.268	1.00
234_V	297_A	1.266	1.00
70_A	99_L	1.261	1.00
574_L	592_M	1.260	1.00
30_P	168_L	1.259	1.00
479_K	486_E	1.259	1.00
34_G	480_L	1.255	1.00
83_R	171_F	1.254	1.00
435_V	482_H	1.250	1.00
563_A	589_L	1.249	1.00
162_Q	165_S	1.247	1.00
557_V	561_Y	1.238	1.00
36_F	76_Y	1.235	1.00
348_K	352_G	1.233	1.00
378_A	382_R	1.233	1.00
417_L	422_A	1.232	1.00
20_Q	50_A	1.232	1.00
221_Q	225_E	1.232	1.00
555_A	559_E	1.229	1.00
279_L	293_A	1.224	1.00
435_V	487_V	1.224	1.00
577_A	590_I	1.218	1.00
61_Y	480_L	1.215	1.00
19_Q	163_L	1.213	1.00
77_S	112_P	1.211	1.00
558_A	563_A	1.208	1.00
489_S	515_V	1.207	1.00
165_S	169_R	1.204	1.00
521_S	551_N	1.194	1.00
349_V	352_G	1.191	1.00
512_K	585_D	1.187	1.00
346_D	349_V	1.185	1.00
381_E	384_S	1.184	1.00
32_V	87_A	1.176	1.00
504_I	508_Q	1.175	1.00
486_E	582_K	1.175	1.00
104_G	465_Y	1.174	1.00
76_Y	481_A	1.171	1.00
432_E	455_V	1.169	1.00
479_K	483_P	1.169	1.00
251_V	272_E	1.165	1.00
188_S	191_V	1.163	1.00
25_D	54_D	1.161	1.00
224_A	228_K	1.154	1.00
556_K	560_G	1.153	1.00
233_P	298_D	1.153	1.00
100_V	146_A	1.147	1.00
353_K	356_G	1.145	1.00
251_V	271_V	1.145	1.00
252_A	255_E	1.144	1.00
241_A	250_L	1.141	1.00
558_A	589_L	1.141	1.00
292_K	296_Q	1.140	1.00
222_G	226_L	1.137	1.00
75_A	79_Q	1.136	1.00
217_E	357_L	1.136	1.00
268_K	273_A	1.130	1.00
35_I	51_L	1.128	1.00
376_W	380_R	1.122	1.00
235_I	253_I	1.120	1.00
26_G	167_L	1.114	1.00
74_M	111_I	1.114	1.00
255_E	277_N	1.113	1.00
223_A	343_V	1.110	1.00
263_E	278_N	1.107	1.00
173_V	183_A	1.104	1.00
88_V	99_L	1.102	1.00
134_E	145_D	1.101	1.00
90_T	115_L	1.101	1.00
252_A	352_G	1.100	1.00
378_A	381_E	1.100	1.00
224_A	358_L	1.099	1.00
100_V	150_V	1.098	1.00
21_Y	25_D	1.097	1.00
271_V	275_F	1.092	1.00
155_D	169_R	1.088	1.00
574_L	578_L	1.088	1.00
155_D	166_S	1.088	1.00
79_Q	478_L	1.087	1.00
123_T	190_D	1.087	1.00
479_K	487_V	1.085	1.00
22_I	196_Y	1.084	1.00
122_A	194_E	1.082	1.00
249_E	355_H	1.080	1.00
107_L	182_P	1.080	1.00
215_P	353_K	1.072	1.00
228_K	359_E	1.071	1.00
230_S	298_D	1.070	1.00
214_Q	353_K	1.069	1.00
565_T	589_L	1.069	1.00
232_K	296_Q	1.069	1.00
254_S	271_V	1.064	1.00
302_G	307_Y	1.064	1.00
237_V	241_A	1.062	1.00
566_Y	590_I	1.060	1.00
249_E	252_A	1.060	1.00
151_S	154_W	1.058	1.00
235_I	250_L	1.057	1.00
18_N	195_A	1.054	1.00
146_A	150_V	1.054	1.00
479_K	484_D	1.052	1.00
228_K	361_Y	1.052	1.00
88_V	115_L	1.052	1.00
433_D	485_R	1.050	1.00
223_A	341_F	1.049	1.00
68_G	499_L	1.049	1.00
125_Q	156_R	1.046	1.00
157_I	166_S	1.045	1.00
97_A	146_A	1.043	1.00
44_V	47_I	1.038	1.00
50_A	53_Q	1.035	1.00
471_E	489_S	1.030	1.00
234_V	262_V	1.028	1.00
568_A	573_E	1.027	1.00
514_N	588_T	1.026	1.00
436_I	451_W	1.025	1.00
252_A	359_E	1.022	1.00
17_L	195_A	1.022	1.00
248_D	251_V	1.022	1.00
229_S	299_L	1.020	1.00
22_I	164_M	1.016	1.00
430_I	436_I	1.014	1.00
343_V	350_T	1.014	1.00
61_Y	509_Y	1.011	1.00
503_L	589_L	1.010	1.00
568_A	574_L	1.007	1.00
34_G	61_Y	1.006	1.00
262_V	279_L	1.005	1.00
374_D	378_A	1.004	1.00
418_P	598_T	1.001	1.00
558_A	565_T	0.998	1.00
229_S	324_K	0.997	1.00
564_K	584_Q	0.995	1.00
228_K	358_L	0.993	1.00
72_A	506_A	0.992	1.00
514_N	590_I	0.991	1.00
154_W	184_T	0.988	1.00
254_S	277_N	0.988	1.00
23_H	116_I	0.988	1.00
486_E	514_N	0.986	1.00
472_V	496_F	0.983	1.00
70_A	88_V	0.980	1.00
500_H	561_Y	0.979	1.00
47_I	187_I	0.976	1.00
496_F	517_L	0.968	1.00
584_Q	588_T	0.968	1.00
256_A	360_G	0.967	1.00
35_I	87_A	0.967	1.00
517_L	554_Y	0.963	1.00
288_L	292_K	0.962	1.00
479_K	586_V	0.960	1.00
96_A	147_L	0.957	1.00
437_I	489_S	0.954	1.00
521_S	593_K	0.953	1.00
223_A	299_L	0.953	1.00
119_D	186_C	0.953	1.00
423_L	490_I	0.952	1.00
563_A	587_S	0.951	1.00
253_I	358_L	0.949	1.00
218_R	221_Q	0.948	1.00
349_V	353_K	0.948	1.00
144_N	154_W	0.946	1.00
506_A	515_V	0.944	1.00
555_A	591_E	0.940	1.00
580_D	583_K	0.938	1.00
314_S	317_A	0.937	1.00
78_K	111_I	0.936	1.00
175_T	180_A	0.935	1.00
26_G	30_P	0.934	1.00
503_L	515_V	0.932	1.00
82_R	175_T	0.929	1.00
114_L	175_T	0.926	1.00
437_I	487_V	0.925	1.00
23_H	47_I	0.923	1.00
234_V	294_A	0.923	1.00
19_Q	160_P	0.920	1.00
510_N	585_D	0.920	1.00
382_R	392_A	0.919	1.00
581_A	588_T	0.919	1.00
110_N	179_K	0.915	1.00
249_E	351_L	0.913	1.00
234_V	300_I	0.912	1.00
380_R	383_L	0.910	1.00
429_T	578_L	0.910	1.00
518_F	594_V	0.907	1.00
577_A	581_A	0.906	1.00
153_Y	166_S	0.904	1.00
70_A	113_V	0.903	1.00
496_F	589_L	0.903	1.00
223_A	226_L	0.902	1.00
455_V	458_T	0.900	1.00
272_E	275_F	0.900	1.00
447_L	490_I	0.899	1.00
51_L	58_L	0.899	1.00
514_N	582_K	0.898	1.00
494_G	523_F	0.897	1.00
251_V	275_F	0.897	1.00
339_D	342_Q	0.897	1.00
225_E	361_Y	0.896	1.00
214_Q	349_V	0.894	1.00
169_R	173_V	0.891	1.00
377_L	381_E	0.888	1.00
103_A	147_L	0.886	1.00
153_Y	173_V	0.883	1.00
513_I	587_S	0.880	1.00
379_E	382_R	0.879	1.00
335_A	342_Q	0.875	1.00
477_G	481_A	0.875	1.00
247_R	251_V	0.874	1.00
421_T	574_L	0.874	1.00
422_A	518_F	0.869	1.00
18_N	50_A	0.869	1.00
97_A	104_G	0.866	1.00
246_A	249_E	0.862	1.00
17_L	22_I	0.862	1.00
504_I	561_Y	0.860	1.00
153_Y	170_A	0.859	1.00
101_A	467_C	0.856	1.00
506_A	587_S	0.855	1.00
75_A	474_G	0.854	1.00
225_E	228_K	0.852	1.00
328_I	343_V	0.851	1.00
226_L	326_L	0.851	1.00
425_T	574_L	0.850	1.00
375_E	378_A	0.848	1.00
559_E	565_T	0.847	1.00
32_V	171_F	0.842	1.00
242_K	270_T	0.839	1.00
100_V	147_L	0.838	1.00
34_G	76_Y	0.837	1.00
49_Q	52_E	0.837	1.00
232_K	298_D	0.837	1.00
217_E	221_Q	0.835	1.00
152_R	183_A	0.835	1.00
144_N	156_R	0.834	1.00
508_Q	550_L	0.832	1.00
490_I	518_F	0.832	1.00
282_M	294_A	0.832	1.00
174_M	183_A	0.831	1.00
237_V	263_E	0.828	1.00
423_L	518_F	0.826	1.00
519_D	593_K	0.826	1.00
103_A	150_V	0.822	1.00
434_S	488_Y	0.821	1.00
26_G	29_E	0.819	1.00
427_N	451_W	0.818	1.00
90_T	117_P	0.817	1.00
222_G	341_F	0.817	1.00
274_D	432_E	0.815	1.00
273_A	278_N	0.813	1.00
160_P	164_M	0.812	1.00
429_T	582_K	0.812	1.00
46_G	193_G	0.810	1.00
235_I	303_I	0.809	1.00
573_E	577_A	0.808	1.00
299_L	324_K	0.807	1.00
514_N	585_D	0.807	1.00
77_S	113_V	0.805	1.00
257_Y	358_L	0.804	1.00
87_A	114_L	0.804	1.00
39_F	62_Q	0.802	1.00
79_Q	460_H	0.801	1.00
215_P	220_L	0.800	1.00
572_E	576_A	0.794	1.00
145_D	149_P	0.793	1.00
67_Q	98_N	0.793	1.00
187_I	192_E	0.790	1.00
228_K	356_G	0.789	1.00
565_T	591_E	0.789	1.00
220_L	353_K	0.789	1.00
553_D	567_R	0.788	1.00
507_I	587_S	0.787	1.00
488_Y	516_L	0.786	1.00
472_V	515_V	0.785	1.00
76_Y	82_R	0.784	1.00
237_V	261_L	0.784	1.00
30_P	175_T	0.782	1.00
553_D	559_E	0.782	1.00
521_S	596_P	0.778	1.00
239_G	266_A	0.778	1.00
153_Y	169_R	0.777	1.00
63_G	68_G	0.777	1.00
38_I	99_L	0.774	1.00
580_D	584_Q	0.772	1.00
223_A	350_T	0.771	1.00
443_L	495_S	0.769	1.00
423_L	451_W	0.769	1.00
476_L	511_K	0.768	1.00
417_L	571_V	0.767	1.00
433_D	455_V	0.767	1.00
33_E	76_Y	0.764	1.00
438_C	461_L	0.761	1.00
89_S	116_I	0.761	1.00
577_A	580_D	0.758	1.00
79_Q	481_A	0.757	1.00
71_H	467_C	0.757	1.00
233_P	259_I	0.755	1.00
35_I	89_S	0.754	1.00
312_T	315_K	0.753	1.00
104_G	150_V	0.753	1.00
49_Q	537_S	0.753	1.00
77_S	111_I	0.752	1.00
515_V	563_A	0.749	1.00
490_I	516_L	0.749	1.00
156_R	186_C	0.748	1.00
265_Q	448_Q	0.748	1.00
430_I	434_S	0.747	1.00
427_N	454_N	0.746	1.00
215_P	349_V	0.746	1.00
271_V	278_N	0.743	1.00
472_V	491_V	0.742	1.00
332_R	344_V	0.742	1.00
246_A	348_K	0.742	1.00
497_L	552_V	0.739	1.00
438_C	459_Y	0.739	1.00
117_P	186_C	0.738	1.00
227_I	257_Y	0.737	1.00
44_V	48_G	0.735	1.00
228_K	357_L	0.733	1.00
497_L	554_Y	0.732	1.00
27_K	87_A	0.730	1.00
44_V	89_S	0.730	1.00
417_L	570_T	0.728	1.00
70_A	115_L	0.728	1.00
36_F	72_A	0.726	1.00
489_S	495_S	0.726	1.00
568_A	590_I	0.725	1.00
235_I	261_L	0.724	1.00
439_S	471_E	0.723	1.00
153_Y	183_A	0.723	1.00
119_D	125_Q	0.723	1.00
475_T	513_I	0.719	1.00
516_L	574_L	0.717	1.00
59_K	483_P	0.717	1.00
350_T	353_K	0.716	1.00
152_R	173_V	0.714	1.00
496_F	554_Y	0.713	1.00
97_A	100_V	0.712	1.00
52_E	537_S	0.712	1.00
157_I	188_S	0.710	1.00
506_A	511_K	0.706	1.00
329_N	334_Q	0.704	1.00
352_G	355_H	0.703	1.00
47_I	192_E	0.701	1.00
437_I	460_H	0.699	1.00
111_I	470_Y	0.698	1.00
28_E	33_E	0.698	1.00
486_E	512_K	0.697	1.00
91_S	131_Q	0.697	1.00
219_E	223_A	0.695	0.99
272_E	454_N	0.695	0.99
376_W	379_E	0.695	0.99
122_A	188_S	0.695	0.99
241_A	270_T	0.694	0.99
435_V	485_R	0.694	0.99
106_A	113_V	0.694	0.99
219_E	343_V	0.693	0.99
233_P	299_L	0.692	0.99
352_G	356_G	0.691	0.99
33_E	57_H	0.691	0.99
263_E	273_A	0.689	0.99
98_N	101_A	0.688	0.99
512_K	587_S	0.688	0.99
90_T	96_A	0.688	0.99
497_L	500_H	0.687	0.99
422_A	516_L	0.686	0.99
563_A	586_V	0.684	0.99
19_Q	22_I	0.684	0.99
375_E	379_E	0.683	0.99
245_G	457_N	0.683	0.99
353_K	357_L	0.682	0.99
277_N	377_L	0.682	0.99
144_N	148_K	0.680	0.99
377_L	380_R	0.680	0.99
247_R	456_P	0.679	0.99
356_G	359_E	0.678	0.99
527_N	531_M	0.676	0.99
507_I	562_G	0.675	0.99
553_D	591_E	0.675	0.99
164_M	168_L	0.675	0.99
438_C	447_L	0.675	0.99
212_R	346_D	0.674	0.99
122_A	158_T	0.673	0.99
240_G	329_N	0.670	0.99
49_Q	53_Q	0.670	0.99
29_E	198_F	0.669	0.99
577_A	588_T	0.669	0.99
301_I	328_I	0.668	0.99
160_P	196_Y	0.668	0.99
335_A	339_D	0.667	0.99
514_N	586_V	0.667	0.99
64_K	508_Q	0.666	0.99
531_M	538_Y	0.665	0.99
75_A	477_G	0.665	0.99
302_G	325_F	0.664	0.99
269_S	273_A	0.663	0.99
152_R	177_P	0.663	0.99
169_R	172_E	0.662	0.99
244_S	346_D	0.661	0.99
507_I	550_L	0.661	0.99
21_Y	54_D	0.661	0.99
522_G	527_N	0.660	0.99
160_P	191_V	0.660	0.99
488_Y	514_N	0.660	0.99
381_E	391_E	0.658	0.99
380_R	384_S	0.657	0.99
249_E	253_I	0.654	0.99
22_I	25_D	0.654	0.99
236_L	302_G	0.652	0.99
434_S	485_R	0.652	0.99
254_S	257_Y	0.652	0.99
173_V	179_K	0.650	0.99
107_L	152_R	0.649	0.99
546_D	549_I	0.644	0.99
29_E	202_F	0.642	0.99
226_L	229_S	0.642	0.99
152_R	179_K	0.642	0.99
47_I	89_S	0.641	0.99
437_I	478_L	0.641	0.99
108_A	465_Y	0.641	0.99
527_N	548_Q	0.640	0.99
283_G	286_G	0.639	0.99
491_V	499_L	0.639	0.99
472_V	502_E	0.637	0.99
355_H	359_E	0.635	0.99
46_G	192_E	0.635	0.99
126_P	132_Q	0.635	0.99
44_V	118_A	0.634	0.99
552_V	560_G	0.634	0.99
433_D	486_E	0.632	0.99
460_H	470_Y	0.631	0.99
236_L	264_T	0.630	0.99
473_S	502_E	0.630	0.99
420_T	598_T	0.629	0.99
116_I	185_I	0.628	0.99
258_N	377_L	0.626	0.99
38_I	523_F	0.626	0.99
437_I	471_E	0.624	0.99
422_A	574_L	0.622	0.99
147_L	184_T	0.622	0.99
257_Y	277_N	0.621	0.99
256_A	358_L	0.620	0.99
119_D	156_R	0.619	0.99
566_Y	584_Q	0.618	0.99
99_L	117_P	0.617	0.99
17_L	21_Y	0.617	0.99
570_T	576_A	0.616	0.99
65_N	98_N	0.616	0.99
327_N	339_D	0.615	0.99
166_S	169_R	0.615	0.99
28_E	58_L	0.615	0.99
426_I	516_L	0.614	0.99
585_D	588_T	0.612	0.99
28_E	56_G	0.611	0.99
234_V	293_A	0.611	0.99
71_H	105_T	0.610	0.99
35_I	58_L	0.608	0.99
214_Q	217_E	0.608	0.99
443_L	518_F	0.608	0.99
122_A	191_V	0.608	0.99
476_L	505_T	0.607	0.99
112_P	174_M	0.602	0.99
155_D	183_A	0.601	0.99
415_T	570_T	0.600	0.99
130_L	466_S	0.599	0.99
236_L	305_T	0.599	0.99
40_G	91_S	0.598	0.98
279_L	290_A	0.598	0.98
475_T	487_V	0.597	0.98
497_L	501_S	0.596	0.98
220_L	354_L	0.595	0.98
268_K	453_S	0.593	0.98
491_V	515_V	0.592	0.98
83_R	86_Y	0.591	0.98
72_A	480_L	0.591	0.98
500_H	560_G	0.591	0.98
215_P	345_A	0.589	0.98
80_M	477_G	0.589	0.98
236_L	300_I	0.588	0.98
231_K	298_D	0.588	0.98
376_W	381_E	0.586	0.98
232_K	376_W	0.585	0.98
34_G	82_R	0.585	0.98
78_K	109_N	0.584	0.98
70_A	103_A	0.583	0.98
250_L	254_S	0.583	0.98
447_L	459_Y	0.583	0.98
64_K	504_I	0.581	0.98
266_A	463_Y	0.580	0.98
24_V	51_L	0.579	0.98
76_Y	80_M	0.576	0.98
172_E	177_P	0.574	0.98
580_D	588_T	0.573	0.98
251_V	455_V	0.572	0.98
76_Y	86_Y	0.572	0.98
334_Q	337_K	0.571	0.98
478_L	487_V	0.571	0.98
171_F	175_T	0.571	0.98
105_T	109_N	0.570	0.98
292_K	295_R	0.570	0.98
269_S	458_T	0.570	0.98
526_I	530_Q	0.570	0.98
228_K	231_K	0.570	0.98
435_V	460_H	0.567	0.98
421_T	575_K	0.567	0.98
122_A	159_R	0.566	0.98
251_V	254_S	0.565	0.98
99_L	102_A	0.565	0.98
527_N	596_P	0.565	0.98
190_D	194_E	0.564	0.98
568_A	576_A	0.564	0.98
472_V	506_A	0.564	0.98
114_L	185_I	0.563	0.98
212_R	216_S	0.563	0.98
347_A	352_G	0.562	0.98
170_A	185_I	0.561	0.98
531_M	536_G	0.561	0.98
578_L	582_K	0.559	0.98
552_V	557_V	0.559	0.98
258_N	276_A	0.558	0.98
162_Q	166_S	0.558	0.98
423_L	447_L	0.557	0.98
26_G	164_M	0.557	0.98
507_I	510_N	0.556	0.98
97_A	133_M	0.555	0.98
20_Q	27_K	0.554	0.98
241_A	351_L	0.554	0.98
252_A	356_G	0.554	0.98
74_M	474_G	0.554	0.98
331_S	334_Q	0.554	0.98
114_L	183_A	0.554	0.98
480_L	509_Y	0.554	0.98
291_N	295_R	0.553	0.98
79_Q	435_V	0.553	0.98
438_C	471_E	0.553	0.98
536_G	539_Y	0.552	0.97
415_T	571_V	0.551	0.97
118_A	192_E	0.550	0.97
416_E	595_L	0.550	0.97
514_N	584_Q	0.550	0.97
505_T	511_K	0.550	0.97
357_L	361_Y	0.549	0.97
468_M	526_I	0.549	0.97
246_A	347_A	0.549	0.97
220_L	343_V	0.548	0.97
496_F	515_V	0.546	0.97
107_L	181_G	0.545	0.97
350_T	354_L	0.545	0.97
430_I	451_W	0.545	0.97
49_Q	530_Q	0.545	0.97
504_I	552_V	0.544	0.97
83_R	88_V	0.544	0.97
204_V	207_V	0.543	0.97
157_I	185_I	0.542	0.97
439_S	489_S	0.542	0.97
107_L	151_S	0.542	0.97
67_Q	499_L	0.542	0.97
336_Y	342_Q	0.539	0.97
413_L	572_E	0.538	0.97
43_N	92_V	0.538	0.97
19_Q	26_G	0.537	0.97
491_V	495_S	0.537	0.97
313_S	316_T	0.536	0.97
87_A	171_F	0.536	0.97
263_E	268_K	0.536	0.97
566_Y	576_A	0.534	0.97
61_Y	505_T	0.534	0.97
553_D	560_G	0.533	0.97
503_L	506_A	0.533	0.97
71_H	102_A	0.532	0.97
442_S	525_C	0.532	0.97
438_C	441_G	0.532	0.97
539_Y	546_D	0.531	0.97
59_K	480_L	0.531	0.97
515_V	589_L	0.531	0.97
526_I	529_L	0.531	0.97
231_K	375_E	0.530	0.97
242_K	457_N	0.529	0.97
455_V	485_R	0.529	0.97
423_L	427_N	0.528	0.97
69_M	90_T	0.528	0.97
172_E	175_T	0.527	0.97
105_T	467_C	0.527	0.97
148_K	154_W	0.526	0.97
559_E	566_Y	0.526	0.97
39_F	48_G	0.525	0.97
116_I	167_L	0.524	0.97
419_Q	446_D	0.524	0.97
357_L	360_G	0.523	0.97
216_S	349_V	0.523	0.97
407_N	410_A	0.522	0.96
117_P	135_Q	0.522	0.96
224_A	253_I	0.521	0.96
223_A	301_I	0.521	0.96
472_V	500_H	0.521	0.96
510_N	586_V	0.521	0.96
248_D	255_E	0.521	0.96
564_K	585_D	0.521	0.96
239_G	306_R	0.521	0.96
430_I	582_K	0.521	0.96
273_A	452_H	0.520	0.96
519_D	554_Y	0.520	0.96
160_P	163_L	0.518	0.96
242_K	247_R	0.517	0.96
503_L	507_I	0.517	0.96
514_N	578_L	0.517	0.96
161_E	197_D	0.516	0.96
500_H	503_L	0.516	0.96
473_S	499_L	0.515	0.96
22_I	26_G	0.514	0.96
326_L	341_F	0.513	0.96
179_K	331_S	0.513	0.96
223_A	354_L	0.512	0.96
91_S	96_A	0.512	0.96
258_N	360_G	0.511	0.96
38_I	498_M	0.511	0.96
77_S	83_R	0.510	0.96
263_E	270_T	0.510	0.96
382_R	391_E	0.509	0.96
168_L	172_E	0.509	0.96
38_I	63_G	0.509	0.96
87_A	116_I	0.508	0.96
324_K	341_F	0.508	0.96
215_P	343_V	0.508	0.96
65_N	101_A	0.508	0.96
571_V	575_K	0.507	0.96
442_S	524_G	0.507	0.96
436_I	459_Y	0.506	0.96
384_S	391_E	0.506	0.96
409_Y	413_L	0.506	0.96
358_L	361_Y	0.505	0.96
45_L	526_I	0.504	0.96
227_I	259_I	0.504	0.96
437_I	474_G	0.503	0.96
497_L	504_I	0.502	0.96
36_F	480_L	0.501	0.96
552_V	561_Y	0.501	0.96
22_I	198_F	0.500	0.96
517_L	591_E	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ozhA	4	0.8571	100	0.218	Contact Map
1t9bA	2	0.9042	100	0.22	Contact Map
4rjjA	5	0.8666	100	0.222	Contact Map
1ybhA	4	0.898	100	0.222	Contact Map
2panA	3	0.9152	100	0.224	Contact Map
2ihtA	4	0.8477	100	0.225	Contact Map
3eyaA	5	0.8257	100	0.231	Contact Map
2uz1A	4	0.8603	100	0.232	Contact Map
2x7jA	4	0.8838	100	0.233	Contact Map
2pgnA	4	0.8854	100	0.234	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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